GEISHA - A Chicken Embryo Gene Expression Database
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NKX2-2
NK2 homeobox 2

Gene
Official SymbolNKX2-2
Official Full NameNK2 homeobox 2
CGNC ID25123
also known asNKX-2.2, homeobox protein Nkx-2.2|NK2 transcription factor related, locus 2
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_001277718
PolypeptideNP_001264647
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.435
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human4821ENSG00000125820MIM:604612
Mouse18088ENSMUSG00000027434All phenotypic alleles (3):Targeted, knock-out(1) Targeted, other(2) MGI:97347
Xenopus100038077, 373624482218
Zebrafish30697, 493627ENSDARG00000053298, ENSDARG00000052550ZDB-GENE-980526-403, ZDB-GENE-050217-3ZFIN:ZDB-GENE-980526-403, ZFIN:ZDB-GENE-050217-3
Gene Ontology
Molecular Function
Biological Process
Cellular Component
Links to other databases
Entrez Gene428549
Ensembl Gene
KEGGgga:428549

Entry 1

GEISHA IdNKX2-2.Gimeno.2007Data SourcePublication
Complete cDNA Template Probeshow
NNNCTGACGCCCACCCAGGTGAATCGTGAATGCCAGAACCACCGCTACAAGATGAAGCGGGCCCGGCTTATAGAAGGTA
TGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGGCAAGCCCTGCCACACGCT
CAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGCGCCCAGTCCCTCCAGCAT
ATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACTTGGTACAGGCGCAGCAAT
GGACTTGGTGA
CitationGimeno L, Martinez S. Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh. Dev Dyn. 2007 Aug;236(8):2285-97.
CopyrightCopyright © 2007 Wiley-Liss, Inc.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_426104).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19-20
stage 20
stage 20
stage 20
Forebrain
Hindbrain
Midbrain
Rhombomeres
 

Entry 2

GEISHA IdNKX2-2.Pedersen.2005Data SourcePublication
Complete cDNA Template Probeshow
NNNCTGACGCCCACCCAGGTGAATCGTGAATGCCAGAACCACCGCTACAAGATGAAGCGGGCCCGGCTTATAGAAGGTA
TGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGGCAAGCCCTGCCACACGCT
CAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGCGCCCAGTCCCTCCAGCAT
ATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACTTGGTACAGGCGCAGCAAT
GGACTTGGTGA
CitationPedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P; Beta Cell Biology Consortium. Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol. 2005 Dec 15;288(2):487-501.
CopyrightCopyright © 2005 Elsevier Inc. All rights reserved.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_426104).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 11
stage 11
Anterior Intestinal Portal
Endoderm
Neural Plate/Tube
Pancreas
Chicken embryos with antisense probes recognizing Nkx6.1, Nkx6.2, Nkx6.3, Nkx2.2, and Pdx1.
Prospective Pancreatic Endoderm
13-17
stage 15
stage 15
stage 17
Endoderm
Head Process
Neural Plate/Tube
Pancreas
Chicken embryos with antisense probes recognizing Nkx6.1, Nkx6.2, Nkx6.3, Nkx2.2, and Pdx1.
Pancreatic Endoderm

Entry 3

GEISHA IdNKX2-2.Agarwala.2005Data SourcePublication
Complete cDNA Template Probeshow
CTGACGCCCACCCAGGTGAATCGTGAATGCCAGAACCACCGCTACAAGATGAAGCGGGCCCGGCTTATAGAAGGTATGG
AAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGGCAAGCCCTGCCACACGCTCAA
AGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGCGCCCAGTCCCTCCAGCATATG
CAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACTTGGTACAGGCGCAGCAATGGA
CTTGGTGA
CitationAgarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21.
CopyrightCopyright © 2005 Elsevier Inc. All rights reserved.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_426104).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
25-26
stage 26
Spinal Cord
Lateral Floor Plate

Entry 4

GEISHA IdNkx2.2.Garcia-Lopez.2009Data SourcePublication
Complete cDNA Template Probeshow
NNNCTGACGCCCACCCAGGTGAATCGTGAATGCCAGAACCACCGCTACAAGATGAAGCGGGCCCGGCTTATAGAAGGTA
TGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGGCAAGCCCTGCCACACGCT
CAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGCGCCCAGTCCCTCCAGCAT
ATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACTTGGTACAGGCGCAGCAAT
GGACTTGGTGA
CitationGarcía-López R, Soula C, Martínez S. Expression analysis of Sulf1 in the chick forebrain at early and late stages of development. Dev Dyn. 2009 Sep;238(9):2418-29.
CopyrightCopyright © 2009 John Wiley & Sons, Inc. All Rights Reserved.
Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_426104.2).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
25-26
stage 26
Neural Plate/Tube
 

