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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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PDX1
pancreatic and duodenal homeobox 1

The human orthologue of this gene is associated
with the following human diseases:

Gene

Official Symbol	PDX1
Official Full Name	pancreatic and duodenal homeobox 1
CGNC ID	15657
also known as	pancreas/duodenum homeobox protein 1, Insulin promoter factor 1 (IPF-1), Islet/duodenum homeobox-1 (IDX-1), Insulin upstream factor 1 (IUF-1), (Glucose-sensitive factor) (GSF). , Pancreas/duodenum homeobox protein 1 (PDX-1), Somatostatin- transactivating factor 1 (STF-1)
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI

Sequence Information

Genomic
RNA	XM_001234635
Polypeptide	XP_001234636

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	3651	ENSG00000139515	MIM:125853	MIM:600733
Mouse	18609		All phenotypic alleles (11):Targeted, knock-out(3) Targeted, other(8)	MGI:102851
Xenopus	100490648, 100337610			483330
Zebrafish	30721	ENSDARG00000002779	ZDB-GENE-990415-122	ZFIN:ZDB-GENE-990415-122

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	771348
Ensembl Gene
KEGG	gga:771348

Entry 1

GEISHA Id	PDX1.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	TACGAGGTGCCCCCCATCAG
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGCGTCCCCCGCTTTTTGTC	cDNA Template Length	435
Forward cDNA Template Probe	show GGGTTGCATTGATCGCATCTTCATTCTCGNCGGTTCGGAACAGATCTTGATGTGTCTCTCGGTCAGGCCTTCAAGAGGG CACAGCTCCCCCGCCTCGGTCGGGAGATGTCCTTGAGTGAAGAGAAACTCCTTCTCCAGCTCCAGCAGCTGAGCCCTCG TGTAGGCCGTCCGCGTCCTCTTGTTCTCCTCCGGCTCCACCACGTAGGAACCCCCTGCCCACTGCCCCTTCCAGGCGTG CGACTTGGTGGACTTCATCCAGGCGAAAGGCACCTGCACCCGAGGCTCCTCCATCGCCCCCGGGTCCGCCCCGTCGGGG AAAGGCACAACGTCCTGTTGGGGGGGAGGGAGGTGAGGGTGGTGATGTTGGTGGTGATGTACGTGGGAGAAACCGGCGT CTTCGCTGATGGGGGGGGCTCAATAAAATCGCTCTGATTATCCTGTTACATTAAACCCGATTGCATCTTACTGTGTGCC TGCTCCATGCCAGATATCTCTTGTGGGTCAAATGACTGCGTAGTCCGATCTACGGTAACCAACCTCCACATTGCTTCAG GCATGATGGATACTTTCTATATAGGACCCACGTGCGATCTCCCGAGATGCCTGCCATGCCACTTATGCACATTAAGACC TAGTCCCGTCCGGTTTCCGTGACTGCATTGAACACATGTTCTCCTGGTTCTCCCGTCGCGGCCATACACGATATCATCG GTTCACTACTCATGATCTTCTTCTATGATCTCCCCAAGATCCGTCCTTAATCAAAAGATCCGGCCGGTCCTTCCCTGAC GTCTTTAATTAAGACGTAATCTGTGCTAACCCATTGGACTGACCTGCCCCGATAATACACCGACTATCCTCTTCCGCTG AATCCGTTCGAAAATATTCTTCTGCCATCCCTCCTGGATCAATACCGGTTTTCCCCCCAATTAGACTTCCATCTGTGGA CAAAAATTATTGGTGGCCGGTTTTCGACATTTCCAACATTTCTCATTCCTTTCAAAATCTTTGCTTCCGCCAAATGGTT GTGACTCGTTCCCTGTCCTTTTTGTCCTAAATAACATTTTTCCCCCCAGTTTATACCCCGGACCAAAGGGATTTTTTTC TCCTGTAAACTTATTCTTTCACCCCCTTGAATTCCTGCTAAACGACTTTTGGCCCTTTTTAAGTCCAACTCTTTAAAGT TTTTTCTTTCAGTCCGGGAGGAGGTTCCCCCCGGCCGGGGGTAATTCCCCCTCTAGATCCTTCGAATACCCCCTTTTGG GATTTACAGTTCACCAAAGATGGTTAAACTTTACGCGAGGGTTTGTTTTCAAATCTTGTTAAGTTGCCCAATTGAAATA CTTCCTTTCTTTTTAAGTTTCCTTTTGAAATTCTTATTCCTTTTATAATATTCAGTTCTCCCAGCCGATTTTTTTTAAT TTTTGACATTTCTCTCCTTCTTTTTGANGTGATGCCCCACCCCACCCGCCTTAGAGCATAGACCATATTACTTCTCGAT CTCCTATACA
Comments	No specific expression detected at or before stage 5.

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 6

Neural Plate/Tube
Primitive Streak

Low level expression.

