GEISHA - A Chicken Embryo Gene Expression Database
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SMAD5
SMAD family member 5

Gene
Official SymbolSMAD5
Official Full NameSMAD family member 5
CGNC ID4741
also known asmothers against decapentaplegic homolog 5|MAD homolog 5|SMAD 5|SMAD, mothers against DPP homolog 5|mothers against DPP homolog 5, Mothers against decapentaplegic homolog 5 (SMAD 5), Mothers against DPP homolog 5
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_001014968
PolypeptideNP_001014968
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.50148
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human4090ENSG00000113658MIM:603110
Mouse17129ENSMUSG00000021540All phenotypic alleles (5):Targeted, knock-out(4) Targeted, other(1) MGI:1328787
Xenopus
Zebrafish30641ENSDARG00000037238ZDB-GENE-990603-9ZFIN:ZDB-GENE-990603-9
Gene Ontology
Molecular Functionmetal ion binding, RNA polymerase II core promoter sequence-specific DNA binding, more...sequence-specific DNA binding transcription factor activity
Biological Processbone development, cardiac muscle contraction, cartilage development, cellular response to BMP stimulus, more...cellular response to organic cyclic compound, erythrocyte differentiation, germ cell development, osteoblast fate commitment, positive regulation of osteoblast differentiation, positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus, protein phosphorylation, transcription, DNA-templated, transforming growth factor beta receptor signaling pathway, ureteric bud development
Cellular Componentcytoplasm, nucleus, transcription factor complex
Links to other databases
Entrez Gene395679
Ensembl Gene
KEGGgga:395679

Entry 1

GEISHA IdSMAD5.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerTTATAAAAGCTTGCGGCCGCAGAATATCGTTAGATGGACGACTTCAGGTTTC
Reverse cDNA Template PrimerGCTCTAGAAATTAACCCTCACTAAAGGAACACTCAGCATAGACTTCCCCACcDNA Template Length890
Complete cDNA Template Probeshow
TTTTTAAAAAGCTGCGGCCGCAGAATATCGTTAGATGGACGACTTCAGGTTTCTCACAGAAAAGGCCTTCCCCATGGTA
ATTTACTGTCGGGGTCTGGCGTTGGCCTGATCTACAAAGCCATCATGAGCTGAAGCCATTGGATATTTGTGAATTTCCT
TTTGGATCTAAACAGAAGGAAGTCTGCATCAATCCTTACCACTATAAGAGGGTGGAGAGCCCAGTTCTACCTCCAGTGT
TAGTGCCTAGACATAGTGAATTCAATCCACAGCACAGTCTACTAGTTCAGTTCAGGAACCTAAGCCACAATGAACCACA
TATGCCACATAATGCGACATTTCCAGATTCCTTCCAGCAACCCAACAGCACTCCATTTTCCATTTCGCCAAACAGTCCC
TATCCACCTTCTCCAGCCAGCAGCACTTACCCAAGCTCCCCAGCTAGCTCTGGACCATCTAGTCCATTTCAGCTACCTG
CTGATACTCCACCTCCTGCATATATGCCCCCTGATGATCAAATGGGGCAGGATAACTCTCAGTCTATGGACACAAGCAA
TACAATGATCCCTCAAATCATGCCAAATATATCTACCAGAGATGTTCAGCCTGTTGCCTATGAAGAACCCAAACACTGG
TGTTCGATTGTGTATTACGAATTAAATAATCGTGTTGGAGAGGCCTTTCATGCATCTTCCACAAGTGTCTTAGTAGATG
GGTTTACAGATCCCTCCAATAATAAAAACAGGTTCTGCTTGGGTTTGCTCTCAAATGTTAATCGCAACTCAACAATTGA
GAACACTAGACGACATATTGGGAAAGGAGTTCATCTCTACTATGTGGTGGGGAAGTCTATGCTGAGTGTTCCTTTAGTG
AGGGTTATTTTCAAAAGAAA
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 6
Early Mesoderm
Headfold
Hensen's Node
Paraxial Mesoderm
Primitive Streak
 
