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Gene Family QuickSearch
Human Disease Gene Search
SOX3 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol SOX3 Official Full Name SRY-box 3 CGNC ID 49006 also known as CH3, SRY-related protein CH3|SRY (sex determining region Y)-box 3|cSox3|transcription factor SOX-3|transcription factor SOX3, SRY-related protein CH3, CH03, Sox3 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id Sox3.Mikawa.2004 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Mikawa, T, Poh, A, Kelly, K, Ishii, Y, Reese, D. Induction and Patterning of the Primitive Streak, an Organizing Center of Gastrulation in the Amniote. Dev Dyn. 2004 Mar;229(3):422-32. Copyright Copyright © 2004 Wiley-Liss, Inc.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3
stage 3
Epiblast
Entry 2 GEISHA Id Sox3.Rex.1997 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Rex M, Orme A, Uwanogho D, Tointon K, Wigmore PM, Sharpe PT, Scotting PJ. Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue. Dev Dyn. 1997 Jul;209(3):323-32. Copyright Wiley-Liss., Inc. 1997 Comments Insufficient information in publication to verify exact sequence used to
synthesize probe. Sequence below was obtained from NCBI (acc # U12467).
Entry 3 GEISHA Id Sox3.Barembaum.2007 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Barembaum M, Bronner-Fraser M. Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm. Development. 2007 Nov;134(21):3805-14. Copyright Published by The Company of Biologists 2007 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204195).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 5
stage 5
Neural Plate/Tube
Entry 4 GEISHA Id Sox3.Abu-Elmagd.2001 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Abu-Elmagd M, Ishii Y, Cheung M, Rex M, Le Rouëdec D, Scotting PJ. cSox3 expression and neurogenesis in the epibranchial placodes. Dev Biol. 2001 Sep 15;237(2):258-69. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204195).
Entry 5 GEISHA Id Sox3.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show GGGCTCAGCGCTGCCCGCGGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTGCGGCC
Comments Images Provided by Susan Chapman.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
Neural Plate/Tube
Entry 6 GEISHA Id Sox3.Matsumata.2005 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Matsumata M, Uchikawa M, Kamachi Y, Kondoh H. Multiple N-cadherin enhancers identified by systematic functional screening indicate its Group B1 SOX-dependent regulation in neural and placodal development. Dev Biol. 2005 Oct 15;286(2):601-17. Epub 2005 Sep 16. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204195).
Entry 7 GEISHA Id Sox3.Linker.2004. Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Linker C, Stern CD (2004). Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists. Development. 2004 Nov;131(22):5671-81. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_204195).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3 stage 3
Neural Plate/Tube
Entry 8 GEISHA Id Sox3.Streit.1999 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Streit A, Stern CD. Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity. Mech Dev. 1999 Apr;82(1-2):51-66. Copyright Copyright © 1999 Elsevier Science Ireland Ltd. All rights reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204195).
Entry 9 GEISHA Id Sox-3.Groves.2000 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Groves AK, Bronner-Fraser M. Competence, specification and commitment in otic placode induction. Development. 2000 Aug;127(16):3489-99.
Copyright This material is protected by copyright. The Company of Biologists' (publishers of Development) hold an Exclusive License obtained from the authors, who retain copyright. Comments Unable to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204195.1).
