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SCX Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol SCX Official Full Name scleraxis bHLH transcription factor CGNC ID 49042 also known as SCXB, basic helix-loop-helix transcription factor scleraxis|class II bHLH protein scleraxis|scleraxis homolog B gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Entrez Gene Ensembl Gene Genetic Phenotypes MOD Fruit Fly Human Mouse Xenopus Zebrafish
Gene Ontology Links to other databases
Entry 1 GEISHA Id pgm2n.pk008.n15 Data Source GEISHA ISH Analysis Forward cDNA Template Probe show GATGCACATGGTGCCGGCGGGGGACGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGG
Comments No expression detected between stage 5-20.
Entry 2 GEISHA Id Scleraxis.Lincoln.2004 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Lincoln J, Alfieri CM, Yutzey KE. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn. 2004 Jun;230(2):239-50. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from GenBank (acc # NM_204253). Sequence is not found in present chicken genome builds.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-36 stage 36
Heart
Entry 3 GEISHA Id Scleraxis.Manfroid.2007 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
Somites 25-30 stage 27
stage 27
stage 27
stage 27
Limb Buds Somites 31-34 stage 34
Limb Buds
Entry 4 GEISHA Id scleraxis.zhao.2007 Data Source Publication Complete cDNA Template Probe show GCGCGACCGCACCAACAGCGTCAACACCGCCTTCACGGCGCTGCGCACCCTCATCCCCACCGAGCCGGCCGATAGGAAG
Citation Zhao B, Etter L, Hinton RB Jr, Benson DW. BMP and FGF regulatory pathways in semilunar valve precursor cells. Dev Dyn. 2007 Apr;236(4):971-80. Copyright Copyright © 2007 Wiley-Liss, Inc.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
Valves 31-37 stage 37
Valves
Entry 5 GEISHA Id Scx.Shukunami.2006 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Shukunami C, Takimoto A, Oro M, Hiraki Y. Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes. Dev Biol. 2006 Oct 1;298(1):234-47. Epub 2006 Jun 27. Copyright Reprinted from Developmental Biology, 298,Chisa Shukunami,Aki Takimoto, Miwa Oro, and Yuji Hiraki, Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes, 234-247, Copyright 2006, with permission from Elsevier.
Copyright © 2006 Elsevier B.V. All rights reserved. Comments Authors said: "he Scx RNA probe was generated from its entire coding sequence in GenBank (AF505881), and from pcScx3′ UTR, which was a generous gift from Dr. Tabin." Thus the sequence below was obtained from NCBI (acc # NM_204253).
Entry 6 GEISHA Id Scleraxis.Tylzanowski.2003 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Tylzanowski P, De Valck D, Maes V, Peeters J, Luyten FP. Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development. Gene Expr Patterns. 2003 Mar;3(1):39-42. Erratum in: Gene Expr Patterns. 2003 Jun;3(3):383. Copyright Copyright © 2003 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204253).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-32 stage 32
Leg Mesenchyme
Entry 7 GEISHA Id SCXB.Mella.2004 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Mella S, Soula C, Morello D, Crozatier M, Vincent A. Expression patterns of the coe/ebf transcription factor genes during chicken and mouse limb development. Gene Expr Patterns. 2004 Sep;4(5):537-42. Copyright Reprinted with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204253).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-29 stage 29
stage 29
Leg Mesenchyme
Entry 8 GEISHA Id Scx.Reijntjes.2007 Data Source Publication Complete cDNA Template Probe show CGCCGACGGCTTCGGCATCAAAGCCGGCAAGAGGAGGAGCGGCAAGAAAGCCGGGCGGCTGCACCGCGAGCCCCGGCAG
Citation Reijntjes S, Stricker S, Mankoo BS. A comparative analysis of Meox1 and Meox2 in the developing somites and limbs of the chick embryo. Int J Dev Biol.(2007); 51(8:753-9. Copyright Reprinted from Int. J. Dev. Biol., 51, Reijntjes S, Stricker S, Mankoo BS, A
comparative analysis of Meox1 and Meox2 in the developing somites and limbs of
the chick embryo, 753-9, Copyright © 2007 UBC Press, with permission. All rights
reserved.
