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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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NKX2-6
NK2 homeobox 6

The human orthologue of this gene is associated
with the following human disease:

Persistent truncus arteriosus

Gene

Official Symbol	NKX2-6
Official Full Name	NK2 homeobox 6
CGNC ID	49622
also known as	NKX2.8, homeobox protein Nkx-2.6\|NK2 transcription factor related, locus 6\|homeobox protein Nkx-2.8
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_205137
Polypeptide	NP_990468
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.610

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	137814	ENSG00000180053	MIM:217095	MIM:611770
Mouse	18092	ENSMUSG00000044186	All phenotypic alleles (3):Targeted, knock-out(1) Targeted, other(2)	MGI:97351
Xenopus	100038094, 373736			486950
Zebrafish	30694	ENSDARG00000021232	ZDB-GENE-990415-179	ZFIN:ZDB-GENE-990415-179

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	396037
Ensembl Gene
KEGG	gga:396037

Entry 1

GEISHA Id	NKX2.6.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	TGCCACCACCCCAAGCAAC
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGTCCGCAGCACCAGAAGTCC	cDNA Template Length
Forward cDNA Template Probe	show AACTCCCTTTCTTGGGCTGGTTGGTGAGGTTGGACGCACCACCTGGCTGTCCATTACGACTCCGGATGCCCCCATCCCT TTCCTGGGCCACATCTCAACTGGTGCTGAGCCCAAGCTCATGGTGTGAGCACCCCAGTATATCCCACCCCATAGCTCAC CCCGTAGGCACTGTAGTAGGTGCTATAGGAGTAGGGGCTGACGGTGATCCCATAAGGAGCCAGGTGGGGTTGGGACCCC TCAAAGCAAGGCTTGCCATCTCTGACCAGCACCGGAACAGCCACTCTACGTGGTGGCAGTGGGTAGGTGGCCATCTCCA GGGATCTATCCTGCCTCTGCCTCTTGCATTTGTAGCGCCGGTTCTGGAACCAGATTTTCACCTGGGTGGAGGTGAGCTG GAGCACGTTGGCCAGGTGTTCCCTTTCCAGTGCAGAGAGGTATTTCTGCTGCTTGAATCGCCGCTCCAACTCCAACACC TGAGTTTGGGAGAACAAAACGCGGGGTTTGCGCCGCTGCGGTTGCTTGGGGTGGTGGCAANA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 6

Unlabeled

Stages 5 & 6.

7-12

stage 7

stage 8

stage 9

stage 10

Anterior Intestinal Portal
Anterior/Second Heart Field
Extraembryonic Mesoderm
Heart Tube
Lateral Plate Mesoderm

13-18

stage 13

stage 14

stage 16

stage 18

Anterior/Second Heart Field
Foregut
Heart
Heart Tube
Outflow Tract
Pharyngeal Arches and Clefts
Pharynx
Sinus Venosus
Spinal Cord

19-24

stage 20

stage 24

Anterior/Second Heart Field
Eye
Head Mesenchyme
Outflow Tract
Pharyngeal Arches and Clefts
Trunk Mesenchyme

stage 25

Anterior/Second Heart Field
Eye
Forebrain
Head Mesenchyme
Outflow Tract
Trunk Mesenchyme

Entry 2

GEISHA Id	NKx2–8.Brand.1997	Data Source	Publication
Complete cDNA Template Probe	show CACCGATCCCCCCCCGGAGGATGCTGCCCACCCCTTTCTCCGTCGAGGATATCCTCAGCCTGGAGCAGAGCAGCGCTCC CGGAGCCCCCCGGGGTCCGCCGCAGCCCTTCCGTGGAGGAGGAACCGCCGTCGGACAATGTCTGCTCTCCCAGCCCTTG CAGGCAGACCAGCAGCAAACTGACCCCTGCCACCACCCCAAGCAACCGCAGCGGCGCAAACCCCGCGTTTTGTTCTCCC AAACTCAGGTGTTGGAGTTGGAGCGGCGATTCAAGCAGCAGAAATACCTCTCTGCACTGGAAAGGGAACACCTGGCCAA CGTGCTCCAGCTCACCTCCACCCAGGTGAAAATCTGGTTCCAGAACCGGCGCTACAAATGCAAGAGGCAGAGGCAGGAT AGATCCCTGGAGATGGCCACCTACCCACTGCCACCACGTAGAGTGGCTGTTCCGGTGCTGGTCAGAGATGGCAAGCCTT GCTTTGAGGGGTCCCAACCCCACCTGGCTCCTTATGGGATCACCGTCAGCCCCTACTCCTATAGCACCTACTCAGTGCC TACGGGGGTGAGCTATGGGGTGGGATATACTGGGGTGCTCACACCATGAGCTTGGGCTCAGCACCAGTTGAGATGTGGC CCAGGAAAGGGATGGGGGCATCCGGAGTCGTAATGGACAGCAGGTGGTGCGTCCAACCTCACCAACCAGCCCAAGGAAA GGGACTTCTGGTGCTGCGGGATTTGGGGACCTCAGTGCAGGGGCATTTATTTATTTGGGCACAAACATGGAGTCCATCC CATCTCACCCCATAGGGATGGTCCTGTGGGATGCATAGGGATGGGATGCTGCTCTTCTTCCTAAGGAAACAGGGTCTGT GCACACCACTGCGCCTTTGCTTTTCCATGAACACTCTATTTAAGGCTTTGAGTTCCTCTCATCTTTTGGGATATTCATA TTTCTTAATGACTTAAAAGCACAGGTGTTCGTTTCTGTCTTGGTTATTGTTATTATTTGCAATTAAAAAAAAATAAGGT GGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Citation	Brand T, Andrée B, Schneider A, Buchberger A, Arnold HH. Chicken NKx2-8, a novel homeobox gene expressed during early heart and foregut development. Mech Dev. 1997 Jun;64(1-2):53-9.
Copyright	Copyright © 1997 Published by Elsevier Ireland Ltd.
Comments	The complete cDNA template sequence was obtained from the information in the publication as described in Brand et al. 1997. NKX2-8 is also known as NKX2-6 in NCBI.