GEISHA - A Chicken Embryo Gene Expression Database
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SOX2
SRY-box 2

The human orthologue of this gene is associated
with the following human diseases:
Gene
Official SymbolSOX2
Official Full NameSRY-box 2
CGNC ID49650
also known astranscription factor SOX-2|SRY (sex determining region Y)-box 2|Sox2 transcription factor|cSox2|delta EF2a, Transcription factor SOX-2
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_205188
PolypeptideNP_990519
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.601
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human6657ENSG00000181449MIM:206900MIM:184429
Mouse20674ENSMUSG00000074637All phenotypic alleles (16):Radiation induced(1) Targeted, knock-out(4) Targeted, other(10) Transgenic(1) MGI:98364
Xenopus407873, 398000484552
Zebrafish378723ENSDARG00000070913ZDB-GENE-030909-1ZFIN:ZDB-GENE-030909-1
Gene Ontology
Molecular FunctionmiRNA binding, sequence-specific DNA binding, more...sequence-specific DNA binding transcription factor activity, transcription regulatory region DNA binding
Biological Processcell cycle arrest, endodermal cell fate specification, eye development, inner ear development, more...negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial cell proliferation, negative regulation of neuron differentiation, osteoblast differentiation, pituitary gland development, positive regulation of MAPK cascade, positive regulation of transcription, DNA-templated, positive regulation of transcription from RNA polymerase II promoter, regulation of cysteine-type endopeptidase activity involved in apoptotic process, response to growth factor, response to wounding, somatic stem cell maintenance, transcription, DNA-templated
Cellular Componentcytosol, nucleus
Links to other databases
Entrez Gene396105
Ensembl Gene
KEGGgga:396105

Entry 1

GEISHA IdSox2.Matsushita.2002Data SourcePublication
Complete cDNA Template Probeshow
TGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGGGAGGCACAGGCAACTCCAACTC
GGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTTCATGGTGTGGTCCCGCGGGCAG
CGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGGCTCGGGGCCGAGTGGAAACTTT
TATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGCACATGAAGGAGCACCCGGATTA
TAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTTGCCAGGGGGCTTACTGGCGCCG
GGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTGAACCAGAGGATGGACAGTTACG
CGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCTACCCGCAGCACCCGGGCTTGAA
CGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCAGTACAACTCCATGACCAGCTCG
CAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACCCCGGGCATGGCGCTGGGCTCCA
TGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGTCTCATTCGAGGGCTCCTTGCCA
AGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGAACCAGCTGCCCCAAGCAGACTT
CATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACACTCCCTCTATCACATATGTGAA
GAC
CitationMatsushita S, Ishii Y, Scotting PJ, Kuroiwa A, Yasugi S. Pre-gut endoderm of chick embryos is regionalized by 1.5 days of development. Dev Dyn. 2002 Jan;223(1):33-47.
CopyrightCopyright © 2002 Wiley-Liss., Inc.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-10
stage 10
Endoderm, early
Gut
Neural Plate/Tube
pre-gut endoderm

Entry 2

GEISHA IdSox2.Rex.1997Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationRex M, Orme A, Uwanogho D, Tointon K, Wigmore PM, Sharpe PT, Scotting PJ. Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue. Dev Dyn. 1997 Jul;209(3):323-32.
CopyrightWiley-Liss., Inc. 1997
CommentsInsufficient information in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # U12532).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 4
stage 4
stage 5
stage 6
Area Pellucida
Epiblast
Hensen's Node
Neural Plate/Tube
 
7-8
stage 8
stage 8
stage 8
Neural Plate/Tube
 

Entry 3

GEISHA IdSox2.Chapman.2008Data SourceDirect Submission
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CommentsImages Provided by Susan Chapman.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 4
stage 4
stage 5
stage 6
stage 6
Neural Plate/Tube
 

