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Gene Family QuickSearch
Human Disease Gene Search
SHH The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol SHH Official Full Name sonic hedgehog CGNC ID 49404 also known as ShhNC, sonic hedgehog protein|shh unprocessed N-terminal signaling and C-terminal autoprocessing domains|sonic hedgehog homolog, Sonic hedgehog protein precursor, SHH gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function calcium ion binding , morphogen activity , peptidase activity , signal transducer activity , zinc ion binding Biological Process anterior/posterior pattern specification , apoptotic signaling pathway , cell-cell signaling , more... embryonic digit morphogenesis , embryonic limb morphogenesis , intein-mediated protein splicing , negative regulation of apoptotic process , polarity specification of anterior/posterior axis , proteolysis , response to retinoic acid Cellular Component extracellular region , extracellular space , plasma membrane
Links to other databases
Entry 1 GEISHA Id Sonic_Hedgehog Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GAATTCGCGGCCGCATCAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGC
Entry 2 GEISHA Id Shh.Maas.2004 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Maas SA, Fallon JF. Isolation of the Chicken Lmbr1 Coding Sequence and Characterization of Its Role During Chick Limb Development. Dev Dyn. 2004 Mar;229(3):520-8. Copyright Copyright © 2004 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 22
stage 22
Wing Mesenchyme
Entry 3 GEISHA Id Shh.Prin.2004 Data Source Publication Complete cDNA Template Probe show GAATTCGCGGCCGCATCAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGC
Citation Prin F, Logan C, D'Souza D, Ensini M, Dhouailly D. Dorsal versus ventral scales and the dorsoventral patterning of chick foot epidermis. Dev Dyn. 2004 Mar;229(3):564-78. Copyright Wiley-Liss, Inc. 2004
Entry 4 GEISHA Id Shh.Hurtado.2006 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Hurtado R, Mikawa T. Enhanced sensitivity and stability in two-color in situ hybridization by means of a novel chromagenic substrate combination. Dev Dyn. 2006 Oct;235(10):2811-6. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
stage 18
stage 18
stage 18
stage 18
stage 18
Central Nervous System Notochord
Entry 5 GEISHA Id Shh.Aglyamova.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Aglyamova GV, Agarwala S. Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord. Dev Dyn. 2007 May;236(5):1363-73 Copyright Copyright © 2007 Wiley-Liss, Inc. Comments According to the authors, "Digoxigenin- or FL-conjugated antisense riboprobes were prepared from chick cDNAs." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (NM_204821).
Entry 6 GEISHA Id Shh.Gimeno.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Gimeno L, Martinez S. Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh. Dev Dyn. 2007 Aug;236(8):2285-97. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments According to the authors, "Digoxigenin and fluorescein RNA antisense probes for chick SHH gene was prepared according to the instructions of the manufacturer (Roche)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (NM_204821).
Entry 7 GEISHA Id Shh.Shin.2006 Data Source Publication Complete cDNA Template Probe show GAATTCGCGGCCGCATCAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGC
Citation Shin M, Noji S, Neubüser A, Yasugi S.
FGF10 is required for cell proliferation and gland formation in the stomach epithelium of the chicken embryo. Dev Biol. 2006 Jun 1;294(1):11-23. Epub 2006 Apr 17. Copyright Reprinted from Developmental Biology, 294, Masahiron Shin, Sumihare Noji, Annette Neubüser, and Sadao Yasugl, 11-23, Copyright 2006, with permission from Elsevier. Copyright © 2005 Elsevier Inc. All rights reserved. Comments Shh was a gift from Dr. T. Nohno, who cloned it using PCR primers similar to Riddle et al. 1993. Their clone sequence is inserted here (Acc. # L28099).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 32
stage 37
stage 38
Stomach
Entry 8 GEISHA Id SHH.Franz-Odendaal.2008 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Franz-Odendaal TA. Toward understanding the development of scleral ossicles in the chicken, Gallus gallus. Dev Dyn. 2008 Nov Copyright Copyright © 2009 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204821.1); insert length is 1.7 kb.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 35
stage 35
stage 35
stage 38
stage 38
Feathers/Scutae
Entry 9 GEISHA Id Shh.Tomonari.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Tomonari S, Takagi A, Noji S, Ohuchi H. Expression pattern of the melanopsin-like (cOpn4m) and VA opsin-like genes in the developing chicken retina and neural tissues. Gene Expr Patterns. 2007 Aug;7(7):746-53. Epub 2007 Jun 13. Copyright "Reprinted from Gene Expression Patterns, Volume number 7, Tomonari S, Takagi A, Noji S, Ohuchi H, Expression pattern of the melanopsin-like (cOpn4m) and VA opsin-like genes in the developing chicken retina and neural tissues.,746-53, Copyright (2007), with permission from Elsevier".
