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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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PTHLH
parathyroid hormone like hormone

The human orthologue of this gene is associated
with the following human disease:

Brachydactyly, type E2

Gene

Official Symbol	PTHLH
Official Full Name	parathyroid hormone like hormone
CGNC ID	12993
also known as	PTHrP, parathyroid hormone-related protein\|PTH-rP
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_001174106
Polypeptide	NP_001167577

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	5744	ENSG00000087494	MIM:613382	MIM:168470
Mouse	19227	ENSMUSG00000048776	All phenotypic alleles (8):Targeted, knock-out(3) Targeted, other(5)	MGI:97800
Xenopus	100462910			959053
Zebrafish	554221, 100536439	ENSDARG00000031737	ZDB-GENE-050119-9, ZDB-GENE-110411-206	ZFIN:ZDB-GENE-050119-9, ZFIN:ZDB-GENE-110411-206

Gene Ontology

Molecular Function	hormone activity, peptide hormone receptor binding
Biological Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, more...
Cellular Component	cytoplasm, extracellular region, nucleus

Links to other databases

Entrez Gene	396281
Ensembl Gene	ENSGALG00000017295
KEGG	gga:396281

Entry 1

GEISHA Id	PTHLP.Roddy.2011	Data Source	Publication
Complete cDNA Template Probe	show GGTTTAAGCCCCGGAGGATATGATGTTCACGAAACTCTTTCAGCAGTGGAGTTTCGCGGTGTTTCTTCTGAGTTATTCT GTGCCCTCCTACGGAAGATCAGTAGAGGGGATCAGCCGCAGACTCAAACGGGCCGTATCAGAGCACCAGCTACTGCATG ACAAGGGCAAATCAATCCAAGACTTACGAAGAAGGATATTCCTTCAAAATTTAATTGAAGGTGTCAACACTGCAGAAAT CCGTGCAACTTCAGAGGTCTCACCTAACCCTAAGCCTGCTACCAACACAAAGAACTACCCTGTCCGTTTTGGCAGTGAA GATGAGGGCAGATACTTAACTCAGGAGACAAACAAATCACAGACCTACAAGGAACAGCCCCTGAAGGTATCAGGGAAGA AAAAGAAAGCGAAGCCTGGAAAACGTAAAGAACAAGAGAAGAAAAAGAGGCGAGCTCGCTCAGCTTGGCTAAATTCTGG CATGTATGGAAGCAATGTAACTGAGAGCCCAGTCTTGGACAACTCTGTTACTACACATAATCATATTTTAAGGAGGCGC TGATATTTTCAGCAAGACAGCTTTGGAAGACATATTGCAGTATTCTGTAATAGTGAACATAGAACATATGGGAAGTATA AAAATATTTATTACCTGTAAATATTGTAAATGCTC
Citation	Roddy KA, Prendergast PJ, Murphy P. Mechanical influences on morphogenesis of the knee joint revealed through morphological, molecular and computational analysis of immobilised embryos. PLoS One. 2011 Feb 28;6(2):e17526.
Copyright	PLoS One is an open access journal.
Comments	The cDNA template used to generate the probe was obtained from EST - ChEST533c1 as described.

Stage

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Location (click to highlight)

Comments (click to highlight)

25-27

stage 27

Leg Mesenchyme

par, periarticular
par, periarticular

Entry 2

GEISHA Id	PTHrP.Zou.1997	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show ACTAGCGTACAATTAACATCATTAGGAATCAGCCCTCCAGCTAACAGAGGAACTGCGACGAACAACGGTTTAAGCCCCG GAGGATATGATGTTCACGAAACTCTTTCAGCAGTGTATTTTCGCGGTGTTTCTTCTGAGTTATTCTGTGCCCTCCTACG GAAGATCAGTAGAGGGGATCAGCCGCAGACTCAAACGGGCCGTATCAGAGCACCAGCTACTGCATGACAAGGGCAAATC AATCCAAGACTTACGAAGAAGGATATTCCTTCAAAATTTAATTGAAGGTGTCAACACTGCAGAAATCCGTGCAACTTCA GAGGTCTCACCTAACCCTAAGCCTGCTACCAACACAAAGAACTACCCTGTCCGTTTTGGCAGTGAAGATGAGGGCAGAT ACCTAACTCAGGAGACAAACAAATCACAGACCTACAAGGAACAGCCCCTGAAGGTATCAGGGAAGAAAAAGAAAGCAAA GCCTGGAAAACGTAAAGAACAAGAGAAGAAAAAGAGGCGAGCTCGCTCAGCTTGGCTAAATTCTGGCATGTATGGAAGC AATGTAACTGAGAGCCCAGTCTTGGACAACTCTGTTACTACACATAATCATATTTTAAGGAGGCGCTGATATTTTCAGC AAGACAACTTTGGAAGACATATTGCAGTATTCTGTAATAGTGAACATAGAACATATGGGAAGTATTAAAATATTTATTA CCTGTAAATATTGTAAATGCTCAGAATAAAACCTTTTTGCCCCATTGC
Citation	Zou H, Wieser R, Massagué J, Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev 1997 Sep 1;11(17):2191-203.
Copyright	Copyright © 1997, Cold Spring Harbor Laboratory Press
Comments	The sequence below was obtained from NCBI (acc # NM_001174106.1 ) using the information provided in the publication as described in Schermer et al. 1991.