7-12
stage 8
stage 8
stage 9
stage 10
stage 11
Cardiovascular
Forebrain
Hindbrain
Lateral Plate Mesoderm
Midbrain
Neural Plate/Tube
Paraxial Mesoderm
Somites
 
13-18
stage 13
stage 14
stage 15
stage 17
Forebrain
Hindbrain
Lateral Plate Mesoderm
Midbrain
Neural Plate/Tube
Somites
Widespread Expression
 
19-24
stage 20
stage 24
Limb Buds
Pharyngeal Arches and Clefts
Somites
Spinal Cord
Widespread Expression
 

Entry 2

GEISHA IdSMAD5.LeDréau.2012Data SourcePublication
Complete cDNA Template Probeshow
TTTTGAAGACGTGTGTCAAATGACGTCAATGGCCAGTTTGTTCTCCTTTACTAGCCCAGCTGTAAAGCGTCTGTTGGGC
TGGAAACAAGGAGATGAAGAGGAAAAATGGGCAGAAAAAGCTGTCGATGCTTTGGTTAAAAAGCTGAAAAAGAAAAAAG
GTGCTATGGAAGAACTGGAGAAAGCTTTGAGCAGTCCAGGACAGCCCAGCAAGTGTGTTACTATCCCCCGTTCGTTAGA
TGGACGACTTCAGGTTTCTCACAGAAAAGGCCTTCCCCATGTAATTTACTGTCGGGTCTGGCGTTGGCCTGATCTACAA
AGCCATCATGAGCTGAAGCCATTGGATATTTGTGAATTTCCTTTTGGATCTAAACAGAAGGAAGTCTGCATCAATCCTT
ACCACTATAAGAGGGTGGAGAGCCCAGTTCTACCTCCAGTGTTAGTGCCTAGACATAGTGAATTCAATCCACAGCACAG
TCTACTAGTTCAGTTCAGGAACCTAAGCCACAATGAACCACATATGCCACATAATGCGACATTTCCAGATTCCTTCCAG
CAACCCAACAGCACTCCATTTTCCATTTCGCCAAACAGTCCCTATCCACCTTCTCCAGCCAGCAGCACTTACCCAAGCT
CCCCAGCTAGCTCTGGACCATCTAGTCCATTTCAGCTACCTGCTGATACTCCACCTCCTGCATATATGCCCCCTGATGA
TCAAATGGGGCAGGATAACTCTCAGTCTATGGACACAAGCAATACAATGATCCCTCAAATCATGCCAAATATATCTACC
AGAGATGTTCAGCCTGTTGCCTATGAAGAACCCAAACACTGGTGTTCGATTGTGTATTACGAATTAAATAATCGTGTTG
GAGAGGCCTTTCATGCATCTTCCACAAGTGTCTTAGTAGATGGGTTTACAGATCCCTCCAATAATAAAAACAGGTTCTG
CTTGGGTTTGCTCTCAAATGTTAATCGCAACTCAACAATTGAGAACACTAGACGACATATTGGGAAAGGAGTTCATCTC
TACTATGTTGGTGGGGAAGTCTATGCTGAGTGTTTAAGTGACAGCAGCATATTTGTACAGAGCAGGAACTGCAACTACC
ACCATGGCTTTCATCCAACAACTGTATGCAAGATTCCTAGTGGGTGCAGCCTGAAAATCTTTAACAATCAGGAATTTGC
TCAGCTTTTAGCTCAGTCTGTCAACCATGGATTTGAAGCAGTGTATGAGCTCACCAAAATGTGCACCATCCGAATGAGT
TTTGTAAAGGGGTGGGGAGCTGAATATCACCGACAAGATGTCACAAGCACCCCATGCTGGATAGAAATTCATCTTCATG
GGCCCCTCCAGTGGCTGGATAAAGTACTTACACAAATGGGTTCTCCTCTTAATCCCATTTCATCTGTTTCATAGTGCTG
AA
CitationLe Dréau G, Garcia-Campmany L, Rabadán MA, Ferronha T, Tozer S, Briscoe J, Martí E. Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord. Development. 2012 Jan;139(2):259-68.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_001014968.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 18
stage 18
Neural Plate/Tube
Somites
 