Entry 4

GEISHA IdSox2.Matsumata.2005Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationMatsumata M, Uchikawa M, Kamachi Y, Kondoh H. Multiple N-cadherin enhancers identified by systematic functional screening indicate its Group B1 SOX-dependent regulation in neural and placodal development. Dev Biol. 2005 Oct 15;286(2):601-17. Epub 2005 Sep 16.
CopyrightCopyright © 2005 Elsevier Inc. All rights reserved.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 10
stage 11
stage 12
stage 12
stage 12
Central Nervous System
Ear/Otic Placcode
Ectoderm
Lens
Sensory Organs
Lens placode
13-14
stage 13
stage 13
stage 14
stage 14
Ectoderm
Lens
Nasal Placcode/Nerve
Lens placode

Entry 5

GEISHA IdSOX2.Streit.2002Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationStreit, A. Extensive cell movements accompany formation of the otic placode. 2002 DEVELOPMENTAL BIOLOGY 249(2), 237-54.
Copyright"Reprinted from Developmental Biology, 249(2), Streit A., Extensive cell movements accompany formation of the otic placode, 237-54, Copyright (2002), with permission from Elsevier". Copyright © (2002) Elsevier B.V. All rights reserved.
CommentsAccording to the authors, cDNAs came from various sources (refs). As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc#NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 5
stage 6
stage 6
stage 6
stage 6
Neural Crest
Neural Plate/Tube
 
7-12
stage 7
stage 7
stage 7
stage 8
stage 8
stage 8
Headfold
Neural Crest
Neural Plate/Tube
double labeled
31-44
stage 44
stage 44
  

Entry 6

GEISHA IdSOX2.Streit.1997Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationStreit A, Sockanathan S, Pérez L, Rex M, Scotting PJ, Sharpe PT, Lovell-Badge R, Stern CD. Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2. Development. 1997 Mar;124(6):1191-202.
CopyrightCopyright: © 1997 Streit. et al.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
Epiblast
Primitive Streak
 
4-6
stage 6
Neural Plate/Tube
 
7-9
stage 8
stage 9
Central Nervous System
Neural Plate/Tube
 

Entry 7

GEISHA IdSOX2.Linker.2004.Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
Citation Linker C, Stern CD (2004). Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists. Development. 2004 Nov;131(22):5671-81.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_205188)
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 5
Neural Plate/Tube
 
7-9
stage 9
Neural Plate/Tube
 

Entry 8

GEISHA IdSox2.Hyre.2003Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationHyer J, Kuhlman J, Afif E, Mikawa T. Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation. Dev Biol. 2003 Jul 15;259(2):351-63.
CopyrightCopyright © 2003 Elsevier Science (USA) All rights reserved.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13
stage 13
stage 13
Eye
Lens
Neuroepithelium

Entry 9

GEISHA IdSox2.Basch.2006Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationBasch ML, Bronner-Fraser M, García-Castro MI. Specification of the neural crest occurs during gastrulation and requires Pax7. Nature. 2006 May 11;441(7090):218-22.
CopyrightCopyright © 2006, Nature Publishing Group
CommentsInsufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 5
stage 6
stage 6
Epiblast
Neural Plate/Tube
double label

Entry 10

GEISHA IdSOX2.Huang.2010Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationHuang C, Chen J, Zhang T, Zhu Q, Xiang Y, Chen CD, Jing N. The dual histone demethylase KDM7A promotes neural induction in early chick embryos. Dev Dyn. 2010 Dec;239(12):3350-7.
CopyrightDev. Dyn Copyright © 2010 John Wiley & Sons, Inc. All Rights Reserved.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 1
stage 2
stage 2
stage 3
Neural Plate/Tube
Notochord
Unlabeled
 
4-6
stage 4
stage 4
stage 4
stage 5
stage 5
stage 5
stage 5
stage 6
Epiblast
Neural Plate/Tube
Notochord
 
7
stage 7
stage 7
Neural Plate/Tube
Notochord
 

Entry 11

GEISHA IdSOX2.Chapman.2003Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationChapman SC, Schubert FR, Schoenwolf GC, Lumsden A. Anterior identity is established in chick epiblast by hypoblast and anterior definitive endoderm. Development. 2003 Nov;130(21):5091-101. Epub 2003 Aug 27.
Copyright© 2003 The Company of Biologists Ltd
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
stage 3
Neural Plate/Tube
St. 3d/4
4-5
stage 4
stage 4
stage 4
stage 5
stage 5
stage 5
stage 5
Neural Plate/Tube
Double in situ hybridization - St. 4+/5
Double in situ hybridization - St. 4/4+
Double in situ hybridization - St. 5+
St. 4/4+
St. 5+

