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Human Disease Gene Search
NKX2-5 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol NKX2-5 Official Full Name NK2 homeobox 5 CGNC ID 2083 also known as CNKX-2.5, NKX-2.5, homeobox protein Nkx-2.5|NK2 transcription factor related, locus 5|homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, Homeobox protein NK-2 homolog E, cNKX-2.5 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id NKX2-5.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATAGGCGGACAAGAAAGAACTGTG
Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGAAGGTGGGGAGAGGAGAATGAG
cDNA Template Length 764 Forward cDNA Template Probe show TNCCCTGGCACAAGAGTCTGGAGCAGGGAGAAGAGAGAGCTGGAGGATCCCGAGCGGCCCAGACAGAGGAAGAGGAGGA
Comments No expression detected at or before stage 5.
Entry 2 GEISHA Id NKX2-5.UAlinear Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAAT
Comments No expression detected at or before stage 4.
Entry 3 GEISHA Id Nkx2.5.Lincoln.2004 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Lincoln J, Alfieri CM, Yutzey KE. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn. 2004 Jun;230(2):239-50. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205164).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
Heart 31-36 stage 36
Heart
Entry 4 Entry 5 GEISHA Id NKX2-5.Liberatore.2000 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Liberatore CM, Searcy-Schrick RD, Yutzey KE. Ventricular expression of tbx5 inhibits normal heart chamber development. Dev Biol. 2000 Jul 1;223(1):169-80. Copyright Reprinted with permission from Elsevier.
Copyright © date Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205164).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 8
stage 11
Heart 13-14 stage 14
Entry 6 GEISHA Id NKX2-5.Theodosiou.2005 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Theodosiou NA, Tabin CJ (2005). Sox9 and Nkx2.5 determine the pyloric sphincter epithelium under the control of BMP signaling. Dev Biol. 2005 Mar 15;279(2):481-90. Copyright Copyright © 2004 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205164).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
stage 23
Gizzard 25-30 stage 25
stage 26
stage 26
Gizzard 31-32 stage 32
Entry 7 GEISHA Id NKX2-5.Ward.2005 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Ward C, Stadt H, Hutson M, Kirby ML. (2005) Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia. Dev Biol. 2005 Aug 1;284(1):72-83. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205164).
Entry 8 GEISHA Id NKX2-5.Waldo.2005 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Waldo KL, Hutson MR, Ward CC, Zdanowicz M, Stadt HA, Kumiski D, Abu-Issa R, Kirby ML. (2005) Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. Dev Biol. 2005 May 1;281(1):78-90. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205164).
Entry 9 GEISHA Id NKX2.5.Smith.2000 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM. Evolutionary relationships between the amphibian, avian, and mammalian stomachs. Evol Dev. 2000 Nov-Dec;2(6):348-59. Copyright Copyright © 2000-2011 by John Wiley & Sons, Inc., or related companies. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to suntheisze probe, the sequence below was obtained from NCBI (acc. # NM_205164)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Splanchnic Mesoderm
Entry 10 GEISHA Id NKX2.5.López-Sánchez.2010 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation López-Sánchez C, Bártulos O, Martínez-Campos E, Gañán C, Valenciano AI, García-Martínez V, De Pablo F, Hernández-Sánchez C. Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation. Cardiovasc Res. 2010 Oct 1;88(1):111-20. Epub 2010 Jun 3.
Copyright © The Author 2010. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205164).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-11 stage 11
stage 11
Heart
Entry 11 GEISHA Id NKX2.5.Cui.2009 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Cui C, Cheuvront TJ, Lansford RD, Moreno-Rodriguez RA, Schultheiss TM, Rongish BJ. Dynamic positional fate map of the primary heart-forming region. Dev Biol. 2009 Aug 15;332(2):212-22. Epub 2009 Jun 2. Copyright Copyright © 2009 Published by Elsevier Inc Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205164.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 5
stage 5
Neural Crest Neural Plate/Tube
Entry 12 GEISHA Id NKX2.5.Nathan.2008 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Nathan E, Monovich A, Tirosh-Finkel L, Harrelson Z, Rousso T, Rinon A, Harel I, Evans SM, Tzahor E. The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development. Development. 2008 Feb;135(4):647-57. doi: 10.1242/dev.007989. Epub 2008 Jan 9. Copyright Copyright held by the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205164.1
Entry 13 GEISHA Id NKX2.5.Litsiou.2005 Data Source Publication Complete cDNA Template Probe show GCAGCGCTCCGGGCCGCCCGCTCCTCGCCTCCCCTTCCATGACCCCGGGCTGCGGCCGCTGCCCCGCTCTCCTCCGCAA
Citation Litsiou A, Hanson S, Streit A. A balance of FGF, BMP and WNT signalling positions the future placode territory in the head. Development. 2005 Sep;132(18):4051-62. Epub 2005 Aug 10 Copyright Authors hold the copyright. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205164.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 6
stage 6
Heart Tube
Entry 14 Entry 15 GEISHA Id NKX2.5.Anderson.2019 Data Source Publication Complete cDNA Template Probe show CCCTTATGGTCCGCTCCTACCTGCGCGCAGCGCACAGGGCCGCCTCCCTCGGGATGCTATGTGCCCCCCCCGGCAGCCC
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205164)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
Heart all
Data from NCBI Unigene EST ProfileGga.638
Mouse Frog Fruit Fly Zebra Finch Zebrafish
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