19-24
stage 24
Neural Plate/Tube
Somites
 

Entry 3

GEISHA IdSmad5.Gont.2000Data SourcePublication
Complete cDNA Template Probeshow
GAATTCAAGCCGATGCTTTGGTTAAAAAGCTGAAAAAGAAAAAAGGTGCTATGGAAGAACTGGAGAAAGCTTTGAGCAG
TCCAGGACAGCCCAGCAAGTGTGTTACTATCCCCCGTTCGTTAGATGGACGACTTCAGGTTTCTCACAGAAAAGGCCTT
CCCCATGTAATTTACTGTCGGGTCTGGCGTTGGCCTGATCTACAAAGCCATCATGAGCTGAAGCCATTGGATATTTGTG
AATTTCCTTTTGGATCTAAACAGAAGGAAGTCTGCATCAATCCTTACCACTATAAGAGGGTGGAGAGCCCAGTTCTACC
TCCAGTGTTAGTGCCTAGACATAGTGAATTCAATCCACAGCACAGTCTACTAGTTCAATTCAGGAACCTAAGCCACAAT
GAACCACATATGCCACATAATGCGACATTTCCAGATTCCTTCCAGCAACCCAACAGCACTCCATTTTCCATTTCGCCAA
ACAGTCCCTATCCACCTTCTCCAGCCAGCAGCACTTACCCAAGCTCCCCAGCTAGCTCTGGACCATCTAGTCCATTTCA
GCTACCTGCTGATACTCCACCTCCTGCATATATGCCCCCTGATGATCAAATGGGGCAGGATAACTCTCAGTCTATGGAC
ACAAGCAATACAATGATCCCTCAAATCATGCCAAATATATCTACCAGAGATGTTCAGCCTGTTGCCTATGAAGAACCCA
AACACTGGTGTTCGATTGTGTATTACGAATTAAATAATCGTGTTGGAGAGGCCTTTCATGCATCTTCCACAAGTGTCTT
AGTAGATGGGTTTACAGATCCCTCCAATAATAAAAACAGGTTCTGCTTGGGTTTGCTCTCAAATGTTAATCGCAACTCA
ACAATTGAGAACACTAGACGACATATTGGGAAAGGAGTTCATCTCTACTATGTTGGTGGGGAAGTCTATGCTGAGTGTT
TAAGTGACAGCAGCATATTTGTACAGAGCAGGAACTGCAACTACCACCATGGCTTTCATCCAACAACTGTATGCAAGAT
TCCTAGTGGGTGCAGCCTGAAAATCTTTAACAATCAGGAATTTGCTCAGCTTTTAGCTCAGTCTGTCAACCATGGATTT
GAAGCAGTGTATGAGCTCACCAAAATGTGCACCATCCGAATGAGTTTTGTAAAGGGGTGGGGAGCTGAATATCACCGAC
AAGATGTCACAAGCACCCCATGCTGGATAGAAAGCTT
CitationGont L, Lough J. Differential expression of cSmad1 and cSmad5 in the primitive streak during chick embryo gastrulation. Anat Rec. 2000 Sep 1;260(1):102-5.
CopyrightCopyright © 2000 Wiley‐Liss, Inc.
CommentsAuthors indicated that 880 nt antisense riboprobe was yielded through linearization with EcoRI of NCBI Accession AF143240. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was the whole sequence of NCBI acc# AF143240.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 2
stage 3
Primitive Streak
 
4-6
stage 4
stage 4
stage 5
stage 6
Ectoderm
Epiblast
Hensen's Node
Mesoderm
Primitive Streak
 
all
 
  
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.50148

Mouse

EmageMGI:1328787
EurexpressMGI:1328787
MGI GXDMGI:1328787

Frog

Xenbase

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-990603-9
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