GEISHA - A Chicken Embryo Gene Expression Database
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SMO
smoothened, frizzled class receptor

Gene
Official SymbolSMO
Official Full Namesmoothened, frizzled class receptor
CGNC ID5983
also known assmoothened homolog|smoothened, frizzled family receptor, Smoothened homolog precursor (SMO)
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNAXM_414970
PolypeptideXP_414970
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.4082
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly33196FBgn0003444
Human6608ENSG00000128602MIM:601500MIM:601500
Mouse319757ENSMUSG00000001761All phenotypic alleles (7):Chemically induced(1) Targeted, knock-out(3) Targeted, other(3) MGI:108075
Xenopus100491644, 100190780487419
Zebrafish30225ZDB-GENE-980526-89ZFIN:ZDB-GENE-980526-89
Gene Ontology
Molecular FunctionG-protein coupled receptor activity
Biological Processmulticellular organismal development, smoothened signaling pathway
Cellular Componentintegral component of membrane
Links to other databases
Entrez Gene395949
Ensembl GeneENSGALG00000007910
KEGGgga:395949

Entry 1

GEISHA IdSMO.McCabe.2007Data SourcePublication
Complete cDNA Template Probeshow
ATCCCAAAGTGCCTTCCAGCTCCCCTCGGCCGTCTGAGCGCACCTGAGAAAAGCTTTGGTTTTTGTTCGTTTTTAAATC
TGTTTTTTAAAGAAAAAGGAACAAATTATATCCGAGCCCTGACGTAGGAGGACACCTGTCCTTGCTGGTGCTTTGTATC
TGCCCCTTAGCCCTGTAAATGTCTTTTGAGTGTTTATTAAACCCCGGTAGGCTCACGGCTT
CitationMcCabe KL, Shiau CE, Bronner-Fraser M. Identification of candidate secreted factors involved in trigeminal placode induction. Dev Dyn. 2007 Oct;236(10):2925-35.
CopyrightCopyright © 2007 Wiley-Liss, Inc.
CommentsSequence below was obtained from NCBI (XM_414970) using the primers provided in the publication: SMO forward primer, 5'-ATCCCAAAGTGCCTTCCAG-3'; and reverse primer, 5'-GAGGAAGCCGTGAGCCTAC-3'.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-10
stage 8
stage 10
Neural Crest
Neural Plate/Tube
Presumptive Trigeminal Placode, Neural Folds
Trigeminal Placode

