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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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NKX6-2
NK6 homeobox 2

Gene

Official Symbol	NKX6-2
Official Full Name	NK6 homeobox 2
CGNC ID	7982
also known as	NKX-6.2, homeobox protein Nkx-6.2\|NK6 transcription factor related, locus 2\|locus 2, NKX6.2
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001199548
Polypeptide	NP_001186477
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.2725

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	84504			MIM:605955
Mouse	14912	ENSMUSG00000041309	All phenotypic alleles (6):Targeted, knock-out(2) Targeted, other(4)	MGI:1352738
Xenopus	100038084, 779266			484526
Zebrafish	565782	ENSDARG00000044075	ZDB-GENE-070626-1	ZFIN:ZDB-GENE-070626-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395591
Ensembl Gene	ENSGALG00000010500
KEGG	gga:395591

Entry 1

GEISHA Id	NKX6-2.Pedersen.2005	Data Source	Publication
Complete cDNA Template Probe	show ATGTTAGCGGTGGGGCAGATGGATGCTAACCGGCAGAGTGCGTTCGTGCTGGGCAGCACGCCGCTGGCCGCGCTGCACA ACATGGCCGAGATGAAGAGCTCTCTCTTCCCCTACGCCCTGCAGAACCCCTCCAGCTTCAAGGCGCCGGCCCTGGGCGG CCTCAACACGCAGTTGCCCCTGGGGACGCCGCACGGCATCAGCGACATCCTGGGGCGGCCCGTGGGCGCCGCCGGCAAC CTGCTGGGCGGGCTGCCCCGCATCAACGGCCTGGCCGCCTCGGCCGGCGTGTACTTCGGCCCCGCCGCCGTATCCCGGT ACCCGAAGCCGCTGGCGGAGCTGCCGGGGCGGCCGCCTATCTTCTGGCCGGGAGTGGTACAGGGCTCTCCGTGGCGGGA CCCGCGCCTCACCTGTCCCGCTCAGACGGGGATGGTTTTGGACAAGGACGGGAAGAAGAAGCACTCGCGCCCGACTTTC TCGGGGCAGCAGATTTTTGCTTTGGAGAAAACCTTCGAGCAGACGAAGTACCTGGCAGGGCCCGAGCGAGCGCGGCTTG CCTATTCGCTGGGGATGACAGAGAGCCAGGTGAAGGTGTGGTTCCAGAACAGACGGACCAAATGGCGGAAGCGGCACGC GGCTGAGATGGCCTCGGCGAAGAAGAAGCACGACTCGGAGACGGAGAAGCTGAAGGAGAGCTCGGACAATGAGGATGAT GACGAATACAACAAACCCCTGGACCCCAACTCAGATGACGAGAAAATCACGAGGCTATTGAAAAAGCACAAATCCACGA ACCTCGCCCTCGTCAGCCCCTGCAGCACCAGCTCGGACACGTTGTGAGCGGTGCGCCTGGATGTCGAAGTGGTGTGTTG TACAGCCCGAGATGTATGTGAAATGTATATATTTTTTACAGAATAAGTTATGAAATTATTTTCTTTCTCATCGATGTAA ATTTCGGAGGAATCTTTCCGACTTCTTGGTTTTCCTTTCATGTCCCTTTCAGGTTCGCTCCTCTCTCTTTCAGCCAATT CCTGCTCCTAACAATCAGCGTTTGTCACCGTTTTGTATGGAGCACAAAACCCCAGCGCGGCCACTTTGTACATAGTGAA CTTCAGATTTTGTGATGTATATTTCTAGTGTAAAAACAGCGTTTTCTTTCACTCCTTCCCTCTGCTCAGGGGTTTGGCG GTTTGATTTCTTCTGCCTCCGGATTTTATGCTTAATAATATCAAAAGAGGGGAAAAAAAAACGCAAGAGAAAAAAAAGG ACACTTGATTTTAAATTGGATTAATACTGTCGTCTCCACACGGGTTGGAAAGACTTCGTATACATCAATAAATTATTTA ACACGCTTTGCCTTCA
Citation	Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P; Beta Cell Biology Consortium. Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol. 2005 Dec 15;288(2):487-501.
Copyright	Copyright © 2005 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_421832).

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 10

stage 11

Endoderm
Neural Plate/Tube

Chicken embryos with antisense probes recognizing Nkx6.1, Nkx6.2, Nkx6.3, Nkx2.2, and Pdx1.
Prospective Pancreatic Endoderm

13-17

stage 15

stage 17

Endoderm
Neural Plate/Tube
Pancreas

Chicken embryos with antisense probes recognizing Nkx6.1, Nkx6.2, Nkx6.3, Nkx2.2, and Pdx1.
Pancreatic Buds
Pancreatic Primordia

