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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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SMAD9
SMAD family member 9

The human orthologue of this gene is associated
with the following human disease:

Pulmonary hypertension, primary

Gene

Official Symbol	SMAD9
Official Full Name	SMAD family member 9
CGNC ID	12809
also known as	SMAD8, mothers against decapentaplegic homolog 9\|SMAD, mothers against DPP 8\|SMAD, mothers against DPP homolog 9\|TGF-beta signal transducer Smad8, Smad8 , Smad9, MAD, mothers against decapentaplegic homolog 9, MAD, mothers against decapentaplegic homolog 8
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001024826
Polypeptide	NP_001019997
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.293

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	4093	ENSG00000120693	MIM:178600	MIM:603295
Mouse	55994	ENSMUSG00000027796	All phenotypic alleles (10):Targeted, knock-out(4) Targeted, other(6)	MGI:1859993
Xenopus	493210, 379659			484685
Zebrafish	445564	ENSDARG00000021938	ZDB-GENE-031014-1	ZFIN:ZDB-GENE-031014-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395543
Ensembl Gene	ENSGALG00000017050
KEGG	gga:395543

Entry 1

GEISHA Id	Smad8.Shin.2006	Data Source	Publication
Complete cDNA Template Probe	show CTTACCCAGCCACATGTTCTCCCAGTCGCCTAACAGCATCAGCTACCCCAACTCACCAGGAAGCTCTTCTGGACCAGGA AGTCCATATCAGCTCACGGTGGAAACTCCACCCCCACCCTACCACGCAAGAGAAACTCCAGGAAGCCACAATGGGCGGT CAATGGATGCTATAGCTGAAAGCCAACTAGTACTGTCTTTGCCCAATGGAGGTAAATCTGCCGATGGAGAAACTGAAAA TTTTCGGCCTGTTTGCTATGAGGAACCACAACACTGGTGCTCAGTTGCCTACTATGAACTCAACAACAGGGTAGGAGAG ACTTTCCAGGCTTCCTCTCGAAGTATCCTTATAGATGGATTTACAGATCCCTCAAATAACAAAAACAGGTTCTGCCTGG GACTGCTCTCGAATGTAAACCGCAATTCGACTATAGAAAACACCAGGAGACACATAGGAAAAGGTGTCCATCTTTATTA TGTTGGTGGAGAAGTGTATGCTGAATGTGTCAGTGACAGCAGTATTTTCGTGCAGAGCCGCAATTGTAACTATCAGCAT GGTTTCCACCCAGCCACTGTCTGTAAGATCCCCAGTGGCTGCAGCCTCAAGATCTTCAACAACCAGCTCTTCGCCCCAG CTGCTTGCCCAGTCAGTCAATCATGGTTTTGAAGTGGTATATGAGCTGACGAAGATGTGTACGATTCGAATGAGCTTTG TTAAAGGCTGGGGAGCAGAGTATCATCGCCAAGATGTTACAAGCACGCCCTGCTGGATTGAGATCCACCTGCACGGACC AA
Citation	Shin M, Noji S, Neubüser A, Yasugi S. FGF10 is required for cell proliferation and gland formation in the stomach epithelium of the chicken embryo. Dev Biol. 2006 Jun 1;294(1):11-23. Epub 2006 Apr 17.
Copyright	Reprinted from Developmental Biology, 294, Masahiron Shin, Sumihare Noji, Annette Neubüser, and Sadao Yasugl, 11-23, Copyright 2006, with permission from Elsevier. Copyright © 2005 Elsevier Inc. All rights reserved.
Comments	Smad8 and Smad9 map as one gene in chick at this time.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