Entry 2

GEISHA IdSMO.Aglyamova.2007Data SourcePublication
Complete cDNA Template Probeshow
ATGGGATGGAAGTGGGATGGAGAGGAGCTCTGCAGTGGGCTGATGCTGTACTGGGATGGAGCTCCGTACTGGGATGGAA
CTGGGATGGAGAGGGGCTGTGCTGGGTGCACTCCTGACCGCTTCCCCGAGGGCTGCCCGAACGAGGTGCAGAACATCAA
GTTCAACAGCTCAGGGCAGTGCGAGGCGCCGTTGGTGCGCACGGACAACCCCAAGAGCTGGTATGAGGATGTGGAGGGC
TGCGGAATCCAGTGCCAGAACCCACTCTTCACTGAGACAGAGCACCGTGAGATGCACGTCTACATCGCCGCCTTCAGCT
CCGTCACCATCTTCTGCACCTTCTTCACTCTGGCCACCTTCGTTGCCGACTGGAGGAACTCCAACCGCTACCCCGCTGT
CATCCTCTTCTATGTCAATGCCTGCTTCTTTGTGGGCAGTATCGGCTGGCTGGCGCAGTTCATGGACGGCGCCCGAGAT
GAGATCGTGTGCCGTGCTGATGGCACCATGAGGCTGGGGGAGCCCACCTCCAACGAGACGCTCTCCTGCGTCATCATCT
TTGTCATTGTCTACTACTCTCTGATGTCGGGTGTCATCTGGTTTGTCATGCTGACCTACGCCTGGCACACGTCCTTCAA
GGCGCTGGGCACCACCTACCAGCCGCTGCTGGGCAAGACCTCCTACTTCCACCTCATCACCTGGTCCATCCCTTTCGTA
CTCACCGTGGCCATCCTGGCTGTGGCACAGGTGGATGGTGACTCCGTCAGCGGTATCTGCTTCGTGGGTTACAAGAACT
ATCGCTACCGTGCCGGCTTTGTCCTGGCACCCATCGGGCTCGTCCTCATCGTTGGGGGCTATTTCCTCATTCGGGGGGT
CATGACGCTCTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCGGCCAGCAAGATCAACGAAACCATG
CTGCGGCTGGGCATCTTTGGGTTCTTGGCTTTTGGCTTTGTCTTCATCACTTTTGGCTGCCACTTCTACGACTTCTTCA
ACCAGGCGGAGTGGGAGCGAAGCTTTCGGGAATATGTCCTGTGTGAGGCCAACGTGACCATCGCTACGCAGACCAATAA
ACCCATCCCAGAGTGTGAGATCAAGAACCGGCCGAGCCTGCTGGTGGAGAAGATCAACCTCTTTGCCATGTTTGGCACT
GGCATCTCCATGAGCACCTGGGTCTGGACCAAGGCCACCCTGCTCATCTGGAAGCGCACCTGGTGCAGGCTGACAGGGC
AGAGCGACGACCAGCCCAAGAGGATCAAGAAGAGCAAGATGATTGCCAAAGCCTTCTCCAAGCGCAAGGAGCTGCTGCG
TGACCCAGGCCGGGAGCTGTCCTTCAGTATGCACACCGTCTCGCACGACGGCCCCGTGGCTGGTTTGGCGTTTGACATC
AATGAGCCATCAGCCGATGTGTCCTCCGCGTGGGCTCAGCACGTCACCAAGATGGTGGCCAGGAGAGGGGCTATCCTGC
CCCAGGATGTCTCCGTCACGCCGGTGGCAACACCTGTGCCACCGGAGGAGCGGAGCAACCTCTGGGTGGTGGAGGCCGA
TGTCTCCCCAGAGCTGCAGAAGCGCAGCCGCAAGAAGAAGCGGAGGAAGAAGAAGAAGGAGGAGGTGTGCCCCGAGCGC
CGCGCCGGGCTCTCCGTGGCCCCCCTGACCCCCAGCTCCGTGCCTCGCCTGCCTCGGCTGCCCCAGCAGCCCTGCTTGG
TGGCCATCCCCCGGCATAGAGGGGACACCTTCATCCCCACTGTCCTCCCGGGGCTGTCCAACGGTGCTGGGGGGCTGTG
GGACGGCCGGCGCCGAGCCCACGTCCCCCACCTCATCACCAACCCCTTCTGCCCTGAGAGTGGCTCCCCAGAGGATGAG
GAGAACCCCGGCCCCAGCGTCGGGCACCGGCAGCACAACGGGGGCCCTCGATGGCCACCTGAGCCCCTTCCTGGTGGCA
GTGGGGTGACGAGGACTCGGGGCAGACGCGCCGGCTTGGCTCCCATCCACTCCCGGACCAACCTGGTGAACGCGGAGCT
GCTGGACGCCGACTTAGACTTCTGAGCCCTGCAGGATCCTGGGGACAACGGAGCCCACCGGCATCCGGGTAGCCCCAAG
GGGACGCTGGAGCCCACCCAACACCGGGGTCCGGATGGATTTGATGTTCATCCCAACCCACCAACGGGATTTGAGGATG
GGAGGAGAGAAGAAACTGGTGGGGCAGCACCCCTGGAAGGCGCTGCCAGGATTTAGGGGTGAAGGGGACGCTCCCTCAC
ACCCAGCGCTGGTAGGCAGCTTAAGGTGTTGATTTCGGTCCCCACACATGGACTGCTCCGCCGCCCCACAGCTAGATGG
TACGTAGAGCTTCCCAACACTTTTACGGTGCCAATAGGGTTTTTAAACAGTTCTTTTTGTATTCTTTGTGATACACCGA
GACGTGGCCGCCCTGCACGGGGTGCAGCAGCATCCCCGTTTTTCGGGCTCTGCTGCGGGGATCCCAAAGTGCCTTCCAG
CTCCCCTCGGCCGTCTGAGCGCACCTGAGAAAAGCTTTGGTTTTTGTTCGTTTTTAAATCTGTTTTTTAAAGAAAAAGG
AACAAATTATATCCGAGCCCTGACGTAGGAGGACACCTGTCCTTGCTGGTGCTTTGTATCTGCCCCTTAGCCCTGTAAA
TGTCTTTTGAGTGTTTATTAAACCCCGGTAGGCTCACGGCTTTCTCCCTACTCCCCCCTACCCCCCACCTCCCCCCTCC
CGGCGACCTCCACGGGTTGATTTTTGCTGTGTAAAGCAGAAACCTTCCTGTATCAGTATTAAATTTGCCAAGTTTCCAA
TTGC
CitationAglyamova GV, Agarwala S. Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord. Dev Dyn. 2007 May;236(5):1363-73
CopyrightCopyright © 2007 Wiley-Liss, Inc.
CommentsAccording to the authors, "Digoxigenin- or FL-conjugated antisense riboprobes were prepared from chick cDNAs." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (XM_414970).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 5
Head Process
Hensen's Node
Neural Plate/Tube
Primitive Streak
 
7-12
stage 10
Isthmus/MHB
Midbrain
Neural Plate/Tube
Notochord
 
13-18
stage 16
Midbrain
Neural Plate/Tube
 
25-26
stage 26
Isthmus/MHB
Midbrain
Neural Plate/Tube
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.4082

Mouse

Emage
EurexpressMGI:108075
MGI GXDMGI:108075

Frog

Xenbase487419

Fruit Fly

BDGPFBgn0003444

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-980526-89
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