Entry 2

GEISHA Id	NKX6.2.Paxton.2010	Data Source	Publication
Complete cDNA Template Probe	show TCGGACAATGAGGATGATGACGAATACAACAAACCCCTGGACCCCAACTCAGATGACGAGAAAATCACGAGGCTATTGA AAAAGCACAAATCCACGAACCTCGCCCTCGTCAGCCCCTGCAGCACCAGCTCGGACACGTTGTGAGCGGTGCGCCTGGA TGTCGAAGTGGTGTGTTGTACAGCCCGAGATGTATGTGAAATGTATATATTTTTTACAGAATAAGTTATGAAATTATTT TCTTTCTCATCGATGTAAATTTCGGAGGAATCTTTCCGACTTCTTGGTTTTCCTTTCATGTCCCTTTCAGGTTCGCTCC TCTCTCTTTCAGCCAATTCCTGCTCCTAACAATCAGCGTTTGTCACCGTTTTGTATGGAGCACAAAACCCCAGCGCGGC CACTTTGTACATAGTGAACTTCAGATTTTGTGATGTATATTTCTAGTGTAAAAACAGCGTTTTCTTTCACTCCTTCCCT CTGCTCAGGGGTTTGGCGGTTTGATTTCTTCTGCCTCCGGATTTTATGCTTAATAATATCAAAAGAGGGGAAAAAAAAA CGCAAGAGAAAAAAAAGGACACTTGATTTTAAATTGGATTAATACTGTCGTCTCCACACGGGTTGGAAAGACTT
Citation	Paxton CN, Bleyl SB, Chapman SC, Schoenwolf GC. Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns. 2010 Jan;10(1):31-43. Epub 2009 Nov 11.
Copyright	2009 Elsevier B.V. All rights reserved.
Comments	The cDNA template used to generate the probe was obtained by PCR as described 5-tcggacaatgaggatgatga-3; 5-aagtctttccaagcccgtgtg-3

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 5

Epiblast

7-12

stage 7

stage 9

stage 11

Hindbrain
Midbrain
Neural Plate/Tube
Spinal Cord

13-18

stage 15

stage 18

Hindbrain
Isthmus/MHB
Midbrain
Neural Plate/Tube
Spinal Cord

Entry 3

GEISHA Id	NKX6-2.Trevers.2023	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show GGCCCCGGACGCGCGGGCGAAGGCGCGGAGCTGAGTGGTGCGGCGCCTACTGGAGCCCTGCGCGGCGTAGGGCCGCAGG CAACCGGGACGTGGCGCGCTCCGTGCACCGCTCTGGTGGTGCCGCTTCTCTCCTCCCGCCGCGCCGTCGGAGCGCGTCT CCGAGAACGGAGCGGGTGGAGCGGTGCCGTGCCGAGCCGAGGTTCTTCCGCTCCGAGCAAACTTTGCCGGCGGCTGCTG CCCGCGACCCACGAACGGAGAGAGGGCTGCGCCGGCGCTCCTCGCGTGGGGCCGTACCGCGAGCTTCGCCCCACTTGGA GCAGGACCGGCGTCCGTGGATGACCGCCAATGTTAGCGGTGGGGCAGATGGATGCTAACCGGCAGAGTGCGTTCGTGCT GGGCAGCACGCCGCTGGCCGCGCTGCACAACATGGCCGAGATGAAGAGCTCTCTCTTCCCCTACGCCCTGCAGAACCCC TCCAGCTTCAAGGCGCCGGCCCTGGGCGGCCTCAACACGCAGTTGCCCCTGGGGACGCCGCACGGCATCAGCGACATCC TGGGGCGGCCCGTGGGCGCCGCCGGCAACCTGCTGGGCGGGCTGCCCCGCATCAACGGCCTGGCCGCCTCGGCCGGCGT GTACTTCGGCCCCGCCGCCGTATCCCGGTACCCGAAGCCGCTGGCGGAGCTGCCGGGGCGGCCGCCTATCTTCTGGCCG GGAGTGGTACAGGGCTCTCCGTGGCGGGACCCGCGCCTCACCTGTCCCGCTCAGACGGGGATGGTTTTGGACAAGGACG GGAAGAAGAAGCACTCGCGCCCGACTTTCTCGGGGCAGCAGATTTTTGCTTTGGAGAAAACCTTCGAGCAGACGAAGTA CCTGGCAGGGCCCGAGCGAGCGCGGCTTGCCTATTCGCTGGGGATGACAGAGAGCCAGGTGAAGGTGTGGTTCCAGAAC AGACGGACCAAATGGCGGAAGCGGCACGCGGCTGAGATGGCCTCGGCGAAGAAGAAGCACGACTCGGAGACGGAGAAGC TGAAGGAGAGCTCGGACAATGAGGATGATGACGAATACAACAAACCCCTGGACCCCAACTCAGATGACGAGAAAATCAC GAGGCTATTGAAAAAGCACAAATCCACGAACCTCGCCCTCGTCAGCCCCTGCAGCACCAGCTCGGACACGTTGTGAGCG GTGCGCCTGGATGTCGAAGTGGTGTGTTGTACAGCCCGAGATGTATGTGAAATGTATATATTTTTTACAGAATAAGTTA TGAAATTATTTTCTTTCTCATCGATGTAAATTTCGGAGGAATCTTTCCGACTTCTTGGTTTTCCTTTCATGTCCCTTTC AGGTTCGCTCCTCTCTCTTTCAGCCAATTCCTGCTCCTAACAATCAGCGTTTGTCACCGTTTTGTATGGAGCACAAAAC CCCAGCGCGGCCACTTTGTACATAGTGAACTTCAGATTTTGTGATGTATATTTCTAGTGTAAAAACAGCGTTTTCTTTC ACTCCTTCCCTCTGCTCAGGGGTTTGGCGGTTTGATTTCTTCTGCCTCCGGATTTTATGCTTAATAATATCAAAAGAGG GGAAAAAAAAACGCAAGAGAAAAAAAAGGACACTTGATTTTAAATTGGATTAATACTGTCGTCTCCACACGGGTTGGAA AGACTTCGTATACATCAATAAATTATTTAACACGCTTTGCCTTCA
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001199548).