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A chicken embryo gene expression database

	Anatomical Location
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	Gene Name
	GEISHA ID
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RB1
retinoblastoma 1

The human orthologue of this gene is associated
with the following human diseases:

Gene

Official Symbol	RB1
Official Full Name	retinoblastoma 1
CGNC ID	12759
also known as	retinoblastoma-associated protein\|p104\|pRb\|rb\|retinoblastoma 1 (including osteosarcoma), retinoblastoma 1 , RB1
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_204419
Polypeptide	NP_989750

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	5925	ENSG00000139687	MIM:109800	MIM:614041
Mouse	19645	ENSMUSG00000022105	All phenotypic alleles (22):Targeted, knock-out(10) Targeted, other(12)	MGI:97874
Xenopus	100493114			1018164
Zebrafish	777733	ENSDARG00000006782	ZDB-GENE-040428-1	ZFIN:ZDB-GENE-040428-1

Gene Ontology

Molecular Function	DNA binding
Biological Process	cell cycle, chromatin modification, regulation of cell cycle, more...
Cellular Component	nucleus

Links to other databases

Entrez Gene	386582
Ensembl Gene	ENSGALG00000016997
KEGG	gga:386582

Entry 1

GEISHA Id	Retinoblastoma.Wagner.2001	Data Source	Publication
Complete cDNA Template Probe	show GAATTCTCTTGGTGTTGTAGCCTCAAATGGATTACCAGAGGTTGACGTTCTCTCAAAACAATATGATGAGCTTTATCTC AAAAACAAAGATATAGATGCAAGATTATTTCTGGATCATGATGAAACTCTACAGCCTGATGTTATAGCATGCTCACAGT TGGAAAGAACACCACGAAAAAATAACCCAGATGAGGAGGTTAATCATGTACTTCCACAGACTCCTGTTCGAGCTGCAAT GAATACTATTCAGCAGTTGATGATGATTTTGAACTCAGCAACTGATAAACCATCAGATACTCTCATTGCATATTTCAAT AATTGCACAGTGAACCCTGAAGACAGCATCCTGAAAAGAGTAGAAAGTCTTGGCCACATCTTCAAAAAGAAATTTGCTG AAGCAGTTGGACAGGGATGTGCTGAGATTGGCTCACAGAGATACCAGCTTGGAGTACGGCTGTATTACAGAGTAATGGA GTCTATGCTGAAGTCGGAAGAAGAGCGCCTCTCAGTGCACAATTTTAGCAAACTTCTGAATGATAACATCTTCCACACA TCTCTTCTGGCATGTGCTCTTGAAATTGTCATGGCTACCTATGGCAGAACTGCTTCACAAAGTGATGGTACCAGTGCTG AAACAGACTTGTCTTTCCCATGGATTCTCAACGTATTTGATTTAAAAGCTTTTGACTTCTACAAGGTGATTGAAAGTTT CATTAAAGTGGAGCCAAGCCTAACGAGGGACATGATAAAGCATCTAGAACGCTGTGAACATCGCATTATGGAATCTCTT GCTTGGCAATCTGATTCACCTCTGTTCGATCTTATCAAGCAGTCAAAAGAACGAGAAGGTCAGACCGATCAGCCTGAGC CCACTTCCACCCTAAATCTGCCTCTCCAGCACAACCACACTGCAGCAGATCTGTATCTTTCTCCTGTGAGATCTCCTAA GAAGAAAGCATCTGGACACCCTCAAAGTGGTACTTCTAATCCAGATGCTCAGCCATCTGCGACCTCACAAACACAGAAG CCACAGAAATCTACCTCCCTCTCTCTGTTCTACAAAAAAGTGTTTCGACTGGCCTATCTTCGATTGCATACCCTGTTCT TTCGGCTTCTCTCCGAACATCCTGACCTGGAGCCGTTGATCTGGACCCTCTTCCAGCACACACTGCAAAATGAGTCTGA GCTTATGAGAGACAGGCACTTGGACCAGATCATGATGTGTTCCATGTATGGCATATGCAAAGTAAAGAATGTGGATCTT AGATTTAAAACAATAGTTTCTGCATACAAAGAGCTGCCCAATACAAATCAAGAGACTTTCAAACGTGTTCTTATCAGGG AAGAGCAGTACGACTCCATTATAGTCTTCTACAACTTAGTGTTCATGCAGAAGCTGAAGACAAACATCCTGCAGTATGC CTCCAACAGGCCTCCTACGCTGTCACCTATCCCACACATTCCTCGCAGCCCCTACCAGTTTTCCAATTCTCCTCGGCGT GTCCCTGCGGGCAATAACATCTACATCTCACCCTTGAAGAGCCCTTACAAGTTCTCTGATGGGTTTCATTCTCCCACAA AGATGACTCCGAGGTCCAGAATTCTGGTGTCAATTGGTGAAACGTTTGGGACTTCTGAAAAGTTTCAAAAAATAAACCA GATGGTGTGCAAC
Citation	Wagner M, Miles K, Siddiqui MA. Early developmental expression pattern of retinoblastoma tumor suppressor mRNA indicates a role in the epithelial-to-mesenchyme transformation of endocardial cushion cells. Dev Dyn. 2001 Mar;220(3):198-211.
Copyright	Copyright © 2001 Wiley-Liss, Inc.
Comments	no expression reported at stage 14 or below.

