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PTCH2 Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol PTCH2 Official Full Name patched 2 CGNC ID 14936 also known as protein patched homolog 2|patched homolog 2 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Entrez Gene Ensembl Gene Genetic Phenotypes MOD Fruit Fly Human Mouse Xenopus Zebrafish
Gene Ontology Molecular Function Biological Process Cellular Component
Links to other databases
Entry 1 GEISHA Id PTC2.Aglyamova.2007 Data Source Publication Complete cDNA Template Probe show NACCCCGGCGTGGCCACCAGCACTCAGATCCCCACCACCGTGCAGGCCTTCACCCAGTGCGACCCCTCGGGCCACCACA
Citation Aglyamova GV, Agarwala S. Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord. Dev Dyn. 2007 May;236(5):1363-73 Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_422426).
Entry 2 GEISHA Id PTC2.Pearse.2001 Data Source Publication Complete cDNA Template Probe show CTTGGCGCTGTTGGGACTGAGCCTCTACGGCACCACCATGGTGCATGACGGGCTCTACCTGACAGACATTGTGCCGCGG
Citation Pearse RV, Vogan KJ, Tabin CJ. Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev Biol. 2001 Nov 1;239(1):15-29. Copyright Reprinted with permission from Elsevier.
Copyright © 2001 Elsevier B.V. All rights reserved. Comments According to the authors, "To generate an antisense Ptc2 probe, a 1.4-kb fragment of Ptc2 coding sequence (nt 339-1774 of the published sequence) was amplified by PCR from a pBluescript clone using M13 forward and reverse primers. A Dig-labeled cRNA probe was then transcribed from the resulting fragment by using T3 RNA polymerase." The sequence below was obtained from NCBI (XM_422426) using the information provided.
Entry 3 GEISHA Id Ptc2.Scherz.2007 Data Source Publication Complete cDNA Template Probe show CCCCGCCATGCCGGCCGAGCCCCCCCGCTCCGCTCCTCCGCGAGCCGCCGCCGCCGCCCTCCGCAAAGCGCTGCCCGAG
Citation Scherz PJ, McGlinn E, Nissim S, Tabin CJ. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb.Dev Biol. 2007 Aug 15;308(2):343-54. Epub 2007 May 31. Copyright Reprinted with permission from Elsevier.
Copyright 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # AF409095.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 21
stage 24
stage 24
Leg
Entry 4 GEISHA Id PTCH2.UAlinear Data Source GEISHA ISH Analysis Complete cDNA Template Probe show NACCCCGGCGTGGCCACCAGCACTCAGATCCCCACCACCGTGCAGGCCTTCACCCAGTGCGACCCCTCGGGCCACCACA
Comments Insufficient information provided to verify exact sequence used to synthesize probe. Sequence above was obtained from NCBI (XM_422426).
Entry 5 GEISHA Id PTC2.Dunn.2011 Data Source Publication Complete cDNA Template Probe show TGCGGGAAGGTGCTGTTCGTGGGGCTGCTGCTGTTCGGGGCGCTGGCCGTGGGGCTGCGGGTGGCCTCCGTCGAGACGG
Citation Dunn IC, Paton IR, Clelland AK, Sebastian S, Johnson EJ, McTeir L, Windsor D, Sherman A, Sang H, Burt DW, Tickle C, Davey MG. The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development. Dev Dyn. 2011 May;240(5):1163-72. Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # XM_422426.3)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-27 stage 27
stage 27
Limb Buds
Entry 6 GEISHA Id PTC2.Davey.2006 Data Source Publication Complete cDNA Template Probe show CCCCGCCATGCCGGCCGAGCCCCCCCGCTCCGCTCCTCCGCGAGCCGCCGCCGCCGCCCTCCGCAAAGCGCTGCCCGAG
Citation Davey MG, Paton IR, Yin Y, Schmidt M, Bangs FK, Morrice DR, Smith TG, Buxton P, Stamataki D, Tanaka M, Münsterberg AE, Briscoe J, Tickle C, Burt DW. The chicken talpid3 gene encodesa novel protein essentialfor Hedgehog signaling. Genes Dev. 2006 May 15; 20(10): 13651377. Copyright Copyright © 2006, Cold Spring Harbor Laboratory Press Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #AF409095.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 20
stage 20
Spinal Cord Splanchnic Mesoderm
Entry 7 GEISHA Id PTC2.Sjödal.2008 Data Source Publication Complete cDNA Template Probe show TGATCCAGACCCCGAAACGCGAAGGGGAGAACATCCTGACGCAGGAGGCCCTGCAGCTCCACCTCGAGGCGGCCCTGGC
Citation Sjödal M, Gunhaga L. Expression patterns of Shh, Ptc2, Raldh3, Pitx2, Isl1, Lim3 and Pax6 in the developing chick hypophyseal placode and Rathke’s pouch. Gene Expr Patterns. 2008 Sep;8(7-8):481-5. Epub 2008 Jul 4.. DOI: 10.1016/j.gep.2008.06.007. Copyright Copyright © 2008 Elsevier B.V. Comments The complete cDNA template sequence was obtained from the information from the publication as described in Sjödal et al. 2008.
Entry 8 GEISHA Id PTCH2.Anderson.2019 Data Source Publication Complete cDNA Template Probe show GTGGCCGCCGGCGGCGGGCGCTGCCGTTGCTTAGCAGCGGCGATGGGCGCTGCCGCGGCGGCGGCGGCCAATGGGAGCG
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_025153073 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
Heart
Data from NCBI Unigene EST ProfileGga.935
Mouse Frog Fruit Fly Zebra Finch Zebrafish