Entry 5

GEISHA IdNKX2.2.Davey.2006Data SourcePublication
Complete cDNA Template Probeshow
ATGTCTCTGACCAACACAAAGACGGGTTTTTCCGTCAAGGACATCCTGGACCTCCCCGACACCAACGACGAGGACGGCT
CCGCCGCGGAAGGGGGAGAGGAGGAGAGCGAAGCGCCGGAGCCTCCCAAGAAAGCGGCGGTGTTGGGCCAAACCCCCTT
GGACGCTGTTCAGACGCTGCCTTTGAAGCCCCCTTTCTATGATAATAGCGATAATCCCTACACGCGCTGGCTGGCGAGC
GCCGAGGGCATCCAGTACTCCCTGCACGGACTGGCGGCCGGAGCAGGCGGCCCGGAGGCCGGCTCCAAGTCCCCGGAGC
CGTCGGCCGACGAATCGCCCGACAACGAGAAGGAGGCGGCGGGCGGAGGGGACGCGGGGAAGAAGAGGAAGAGGAGGGT
GCTCTTCTCCAAGGCGCAGACCTACGAGCTGGAGCGGCGGTTCCGGCAGCAGCGGTACCTGTCGGCGCCGGAGAGGGAG
CACCTGGCCAGCCTGATCCGCCTGACGCCCACCCAGGTGAAGATCTGGTTCCAGAACCACCGCTACAAGATGAAGCGGG
CCCGGGCCGAGAAAGGTATGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGG
CAAGCCCTGCCACACGCTCAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGC
GCCCAGTCCCTCCAGCATATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACT
TGGTACAGGCGCAGCAATGGACTTGGTGAGCGCGGGGTGAGCGCACGCACACGGCCCTCGCGCGCACCCACACACGCAG
AGAGGAGGAAAAAATAACGATAAAGAGACACGAAAA
CitationDavey MG, Paton IR, Yin Y, Schmidt M, Bangs FK, Morrice DR, Smith TG, Buxton P, Stamataki D, Tanaka M, Münsterberg AE, Briscoe J, Tickle C, Burt DW. The chicken talpid3 gene encodesa novel protein essentialfor Hedgehog signaling. Genes Dev. 2006 May 15; 20(10): 1365–1377.
CopyrightCopyright © 2006, Cold Spring Harbor Laboratory Press
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_003643807.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19-20
stage 20
stage 20
Spinal Cord
 

Entry 6

GEISHA IdNKX2.2.Ferran.2007Data SourcePublication
Complete cDNA Template Probeshow
ATGTCTCTGACCAACACAAAGACGGGTTTTTCCGTCAAGGACATCCTGGACCTCCCCGACACCAACGACGAGGACGGCT
CCGCCGCGGAAGGGGGAGAGGAGGAGAGCGAAGCGCCGGAGCCTCCCAAGAAAGCGGCGGTGTTGGGCCAAACCCCCTT
GGACGCTGTTCAGACGCTGCCTTTGAAGCCCCCTTTCTATGATAATAGCGATAATCCCTACACGCGCTGGCTGGCGAGC
GCCGAGGGCATCCAGTACTCCCTGCACGGACTGGCGGCCGGAGCAGGCGGCCCGGAGGCCGGCTCCAAGTCCCCGGAGC
CGTCGGCCGACGAATCGCCCGACAACGAGAAGGAGGCGGCGGGCGGAGGGGACGCGGGGAAGAAGAGGAAGAGGAGGGT
GCTCTTCTCCAAGGCGCAGACCTACGAGCTGGAGCGGCGGTTCCGGCAGCAGCGGTACCTGTCGGCGCCGGAGAGGGAG
CACCTGGCCAGCCTGATCCGCCTGACGCCCACCCAGGTGAAGATCTGGTTCCAGAACCACCGCTACAAGATGAAGCGGG
CCCGGGCCGAGAAAGGTATGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGG
CAAGCCCTGCCACACGCTCAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGC
GCCCAGTCCCTCCAGCATATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACT
TGGTACAGGCGCAGCAATGGACTTGGTGAGCGCGGGGTGAGCGCACGCACACGGCCCTCGCGCGCACCCACACACGCAG
AGAGGAGGAAAAAATAACGATAAAGAGACACGAAAA
CitationFerran JL, Sánchez-Arrones L, Sandoval JE, Puelles L. A model of early molecular regionalization in the chicken embryonic pretectum. J Comp Neurol. 2007 Dec 1;505(4):379-403.
CopyrightCopyright © 1999–2012 John Wiley & Sons, Inc. All Rights Reserved.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # XM_003643807.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 18
stage 18
Diencephalon
ABB, alar basal boundary