Entry 12

GEISHA IdSOX2.Stuhlmiller.2012Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationStuhlmiller TJ, García-Castro MI. FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction. Development. 2012 Jan;139(2):289-300.
Copyright© 2012. Published by The Company of Biologists Ltd
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205188.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-5
stage 5
stage 5
Epiblast
 

Entry 13

GEISHA IdSOX2.Wakamatsu.2000Data SourcePublication
Complete cDNA Template Probeshow
GATCTTGAGGAGAGGGCAGTGGTTTCTATCTCTAGCTGTGAAAAGGGACACAATGTCCAGAAAAATGGCTTCAAGGCGT
TTCTTTGGAGAGTCTCTTCCCAAGTGTAACCTTTTCCATTGGCTATTGGGAGACCTCTGACCATGCTTCTATTTCTGAA
AGTCCTGCAGCTTGTTGCCCCACACCAGCTGCTCAGGTCAAGCCTTCCTGCACCACGGCAAGGTGATCTCCTTCTTACT
GCAGCTGTTGAGAAGGATGACCAACTGACAGTAAAATTGCTTGGTACTGATGAGCCTTTGGCTTTGTTACTGTGGTAAA
ACATACATCATTTGACAGCTGCTTGTGCATGGAGAAAACCATAGATGATTAACGGTTTCCTGTCTTTTCTTGCTACTGA
TCTTCTTTGCTTATGACAGATGAGACTCAGATGTCTTTTTTTAAGAGGCAGAGAGAGAAAGGGAGGATATTTAAACTTG
TTCTCACCTAAGTCTTTTATGTTATCCTAAGGACCTTATTTGTAGTAGAGATTTTTTTTTCTGCATTTTAGCTCTCCTA
AAATGATCAGATCTGTCATTCAGCTTTAAAAGGGAATGTATATTCTTCCTCTCCTGGATTTTTTTTCCCCCAAGGGGTA
TAATGCTAATTTTACTTATTCAGAAATTAAAATAGCAAACAGTTTATGTGAGGTGTTGATAATTACCTATATTACTGTA
ACGCTGTGACAGATGTTGGCAAAAAGAAGCAGAAAATGCCTACAGCTGTGCACTCCATGACATCCAGTTTATACTCAGA
CAGAAGGCTAACAGATGTTCTGAACTGTCACTTTGCCTAAATGTTTTTAAAGTCTAAGGACCTGCTTTATAATTCACTG
GGGCCTCATTTGGTTTCGCAGAGGTCCTCAGAATTCCCATCTGTGACAATTAATGTTGAAGACTTTTATAAATCAACCC
TTGTCCTTATTAGCCCTCTGCAAATAGATATTGTGTATCTGTATACTCCCGAGACTTCTATTTTTTGTGACCTCGTTAT
TAATTGCTACTACTTGTGTATAACATAATTCATGTTTCAAGCAGAAAGAGAAATGGATTACATGAATGAGCATCAAAGA
TCACCCAGGTACATTTGACTAACCTCAGAGTACCTATGTTAAAACATTCTCTATTGTATCCCCAATTCTGTGGTCATTT
CTAAAGTGATTTGAAAATGCTGACATCTCCAACCTACCTACTCAGTTTCCCAAAGGAAAATACGAATTTTGGTGGTACA
AAAAGGTAGCACTTAGGCAGATATGTTCAGCTGCTGGAGCTATTTCTATTCCTGGAGAGTGTTCTAATTCAAAAATAGT