Stage

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13-18

stage 16

stage 17

stage 18

Endocardium

isolated heart

Entry 2

GEISHA Id	RB.Marx.2010	Data Source	Publication
Complete cDNA Template Probe	show AGCGGAGCCCCTTGGTGGCCGCTTGTACGGCGGGGGCCCGACGGTCACCATGCCGCCCAAGCCCCTTCGCAGGGCGGGC GCCGCCAGGAGTCAGCGCACCAGCCCCGAGGGCGGCGCCGGCACCGCCTCACCGCCCGGCGGCACCCGGCTGGAAGTGG GGGAAGCGGAGTTCGTGGCTCTGTGCGATGCGCTGAAGGCGCCGGACAGCGTGAGGGAGAAGGCCTGGATGACGTACCA GAGCTTGGCGGCCGCCGACGGGGCTTCGGCTTATAACAAAAAGAAGAAGGAAACATGGGGAGTCTGTATCTTTATTGTA GCAATTGATCTGGATGAAATGACATTCACTTTTACAGAGCTGCTGAAAAGTTTAAGCATAAGCGTGTGCACATTTTTTC AGTTTCTCAAAGAGGTGGATGTTAACATGGATACTGTAAGCACTAAAGTTGATAGCACTGTATCAAGGCTGAAAAAGAA ATACGATGTCTTACTTGCACTGTATCACAAGTTCGAAAGGACTTGTGGCCTTATTTATCTGGAGCAACCCAGTAGTGAG ATTTCTGCTGAACTCAGTTCTGTATTAGTCCTAAAAAATTACTGGATTACTTTTTTGCTGGCAAAAGGTAAAGTGTTGC AAATGGAAGATGACCTCGTGATCTCTTTCCAGTTGTTGCTGTGCGTCTTAGATTATTTTATCAAACTGTCACCTCCTGC TATGCTCAAGGAACCATACAAGTCTGCTGTGACTGCACTGACTGTTAATGGTTCAACTCGAACCCCACGAAGAGGTCAG AACAGGAATGCACGCGCTTCAAAGCAAATTGATACAGATACAAAAGTTATTGAAATCCTTTGTAAAGAGCATGATTGTA ATTTAGACGAGGTAAAAAATGTGTATTTCACAAGCTTTATTCCTTTCTTGAATTCTCTTGGTGTTGTAGCCTCAAATGG ATTACCAGAGGTTGACGTTCTCTCAAAACAATATGATGAGCTTTATCTCAAAAACAAAGATATAGATGCAAGATTATTT CTGGATCATGATGAAACTCTACAGCCTGATGTTATAGCATGCTCACAGTTGGAAAGAACACCACGAAAAAATAACCCAG ATGAGGAGGTTAATCATGTACTTCCACAGACTCCTGTTCGAGCTGCAATGAATACTATTCAGCAGTTGATGATGATTTT GAACTCAGCAACTGATAAACCATCAGATACTCTCATTGCATATTTCAATAATTGCACAGTGAACCCTGAAGACAGCATC CTGAAAAGAGTAGAAAGTCTTGGCCACATCTTCAAAAAGAAATTTGCTGAAGCAGTTGGACAGGGATGTGCTGAGATTG GCTCACAGAGATACCAGCTTGGAGTACGGCTGTATTACAGAGTAATGGAGTCTATGCTGAAGTCGGAAGAAGAGCGCCT CTCAGTGCACAATTTTAGCAAACTTCTGAATGATAACATCTTCCACACATCTCTTCTGGCATGTGCTCTTGAAATTGTC ATGGCTACCTATGGCAGAACTGCTTCACAAAGTGATGGTACCAGTGCTGAAACAGACTTGTCTTTCCCATGGATTCTCA ACGTATTTGATTTAAAAGCTTTTGACTTCTACAAGGTGATTGAAAGTTTCATTAAAGTGGAGCCAAGCCTAACGAGGGA CATGATAAAGCATCTAGAACGCTGTGAACATCGCATTATGGAATCTCTTGCTTGGCAATCTGATTCACCTCTGTTCGAT CTTATCAAGCAGTCAAAAGAACGAGAAGGTCAGACCGATCAGCCTGAGCCCACTTCCACCCTAAATCTGCCTCTCCAGC ACAACCACACTGCAGCAGATCTGTATCTTTCTCCTGTGAGATCTCCTAAGAAGAAAGCATCTGGACACCCTCAAAGTGG TACTTCTAATCCAGATGCTCAGCCATCTGCGACCTCACAAACACAGAAGCCACAGAAATCTACCTCCCTCTCTCTGTTC TACAAAAAAGTGTTTCGACTGGCCTATCTTCGATTGCATACCCTGTTCTTTCGGCTTCTCTCCGAACATCCTGACCTGG AGCCGTTGATCTGGACCCTCTTCCAGCACACACTGCAAAATGAGTCTGAGCTTATGAGAGACAGGCACTTGGACCAGAT CATGATGTGTTCCATGTATGGCATATGCAAAGTAAAGAATGTGGATCTTAGATTTAAAACAATAGTTTCTGCATACAAA GAGCTGCCCAATACAAATCAAGAGACTTTCAAACGTGTTCTTATCAGGGAAGAGCAGTACGACTCCATTATAGTCTTCT