Entry 7

GEISHA IdNKX2.2.GarciaCampmany.2007Data SourcePublication
Complete cDNA Template Probeshow
ATGTCTCTGACCAACACAAAGACGGGTTTTTCCGTCAAGGACATCCTGGACCTCCCCGACACCAACGACGAGGACGGCT
CCGCCGCGGAAGGGGGAGAGGAGGAGAGCGAAGCGCCGGAGCCTCCCAAGAAAGCGGCGGTGTTGGGCCAAACCCCCTT
GGACGCTGTTCAGACGCTGCCTTTGAAGCCCCCTTTCTATGATAATAGCGATAATCCCTACACGCGCTGGCTGGCGAGC
GCCGAGGGCATCCAGTACTCCCTGCACGGACTGGCGGCCGGAGCAGGCGGCCCGGAGGCCGGCTCCAAGTCCCCGGAGC
CGTCGGCCGACGAATCGCCCGACAACGAGAAGGAGGCGGCGGGCGGAGGGGACGCGGGGAAGAAGAGGAAGAGGAGGGT
GCTCTTCTCCAAGGCGCAGACCTACGAGCTGGAGCGGCGGTTCCGGCAGCAGCGGTACCTGTCGGCGCCGGAGAGGGAG
CACCTGGCCAGCCTGATCCGCCTGACGCCCACCCAGGTGAAGATCTGGTTCCAGAACCACCGCTACAAGATGAAGCGGG
CCCGGGCCGAGAAAGGTATGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGG
CAAGCCCTGCCACACGCTCAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGC
GCCCAGTCCCTCCAGCATATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACT
TGGTACAGGCGCAGCAATGGACTTGGTGAGCGCGGGGTGAGCGCACGCACACGGCCCTCGCGCGCACCCACACACGCAG
AGAGGAGGAAAAAATAACGATAAAGAGACACGAAAA
CitationGarcía-Campmany L, Martí E. The TGFbeta intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord. Development. 2007 Jan;134(1):65-75. Epub 2006 Nov 30.
CopyrightCopyright by the authors. Published by the Company of Biologists Ltd.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_001277718.1
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 16
stage 16
stage 18
stage 18
Neural Plate/Tube
Spinal Cord
 
19-20
stage 20
stage 20
Spinal Cord
 

Entry 8

GEISHA IdNKX2.2.Zhou.2001Data SourcePublication
Complete cDNA Template Probeshow
ATGTCTCTGACCAACACAAAGACGGGTTTTTCCGTCAAGGACATCCTGGACCTCCCCGACACCAACGACGAGGACGGCT
CCGCCGCGGAAGGGGGAGAGGAGGAGAGCGAAGCGCCGGAGCCTCCCAAGAAAGCGGCGGTGTTGGGCCAAACCCCCTT
GGACGCTGTTCAGACGCTGCCTTTGAAGCCCCCTTTCTATGATAATAGCGATAATCCCTACACGCGCTGGCTGGCGAGC
GCCGAGGGCATCCAGTACTCCCTGCACGGACTGGCGGCCGGAGCAGGCGGCCCGGAGGCCGGCTCCAAGTCCCCGGAGC
CGTCGGCCGACGAATCGCCCGACAACGAGAAGGAGGCGGCGGGCGGAGGGGACGCGGGGAAGAAGAGGAAGAGGAGGGT
GCTCTTCTCCAAGGCGCAGACCTACGAGCTGGAGCGGCGGTTCCGGCAGCAGCGGTACCTGTCGGCGCCGGAGAGGGAG
CACCTGGCCAGCCTGATCCGCCTGACGCCCACCCAGGTGAAGATCTGGTTCCAGAACCACCGCTACAAGATGAAGCGGG
CCCGGGCCGAGAAAGGTATGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGG
CAAGCCCTGCCACACGCTCAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGC
GCCCAGTCCCTCCAGCATATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACT
TGGTACAGGCGCAGCAATGGACTTGGTGAGCGCGGGGTGAGCGCACGCACACGGCCCTCGCGCGCACCCACACACGCAG
AGAGGAGGAAAAAATAACGATAAAGAGACACGAAAA
CitationZhou Q, Choi G, Anderson DJ. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron. 2001 Sep 13;31(5):791-807
CopyrightCopyright 2001 by Cell Press
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_001277718.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
25-30
stage 28
Spinal Cord
 
31-36
stage 31
stage 34
stage 36
Spinal Cord
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.435

Mouse

EmageMGI:97347
EurexpressMGI:97347
MGI GXDMGI:97347

Frog

Xenbase482218

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-980526-403, ZDB-GENE-050217-3
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