GAAATCACTAAGGGAGACTTTAAAATAATTCAAGCTTCCTGTATTATTTCAAAATGGAGTTGTTATGAGGATGGCATGT
AAGTAATGTGTGCAGGTAGGAAATCTGAGATTTGAAATAGTCTTTGGGCTCTAAGCTCCACCCAGATTTTCTAGCATAC
CTTTAGATAAGCAAAAAATGTCTGTAGCATAAAACAACTTAATACTTTATTGATAGTTGCCATTTCTTTTTAAAAGCTG
GGTTCCTGTTGTACAGCAGTTTAATAGCTTTAACATTGCACTGCCGTAATCGGTGTTTGGCCTCTTCTGTTCCCCAATC
CTGTATGGAAGCAGAACTCCAAATTGTACATCTTTCTGGGTTTGTTTCTAAATTACTCCCCACACTTAATTACGAGGAT
GAGAGGGATGCCTTATTCCTCTTTGTTATAGGCTAAGCTCTCAGTAATCCCAAACAAAAGAGCCAGTTCTGGAAGATAT
AGGATTTGCTAGCAGGATTATGGTCTCATAGATAATGATGTGCAGTCAGCAGAAGCGAAGCTTTATTTTAATTCAAATA
AGCTAGTAAACAAACCACTGACAAGTCTGCTGGTGAGAGTAACTGGCTTCTGTTGCCACATTGGCAGCTAAATTATAGA
AAATCTATTATACCCTGTTCACCATATGTTTAATTTAATACAGATACAAATTAAACTATCCACAGTGCCTATTAAAATA
ACAATACATATTTTTAAAATATATGAATGTTTTAAGATACATTCCCCTGACCTTAAGAAGGGCAAATGCTGATTTGGGA
GACTACAGCAAAACACATGCTGTAGTCAACAGATTCTCTTCAACAACAACAACAGTAATTTGAAAACCCCTGAATATTA
ATAGTACAGTTTTGTAAAAGATAATGAGGTTAATTGGGGTGTTTTACCTTCTAAGCATCTGCTCTTCCGTGTTTCCCTC
CCCCTAGGTTCCTGGGCATGGATTTGATAGAAGTGGCTGATATCTAATCCGTTGTACACTTTTTAATTCTGTGCCAGAT
GCAGTGTGAGTTGTTTGCCCTTTTCCTGCTGCAAATAGATATCCCTCATTTCTGCATATCCTCATTTGTTAACGTTCTC
CTACACAGCCCTCAGCTGGATTTTTGACCTGTTGGGAGCTGCTACTCTGTATCAGTGGCAGAGGGTTTCAAATTGTGTG
GAGGGGTTCGTACTCATTGCCCGCGTTCAGAGCAAAAAGTGTTGAGCACTGTGTATTTTGGCCCTCCTTGCACCCTCAT
TGCTGTCTCGAGTCCTGTGACGGCTGCAGTGAGAGTCTCTGAGTCTGGGTGCTTCCACATAAACTGAACATACCTCATA
AAGTCACTGAGTCTCCAAGTCACTGCTCATAGCAGGCTACGGAGAATGGGGTTAAAGATCAGCAGCTGTCCCTGTGGTG
AGGTGGTGATGATGAGGGACTACCTGAAACCGTACAGAAAGCACGGAGAAAACCTCTCCAAATTCACATTGCAACTGAA
GTGAGTGATGACAAAGTGCCAGGCAGCACTGTGCCAGGAAACTGTTCTCTGGATGTTGCTGGAAGCCCTCTGCCAAGGT
TGGCTCTGTCTCTTCGTAGTCCCAGGCTGCTGACAGCAGCAATGAGCGTGTAATGGGACAGGAGTTCTGAGAAATGACC
TGATGTGGTTTGGGGACTGCCACCTTACTCACAGCAATATGTTCAGAATTCAGCATTCAGAATGATCTCTTATCACTTA
GGATGTAAGAACACATGCATACCCCACAGACGTGTGGAAGTGTGTGTGCAGAAAGGGGTCTCAGTCCTCTGAATGCCAG
