Quick Search
X XI XII XIII XIV 1 2 3 4 5 6 7 8 9 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
25 26 27 28 29 30 31 32 33 34 35 36
37 38 38 40 41 42 43 44
Gene Family QuickSearch
Human Disease Gene Search
ALDH1A2 Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol ALDH1A2 Official Full Name aldehyde dehydrogenase 1 family member A2 CGNC ID 3140 also known as RALDH2, retinal dehydrogenase 2|RALDH 2|RALDH(II)|aldehyde dehydrogenase 1A2|aldehyde dehydrogenase family 1 member A2|retinaldehyde dehydrogenase 2|retinaldehyde-specific dehydrogenase type 2, Retinal dehydrogenase 2, RALDH 2, Aldehyde dehydrogenase family 1 member A2, Retinaldehyde-specific dehydrogenase type 2 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id Y11 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show GCAACAGGAGAGCAGATCTGTGAGATCCAGGAAGCAGACAAGGTTGACACGGACAAGGCAGTGAGAGCAGCTCGCCTTG
Reverse cDNA Template Probe show GAAGAACTCCCCAACTTTTTTTAATGGTTTTGCTTTATGTTTTAACTTAGAATTAAGACAATGTATTTTAAAAGTGCAG
Entry 2 GEISHA Id ChEST564A12 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CCCAGTATACAATCCAGCAACAGGAGAGCAGATCTGTGAGATCCAGGAAGCAGACAAGGTTGACACGGACAAGGCAGTG
Entry 3 GEISHA Id Raldh2.Reijntjes.2004 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Reijntjes S, Gale E, Maden M. Generating gradients of retinoic acid in the chick embryo: Cyp26C1 expression and a comparative analysis of the Cyp26 enzymes. Dev Dyn. 2004 Jul;230(3):509-17. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from GenBank (acc # NM_204995).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 6
stage 6
Mesoderm, early
Entry 4 GEISHA Id Raldh2.Bothe.2006 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Bothe I, Dietrich S. The molecular setup of the avian head mesoderm and its implication for craniofacial myogenesis. Dev Dyn. 2006 Oct;235(10):2845-60. Copyright Copyright © 2006 Wiley-Liss, Inc.
Entry 5 GEISHA Id Raldh2.Cui.2003 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Cui, J, Michaille, JJ, Jiang, W, Zile, MH. Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid. Dev Biol. 2003 Aug 15;260(2):496-511. Copyright "Reprinted from Developmental Biology, 260, Cui, J, Michaille, JJ, Jiang, W, Zile, MH, Retinoid receptors and vitamin A deficiency: differential patterns of transcription during early avian development and the rapid induction of RARs by retinoic acid. 496-511, Copyright (2003), with permission from Elsevier".
Copyright © 2003 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204995.1)
Entry 6 GEISHA Id Raldh2.Rodriguez-Guzman.2007 Data Source Publication Complete cDNA Template Probe show ATTCCTGCAAGCCTTCTACGTAGATCTTCAAGGAGTCATAAAAACCCTGAGGTATTACGCTGGTTGGGCAGACAAAATC
Citation Rodriguez-Guzman m, Montero JA, Santesterban E, Gañan Y, Macias D, Hurle JM. Tendon-muscle crosstalk controls muscle bellies morphogenesis, which is mediated by cell death and retinoic acid signaling. Dev Biol. 2007 Feb 1;302(1):267-80. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments The following primers were designed: 5′-ATTCCTGCAAGCCTTCTACG-3′ and 5′-TTGCTCCTTCAGTAATGCCG-3′ for retinaldehyde dehydrogenase 2 (RALDH2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-32 stage 32
Wing Muscles
Entry 7 GEISHA Id RALDH2.Olivera-Martinez.2007 Data Source Publication Complete cDNA Template Probe show ATGGCATCTCTGCATCTGCTGCCTTCTCCCACTCTCAACCTTGAAATCAAACACACGAAGATTTTTATCAATAATGAGT
Citation Olivera-Martinez I, Storey KG., Wnt signals provide a timing mechanism for the FGF-retinoid differentiation switch during vertebrate body axis extension. Development. 2007 Jun;134(11):2125-35. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Storey.