31-43

stage 32

stage 36

stage 37

stage 43

Stomach

Anatomy.
proventriculus

Entry 2

GEISHA Id	Smad8.Shin.2005	Data Source	Publication
Complete cDNA Template Probe	show CTCTGCTTCTTATGCACTCCAGCACCCCTATCAGTTCCTTGTTCTCCTTCACCAGCCCTGCAGTGAAAAGGCTGCTGGG CTGGAAACAAGGAGATGAAGAGGAAAAGTGGGCAGAAAAAGCTGTTGATTCCCTGGTGAAGAAATTAAAGAAGAAAAAA GGTGCCATGGAAGAACTGGAAAGGGCTCTAAGCTGCCCAGGTCAGCCCAGTAAATGTGTCACGATCCCACGTTCCTTGG ATGGGCGGCTGCAGGTTTCTCACCGCAAGGGGCTCCCTCATGTCATATACTGCAGAGTGTGGCGTTGGCCTGATTTACA ATCTCACCATGAATTGAAGCCACTGGAATGCTGTGAGTTCCCATTTGGCTCAAAACAGAAAGAAGTGTGCATTAACCCC TACCATTACCGGCGGGTGGAAACTCCAGTCCTACCTCCAGTACTTGTTCCAAGACACAGCGAGTTTAACCCTCACCTCA GCCTTCTCGCCAAGTTTCGAAATACTTCTCTGCACAGTGAGCCACTGATGCCACACAATGCCACCTATCCTGATTCTTT CCAACATCCTCCATGCACCCCGTTTCCACCATCACCCAGCCACATGTTCTCCCAGTCGCCTAACAGCATCAGCTACCCC AACTCACCAGGAAGCTCTTCTGGACCAGGAAGTCCATATCAGCTCACGGTGGAAACTCCACCCCCACCCTACCACGCAA GAGAAACTCCGGGAAGCCACAATGGGCGGTCAATGGATGCTATAGCTGAAAGCCAACTAGTACTGTCTTTGCCCAATGG AGGTAAATCTGCCGATGGAGAAACTGAAAATTTTCGGCCTGTTTGCTATGAGGAGCCACAACACTGGTGCTCAGTTGCC TACTATGAACTCAACAACAGGGTAGGAGAGACTTTCCAGGCTTCCTCTCGAAGTATCCTTATAGATGGATTTACAGATC CCTCAAATAACAAAAACAGGTTCTGCCTGGGACTGCTCTCGAATGTAAACCGCAATTCGACTATAGAAAACACCAGGAG ACACATAGGAAAAGGTGTCCATCTTTATTATGTTGGTGGAGAAGTGTATGCTGAATGTGTCAGTGACAGCAGTATTTTC GTGCAGAGCCGCAATTGTAACTATCAGCATGGTTTCCACCCAGCCACTGTCTGTAAGATCCCCAGTGGCTGCAGCCTCA AGATCTTCAACAACCAGCTCTTCGCCCAGCCGCTTGCCCAGTCAGTCAATCATGGTTTTGAAGTGGTATATGAGCTGAC GAAGATGTGTACGATTCGAATGAGCTTTGTTAAAGGCTGGGGAGCAGAGTATCATCGCCAAGATGTTACAAGCACGCCC TGCTGGATTGAGATCCACCTGCACGGACCATTGCAATGGCTGGATAAGGTTCTGACACAGATGGGCTCACCTCATAACC CCATCTCTTCCGTCTCTTAAGAATCATCTCTA
Citation	Shin M, Watanuki K, Yasugi S (2005). Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. Gene Expr Patterns. 2005 Apr;5(4):511-6.
Copyright	Copyright © 2004 Elsevier B.V. All rights reserved.
Comments	According to authors, "cSmad8, cGata4, cFgf10 (a gift from Dr T. Nohno; Ohuchi et al., 1997). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #AY953145).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

