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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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SUFU
SUFU negative regulator of hedgehog signaling

The human orthologue of this gene is associated
with the following human disease:

Medulloblastoma, desmoplastic

Gene

Official Symbol	SUFU
Official Full Name	SUFU negative regulator of hedgehog signaling
CGNC ID	6132
also known as	suppressor of fused homolog, SUFU, suppressor of fused homolog
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_204264
Polypeptide	NP_989595

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	41565			FBgn0005355
Human	51684	ENSG00000107882	MIM:155255	MIM:607035
Mouse	24069	ENSMUSG00000025231	All phenotypic alleles (8):Targeted, knock-out(2) Targeted, other(5) Gene trapped(1)	MGI:1345643
Xenopus	100170148, 444442			479288
Zebrafish	100001615		ZDB-GENE-030131-6223	ZFIN:ZDB-GENE-030131-6223

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	374118
Ensembl Gene	ENSGALG00000008096
KEGG	gga:374118

Entry 1

GEISHA Id	SUFU.Aglyamova.2007	Data Source	Publication
Complete cDNA Template Probe	show ATGGAAGGCACGCGGCCTGGCGGGGCTGCCCCCGCGGGCGGGGCGGGCTCCGGCTCGGGCTCGGGCTCCAGCTCCTTCC CGTCCCTCTTCCCGCCGGGCCTTCACGGAATCTACGGCGAGTGCCGCCGCCTCTACCCCGAGCAGCCCAACCCGCTGCA GGTCACCGCCATCCTCAAGTACTGGTTGGGGGGACCCGATCCTCTGGACTACGTTAGCATGTACAGAAACATAGGGAAC CCAGCGCTGAATGTTCCTGAGCACTGGCACTATGTCAGTTTTGGGTTAAGTGACTTGTATGGAGACAACAGAGTACATG AGTTTACGGGAACAGATGGACCAAGTGGTTTTGGATTTGAGTTGACATTTCGACTAAAGAGAGAAACGGGGGAGTCAGC TCCACCTACCTGGCCAGCAGAGTTAATGCAAGGCTTAGCAAGATATGTCTTCCAGTCAGAAAACACCTTCTGCAGCGGT GACCATGTGTCATGGCACAGCCCTTTGGACAACAGTGAGTCCAGAATCCAGCATATGTTGCTGACAGAAGACCCTCAGA TGCAGCCTGTGCAGACTCCTTTTGGGGTTGTTACTTTCCTACAGATTGTTGGGGTTTGCACTGAGGAACTGCATGCAGC TCAGCAATGGAACGGGCAAGGAATCTTGGAGCTGCTTCGGACTGTCCCAGTAGCTGGAGGCCCTTGGCTGATAACAGAC ATGCGAAGAGGAGAAACAATATTTGAAATTGACCCGCATCTGCAAGAGAGAGTCGACAAAGGGATTGAGACAGATGGCT CAAACCTAAGTGGAGTGAGTGCCAAATGTGCCTGGGATGATCTCAGCCGGCCCCCTGAGGATGACGAAGACAGCAGGAG CATTTGCATCGGAACCCAGCCGCGGCGGCTCTCCGGGAAAGATACGGAGCAAATCAGGGAGACTTTGCGAAGAGGGCTG GAGATTAACAGCAAACCTGTTCTACCTCCAATAAATGCACAAAGACAGAATGGGTTGAACCATGACCGAGCACCAAGCC GGAAGGACAGTTTAGAAAGCGAGAGCTCAGCAGCTATCATTCCTCATGAGCTAATCCGCACGAGACAGCTGGAAAGCGT ACACCTGAAGTTTAACCAGGAGTCTGGAGCGCTGATTCCCCTCTGCCTAAGGGGAAGGCTCTTACATGGACGGCACTTT ACATATAAAAGTATTACAGGGGACACAGCAATCACGTTTGTATCAACGGGAGTAGAAGGAGCATTTGCTACAGAGGAGC ACCCCTATGCAGCACATGGACCTTGGTTACAAATCCTATTGACTGAAGAGTTCGTAGAGAGAATGCTGGAAGATTTAGA AGATCTGAATTCTCCAGAGGAATTTAAACTTCCAAAGGAGTACAGCTGGCCTGAAAAGAAACTGAAAGTCTCCATCTTG CCAGATGCTGTGTTCGACAACCCGCTGCATTAG
Citation	Aglyamova GV, Agarwala S. Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord. Dev Dyn. 2007 May;236(5):1363-73
Copyright	Copyright © 2007 Wiley-Liss, Inc.
Comments	According to the authors, "Digoxigenin- or FL-conjugated antisense riboprobes were prepared from chick cDNAs." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (NM_204264).