Copyright © (2007) Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821 ).
Entry 10 GEISHA Id Shh.Garcia-Calero.2006 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation García-Calero E, Garda AL, Marín F, Puelles L. Expression of Lrrn1 marks the prospective site of the zona limitans thalami in the early embryonic chicken diencephalon. Gene Expr Patterns. 2006 Oct;6(8):879-85. Epub 2006 Feb 28. Copyright Reprinted with permission from Elsevier. Copyright © 2006 Elsevier B.V. All rights reserved. Comments According to the authors, "Digoxigenin-labeled RNA probes were prepared from plasmids kindly provided by J.L.R. Rubenstein (Shh)..." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 14
stage 16
stage 17
stage 18
Diencephalon Midbrain 25 stage 25
Diencephalon
Entry 11 GEISHA Id Shh.Ha.2003 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Ha AS, Riddle RD. cBlimp-1 expression in chick limb bud development. Gene Expr Patterns. 2003 Jun;3(3):297-300. Copyright Reprinted from Gene Expr Patterns, Volume 3, Issue 3, Alice S. Ha and Robert D. Riddle, cBlimp-1 expression in chick limb bud development, Pages 297-300, Copyright 2003, with permission from Elsevier.
Copyright © 2003 Elsevier Science B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 20
Leg Mesenchyme
Entry 12 GEISHA Id Shh.Cheng.2004 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Cheng L, Alvares LE, Ahmed MU, El-Hanfy AS, Dietrich S. The epaxial-hypaxial subdivision of the avian somite. Dev Biol. 2004 Oct 15;274(2):348-69. Copyright Reprinted from Developmental Biology, Volume 274, Issue 2, Louise Cheng, Lúcia E. Alvares, Mohi U. Ahmend, Amira S. El-Hanfy, and Susanne Dietrich, The epaxial-hypaxial subdivision of the avian somite, Pages 348-369, Copyright 2004, with permission from Elsevier.
Copyright © 2004 Elsevier B.V. All rights reserved. Comments Authors indicate they used the same probe as Johnson et al., 1994. No probe information is listed in that paper. As information provided is insufficient to verify exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (Acc# NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7 stage 7
Notochord Spinal Cord
Entry 13 GEISHA Id Shh.Lobjois.2004 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Lobjois V, Benazeraf B, Bertrand N, Medevielle F, Pituello F. Specific regulation of cyclins D1 and D2 by FGF and Shh signaling coordinates cell cycle progression, patterning, and differentiation during early steps of spinal cord development. Dev Biol. 2004 Sep 15;273(2):195-209. Copyright Reprinted from Developmental Biology, Volume 273, Issue 2, Valérie Lobjois, Bertrand Benazeraf, Nicolas Betrand, François Medevielle and Fabienne Pituello, Specific regulation of cyclins D1 and D2 by FGF and Shh signaling coordinates cell cycle progression, patterning, and differentiation during early steps of spinal cord development, Pages 195-209, Copyright 2004, with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved. Comments Authors said: chicken Gli 1 cDNA (2.2 kb), Shh cDNA (1.6 kb), and Patched1 cDNA (802 bp), gifts from C. Tabin. As information provided is insufficient to verify exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (Acc# NM_204821.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Notochord
Entry 14 GEISHA Id Shh.Maden.2007 Data Source Publication Complete cDNA Template Probe show CCCACCAGTGGCCAGGCATTCTTTGCCAGCAATGTGAAGCCTGGCCAACGTGTNTATGTGCTGGGAGAGGGCGGGCGGC
Citation Maden M, Blentic A, Reijntjes S, Seguin S, Gale E, Graham A. (2007). Retinoic acid is required for specification of the ventral eye field and for Rathke's pouch in the avian embryo. Int J Dev Biol. 2007;51(3):191-200. Copyright "Reprinted from Int. J. Dev. Biol., 51, Maden M, Blentic A, Reijntjes S, Seguin S, Gale E, Graham A, Retinoic acid is required for specification of the ventral eye field and for Rathke's pouch in the avian embryo, 191-200, Copyright (2007), with permission from Copyright © 2007 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #AF022882). Images and sequence given are quail, but map shown is chick.