Entry 8 GEISHA Id RALDH2.Blentic.2003 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Blentic A, Gale E, Maden M. Retinoic acid signalling centres in the avian embryo identified by sites of expression of synthesising and catabolising enzymes. Dev Dyn. 2003 May;227(1):114-27. Copyright Copyright © 2003 John Wiley & Sons, Inc. All Rights Reserved. Comments Authors specified AF064253 as the probe in the paper.
Entry 9 GEISHA Id RALDH2.Mou.2011 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Mou C, Pitel F, Gourichon D, Vignoles F, Tzika A, Tato P, Yu L, Burt DW, Bed'hom B, Tixier-Boichard M, Painter KJ, Headon DJ. Cryptic patterning of avian skin confers a developmental facility for loss of neck feathering. PLoS Biol. 2011 Mar;9(3):e1001028. Epub 2011 Mar 15. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204995).
Entry 10 GEISHA Id RALDH2.Bok.2011 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Bok J, Raft S, Kong KA, Koo SK, Dräger UC, Wu DK. Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):161-6. Epub 2010 Dec 20. Copyright copyright © by the National Academy of Sciences Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204995).
Entry 11 GEISHA Id RALDH2.Halilagic.2007 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Halilagic A, Ribes V, Ghyselinck NB, Zile MH, Dollé P, Studer M. Retinoids control anterior and dorsal properties in the developing forebrain. Dev Bio 2007 Mar 1;303(1):244-58 Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AF064253). Images are quail, but sequence and map shown are chick.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Ectoderm Head Mesenchyme
Entry 12 GEISHA Id RALDH2.Bothe.2011 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Bothe I, Tenin G, Oseni A, Dietrich S., Dynamic control of head mesoderm patterning., Development. 2011 Jul;138(13):2807-21. Copyright Permission from the authors and the Company of Biologists Ltd. Copyright held by the authors. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204995.1 ).
Entry 13 GEISHA Id RALDH2.Bayha.2009 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Bayha E, Jørgensen MC, Serup P, Grapin-Botton A. Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. PLoS One. 2009 Jun 10;4(6):e5845. Copyright http://creativecommons.org/licenses/by/2.5/ Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204995).
Entry 14 GEISHA Id RALDH2.Chambers.2007 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Chambers D, Wilson L, Maden M, Lumsden A. RALDH-independent generation of retinoic acid during vertebrate embryogenesis by CYP1B1. Development. 2007 Apr;134(7):1369-83. Copyright © 2007 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. #AF064253.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-11 stage 11
stage 11
Foregut Somites
Entry 15 GEISHA Id RALDH2.Bell.2004 Data Source Publication Forward cDNA Template Probe show GCAACAGGAGAGCAGATCTGTGAGATCCAGGAAGCAGACAAGGTTGACACGGACAAGGCAGTGAGAGCAGCTCGCCTTG
Reverse cDNA Template Probe show GAAGAACTCCCCAACTTTTTTTAATGGTTTTGCTTTATGTTTTAACTTAGAATTAAGACAATGTATTTTAAAAGTGCAG
Citation Bell GW, Yatskievych TA, Antin PB. GEISHA, a whole-mount in situ hybridization gene expression screen in chicken embryos. Dev Dyn. 2004 Mar;229(3):677-87. Copyright Copyright © 2004 Wiley-Liss, Inc. Comments The probe sequence below was obtained from the GEISHA database using information provided in the publication, Geisha Y11.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-8 stage 8
stage 8
Lateral Plate Mesoderm Somites
Entry 16 GEISHA Id RALDH2.Braitsch.2012 Data Source Publication Complete cDNA Template Probe show GCTCGCCTTGCTTTTTCTCTGGGTTCAGTTTGGAGGAGAATGGATGCATCGGAAAGAGGCCAACTTTTGGATAAACTGG
Citation Braitsch CM, Combs MD, Quaggin SE, Yutzey KE. Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Dev Biol. 2012 Aug 15;368(2):345-57. Copyright Copyright © 2012 Elsevier Inc. Comments The cDNA template used to generate the probe was obtained by PCR as described Braitsch et al., 2012.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31 stage 31
stage 31
Epicardium
Entry 17 GEISHA Id RALDH2.Mercader.2000 Data Source Publication Complete cDNA Template Probe show AACCCTGAGGTATTACGCTGGTTGGGCAGACAAAATCCATGGAATGACCATACCTGTAGATGGAGATTATTTTACGTTT
Citation Mercader N, Leonardo E, Piedra ME, Martínez-A C, Ros MA, Torres M. Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. Development. 2000 Sep;127(18):3961-70.