GTATCGTGTGCCATGCATATATAGACTGTGTACTGTCACAGTGTGTAGCATATGTGCAGGTATGTGAAGTACACACATA
CTGTATGCATAAATACACACATTGACTATTTAAATTGCTTTAAATTACTGTTGTTATTTGCCCAAGTATTTTCAGAATC
AATGTATTTGTGATACGTTGACAGAACGTACACAGGAAGGTATCAGTTATCAGAAGCAAGTCTAACTTCTGTGACAAAT
TCATCTTCAGAGTGTGGAAGAAGCCCAACTCCAGAGAAAGTTGCCATCTAAAGGACTGAAAAAAAGGGAGTTGTCGAGT
CCTTAAGATGTGTGGGCAAAGTGCTAACAGATTATTTCCCAGGAGAAATGCATCCTTTCCTCTGTGCTCATCTTTCAGT
AAAGGCGTATTTGGCACTGCAGCTATCCACAGCAATTGGCAGCAGAAATATTGCAGTGAATGTTGAGATAATGAATGAA
CAATTTCGCATCTCTTAGAGCGGTCACGGGGAGGGAAAAAAAAAAAAGCCAACTAAGAAGTCTCCAGGTTTGGGAGGCA
CGGCTGAAGCTCACACGTACATTTCTGCACAGCGAAGGGCCTGCCTGCCCTGCAAACCTGCAGCTCCTCGGGAGACTGC
GTGTTCTTTGCTTGCAGTTAAGCGGGCTCCTTACTATCGTATCCCAGGACAAAACAAACAACCTGCTGTCACAAATGTT
CTTTTAACACCGTGAGGTGGTGGGAAGCTTTTCTAGCTCTTCGAAGGACCGCGTGTCCGTACGACGGGTGTGAATTCTG
GTGAGCTGTCTGCACGCCATGGGGATAGAAAAGCCCGAACGTGCTTTAAGTGAAGGCGTGCTGCCGAGAACTTATGGGA
ACGATCGCACGGGAGAACTTTCCCTGGTGAAAAGAGGGAAACGCAGTGAAAGGACTCGCGAGTGAGCGGCCCCGCGGCC
CGGGGTCCTTTCGGGCACCTCCATCGCCGTCCTCCGGGGCGCGGGGAGCGCAGCGGCTCCGCTCGGGGGCGGCTGCGGG
ACGGCCGTGTGCACGCTGTGAGCGTCCCGAGCCGAACCCGCGGCGAGCAGAGCGCGTCCGTGTGTACGCCGGGAGCGCG
CAGCCTGCGGCCGGGCAACGGGCAGAGCGCTCCTGGTGCCGAGGTGTTCGTTGGCGCGGGGCCCTGCTTGCCCCGGGCG
GGGCGGCCCGACTTCGGGAGTCGTTTGCTCCCCGGGCGCGGCGGTGCGTCGGGCGTCGCTGAGCGCCTCTTACAGAGAG
CGCCTCTGGCCAACTGCTCGGGTATCCGGTGTGAGATAAGATAGGGATCTGCTGCGTAAATTTGGAGTTATGCGCTATT
TCATCTATACTGCTAGATGCAGGTGTTTTGTTCTGTTCTGTTTCTCGAGTCTTAAATGAATTGTGAAAACCAAAATACC
ACTCTGTGGTTCTATGACATTCAATTTCCCATCCCGTGGGAGCGGTTTCGGGACACAGCTTACGCGTATCGGTGCCGCG
CGGGGCGAGAAAGGCGTGTTGGGATGTGAGTTTCCCTCAGAGCCCTTCCAGCCCGCGGTTCACGCGTTTTCCTTCTTTT
TTTTCTTCTTGGTTATTCCCCCTCCCCGAGGAGGTGTCACACGTTGATCCCGCGCATCTGAAAGTTGCAGCCGCCCGGT
CCCACGCGCTGATGATTTCGTTTCCGGCTATCAGCAAAATGAGCTTTAAGCCAATTTCGTGCTTCGGGCTAAAGAGAGA
GGGATTCGTGTTTCCCTCCTCGGTGCTTGGCATTCCCGGAATCTCTTTGTCAGCTTGCTGTAGGACGCTGCTGTAATTT
