GEISHA - A Chicken Embryo Gene Expression Database
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PDGFC
platelet derived growth factor C

Gene
Official SymbolPDGFC
Official Full Nameplatelet derived growth factor C
CGNC ID7129
also known asSCDGF, platelet-derived growth factor C|PDGF-C|spinal cord-derived growth factor
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_204721
PolypeptideNP_990052
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.1907
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human56034MIM:608452
Mouse54635ENSMUSG00000028019All phenotypic alleles (8):Targeted, knock-out(3) Targeted, other(4) Gene trapped(1) MGI:1859631
Xenopus100494492985687
Zebrafish560564ENSDARG00000077588ZDB-GENE-071217-2ZFIN:ZDB-GENE-071217-2
Gene Ontology
Molecular Functiongrowth factor activity, platelet-derived growth factor receptor binding, more...protein homodimerization activity
Biological Processactivation of transmembrane receptor protein tyrosine kinase activity, more...cellular response to amino acid stimulus, organ morphogenesis, platelet-derived growth factor receptor signaling pathway, positive regulation of cell division, positive regulation of DNA replication, positive regulation of fibroblast proliferation, regulation of peptidyl-tyrosine phosphorylation
Cellular Componentcell surface, extracellular space, membrane
Links to other databases
Entrez Gene395469
Ensembl GeneENSGALG00000009378
KEGGgga:395469

Entry 1

GEISHA IdPDGFC.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerTTATAAAAGCTTGCGGCCGCAGAATATGGTTCCAGTAGTGTGCCAAGTAGAC
Reverse cDNA Template PrimerGCTCTAGAAATTAACCCTCACTAAAGGCTCATTGATGCCTTTCTCCCGcDNA Template Length893
Forward cDNA Template Probeshow
NNTTTAAGNNTTGTTTTCNNNNNTTTCCAAATCTGCAAGGACACCAGATCAGAATAAGATTTGTGTCTGATGAATATTT
TCCTTCTTAACCGGGCATTCTGCATCCATTATACAACTTCTTGTGCCACACCACACAGAAGCACCATAGCCCATCGTCG
CTACCCCCATCAGCTTTGCCACTAGATGTATTGAACGATGCTGTTGCTGGATTTAGTACTGTGGAAGAACTTATCCGGT
ACCTTGAACCACATCGGTGGCAGCTGGATTTGGAAGACTTGGACAGGCCGAACGTGGCAACTTCTTGGAAAGGCATATA
TTCATGGGAGAAAATCGAGAGTGGTTGATCTCAACTTGGTAAAGGAGGAAGTGCGGCTGTATAGTTGTACTCCTCGCAA
CTTCTCATTGTCACTGAGAGAGGAGCTGAAGCGAACTGACACCATTTTCTGGCCACTGTGTCTTCTGGTTAAGCGTTGT
GGTGGAAACTGTGCCTGTTGTCATCAGAACTGCAATGAGTGCCAATGTATACCAACAAAAGTCACCAAAAAGTACCACG
AGGTTCTTCAGCTGATGCCAAGGAGTGGTGTCCGAGGACTGCATATATCACTGACTGATGTACTCTTGGAACACCACCA
TGAGTGTGACTGTGTATGCAAAGGGAATAGTGAAGGATAAACATGATTTACTTGTGCTGTTTTCTTTGAAGCACGTTCA
ATCCTTGCTGATTCTATTATGGGGCTTGTGCATTATCTCCTTCTGTAATCTCAGTTGTTTGCTTTGGGGAACTTCCGTC
TTCAAGATTTACAGTGAGCTCTAAAAAGAGAAACAAAACTGGGAATATGTGATGTATGACGACTCTGTTTGGATGCCCA
ATTAACGACTGGAGAAAGCATCAATGATCCTTTAGTGGGGGTTATTTTTTAAAAACAAA
CommentsNo specific expression detected at or below stage 12.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 18
Lung
 
19-24
stage 21
Leg Mesenchyme
Lung
Retina
Spinal Ganglia and Nerves
Wing Mesenchyme
 
25
stage 25
Head Mesenchyme
Leg Mesenchyme
Retina
Somatic Mesoderm
Spinal Ganglia and Nerves
Wing Mesenchyme
 