25-30

stage 27

stage 29

stage 30

Gut
Unlabeled

Presumptive glandular epithelium of the proventriculus

31-39

stage 36

stage 39

Gut

Presumptive glandular epithelium of the proventriculus

all

Entry 3

GEISHA Id	Smad8.Zuzarte.2004	Data Source	Publication
Complete cDNA Template Probe	show AGGTGCCATGGAAGAACTGGAAAGGGCTCTAAGCTGCCCAGGTCAGCCCAGTAAATGTGTCACGATCCCACGTTCCTTG GATGGGCGGCTGCAGGTTTCTCACCGCAAGGGGCTCCCTCATGTCATATACTGCAGAGTGTGGCGTTGGCCTGATTTAC AATCTCACCATGAATTGAAGCCACTGGAATGCTGTGAGTTCCCATTTGGCTCAAAACAGAAAGAAGTGTGCATTAACCC CTACCATTACCGGCGGGTGGAAACTCCAGTCCTACCTCCAGTACTTGTTCCAAGACACAGCGAGTTTAACCCTCACCTC AGCCTTCTCGCCAAGTTTCGAAATACTTCTCTGCACAGTGAGCCACTGATGCCACACAATGCCACCTATCCTGATTCTT TCCAACATCCTCCATGCACCCCGTTTCCACCATCACCCAGCCACATGTTCTCCCAGTCGCCTAACAGCATCAGCTACCC CAACTCACCAGGAAGCTCTTCTGGACCAGGAAGTCCATATCAGCTCACGGTGGAAACTCCACCCCCACCCTACCACGCA AGAGAAACTCCGGGAAGCCACAATGGGCGGTCAATGGATGCTATAGCTGAAAGCCAACTAGTACTGTCTTTGCCCAATG GAGGTAAATCTGCCGATGGAGAAACTGAAAATTTTCGGCCTGTTTGCTATGAGGAGCCACAACACTGGTGCTCAGTTGC CTACTATGAACTCAACAACAGGGTAGGAGAGACTTTCCAGGCTTCCTCTCGAAGTATCCTTATAGATGGATTTACAGAT CCCTCAAATAACAAAAACAGGTTCTGCCTGGGACTGCTCTCGAATGTAAACCGCAATTCGACTATAGAAAACACCAGGA GACACATAGGAAAAGGTGTCCATCTTTATTATGTTGGTGGAGAAGTGTATGCTGAATGTGTCAGTGACAGCAGTATTTT CGTGCAGAGCCGCAATTGTAACT
Citation	Zuzarte-Luís V, Montero JA, Rodriguez-León J, Merino R, Rodríguez-Rey JC, Hurlé JM. A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Dev Biol. 2004 Aug 1;272(1):39-52.
Copyright	Reprinted from Developmental Biology, Volume 272, Issue 1, V Zuzarte-Luıs, J.A. Montero, J Rodriguez-León, R Merino, J.C Rodrıguez-Rey, and J.M Hurlé, A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways, Pages 39-52, Copyright 2004, with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved.
Comments	Fragments of chicken ... Smad8 (972 bp) genes were obtained by RT-PCR. cSmad8, 5′-AGGTGCCATGGAAGAACTGG-3′(sense) and 5′-AGTTACAATTGCGGCTCTGC-3′ (antisense).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

25-28

stage 28

Leg Mesenchyme
Wing Mesenchyme

Entry 4

GEISHA Id	SMAD8.LeDréau.2012	Data Source	Publication
Complete cDNA Template Probe	show CTCTGCTTCTTATGCACTCCAGCACCCCTATCAGTTCCTTGTTCTCCTTCACCAGCCCTGCAGTGAAAAGGCTGCTGGG CTGGAAACAAGGAGATGAAGAGGAAAAGTGGGCAGAAAAAGCTGTTGATTCCCTGGTGAAGAAATTAAAGAAGAAAAAA GGTGCCATGGAAGAACTGGAAAGGGCTCTAAGCTGCCCAGGTCAGCCCAGTAAATGTGTCACGATCCCACGTTCCTTGG ATGGGCGGCTGCAGGTTTCTCACCGCAAGGGGCTCCCTCATGTCATATACTGCAGAGTGTGGCGTTGGCCTGATTTACA ATCTCACCATGAATTGAAGCCACTGGAATGCTGTGAGTTCCCATTTGGCTCAAAACAGAAAGAAGTGTGCATTAACCCC TACCATTACCGGCGGGTGGAAACTCCAGTCCTACCTCCAGTACTTGTTCCAAGACACAGCGAGTTTAACCCTCACCTCA GCCTTCTCGCCAAGTTTCGAAATACTTCTCTGCACAGTGAGCCACTGATGCCACACAATGCCACCTATCCTGATTCTTT CCAACATCCTCCATGCACCCCGTTTCCACCATCACCCAGCCACATGTTCTCCCAGTCGCCTAACAGCATCAGCTACCCC AACTCACCAGGAAGCTCTTCTGGACCAGGAAGTCCATATCAGCTCACGGTGGAAACTCCACCCCCACCCTACCACGCAA GAGAAACTCCGGGAAGCCACAATGGGCGGTCAATGGATGCTATAGCTGAAAGCCAACTAGTACTGTCTTTGCCCAATGG AGGTAAATCTGCCGATGGAGAAACTGAAAATTTTCGGCCTGTTTGCTATGAGGAGCCACAACACTGGTGCTCAGTTGCC TACTATGAACTCAACAACAGGGTAGGAGAGACTTTCCAGGCTTCCTCTCGAAGTATCCTTATAGATGGATTTACAGATC CCTCAAATAACAAAAACAGGTTCTGCCTGGGACTGCTCTCGAATGTAAACCGCAATTCGACTATAGAAAACACCAGGAG ACACATAGGAAAAGGTGTCCATCTTTATTATGTTGGTGGAGAAGTGTATGCTGAATGTGTCAGTGACAGCAGTATTTTC GTGCAGAGCCGCAATTGTAACTATCAGCATGGTTTCCACCCAGCCACTGTCTGTAAGATCCCCAGTGGCTGCAGCCTCA AGATCTTCAACAACCAGCTCTTCGCCCAGCCGCTTGCCCAGTCAGTCAATCATGGTTTTGAAGTGGTATATGAGCTGAC GAAGATGTGTACGATTCGAATGAGCTTTGTTAAAGGCTGGGGAGCAGAGTATCATCGCCAAGATGTTACAAGCACGCCC TGCTGGATTGAGATCCACCTGCACGGACCATTGCAATGGCTGGATAAGGTTCTGACACAGATGGGCTCACCTCATAACC CCATCTCTTCCGTCTCTTAAGAATCATCTCTA
Citation	Le Dréau G, Garcia-Campmany L, Rabadán MA, Ferronha T, Tozer S, Briscoe J, Martí E. Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord. Development. 2012 Jan;139(2):259-68.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AY953145.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 18

