Geisha

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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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SIM2
SIM bHLH transcription factor 2

Gene

Official Symbol	SIM2
Official Full Name	SIM bHLH transcription factor 2
CGNC ID	11985
also known as	single-minded homolog 2\|single-minded family bHLH transcription factor 2
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	Gallus-Browse

Sequence Information

Genomic
RNA	XM_416724
Polypeptide	XP_416724
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	6493	ENSG00000159263		MIM:600892
Mouse	20465	ENSMUSG00000062713	All phenotypic alleles (2):Targeted, knock-out(2)	MGI:98307
Xenopus	100492082, 373634			1013957
Zebrafish	114450		ZDB-GENE-010803-1	ZFIN:ZDB-GENE-010803-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	418515
Ensembl Gene	ENSGALG00000016044
KEGG	gga:418515

Entry 1

GEISHA Id	SIM2.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	CGGCGAAGACAAGGCGGG
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGGTGATTTTGGCAGCAAGGAGTTAGC	cDNA Template Length	1814
Forward cDNA Template Probe	show NCCGTTTACTGTGCACGTTCATGCAGGNCTGGNATCGCCAGNTTTCCCACCTGGGCTGCATTCCAGTTTGTCTGTTTGG AATGAGCTGTATTGCTGTTGTGGGTAAGGCGTTGTTCTGAGTTTTGCTTTCATCTTATTACTTTTGGGTTTTACTATTT TCCTTGTTTCCTGCGAGGTAGATACTGAGTTTCTGCATGAAAACTGTGACTTAGAAATGGTAACCTGGTCCAGTGACAG CTGAAGTTCCTTATACTCAATATCTGTAAGGACATAATTGACACTCACTATGCAGTGAGGCCGTGATGAACGGCTGTTA TGCACAATGGTAGCGTAGCTCTGTACCCAAACCCAGCCTCCTTGTTTGGACAGTAGTCGATAGTACTTGGTTGTTACTT GGCCTTTCACCAACAACAGATGATGAGCATATCGTAAATGGAACACATCACAGCCATGAACATGGTGATAGAGCGTTTT TTCTATCAGATCTTGGGGTTCATATCCAGTTAATTCAGTCACTCTGGAATCTAGGAATATTAACTTCAAGTCCAAACTT GCTCTGAACATAAACATGTTACTATGAAGTTTGATCTCAGTGATTGCACTAGGGGGTAAAGATTGACCTACAGCCACCA GTCCAACAATTTGGTAACAGGAATCATACAAAGACATATCGAGCATATACTGCCGTATCTTCAAATAGCCACTGCAGTG GATCACCTTGTAGCCACTGCATGTCAATCCTGCATTCCTCTTGGCTAGGACACACTTCATTCTCAGGAAAAATGATCTC TCAATTTCATATTCTTGTAAGAGGTGAGGATGAAGAGGCTGGTGAGCAGTAAGAACAGCCGTCATCTCATCGTGGTCGG AAGGGTGTATATACTCATAAATGCTATTACCAGTAAGCTCCACCTGAATAAACCCAAGAAAA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 14

stage 15

stage 17

Midbrain

19-24

stage 22

stage 23

Aorta
Cranial PNS
Eye
Gut
Leg Mesenchyme
Mesencephalon
Midbrain
Oral Pharynx
Pharyngeal Arches and Clefts
Spinal Ganglia and Nerves
Wing Mesenchyme

anteriorward
left wing, medial view

stage 25

Leg Mesenchyme
Midbrain
Oral Pharynx
Pharyngeal Arches and Clefts
Spinal Ganglia and Nerves
Wing Mesenchyme

Lateral view.
Medial view.