Entry 9 GEISHA Id Scleraxis.Montero.2007 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Montero JA, Zuzarte-Luis V, Garcia-Martinez V, Hurle JM. Role of RhoC in digit morphogenesis during limb development. Dev Biol. 2007 Mar 1;303(1):325-35. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments As insufficient information is provided in the publication to verify the exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (acc # NM_204253.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-28 stage 28
stage 28
stage 28
stage 28
stage 28
Limb Buds
Entry 10 GEISHA Id Scx.Brent.2004 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Brent AE, Tabin CJ. FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Development. 2004 Aug;131(16):3885-96. Epub 2004 Jul 14. Copyright This material is protected by copyright. The Company of Biologists' (publishers of Development) hold an Exclusive License obtained from the authors, who retain copyright. Comments The authors said they got the probe from others. As the exact sequence could not be determined from this information, the sequence shown is from NCBI Acc# NM_204253.1.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 20
stage 20
Dermomyotome Limb Buds
Entry 11 GEISHA Id SCLERAXIS.Edom-Vovard.2002 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Edom-Vovard F, Schuler B, Bonnin MA, Teillet MA, Duprez D (2002). Fgf4 positively regulates scleraxis and tenascin expression in chick limb tendons. Dev Biol. 2002 Jul 15;247(2):351-66. Copyright "Reprinted from Developmental Biology, 247(2), Edom-Vovard F, Schuler B, Bonnin MA, Teillet MA, Duprez D, Fgf4 positively regulates scleraxis and tenascin expression in chick limb tendons., Copyright (2002), with permission from Elsevier".
Copyright © (2002) Elsevier B.V. All rights reserved. Comments According to authors , "The digoxigeninlabelled mRNA probes were prepared as described: scleraxis and Fgf8 (Ref. given)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204253).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
Wing Muscles 31-44 stage 34
stage 34
stage 35
stage 35
stage 35
stage 35
stage 44
stage 44
stage 44
stage 44
stage 44
Wing Muscles
Entry 12 GEISHA Id SCX.Yamamoto-Shiraishi.2013 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Yamamoto-Shiraishi Y, Kuroiwa A. Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor. Dev Biol. 2013 May 15;377(2):363-74 Copyright © Elsevier Inc. All rights reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204253.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 26
stage 30
Leg Leg Bones all
Entry 13 GEISHA Id SCX.LeGuen.2009 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Le Guen L, Notarnicola C, de Santa Barbara P.
Intermuscular tendons are essential for the development of vertebrate stomach.
Development. 2009 Mar;136(5):791-801. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204253 ).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
stage 29
Stomach 31-38 stage 35
stage 35
stage 35
stage 38
Gizzard Stomach
Entry 14 GEISHA Id SCX.García-Andrés.2010 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation García-Andrés C, Torres M.
Comparative expression pattern analysis of the highly conserved chemokines SDF1 and CXCL14 during amniote embryonic development.
Dev Dyn. 2010 Oct;239(10):2769-77. Copyright © 2010 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204253).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31 stage 31
stage 31
stage 31
stage 31
stage 31
Leg
Entry 15 GEISHA Id SCLERAXIS.Roddy.2009 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Roddy KA, Nowlan NC, Prendergast PJ, Murphy P. 3D representation of the developing chick knee joint: a novel approach integrating multiple components. J Anat. 2009 Mar;214(3):374-87. Copyright © 2009 The Authors (requested) Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc #NM_204253.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
Leg Leg Bones 31-34 stage 32
stage 34
stage 34
Leg Leg Bones
Entry 16 GEISHA Id SCX.Reijntjes.2010 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CGCCGACGGCTTCGGCATCAAAGCCGGCAAGAGGAGGAGCGGCAAGAAAGCCGGGCGGCTGCACCGCGAGCCCCGGCAG
Citation Reijntjes S, Francis-West P, Mankoo BS. Retinoic acid is both necessary for and inhibits myogenic commitment and differentiation in the chick limb. Int J Dev Biol. 2010;54(1):125-34 Copyright © 2009 UBC Press Comments The sequence was obtained from NCBI (acc # BU401515) using the information provided in the publication as described in Reijntjes et al. 2010.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 22
stage 22
stage 22
Limb Buds Somites 31-44 stage 44
Entry 17 GEISHA Id scleraxis.Bonnin.2002 Data Source Publication Complete cDNA Template Probe show GGCCGCGGAGGCGGCGGCCGTGCGCGGTCCTTAAGCCGTCGGGCGAGGGGATACGGGGGCACGGGGGTACGGGGACCCC
Citation Bonnin MA, Edom-Vovard F, Kefalas P, Duprez D. CRP2 transcript expression pattern in embryonic chick limb. Mech Dev. 2002 Aug;116(1-2):151-5. Copyright Copyright © 2002 Elsevier Science Ireland Ltd. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204253). scleraxis is also known as SCX in NCBI.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44 stage 36
stage 36
stage 36
stage 44
Wing
Data from NCBI Unigene EST ProfileGga.49818
Mouse Frog Fruit Fly Zebra Finch Zebrafish