Entry 2

GEISHA IdPDGFC.McCabe.2008Data SourcePublication
Complete cDNA Template Probeshow
ANTCAGNGCTGCCTACTCCCCTGGCGGCGCTGAGAGACGCCCGGGCCTCGGTGCCGCTCCGCCAGCGCCTGCTCCGCCG
CAGCCCCTCGCCCCGCCGGCCCAATGCTCCTCCTCGGGCTGCTCCTGCTGACATCCGCCCTGGCCGGCCGGAGGCATGG
GGCCGCCGCGGAGTCCGACCTCAGCAGCAAGTTCTCCTTCCCCGGCGCTAAGGAGCAGAACGGTGTGCAGGATCCTCAG
CATGAGAAAATAATAACTGTGACTTCTAATGGAAGTATTCACAGCCCCAAGTTTCCACACACATACCCACGCAATACTG
TACTGGTGTGGAGATTAGTAGCAGTAGATGAAAATGTATGGATACAACTTACTTTTGATGAAAGATTTGGGCTTGAGGA
CCCAGAAGATGATATTTGCAAGTATGACTTTGTAGAAGTTGAAGAACCTAGTGATGGCACTGTTTTAGGGCGCTGGTGT
GGTTCCAGTAGTGTGCCAAGTAGACAAATCTCCAAAGGAAACCAGATCAGAATAAGATTTGTGTCTGATGAATATTTTC
CTTCTCAACCTGGATTCTGCATCCATTATACACTTCTTGTGCCACACCACACAGAAGCACCTAGCCCATCATCGCTACC
CCCATCAGCTTTGCCACTAGATGTATTAAACAATGCTGTTGCTGGATTTAGTACTGTGGAAGAACTTATCCGGTACCTT
GAACCAGATCGGTGGCAGCTGGATTTGGAAGACTTGTACAGGCCAACGTGGCAACTTCTTGGAAAGGCATATATTCATG
GGAGAAAATCAAGAGTGGTTGATCTCAACTTGCTAAAGGAGGAAGTGCGGCTGTATAGTTGTACTCCTCGCAACTTCTC
AGTGTCACTGAGAGAGGAGCTGAAGCGAACTGACACCATTTTCTGGCCACTGTGTCTTCTGGTTAAGCGTTGTGGTGGA
AACTGTGCCTGTTGTCATCAGAACTGCAATGAGTGCCAATGTATACCAACAAAAGTCACCAAAAAGTACCACGAGGTTC
TTCAGCTGAAGCCAAGGAGTGGTGTCCGAGGACTGCATAAATCACTGACAGATGTACCCTTGGAACACCACGAGGAGTG
TGACTGTGTATGCAAAGGGAATAGTGAAGGATAAACATGATTTAATTGTGCTGTTTTCTTTGAAGCACGTTCAATCCTT
GCTGATTCTATTATGGGGCTTGTGCATTATCTCCTTCTGTAATCTCAGTTGTTTGCTTTGGGGAACTTCCATCTTCAAG
ATTTACAGTGAGCTCTAAAAAGAGAACCAAAACTGGGATTATGTGATGTATGACAGCTCTGTTTGGAGGCCCAGTTAAA
GGACGGGAGAAAGGCATCAATGAGGGATTTAAAATACATGTTGTTGTTGGTTTTGTTTTTTTTTTCTTTTTGTCCCCTC
CAGTTTTCTTGACAATACATGGATTTATAATTTAGGAGTAAAAATAAAGTTAGGAGGCTTGCATCATGGAGACTTGATC
CTGCTGGCTGTTTCATTTCTACACCTCCAGAACATCTGGCCCCTAGCTGAAAACATCTGAAATCTTTCTGTGTTCAACT
ACTCCTATGTACTCNAAACATTCTCTGCTTTATAATTTGGTTTATAACANACTGTCTTGTTCTGAATTAAACTTAATTT
GTCTAAAAAAAAAAAA
CitationMcCabe KL, Bronner-Fraser M. Essential role for PDGF signaling in ophthalmic trigeminal placode induction. Development. 2008 May;135(10):1863-74. Epub 2008 Apr 16.
CopyrightPublished by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Bronner-Fraser.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204721).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-10
stage 8
stage 8
stage 8
stage 10
stage 10
stage 10
Ectoderm
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Primitive Streak
Somites
Surface Ectoderm
 

Entry 3

GEISHA IdPDGFC.Yang.2008Data SourcePublication
Complete cDNA Template Probeshow
TACGCGGGCTAGCACAGATTTGGGCTTGAGGACCCAGAAGATGACATTTGCAAGTATGACTTTGTAGAAGTTGAAGAAC
CTAGTGATGGCACTGTTTTAGGGCGCTGGTGTGGTTCCAGTAGTGTGCCAAGTAGACAAATCTCCAAAGGAAACCAGAT
CAGAATAAGATTGTGTCTGATGAATATTTTCCTTCTCAACCTGGATTCTGCATCCATTATACACTTCTTGTGCCACACC
ACACAGAAGCACCTAGCCCATCATCGCTACCCCCATCAGCTTTGCCACTAGATGTATTAAACAATGCTGTTGCTGGATT
TAGTACTGTGGAAGAACTTATCCGGTACCTTGAACCAGATCGGTGGCAGCTGGATTTGGAAGACTTGTACAGGCCAACG
TGGCAACTTCTTGGAAAGGCATATATTCATGGGAGAAAATCAAGAGTGGTTGATCTCAACTTGCTAAAGGAGGAAGTGC
GGCTGTATAGTTGTACTCCTCGCAACTTCTCAGTGTCACTGAGAGAGGAGCTGAAGCGAACTGACACCATTTTCTGGCC
ACTGTGTCTTCTGGTTAAGCGTTGTGGTGGAAACTGTGCCTGTTGTCATCAGAACTGCAATGAGTGCCAATGTATACCA
ACAAAAGTCACCAAAAAGTACCACGAGGTTCTTCAGCTGAAGCCAAGGAGTGGTGTCCGAGGACTTGCATAAATCACTG
ACAGATGTACCCTTGGAACACCACGAGGAGTGTGACTGTGTATGCCAAAGGGAAATAGTGAAAGGATTACACCATGATT
TTAAATTGTGCTGGTTTTTCTTTGAAAGACACGTTCAATCCCTTGCCTGATTTCTAATTATGGGGGCTTGTGCATTTAT
CTCCTTCTGGTCAATCTCAAGTTGTTGGCTTTGGGGGAACTTCCCTTCTTCAAGAATTTACCCGTGAGCCTTAAAAAGA
GAAAGCAAAACTGGGGATTCTGCTGAGGTTTGAC
CitationYang X, Chrisman H, Weijer CJ. PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression. Development. 2008 Nov;135(21):3521-30. Epub 2008 Oct 2.
Copyright© 2008
CommentsThe cDNA template used to generate the probe was obtained from EST - ChEST270m4 as described in Yang et al.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 6
stage 6
Neural Plate/Tube
 
7-8
stage 7
stage 8
Neural Plate/Tube
Somites
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.1907

Mouse

EmageMGI:1859631
EurexpressMGI:1859631
MGI GXDMGI:1859631

Frog

Xenbase985687

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-071217-2
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