Entry 2

GEISHA Id	SIM2.Caqueret.2005	Data Source	Publication
Complete cDNA Template Probe	show ATGAAGGAAAAATCCAAGAACGCGGCGAAGACAAGGCGGGAAAAGGAAAATGGAGAGTTCTACGAACTGGCCAAGCTCC TGCCGCTGCCCTCGGCCATCACCTCGCAGCTGGACAAGGCGTCCATCATCCGCCTCACCACCAGCTATCTGAAGATGCG AGCCGTCTTCCCCGAAGGTCTGGGCGACGCCTGGGGACAGCCGAGCAGGATAGGGCCCTTGGATAACGTGGCCAAGGAG CTCGGATCCCACTTGCTTCAGACTTTGGATGGCTTTGTTTTTGTGGTAGCATCAGATGGCAAAATAATGTACATCTCAG AAACAGCGTCTGTACATCTTGGCTTATCTCAGGTGGAGCTTACTGGTAATAGCATTTATGAGTATATACACCCTTCCGA CCACGATGAGATGACGGCTGTTCTTACTGCTCACCAGCCTCTTCATCCTCACCTCTTACAAGAATATGAAATTGAGAGA TCATTTTTCCTGAGAATGAAGTGTGTCCTAGCCAAGAGGAATGCAGGATTGACGTGCAGTGGCTACAAGGTGATCCACT GCAGTGGCTATTTGAAGATACGGCAGTATATGCTCGATATGTCTTTGTATGATTCCTGTTACCAAATTGTTGGACTGGT GGCTGTAGGTCAATCTTTACCCCCTAGTGCAATCACTGAGATCAAACTTCATAGTAACATGTTTATGTTCAGAGCAAGT TTGGACTTGAAGTTAATATTCCTAGATTCCAGAGTGACTGAATTAACTGGATATGAACCCCAAGATCTGATAGAAAAAA CGCTCTATCACCATGTTCATGGCTGTGATGTGTTCCATTTACGATATGCTCATCATCTGTTGTTGGTGAAAGGCCAAGT AACAACCAAGTACTATCGACTACTGTCCAAACAAGGAGGCTGGGTTTGGGTACAGAGCTACGCTACCATTGTGCATAAC AGCCGTTCATCACGGCCTCACTGCATAGTGAGTGTCAATTATGTCCTTACAGATATTGAGTATAAGGAACTTCAGCTGT CACTGGACCAGGTTACCATTTCTAAGTCACAGTTTTCATGCAGAAACTCAGTATCTACCTCGCAGGAAACAAGGAAAAT AGTAAAACCCAAAAGTAATAAGATGAAAGCAAAACTCAGAACAACGCCTTACCCACAACAGCAATACAGCTCATTCCAA ACAGACAAACTGGAATGCAGCCAGGTGGGAAACTGGCGATCCAGCCCTGCAGTGAACGCTGCCACCATTCAAGAACAAA ACTTTCATTCAGAAAACAGTGAACTTTTATATGCCCCGTCATATAGCTTGCCTTTCTCTTACCATTATGGACACTTCCC TGTAGACTCTCATGTCTTCAGCAGCAAAAAGCAAATGCTGCCTCCTAAGTTTGGGCAGTCTCAAGGAGCACCTTGTGAA GTGGCTCGATTTTTCTTGAGTACGCTGCAGACAAATGGAGAATGCCAGTGGCATTACGCCAACTCCTTGGTACCCAACA GCCAGTCACCATCCAAAAATCTTCCTGAGCAGCCAGTGAACATCATCCGACATAATCTTGGACAGAGTTATGAAGCAGA CAAGCGATTTACCACTGATGCTCTCTCCGACAACTTTACAAGTTGCACAGCACCCATGCCAGGCAGCAGATACAAAGAA GAGATTTATGATTCCAGCATCATGAAAACCAACAAAATGGAAAACAGGATTCAGCCACCTCACCATCTCATTAAAGAAG AAAACAAGCTAGCTTTTAACAGAGACCTACAAGAAAAAATGAGCATTAATGAGAGTTCTTTTTCAAACTCAGTTGCTAA CTCCTTGCTGCCAAAATCAGAATGTTTCCAGTCTAAAGCTTTAGGACAATTAAGCCATCTCCTACCCGTGCCCACAGTG TATGAACAAACAAGACGGATTTGTATGAAGGAACCCAAATATGGGCATATTAGTCACCACGCTACAAGCCTAAATGAAC TGGACAGTGATGAGAGGATGACTGTAAAGCTTGATCACGACTCTGAGAGTGAGCGCGTGATGGATGTAAGACCCTCTGG ACAAGTTCCATTTGTGCTTCTAAATTATCATCATGTTTTAGCCAAACATGGCACATTTCAAACTTCATCATGTACAGCA ACGGGACACGTAGGAGAAAATTATGGATACAATTCTGAGGAAGTAAATACGTTTATGTACAAAAACCAAAGCCCCTCAT CAGCCTCTTCTCCAGAAACCCACAAGGAAACGACACTACCCCATTATATTGGAACTTCTGTAATAATAGCCAATGGAAG GTGA
Citation	Caqueret A, Coumailleau P, Michaud JL. Regionalization of the anterior hypothalamus in the chick embryo. Dev Dyn. 2005 Jun;233(2):652-8.
Copyright	Copyright © 2005 Wiley-Liss, Inc.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 14