Entry 10 GEISHA Id SOX3.Abello.2010 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Abelló G, Khatri S, Radosevic M, Scotting PJ, Giráldez F, Alsina B., Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling influences the neurogenic and non-neurogenic domains in the chick otic placode. Dev Biol. 2010 Mar 1;339(1):166-78. Epub 2010 Jan 4. Copyright Copyright © 2009 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204195.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 8
stage 8
stage 8
stage 9
stage 9
stage 9
stage 9
stage 9
stage 10
stage 10
stage 10
Head Mesenchyme Neural Plate/Tube Rhombomeres
Entry 11 GEISHA Id SOX3.Acloque.2011 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Hervé Acloque, Oscar H. Ocaña, Ander Matheu, Karine Rizzoti, Clare Wise, Robin Lovell-Badge, M. Angela Nieto Reciprocal Repression between Sox3 and Snail Transcription Factors Defines Embryonic Territories at Gastrulation. Dev Cell. 2011 September 13; 21(3): 546558. Copyright Copyright © 2011 Published by Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204195.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) X-XIV stage XIV
Area Pellucida 1-3 stage 2
stage 3
stage 3
Epiblast 4 stage 4
stage 4
Epiblast
Entry 12 GEISHA Id SOX3.Qiao.2012 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Qiao Y, Zhu Y, Sheng N, Chen J, Tao R, Zhu Q, Zhang T, Qian C, Jing N. AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning. Cell Res. 2012 Nov;22(11):1546-61. Copyright © 2012 Shanghai Institutes for Biological Sciences Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204195.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 4
stage 4
stage 4
stage 4
stage 5
stage 6
Ectoderm Epiblast Neural Plate/Tube
Entry 13 GEISHA Id SOX3.Christophorou.2009 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Christophorou NA, Bailey AP, Hanson S, Streit A. Activation of Six1 target genes is required for sensory placode formation. Dev Biol. 2009 Dec 15;336(2):327-36. doi: 10.1016/j.ydbio.2009.09.025. Epub 2009 Sep 23. Copyright Copyright © 2013 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI AB011803.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
stage 4
Neural Plate/Tube
Entry 14 GEISHA Id Sox3.Ishii.2001 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Ishii Y, Abu-Elmagd M, Scotting PJ. Sox3 expression defines a common primordium for the epibranchial placodes in chick. Dev Biol. 2001 Aug 15;236(2):344-53. Copyright Copyright © 2001 Academic Press. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204195.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 9
stage 10
stage 11
stage 12
stage 12
Ectoderm 13-18 stage 13
stage 13
stage 13
stage 13
stage 14
stage 16
stage 17
stage 17
stage 17
stage 18
Ectoderm Unlabeled 19-24 stage 19
stage 21
stage 21
Ectoderm 31-44 stage 44
stage 44
stage 44
stage 44
stage 44
Entry 15 GEISHA Id Sox3.Vieceli.2013 Data Source Publication Complete cDNA Template Probe show AAGAAGGACAAATACTCGCTGCCGGGCAACCTGCTGGCCCCCGGAGGGGGCAACGCGGTGAGCAGCCCCGTCGGGGTGG
Citation Vieceli FM, Simões-Costa M, Turri JA, Kanno T, Bronner M, Yan CY. The transcription factor chicken Scratch2 is expressed in a subset of early postmitotic neural progenitors. Gene Expr Patterns. 2013 Jun-Jul;13(5-6):189-96. DOI: 10.1016/j.gep.2013.03.004. Copyright Copyright © 2013 Elsevier B.V. Comments Authors indicated the probe for Sox3 was synthesized from 572-1370 nucleotides of NCBI sequence NM_204195. Above sequence was extracted from NCBI (NM_204195.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25 stage 25
Spinal Cord all
Entry 16 GEISHA Id SOX3.Freter.2012 Data Source Publication Complete cDNA Template Probe show TGCGCGTCGCTCAGCGCTGCCCGCGGGAACCTCCGCTGCACCTCGGGGAGCGGCACGGGAAAACTCCTTCCCCCTCCTG
Citation Freter S, Muta Y, O'Neill P, Vassilev VS, Kuraku S, Ladher RK. Pax2 modulates proliferation during specification of the otic and epibranchial placodes. Dev Dyn. 2012 Nov;241(11):1716-28 Copyright Copyright © 2012 Wiley Periodicals, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204195.1).
Entry 17 Data from NCBI Unigene EST ProfileGga.3795
Mouse Frog Fruit Fly Zebra Finch Zebrafish