Copyright © The Company of Biologists Limited 2000 Comments The sequence below was obtained from NCBI (acc # NM_204995.1 - Showing 700 bp region from base 487 to 1186) using the information provided in the publication.
Entry 18 GEISHA Id RALDH2.Tenin.2010 Data Source Publication Complete cDNA Template Probe show ATGGCATCTCTGCATCTGCTGCCTTCTCCCACTCTCAACCTTGAAATCAAACACACGAAGATTTTTATCAATAATGAGT
Citation Tenin G, Wright D, Ferjentsik Z, Bone R, McGrew MJ, Maroto M. The chick somitogenesis oscillator is arrested before all paraxial mesoderm is segmented into somites. BMC Dev Biol. 2010 Feb 25;10:24. Copyright authors retain copyright of their article, and grant any third party the right to use reproduce and disseminate the article, subject to the terms of BMC Developmental Biology copyright and license agreement Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204995
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 21
stage 22
stage 23
stage 24
stage 24
Somites Tail
Entry 19 GEISHA Id RALDH2.Wilson.2007 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204995.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 21
Hindbrain 25-30 stage 26
stage 29
Hindbrain 31-34 stage 34
stage 34
Hindbrain
Entry 20 GEISHA Id RALDH2.Sánchez-Guardado.2009 Data Source Publication Complete cDNA Template Probe show GCACATCGGGTCAGAGCGGGGGGCTCGGCTGCTCCGTATCCCCCCCGAGACTATGACTTCCAGTAAAATTGAGATGCCA
Citation Sánchez-Guardado LO, Ferran JL, Mijares J, Puelles L, Rodríguez-Gallardo L, Hidalgo-Sánchez M. Raldh3 gene expression pattern in the developing chicken inner ear. J Comp Neurol. 2009 May 1;514(1):49-65. doi: 10.1002/cne.21984. Copyright Copyright © 19992013 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204995.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
stage 18
stage 18
Ear/Otic Placode Retina
Entry 21 GEISHA Id RALDH2.Smith.2018 Data Source Publication Complete cDNA Template Probe show ATGCATCGGAAAGAGGCCAACTTTTGGATAAACTGGCAGACTTGGTTGAAAGAGACAGGGCAGTTCTTGCTACTATGGA
Citation Jonathan N Smith, Heather M Walker, Hannah Thompson, J Martin Collinson, Neil Vargesson, Lynda Erskine. Lens-regulated retinoic acid signalling controls expansion of the developing eye. Development. 2018 Oct 10;145(19):dev167171. DOI: 10.1242/dev.167171. Copyright Copyright © 2018. Published by The Company of Biologists Ltd. Comments The complete cDNA template sequence was obtained from the information from the publication as described in Smith et al. 2018. RALDH2 is also known as ALDH1A2.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-23 stage 23
Retina all
Data from NCBI Unigene EST ProfileGga.2996
Mouse Frog Fruit Fly Zebra Finch Zebrafish