Hypothalamus

19-24

stage 20

Hypothalamus

25-30

stage 26

Brainstem Nuclei
Hypothalamus

EdingerâWestphal

31-40

stage 40

Hypothalamus

Entry 3

GEISHA Id	SIM2.Havis.2012	Data Source	Publication
Complete cDNA Template Probe	show ATGAAGGAAAAATCCAAGAACGCGGCGAAGACAAGGCGGGAAAAGGAAAATGGAGAGTTCTACGAACTGGCCAAGCTCC TGCCGCTGCCCTCGGCCATCACCTCGCAGCTGGACAAGGCGTCCATCATCCGCCTCACCACCAGCTATCTGAAGATGCG AGCCGTCTTCCCCGAAGGTCTGGGCGACGCCTGGGGACAGCCGAGCAGGATAGGGCCCTTGGATAACGTGGCCAAGGAG CTCGGATCCCACTTGCTTCAGACTTTGGATGGCTTTGTTTTTGTGGTAGCATCAGATGGCAAAATAATGTACATCTCAG AAACAGCGTCTGTACATCTTGGCTTATCTCAGGTGGAGCTTACTGGTAATAGCATTTATGAGTATATACACCCTTCCGA CCACGATGAGATGACGGCTGTTCTTACTGCTCACCAGCCTCTTCATCCTCACCTCTTACAAGAATATGAAATTGAGAGA TCATTTTTCCTGAGAATGAAGTGTGTCCTAGCCAAGAGGAATGCAGGATTGACGTGCAGTGGCTACAAGGTGATCCACT GCAGTGGCTATTTGAAGATACGGCAGTATATGCTCGATATGTCTTTGTATGATTCCTGTTACCAAATTGTTGGACTGGT GGCTGTAGGTCAATCTTTACCCCCTAGTGCAATCACTGAGATCAAACTTCATAGTAACATGTTTATGTTCAGAGCAAGT TTGGACTTGAAGTTAATATTCCTAGATTCCAGAGTGACTGAATTAACTGGATATGAACCCCAAGATCTGATAGAAAAAA CGCTCTATCACCATGTTCATGGCTGTGATGTGTTCCATTTACGATATGCTCATCATCTGTTGTTGGTGAAAGGCCAAGT AACAACCAAGTACTATCGACTACTGTCCAAACAAGGAGGCTGGGTTTGGGTACAGAGCTACGCTACCATTGTGCATAAC AGCCGTTCATCACGGCCTCACTGCATAGTGAGTGTCAATTATGTCCTTACAGATATTGAGTATAAGGAACTTCAGCTGT CACTGGACCAGGTTACCATTTCTAAGTCACAGTTTTCATGCAGAAACTCAGTATCTACCTCGCAGGAAACAAGGAAAAT AGTAAAACCCAAAAGTAATAAGATGAAAGCAAAACTCAGAACAACGCCTTACCCACAACAGCAATACAGCTCATTCCAA ACAGACAAACTGGAATGCAGCCAGGTGGGAAACTGGCGATCCAGCCCTGCAGTGAACGCTGCCACCATTCAAGAACAAA ACTTTCATTCAGAAAACAGTGAACTTTTATATGCCCCGTCATATAGCTTGCCTTTCTCTTACCATTATGGACACTTCCC TGTAGACTCTCATGTCTTCAGCAGCAAAAAGCAAATGCTGCCTCCTAAGTTTGGGCAGTCTCAAGGAGCACCTTGTGAA GTGGCTCGATTTTTCTTGAGTACGCTGCAGACAAATGGAGAATGCCAGTGGCATTACGCCAACTCCTTGGTACCCAACA GCCAGTCACCATCCAAAAATCTTCCTGAGCAGCCAGTGAACATCATCCGACATAATCTTGGACAGAGTTATGAAGCAGA CAAGCGATTTACCACTGATGCTCTCTCCGACAACTTTACAAGTTGCACAGCACCCATGCCAGGCAGCAGATACAAAGAA GAGATTTATGATTCCAGCATCATGAAAACCAACAAAATGGAAAACAGGATTCAGCCACCTCACCATCTCATTAAAGAAG AAAACAAGCTAGCTTTTAACAGAGACCTACAAGAAAAAATGAGCATTAATGAGAGTTCTTTTTCAAACTCAGTTGCTAA CTCCTTGCTGCCAAAATCAGAATGTTTCCAGTCTAAAGCTTTAGGACAATTAAGCCATCTCCTACCCGTGCCCACAGTG TATGAACAAACAAGACGGATTTGTATGAAGGAACCCAAATATGGGCATATTAGTCACCACGCTACAAGCCTAAATGAAC TGGACAGTGATGAGAGGATGACTGTAAAGCTTGATCACGACTCTGAGAGTGAGCGCGTGATGGATGTAAGACCCTCTGG ACAAGTTCCATTTGTGCTTCTAAATTATCATCATGTTTTAGCCAAACATGGCACATTTCAAACTTCATCATGTACAGCA ACGGGACACGTAGGAGAAAATTATGGATACAATTCTGAGGAAGTAAATACGTTTATGTACAAAAACCAAAGCCCCTCAT CAGCCTCTTCTCCAGAAACCCACAAGGAAACGACACTACCCCATTATATTGGAACTTCTGTAATAATAGCCAATGGAAG GTGA
Citation	Havis E, Coumailleau P, Bonnet A, Bismuth K, Bonnin MA, Johnson R, Fan CM, Relaix F, Shi DL, Duprez D. Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development. 2012 Jun;139(11):1910-20.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # XM_416724.3).