Neural Plate/Tube

floor plate

19-24

stage 24

Neural Plate/Tube

Entry 5

GEISHA Id	SMAD9.Trevers.2023	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show CTCTGCTTCTTATGCACTCCAGCACCCCTATCAGTTCCTTGTTCTCCTTCACCAGCCCTGCAGTGAAAAGGCTGCTGGG CTGGAAACAAGGAGATGAAGAGGAAAAGTGGGCAGAAAAAGCTGTTGATTCCCTGGTGAAGAAATTAAAGAAGAAAAAA GGTGCCATGGAAGAACTGGAAAGGGCTCTAAGCTGCCCAGGTCAGCCCAGTAAATGTGTCACGATCCCACGTTCCTTGG ATGGGCGGCTGCAGGTTTCTCACCGCAAGGGGCTCCCTCATGTCATATACTGCAGAGTGTGGCGTTGGCCTGATTTACA ATCTCACCATGAATTGAAGCCACTGGAATGCTGTGAGTTCCCATTTGGCTCAAAACAGAAAGAAGTGTGCATTAACCCC TACCATTACCGGCGGGTGGAAACTCCAGTCCTACCTCCAGTACTTGTTCCAAGACACAGCGAGTTTAACCCTCACCTCA GCCTTCTCGCCAAGTTTCGAAATACTTCTCTGCACAGTGAGCCACTGATGCCACACAATGCCACCTATCCTGATTCTTT CCAACATCCTCCATGCACCCCGTTTCCACCATCACCCAGCCACATGTTCTCCCAGTCGCCTAACAGCATCAGCTACCCC AACTCACCAGGAAGCTCTTCTGGACCAGGAAGTCCATATCAGCTCACGGTGGAAACTCCACCCCCACCCTACCACGCAA GAGAAACTCCGGGAAGCCACAATGGGCGGTCAATGGATGCTATAGCTGAAAGCCAACTAGTACTGTCTTTGCCCAATGG AGGTAAATCTGCCGATGGAGAAACTGAAAATTTTCGGCCTGTTTGCTATGAGGAGCCACAACACTGGTGCTCAGTTGCC TACTATGAACTCAACAACAGGGTAGGAGAGACTTTCCAGGCTTCCTCTCGAAGTATCCTTATAGATGGATTTACAGATC CCTCAAATAACAAAAACAGGTTCTGCCTGGGACTGCTCTCGAATGTAAACCGCAATTCGACTATAGAAAACACCAGGAG ACACATAGGAAAAGGTGTCCATCTTTATTATGTTGGTGGAGAAGTGTATGCTGAATGTGTCAGTGACAGCAGTATTTTC GTGCAGAGCCGCAATTGTAACTATCAGCATGGTTTCCACCCAGCCACTGTCTGTAAGATCCCCAGTGGCTGCAGCCTCA AGATCTTCAACAACCAGCTCTTCGCCCAGCCGCTTGCCCAGTCAGTCAATCATGGTTTTGAAGTGGTATATGAGCTGAC GAAGATGTGTACGATTCGAATGAGCTTTGTTAAAGGCTGGGGAGCAGAGTATCATCGCCAAGATGTTACAAGCACGCCC TGCTGGATTGAGATCCACCTGCACGGACCATTGCAATGGCTGGATAAGGTTCTGACACAGATGGGCTCACCTCATAACC CCATCTCTTCCGTCTCTTAAGAATCATCTCTA
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001024826).