Entry 15 GEISHA Id Shh.Bardot.2004 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Bardot B, Lecoin L, Fliniaux I, Huillard E, Marx M, Viallet JP. Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development. Int J Dev Biol. 2004;48(2-3):149-56. Copyright "Reprinted from Int. J. Dev. Biol., 48, Bardot B, Lecoin L, Fliniaux I, Huillard E, Marx M, Viallet JP, Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development, 149-56, Copyright (2004), with permission from Copyright © 2004 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_204821).
Entry 16 GEISHA Id Shh.Christ.2002 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Christ B, Brand-Saberi B. Limb muscle development. Int J Dev Biol. 2002;46(7):905-14. Copyright "Reprinted from Int. J. Dev. Biol., 46, Christ B, Brand-Saberi B, Limb muscle development, 905-14, Copyright (2002), with permission from Copyright © 2002 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
Limb Buds 31-44 stage 44
Limb Buds
Entry 17 GEISHA Id Shh.Pearse.2001 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Pearse RV, Vogan KJ, Tabin CJ. Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev Biol. 2001 Nov 1;239(1):15-29. Copyright Reprinted with permission from Elsevier.
Copyright © 2001 Elsevier B.V. All rights reserved. Comments According to the authors, "Digoxigenin (Dig)-labeled antisense RNA probes for Shh were generated from linearized DNA templates as described previously (Riddle et al., 1993)." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (NM_204821).
Entry 18 GEISHA Id Shh.Agarwala.2005 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments According to the authors, "Digoxigenin
(DIG)- and fluorescein-labeled riboprobes were synthesized from chick cDNA plasmids..." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (NM_204821).
Entry 19 GEISHA Id SHH.Scherz.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Scherz PJ, McGlinn E, Nissim S, Tabin CJ. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb.Dev Biol. 2007 Aug 15;308(2):343-54. Epub 2007 May 31. Copyright Reprinted with permission from Elsevier.
Copyright 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc #NM_204821.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 21
stage 24
stage 24
Leg
Entry 20 GEISHA Id Shh.Vieira.2005 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Vieira C, Garda AL, Shimamura K, Martinez S. Thalamic development induced by Shh in the chick embryo. Dev Biol. 2005 Aug 15;284(2):351-63. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments According to the authors, "Digoxigenin and fluorescein-labeled RNA probes were
prepared from plasmids kindly provided by J.L.R. Rubenstein." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (NM_204821).
Entry 21 GEISHA Id Shh.Nissim.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Nissim S, Allard P, Bandyopadhyay A, Harfe BD, Tabin CJ. Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb. Dev Biol. 2007 Apr 1;304(1):9-21. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in the publication to verify the exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (acc # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
Limb Buds 25 stage 25
Limb Buds
Entry 22 GEISHA Id Shh.Liu.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Liu G, Moro A, Zhang JJ, Cheng W, Qiu W, Kim PC. The role of Shh transcription activator Gli2 in chick cloacal development. Dev Biol. 2007 Mar 15;303(2):448-60. Epub 2006 Dec 15 Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204821).