ACAACTTAGTGTTCATGCAGAAGCTGAAGACAAACATCCTGCAGTATGCCTCCAACAGGCCTCCTACGCTGTCACCTAT CCCACACATTCCTCGCAGCCCCTACCAGTTTTCCAATTCTCCTCGGCGTGTCCCTGCGGGCAATAACATCTACATCTCA CCCTTGAAGAGCCCTTACAAGTTCTCTGATGGGTTTCATTCTCCCACAAAGATGACTCCGAGGTCCAGAATTCTGGTGT CAATTGGTGAAACGTTTGGGACTTCTGAAAAGTTTCAAAAAATAAACCAGATGGTGTGCAACAGCGAGAGCCACGTAAA GCGCAGTGCGGAGCCCAGCGATGCCCCCAAGCCACTGAAGAGGCTGCGCTTCGATATAGAAGGGCAGGACGAGGCAGAT GGAGGCAAACACCTTCCCCAGGAGTCCAAGTTCCAACAAAAGCTTGCAGAAATGACATCTACTCGAACAAGAATGCAGA AGCAGAAACTGAATGATGGAAACGATACCTCAGCCAACGAAGAAAAGTGAGATTCTCCTCAGGACCAGGGGCTGCTGCA GGCCCTCCCAGCTTTTGTTTTACTGCCTTCATTCACTGAGTTGCTTCTTCAGTCGCTTTTATCCCAAACCAATAGTTGA AAACCCTTGGACTTTATTTTCTTCAAGGTTTTTCACGATACTTTGCCTTATGATGTAGCATGTATGCGATGTAAGCCAC TGAATTTAATTTATATATTTTCGGGGGATTTTAAAAAGCAGCTTGGGAAGTGTCTTAGTTTGCTATTGCAGCGTTACTG ATTGAAGCCAGTTCAATCTACCTGGATTGAATATTTTCTGTCTCAAGACAAAACGTTAGCTAGGGATCTGAAGTGCACT AATTTTACTTCTTAGATTTCATTTTAATGTCGGATCTCAAAGCATTATTTGCAAGTATTGAAAATGAGGGGTCAGATGC CGCAAGGATTTCTGTCTCTGTGTGTAATTAACACATCCAATTCCCATTAACTTAGCTGCACAGCAGCCGTGCAGGGTCA GGCTCTCCCCGCAGAAGCAGGAAGCAGTGAGCACGTCGTGTTAGCGGTACTACTGAAAGCAGTGAGCTGTGCTGCACCT CAGGTACGTCCCGTTCTGCAGTCCCCCAGCTCTCACCCCACACATTTCAGAGGGCCCACGTTGAATTTCATTGAATCTC ACAGAGGTTGAGTCCCACGAAGCAAAAAGGCGCATTCCCAAATGCAAAGTACCACGTTGTGCACTTTCGTATCTCGGAA AACCTCGATTTAAGAAAACACAAAGTAGAACACCCCCAACCTACATCACACCTCGCACACAGAAGATGGCAAAGGTCTC ACAATGTAGGATTCTCTTGAAGTGATTTCTACAGGTGTCCATGTGGCCGAACGTCACAGCACGAAGCTGTGTGCCTGAG GCGGTGCCTTACCCAAAAGGCAGAGCTCAATGGGCAACTTGGGAGCAAACGTTTTTAAGTGTATTTATAAGTTATGGAC TCAGATAGTGGATTTTTTTTTTCTTGCAGTGATAAAAGGTCTGCAGAATAGCCAGCTAAGAAAAGGGTGTTTTGTTTCT AGTGAACTAAATACAATAAATGAGGTGCCACGTTTTTAAATGACCCATTTTAATGAAATCTAGCTCATGCAGCTGCTTA AATCAGATGAGTTAGGGTAGCAAAGCATGCTGCTCATTACACAGTAACACTTCTCCGCATAGGAGGTGTTTAGAAATGG TGTAGTGAACCTAGAATGCCTACAGTAGTACCCGCTGAGGACCAGTTCTGGTGTTGACCAAAAGCTGAACCTGGAGGTA CAGAAACCTCCACAAACGGCACACGGATTGGTCACTGAATTGTAAAATGAGATTATTTTTTTATTCTCAGTACGGCTTC AACTTTCATCCCGAAGAATGTACAGAAGTGTTAAGAGTACACAACGTTTATTTTTTCACTTTCAACAGAGTTTTACAGA CAGAATGTGTGTTGCATTGGGGCTCGCTGGTCCCAAGCTCTGTTACAGCAGCTGAAGTTCTTCGGTGACCCTCGGGTGA GAGCGCTGCAGGCGCGACACGGCAGAGCCCCGCACCTAACAGATCTCCTAGCGCCTGACTGGGACACTGTGTTTGTTCG TTCCAACAGACCGAAGGCTTTACATCAAATGTATGGCAAT
Citation	Marx M, Lebuhotel C, Laugier D, Chapelle A, Calothy G, Saule S., Down regulation of pRb in cultures of avian neuroretina cells promotes proliferation of reactive Müller-like cells and emergence of retinal stem/progenitors. Exp Eye Res. 2010 Jun;90(6):791-801. Epub 2010 Apr 7.
Copyright	Copyright © 2012 Elsevier B.V. All rights reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204419.1 ).