7-12

stage 7

stage 9

stage 11

stage 12

Amnion
Anterior Intestinal Portal
Anterior Neuropore
Blood Islands
Dermomyotome
Ectoderm
Endoderm
Extraembryonic Mesoderm
Forebrain
Foregut
Head Mesenchyme
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Neural Plate/Tube
Notochord
Primitive Streak
Somites
extraembryonic endoderm

13-18

stage 16

stage 18

Endoderm
Neural Plate/Tube
Pancreas

19-24

stage 22

stage 23

Gut
Pancreas

stage 25

Gut
Pancreas

Entry 2

GEISHA Id	PDX1.Pedersen.2005	Data Source	Publication
Complete cDNA Template Probe	show ATGAACACCGAGGAGCAGTACTACGCCTCCGCGCAGCTCTACAAGGAGCCGTGCGCCTTTCAGAGAGCGCAGGATTACA GCCCCAGCCCCCCCGCCTGCCTCTACGTGGGCCGGCAGCAGCAGGCTCCGTACCCCGGCTCTCTGGGGGCGCTGGAGCA GGGCAGCCCGTCGGACATCTCGCCCTACGAGGTGCCCCCCATCAGCGAGGATGCCGGGGTCTCCCACCTGCATCACCAC CACCATCACCACCCTCACCTCCCTCCCCCCCACCAGGACGCTCTGCCTTTCGCCGACGGGGCGGACCCGGGGGCGATGG AGGAGCCTCGGGTGCAGGTGCCTTTCGCCTGGATGAAGTCCACCAAGTCGCACGCCTGGAAGGGGCAGTGGGCAGGGGG TTCCTACGTGGTGGAGCCGGAGGAGAACAAGAGGACGCGGACGGCCTACACGAGGGCTCAGCTGCTGGAGCTGGAGAAG GAGTTTCTCTTCAACAAGTACATCTCCCGACCGAGGCGGGTGGAGCTGGCCGTCATGTTAAACCTGACCGAGAGACACA TCAAGATCTGGTTCCAGAACCGACGGATGAAATGGAAGAAAGAAGAAGACAAAAAGCGGGGGACGGCCAACAGCGCTGA TCCCGAGCAGGACTGCGTCGTGTCCTCCGGGAAGCTGCAGGGCAAAGAGGATCTGCAGCCGTGA
Citation	Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P; Beta Cell Biology Consortium. Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol. 2005 Dec 15;288(2):487-501.
Copyright	Copyright © 2005 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_001234635).

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 10

stage 11

Endoderm
Pancreas

Chicken embryos with antisense probes recognizing Nkx6.1, Nkx6.2, Nkx6.3, Nkx2.2, and Pdx1.
Prospective Pancreatic Endoderm

13-17

stage 15

stage 17

Endoderm
Pancreas

Chicken embryos with antisense probes recognizing Nkx6.1, Nkx6.2, Nkx6.3, Nkx2.2, and Pdx1.
Pancreatic Buds
Pancreatic Primordia

Entry 3

GEISHA Id	PDX1.Kumar.2003	Data Source	Publication
Complete cDNA Template Probe	show ATGAACACCGAGGAGCAGTACTACGCCTCCGCGCAGCTCTACAAGGAGCCGTGCGCCTTTCAGAGAGCGCAGGATTACA GCCCCAGCCCCCCCGCCTGCCTCTACGTGGGCCGGCAGCAGCAGGCTCCGTACCCCGGCTCTCTGGGGGCGCTGGAGCA GGGCAGCCCGTCGGACATCTCGCCCTACGAGGTGCCCCCCATCAGCGAGGATGCCGGGGTCTCCCACCTGCATCACCAC CACCATCACCACCCTCACCTCCCTCCCCCCCACCAGGACGCTCTGCCTTTCGCCGACGGGGCGGACCCGGGGGCGATGG AGGAGCCTCGGGTGCAGGTGCCTTTCGCCTGGATGAAGTCCACCAAGTCGCACGCCTGGAAGGGGCAGTGGGCAGGGGG TTCCTACGTGGTGGAGCCGGAGGAGAACAAGAGGACGCGGACGGCCTACACGAGGGCTCAGCTGCTGGAGCTGGAGAAG GAGTTTCTCTTCAACAAGTACATCTCCCGACCGAGGCGGGTGGAGCTGGCCGTCATGTTAAACCTGACCGAGAGACACA TCAAGATCTGGTTCCAGAACCGACGGATGAAATGGAAGAAAGAAGAAGACAAAAAGCGGGGGACGGCCAACAGCGCTGA TCCCGAGCAGGACTGCGTCGTGTCCTCCGGGAAGCTGCAGGGCAAAGAGGATCTGCAGCCGTGA
Citation	Kumar M, Jordan N, Melton D, Grapin-Botton A. Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol. 2003 Jul 1;259(1):109-22.
Copyright	Copyright © 2003 Elsevier Science (USA). All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_001234635).