Entry 23 GEISHA Id Shh.Haworth.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Haworth KE, Wilson JM, Grevellec A, Cobourne MT, Healy C, Helms JA, Sharpe PT, Tucker AS. Sonic hedgehog in the pharyngeal endoderm controls arch pattern via regulation of Fgf8 in head ectoderm. Dev Biol. 2007 Mar 1;303(1):244-58. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Authors indicate Shh was linearised with Sal1 and transcribed with Sp6. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204821.1).
Entry 24 GEISHA Id Shh.Zhang.2001 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Zhang XM, Yang XJ (2001). Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev Biol. 2001 May 15;233(2):271-90. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204821).
Entry 25 GEISHA Id Shh.Levin.1995 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Levin M, Johnson RL, Stern CD, Kuehn M, Tabin C (1995). A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell. 1995 Sep 8;82(5):803-14. Copyright Copyright © 1995 Elsevier Inc. All Rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 4
stage 4
stage 4
stage 4
stage 4
Head Process Hensen's Node 7-12 stage 7
Hensen's Node 31-44 stage 44
stage 44
stage 44
stage 44
Entry 26 GEISHA Id Shh.Vasiliauskas.1999 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Vasiliauskas D, Hancock S, Stern CD. SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. Mech Dev. 1999 Apr;82(1-2):79-94
Copyright Copyright © 1999 Elsevier Science Ireland Ltd. All rights reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI NM_204821).
Entry 27 GEISHA Id Shh.McKinnell.2004 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation McKinnell IW, Turmaine M, Patel K (2004). Sonic Hedgehog functions by localizing the region of proliferation in early developing feather buds. Dev Biol. 2004 Aug 1;272(1):76-88. Copyright Copyright © 2004 Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
stage 30
Feathers/Scutae 31-33 stage 31
stage 33
stage 33
Feathers/Scutae
Entry 28 GEISHA Id Shh.Bok.2005 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Bok J, Bronner-Fraser M, Wu DK. Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear. Development. 2005 May;132(9):2115-24. Epub 2005 Mar 23. Copyright Copyright for articles in Development are retained by the authors. Permission granted by MBF. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204821).
no images
Entry 29 GEISHA Id Shh.Garcia-Castro.2000 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation García-Castro MI, Vielmetter E, Bronner-Fraser M. N-Cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry. Science. 2000 May 12;288(5468):1047-51. Copyright Copyright © 2000, The American Association for the Advancement of Science Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204821).
Entry 30 GEISHA Id SHH.Quinlan.2009 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Quinlan R, Graf M, Mason I, Lumsden A, Kiecker C. Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain. Neural Dev. 2009 Sep 4;4:35. Copyright Copyright © 2009 Quinlan et al; licensee BioMed Central Ltd. [This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.] Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
stage 24
Forebrain Hindbrain Midbrain
Entry 31 GEISHA Id Shh.Garcia-Lopez.2009 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation García-López R, Soula C, Martínez S. Expression analysis of Sulf1 in the chick forebrain at early and late stages of development. Dev Dyn. 2009 Sep;238(9):2418-29. Copyright Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-26 stage 26
Neural Plate/Tube
Entry 32 GEISHA Id SHH.Agarwala.2001 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Agarwala S, Sanders TA, Ragsdale CW. Sonic hedgehog control of size and shape in midbrain pattern formation. Science. 2001 Mar 16;291(5511):2147-50. Epub 2001 Mar 1. Copyright © 2011 American Association for the Advancement of Science. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204821.1).
Entry 33 GEISHA Id SHH.Agarwala.2002 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Agarwala S, Ragsdale CW. A role for midbrain arcs in nucleogenesis. Development. 2002 Dec;129(24):5779-88. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Ragsdale. Comments As insufficient information is provided in publication to verify exact
sequence used to synthesize probe, the sequence below was obtained
from NCBI (acc #NM_204821.1).
Two-color whole-mount in situ hybridization was carried out on
chick brain with digoxigenin- and fluorescein-labeled riboprobes
synthesized from chick cDNA plasmids for SHH
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
Midbrain 25-26 stage 26
stage 26
stage 26
stage 26
Ectoderm Midbrain
Entry 34 GEISHA Id SHH.Parkinson.2010 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Parkinson N, Collins MM, Dufresne L, Ryan AK. Expression patterns of hormones, signaling molecules, and transcription factors during adenohypophysis development in the chick embryo. Dev Dyn. 2010 Apr;239(4):1197-210. Copyright Copyright © 2010 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821.1).