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 5

Hensen's Node
Neural Plate/Tube
Primitive Streak

7-12

stage 8

stage 10

Isthmus/MHB
Midbrain
Neural Plate/Tube

13-18

stage 15

Midbrain
Neural Plate/Tube

rostral Floor Plate

25-26

stage 26

Midbrain
Neural Plate/Tube

Tectum

Entry 2

GEISHA Id	SUFU.Agarwala.2005	Data Source	Publication
Complete cDNA Template Probe	show ATGGAAGGCACGCGGCCTGGCGGGGCTGCCCCCGCGGGCGGGGCGGGCTCCGGCTCGGGCTCGGGCTCCAGCTCCTTCC CGTCCCTCTTCCCGCCGGGCCTTCACGGAATCTACGGCGAGTGCCGCCGCCTCTACCCCGAGCAGCCCAACCCGCTGCA GGTCACCGCCATCCTCAAGTACTGGTTGGGGGGACCCGATCCTCTGGACTACGTTAGCATGTACAGAAACATAGGGAAC CCAGCGCTGAATGTTCCTGAGCACTGGCACTATGTCAGTTTTGGGTTAAGTGACTTGTATGGAGACAACAGAGTACATG AGTTTACGGGAACAGATGGACCAAGTGGTTTTGGATTTGAGTTGACATTTCGACTAAAGAGAGAAACGGGGGAGTCAGC TCCACCTACCTGGCCAGCAGAGTTAATGCAAGGCTTAGCAAGATATGTCTTCCAGTCAGAAAACACCTTCTGCAGCGGT GACCATGTGTCATGGCACAGCCCTTTGGACAACAGTGAGTCCAGAATCCAGCATATGTTGCTGACAGAAGACCCTCAGA TGCAGCCTGTGCAGACTCCTTTTGGGGTTGTTACTTTCCTACAGATTGTTGGGGTTTGCACTGAGGAACTGCATGCAGC TCAGCAATGGAACGGGCAAGGAATCTTGGAGCTGCTTCGGACTGTCCCAGTAGCTGGAGGCCCTTGGCTGATAACAGAC ATGCGAAGAGGAGAAACAATATTTGAAATTGACCCGCATCTGCAAGAGAGAGTCGACAAAGGGATTGAGACAGATGGCT CAAACCTAAGTGGAGTGAGTGCCAAATGTGCCTGGGATGATCTCAGCCGGCCCCCTGAGGATGACGAAGACAGCAGGAG CATTTGCATCGGAACCCAGCCGCGGCGGCTCTCCGGGAAAGATACGGAGCAAATCAGGGAGACTTTGCGAAGAGGGCTG GAGATTAACAGCAAACCTGTTCTACCTCCAATAAATGCACAAAGACAGAATGGGTTGAACCATGACCGAGCACCAAGCC GGAAGGACAGTTTAGAAAGCGAGAGCTCAGCAGCTATCATTCCTCATGAGCTAATCCGCACGAGACAGCTGGAAAGCGT ACACCTGAAGTTTAACCAGGAGTCTGGAGCGCTGATTCCCCTCTGCCTAAGGGGAAGGCTCTTACATGGACGGCACTTT ACATATAAAAGTATTACAGGGGACACAGCAATCACGTTTGTATCAACGGGAGTAGAAGGAGCATTTGCTACAGAGGAGC ACCCCTATGCAGCACATGGACCTTGGTTACAAATCCTATTGACTGAAGAGTTCGTAGAGAGAATGCTGGAAGATTTAGA AGATCTGAATTCTCCAGAGGAATTTAAACTTCCAAAGGAGTACAGCTGGCCTGAAAAGAAACTGAAAGTCTCCATCTTG CCAGATGCTGTGTTCGACAACCCGCTGCATTAG
Citation	Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21.
Copyright	Copyright © 2005 Elsevier Inc. All rights reserved.
Comments	According to the authors, "Digoxigenin (DIG)- and fluorescein-labeled riboprobes were synthesized from chick cDNA plasmids..." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (NM_204264).