Stage

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Location (click to highlight)

Comments (click to highlight)

25-30

stage 30

Leg

tarsal region

31-34

stage 34

Wing

carpal region

Entry 3

GEISHA Id	PTHRP.Zhang.2003	Data Source	Publication
Complete cDNA Template Probe	show ACTAGCGTACAATTAACATCATTAGGAATCAGCCCTCCAGCTAACAGAGGAACTGCGACGAACAACGGTTTAAGCCCCG GAGGATATGATGTTCACGAAACTCTTTCAGCAGTGTATTTTCGCGGTGTTTCTTCTGAGTTATTCTGTGCCCTCCTACG GAAGATCAGTAGAGGGGATCAGCCGCAGACTCAAACGGGCCGTATCAGAGCACCAGCTACTGCATGACAAGGGCAAATC AATCCAAGACTTACGAAGAAGGATATTCCTTCAAAATTTAATTGAAGGTGTCAACACTGCAGAAATCCGTGCAACTTCA GAGGTCTCACCTAACCCTAAGCCTGCTACCAACACAAAGAACTACCCTGTCCGTTTTGGCAGTGAAGATGAGGGCAGAT ACCTAACTCAGGAGACAAACAAATCACAGACCTACAAGGAACAGCCCCTGAAGGTATCAGGGAAGAAAAAGAAAGCAAA GCCTGGAAAACGTAAAGAACAAGAGAAGAAAAAGAGGCGAGCTCGCTCAGCTTGGCTAAATTCTGGCATGTATGGAAGC AATGTAACTGAGAGCCCAGTCTTGGACAACTCTGTTACTACACATAATCATATTTTAAGGAGGCGCTGATATTTTCAGC AAGACAACTTTGGAAGACATATTGCAGTATTCTGTAATAGTGAACATAGAACATATGGGAAGTATTAAAATATTTATTA CCTGTAAATATTGTAAATGCTCAGAATAAAACCTTTTTGCCCCATTGC
Citation	Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ.ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003 Sep; 18(9):1593-604
Copyright	Copyright © 1999 - 2018 John Wiley & Sons, Inc.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_001174106.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

19-23

stage 23

Wing

Entry 4

GEISHA Id	PTHRP.Singh.2016	Data Source	Publication
Complete cDNA Template Probe	show ACTAGCGTACAATTAACATCATTAGGAATCAGCCCTCCAGCTAACAGAGGAACTGCGACGAACAACGGTTTAAGCCCCG GAGGATATGATGTTCACGAAACTCTTTCAGCAGTGTATTTTCGCGGTGTTTCTTCTGAGTTATTCTGTGCCCTCCTACG GAAGATCAGTAGAGGGGATCAGCCGCAGACTCAAACGGGCCGTATCAGAGCACCAGCTACTGCATGACAAGGGCAAATC AATCCAAGACTTACGAAGAAGGATATTCCTTCAAAATTTAATTGAAGGTGTCAACACTGCAGAAATCCGTGCAACTTCA GAGGTCTCACCTAACCCTAAGCCTGCTACCAACACAAAGAACTACCCTGTCCGTTTTGGCAGTGAAGATGAGGGCAGAT ACCTAACTCAGGAGACAAACAAATCACAGACCTACAAGGAACAGCCCCTGAAGGTATCAGGGAAGAAAAAGAAAGCAAA GCCTGGAAAACGTAAAGAACAAGAGAAGAAAAAGAGGCGAGCTCGCTCAGCTTGGCTAAATTCTGGCATGTATGGAAGC AATGTAACTGAGAGCCCAGTCTTGGACAACTCTGTTACTACACATAATCATATTTTAAGGAGGCGCTGATATTTTCAGC AAGACAACTTTGGAAGACATATTGCAGTATTCTGTAATAGTGAACATAGAACATATGGGAAGTATTAAAATATTTATTA CCTGTAAATATTGTAAATGCTCAGAATAAAACCTTTTTGCCCCATTGC
Citation	Singh PN, Ray A, Azad K, Bandyopadhyay A. A comprehensive mRNA expression analysis of developing chicken articular cartilage. Gene Expr Patterns. 2016 Jan;20(1):22-31.
Copyright	Copyright © 2015 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001174106). Pthrp is also known as PTHLH in NCBI.