Entry 35 GEISHA Id SHH.Halilagic.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Halilagic A, Ribes V, Ghyselinck NB, Zile MH, Dollé P, Studer M. Retinoids control anterior and dorsal properties in the developing forebrain. Dev Bio 2007 Mar 1;303(1):244-58 Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821.1). Images are quail, but sequence and map shown are chick.
Entry 36 GEISHA Id SHH.Mao.2009 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Mao J, McGlinn E, Huang P, Tabin CJ, McMahon AP. Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell. 2009 Apr;16(4):600-6. Copyright don't have permission yet Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
stage 17
stage 17
Limb Buds
Entry 37 GEISHA Id SHH.Luo.2006 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Luo J, Ju MJ, Redies C. Regionalized cadherin-7 expression by radial glia is regulated by Shh and Pax7 during chicken spinal cord development. Neuroscience. 2006 Nov 3 Copyright © 2006 IBRO. Published by Elsevier Ltd. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 23
stage 23
Spinal Cord 25-28 stage 28
Spinal Cord
Entry 38 GEISHA Id SHH.Dunn.2011 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Dunn IC, Paton IR, Clelland AK, Sebastian S, Johnson EJ, McTeir L, Windsor D, Sherman A, Sang H, Burt DW, Tickle C, Davey MG. The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development. Dev Dyn. 2011 May;240(5):1163-72. Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Limb Buds Somites 25-26 stage 25
stage 25
stage 25
stage 26
Limb Buds Somites Unlabeled
Entry 39 GEISHA Id SHH.Grevellec.2011 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Grevellec A, Graham A, Tucker AS. Shh signalling restricts the expression of Gcm2 and controls the position of the developing parathyroids. Dev Biol. 2011 May 15;353(2):194-205. Epub 2011 Feb 22. Copyright Copyright © 2011 Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821.1).
Entry 40 GEISHA Id SHH.Chambers.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Chambers D, Wilson L, Maden M, Lumsden A. RALDH-independent generation of retinoic acid during vertebrate embryogenesis by CYP1B1. Development. 2007 Apr;134(7):1369-83. Copyright © 2007 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204821.1).
Entry 41 GEISHA Id SHH.Gros.2010 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Gros J, Feistel K, Viebahn C, Blum M, Tabin CJ. Cell movements at Hensens node establish Left/Right asymmetric gene expression in the chick. Science. 2009 May 15; 324(5929): 941944. Copyright © 2012 American Association for the Advancement of Science. All Rights Reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3 stage 3
Hensen's Node 4-5 stage 4
stage 5
stage 5
stage 5
stage 5
Head Process Hensen's Node
Entry 42 GEISHA Id SHH.Golden.1999 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Golden JA, Bracilovic A, McFadden KA, Beesley JS, Rubenstein JL, Grinspan JB. Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2439-44. Copyright Copyright © 2012 National Academy of Sciences. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204821.1 ).
Entry 43 GEISHA Id SHH.Kolpak.2005 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Kolpak A, Zhang J, Bao ZZ Sonic Hedgehog Has a Dual Effect on the Growth of Retinal Ganglion Axons Depending on Its Concentration. J Neurosci. 2005 March 30; 25(13): 34323441. Copyright Copyright © 2012 by the Society for Neuroscience Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204821.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Retina 25-30 stage 27
stage 29
Retina 31-35 stage 31
stage 35
stage 35
Retina
Entry 44 GEISHA Id SHH.Tapadia.2005 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Tapadia MD, Cordero DR, Helms JA. It's all in your head: new insights into craniofacial development and deformation. J Anat. 2005 November; 207(5): 461477. Copyright Copyright © 2005 The Author Journal compilation © 2005 Anatomical Society of Great Britain and Ireland Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204821.1).