Stage

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Location (click to highlight)

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25-30

stage 29

Retina

31-38

stage 35

stage 38

Retina

Entry 3

GEISHA Id	RB1.Trevers.2023	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show AATTTATATATTTTCGGGGGATTTTAAAAAGCAGCTTGGGAAGTGTCTTAGTTTGCTATTGCAGCGTTACTGATTGAAG CCAGTTCAATCTACCTGGATTGAATATTTTCTGTCTCAAGACAAAACGTTAGCTAGGGATCTGAAGTGCACTAATTTTA CTTCTTAGATTTCATTTTAATGTCGGATCTCAAAGCATTATTTGCAAGTATTGAAAATGAGGGGTCAGATGCCGCAAGG ATTTCTGTCTCTGTGTGTAATTAACACATCCAATTCCCATTAACTTAGCTGCACAGCAGCCGTGCAGGGTCAGGGTCTC CCCGCAGAAGCAGGAAGCAGTGAGCACGTCGTGTTAGCGGTACTACTGAAAGCAGTGAGCTGTGCTGCACCTCAGGTAC GTCCCGTTCTGCAGTCCCCCAGCTCTCACCCCACACATTTCAGAGGGCCCACGTTGAATTTCATTGAATCTCACAGAGG TTGAGTCCCACGAAGCAAAAAGGCGCATTCCCAAATGCAAAGTACCACGTTGTGCACTTTTGTATCTCGGAAAACCTCG ATTTAAGAAAACACAAAGTAGAACACCCCCAACCTACATCACACCTCGCACACAGAAGATGGCAAAGGTCTCACAATGT AGGATTCTCTTGAAGTGATTTCTACAGGTGTCCATGTGGCCGAACGTCACAGCACGGAGCTGTGTGCCTGAGGCGGTGC CTTACCC
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Trevers et al. 2023.