Entry 45 GEISHA Id SHH.Brito.2006 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation José M. Brito, Marie-Aimée Teillet, Nicole M. Le Douarin. An early role for Sonic hedgehog from foregut endoderm in jaw development: Ensuring neural crest cell survival. Proc Natl Acad Sci U S A. 2006 August 1; 103(31): 1160711612. Copyright Copyright © 2006 by The National Academy of Sciences of the USA
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 8
stage 8
stage 9
stage 9
stage 9
stage 9
stage 9
stage 9
stage 9
stage 9
stage 9
Endoderm Foregut Gut Neural Plate/Tube 19-21 stage 21
stage 21
Entry 46 GEISHA Id SHH.Davey.2006 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Davey MG, Paton IR, Yin Y, Schmidt M, Bangs FK, Morrice DR, Smith TG, Buxton P, Stamataki D, Tanaka M, Münsterberg AE, Briscoe J, Tickle C, Burt DW. The chicken talpid3 gene encodesa novel protein essentialfor Hedgehog signaling. Genes Dev. 2006 May 15; 20(10): 13651377. Copyright Copyright © 2006, Cold Spring Harbor Laboratory Press Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 19
stage 19
stage 20
stage 20
Limb Buds Neural Plate/Tube Notochord
Entry 47 GEISHA Id SHH.Psychoyos.2008 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Psychoyos D, Finnell R. Double Whole Mount in situ Hybridization of Early Chick Embryos. J Vis Exp. 2008; (20): 904. Copyright Copyright © 2008, Journal of Visualized Experiments
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-8 stage 8
stage 8
Neural Plate/Tube Notochord
Entry 48 GEISHA Id SHH.Fisher.2008 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Fisher ME, Clelland AK, Bain A, Baldock RA, Murphy P, Downie H, Tickle C, Davidson DR, Buckland RA. Integrating technologies for comparing 3D gene expression domains in the developing chick limb. Dev Biol. 2008 May 1;317(1):13-23. Epub 2008 Feb 7. Copyright Copyright © 2008 Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204821.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-23 stage 22
stage 22
stage 22
stage 22
stage 22
stage 22
stage 22
stage 22
stage 22
stage 22
stage 22
stage 23
stage 23
stage 23
Gut Leg Limb Buds Neural Plate/Tube Notochord Wing
Entry 49 GEISHA Id SHH.Lancman.2006 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Lancman JJ, Caruccio NC, Harfe BD, Pasquinelli AE, Schageman JJ, Pertsemlidis A, Fallon JF. Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn. 2005 Dec;234(4):948-60. Copyright Copyright © 2005 Wiley-Liss, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 24
stage 24
Leg
Entry 50 GEISHA Id SHH.WangS.2004 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Wang S, Yu X, Zhang T, Zhang X, Zhang Z, Chen Y. Chick Pcl2 regulates the left-right asymmetry by repressing Shh expression in Hensen's node. Development. 2004 Sep;131(17):4381-91. Epub 2004 Aug 4. Copyright copyright 2004 to the authors. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204821.1 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 4
stage 4
Hensen's Node Notochord 7-11 stage 11
stage 11
Hensen's Node
Entry 51 GEISHA Id SHH.Tao.2002 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Tao H, Yoshimoto Y, Yoshioka H, Nohno T, Noji S, Ohuchi H. FGF10 is a mesenchymally derived stimulator for epidermal development in the chick embryonic skin. Mech Dev. 2002 Aug;116(1-2):39-49. Copyright Copyright © 2012 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204821.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 20
Feathers/Scutae Leg 31 stage 31
stage 31
Feathers/Scutae
Entry 52 GEISHA Id SHH.Katsu.2012 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Katsu K, Tokumori D, Tatsumi N, Suzuki A, Yokouchi Y. BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo. Dev Biol. 2012 Mar 1;363(1):15-26. Copyright Copyright © 2012. Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 6
stage 6
Hensen's Node
Entry 53 GEISHA Id SHH.Senthinathan.2012 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Senthinathan B, Sousa C, Tannahill D, Keynes R. The generation of vertebral segmental patterning in the chick embryo. J Anat. 2012 Jun;220(6):591-602. Copyright © 2012 The Authors. Journal of Anatomy © 2012 Anatomical Society. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-29 stage 29
stage 29
Notochord
Entry 54 GEISHA Id SHH.Ferran.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Ferran JL, Sánchez-Arrones L, Sandoval JE, Puelles L. A model of early molecular regionalization in the chicken embryonic pretectum. J Comp Neurol. 2007 Dec 1;505(4):379-403. Copyright Copyright © 19992012 John Wiley & Sons, Inc. All Rights Reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-16 stage 16
stage 16
Diencephalon Hypothalamus
Entry 55 GEISHA Id SHH.Wade.2012 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Wade C, Brinas I, Welfare M, Wicking C, Farlie PG.
Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1. Dev Biol. 2012 Oct 1;370(1):145-53.
Copyright Copyright © 2012 Elsevier Inc. All rights reserved
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25 stage 25
stage 25
stage 25
stage 25
Leg
Entry 56 GEISHA Id SHH.Tsikolia.2012 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Comments According to the authors, "Digoxigenin-labeled mRNA probes for nodal, shh, fgf8 were produced using the plasmid DNAs previously published ( Boettger et al., 1999, Essner et al., 2002 and Levin et al., 1995)" As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc# NM_204821.1).
Entry 57 GEISHA Id SHH.Richardson.2011 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Richardson J, Shono T, Okabe M and Graham A. The presence of an embryonic opercular flap in amniotes. PLoS One. 2012; 7(9): e44903. Published online 2012 September 11. Copyright PLoS One. 2012; 7(9): e44903. Published online 2012 September 11. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204821.1).
Entry 58 GEISHA Id SHH.Mercier.2012 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Mercier S, David V, Ratié L, Gicquel I, Odent S, Dupé V.. NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryos. Dis Model Mech. 2013 March; 6(2): 537543. Published online 2012 December 20. Copyright Copyright © 2013. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-ncsa/ 3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205066.1 NM_204821.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Head Mesenchyme
Entry 59 GEISHA Id SHH.Guinazu.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Guinazu MF, Chambers D, Lumsden A, Kiecker C. Tissue interactions in the developing chick diencephalon. Neural Dev. 2007 Nov 13;2:25. Copyright Copyright © 2007 Guinazu et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204821.1
Entry 60 GEISHA Id SHH.Hirashima.2008 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Hirashima M, Kobayashi T, Uchikawa M, Kondoh H, Araki M. Anteroventrally localized activity in the optic vesicle plays a crucial role in the optic development. Dev Biol. 2008 May 15;317(2):620-31. doi: 10.1016/j.ydbio.2008.03.010. Epub 2008 Mar 20. Copyright Copyright © 2008 Elsevier Inc. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204821.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-11 stage 11
stage 11
Head Process Notochord
Entry 61 GEISHA Id SHH.Manning.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Manning L, Ohyama K, Saeger B, Hatano O, Wilson SA, Logan M, Placzek M. Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation. Dev Cell. 2006 Dec;11(6):873-85. Copyright Copyright © 2006 Elsevier Inc. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204821.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 7
stage 8
stage 10
stage 10
stage 10
Head Process Hypothalamus Notochord 13-18 stage 13
stage 14
stage 15
stage 15
stage 16
stage 16
stage 17
stage 18
stage 18
stage 18
stage 18
Diencephalon Hypothalamus
Entry 62 GEISHA Id SHH.Marcucio.2005 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Marcucio RS, Cordero DR, Hu D, Helms JA. Molecular interactions coordinating the development of the forebrain and face. Dev Biol. 2005 Aug 1;284(1):48-61. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204821.1).
Entry 63 GEISHA Id SHH.Tzahor.2003 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Tzahor E, Kempf H, Mootoosamy RC, Poon AC, Abzhanov A, Tabin CJ, Dietrich S, Lassar AB. Antagonists of Wnt and BMP signaling promote the formation of vertebrate head muscle. Genes Dev. 2003 Dec 15;17(24):3087-99. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. #NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
stage 17
stage 17
Pharyngeal Arches and Clefts
Entry 64 GEISHA Id SHH.Chen.1996 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Chen Y1, Dong D, Kostetskii I, Zile MH.
Hensen's node from vitamin A-deficient quail embryo induces chick limb bud duplication and retains its normal asymmetric expression of Sonic hedgehog (Shh). Biol. 1996 Jan 10;173(1):256-64. Copyright Copyrightq1996 by Academic Press, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (Acc. # NM_204269.1).
Entry 65 GEISHA Id SHH.Ratie.2013 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Leslie Ratié, Michelle Ware, Frédérique Barloy-Hubler, Hélène Romé, Isabelle Gicquel, Christèle Dubourg, Véronique David and Valérie Dupé. Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev. 2013 Dec 23;8:25. doi: 10.1186/1749-8104-8-25. Copyright © 2013 Ratié et al.; licensee BioMed Central Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (ACC. # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-14 stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
Hypothalamus
Entry 66 GEISHA Id SHH.Ware.2014 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Ware M, Hamdi-Rozé H and Dupé V (2014) Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus. Front Neuroanat. 2014 Dec 2;8:140. doi: 10.3389/fnana.2014.00140. Copyright Copyright © 2014 Ware, Hamdi-Rozé and Dupé Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence was obtained from NCBI (Acc. # NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-15 stage 15
stage 15
stage 15
stage 15
Hypothalamus
Entry 67 GEISHA Id Shh.Abzhanov.2004 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Abzhanov A, Tabin CJ. Shh and Fgf8 act synergistically to drive cartilage outgrowth during cranial development. Dev Biol 2004 Sep 1;273(1):134-48. Copyright Copyright © 2004 Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the complete sequence was obtained from NCBI (acc # NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-36 stage 36
stage 36
Face Mesenchyme
Entry 68 GEISHA Id Shh.Abzhanov.2007 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Abzhanov, A., Cordero, D. R., Sen, J., Tabin, C. J. and Helms, J. A. Cross–regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence. Congenit Anom (Kyoto). 2007 Dec;47(4):136-48. Copyright Copyright © 2007 The Authors, Journal compilation © 2007 Japanese Teratology Society Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (acc # NM_204821).
Entry 69 GEISHA Id Shh.Cauthen.2001 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Cauthen CA, Berdougo E, Sandler J, Burrus LW. Comparative analysis of the expression patterns of Wnts and Frizzleds during early myogenesis in chick embryos. Mech Dev. 2001 Jun;104(1-2):133-8. Copyright Copyright © 2001 Elsevier Science Ireland Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204821.1).
Entry 70 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-27 stage 27
Face Mesenchyme all
Entry 71 GEISHA Id Shh.Pickering.2019 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Pickering J, Chinnaiya K, Towers M. An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development. Elife. 2019 Sep 23;8. pii: e47625. DOI: 10.7554/eLife.47625. Copyright Copyright © 2019, Pickering et al. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_204821.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
ZPA 25 stage 25
ZPA all
Entry 72 GEISHA Id Shh.Sjödal.2008 Data Source Publication Complete cDNA Template Probe show CAGACCCTTTTTGTCTCTCGATTGCTGTCTCCCGACCAAACTCCGATGTGTTCCGTTATCAGCGACCTAAAGGCTGCCA
Citation Sjödal M, Gunhaga L. Expression patterns of Shh, Ptc2, Raldh3, Pitx2, Isl1, Lim3 and Pax6 in the developing chick hypophyseal placode and Rathke’s pouch. Gene Expr Patterns. 2008 Sep;8(7-8):481-5. Epub 2008 Jul 4.. DOI: 10.1016/j.gep.2008.06.007. Copyright Copyright © 2008 Elsevier B.V. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204821).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 6
Mesoderm 7-12 stage 9
stage 10
Mesoderm 13-18 stage 13
stage 13
stage 17
stage 17
Ectoderm 19-24 stage 20
stage 20
stage 24
stage 24
Ectoderm all
Data from NCBI Unigene EST ProfileGga.345
Mouse Frog Fruit Fly Zebra Finch Zebrafish