GCTTGGAAACTCTCTCCAAGAGCTGTATACAGCTGTTAAGAACGACGTGCAATTTCTGAGCCATCGGGATGCTTTGTCT
GAAAAAAAAAAAAAAAATCATCTTTCCCCGCTAAGTCCGTATTAAACTGCTCAGAGCCCGGTTCCCATTTAACCCAAAG
CACCTCTATAGGTAGCGAAACGCGCCTTTCCTACTAATCCCTTTCCTTCACTGCTGTGAGTAACAAAATACCTCTTCTA
TAGAAGCGGCACTTTCTTCCCTAATGTTGCCCTGTGTTTAGGAAAGCACTTGCACGATTTCCCCAACTTTGGCACGTTT
GGGTTCTTGCGCCACTGACATTTTTTTTCCTTCGCGCTTAGAGGTGCAGTGATAGGAGGTCTCTTATGTGCGCTCCGCT
GCCCTCTGGGCGTTAAGCCCGGGCAGAGCAGTGCCCCCGTCCGCTGGCAGCGGGGGCCGAGGGGCGGCACGGGGCGGCT
GGAGGGGCCCGGGACCGAGCGGAGCGGCCGTGCGGGGAGCGGAGGGAACGCGGCCACCGCCCCGGGGCCGCTCGGAGCC
GCCTCGGCGTCGCTCCCCGCTCCCTCCCCGCTCGGCTGGGGCGAGCCGGCGCGAAGATGTTTATCCTGAGATAGAAAAT
GGGTTGTTGAAAAACAAGCTATGCGCAAATAGTTTAATTTTCCGTTTTGATGCTTATCTTTGTCTCCCGAATTTCATCG
GAGAGGCTTTAATTGGCGTGTGGGTAATAGTTCCTAAATAATCCCTTATTAGATGACTTCAGACGAGTTGGGAACCAAT
AACGTCTTAGTCCCAAAAGTGAAAGTAGAATTGGAAGGCGCGGGTCAGTTTTTGTCAAAGGGCTCATTTGGGCATCTTT
GCGTCTGCTGAAAAAGCTAATTAAAGAATGTTTGAAGGTTAAAGTCATTATTCCGTGCTGTTGTCGTGCTACAAGTGAG
CCGAGTTTTGTGAAAACACAAAGGGCAGAAGTCACAGAGGTGGATTACTGTCAGTCCCGGCTACAGAGGCACAGAGCAC
TGTGGCATTAATTCCTATAGAAAGGTAGACAAACACAGGCACTGCCTAACAACTTTCCCGCAGAGCCCCATTGTCTAAG
CACTTTCTTTGGCTTCGGGGCTCTCCTCTGCTCGCTACAGTCTCAACCGCGTTTAGAAGCGGGCAACGGGCAGCGCTTC
GGGCGCGCTATTCTGGACCCGGGAAAGAATTTCCCAGCTGCGCTTCTCGCCGGTTCCGTGCTGTCCATTTTTCCCTCGG
AGCGCTGCTCGTGTATTCATTACTCGGCACAAAGTTGGCGGGGCACGAGAACTCCGCGGCAGTTCGCTGCCCCCACCCG
CACGGTGCGCCCCGGGGCTGCAGCTCGGCAGCTGCGGAGGGGTCGGAGAGGCTCCCGGCGTGCAGGGACGAGCGGGGGC
CGACGGAACGAGGTCGGCCCCGTTCCCACGCCGGGAGCTGCTCCCGGGGTGCGCGTTCGTGCGCGGGGACGGCAGGTCG
CCAAACGACGCGCGCAGAGATGCGCACACGCGCTGTTCGGCCCCGCTTCTCGCGGCTCCTCTGCCTTCGCCTCGGGGCC
GCTGTGCCCCTCTCTGCCCCACAGTCCGGGTCGGAGGGGCCGCTGCGGCTGCGGAGCTCCCCACATTCAGAGAAACAGA
TGTTTGGGCTGAGCTGAGGGTGGGGGGAGGTGGGGGGAACCCTGCAGCTGCAAGTCAAAGAAATATATTGATAAAATAT
TTCAGTAGTAGTAAATACGCGGGGATCGGCTCGACCTTGCGAGGTCTTCATTTTAATTTTTTTTTTCCCCCTATATACA
AAAATCTTTATCAAACCTCTATTCTATGGCTTCAATAAACAGAACCCATTACCTCACGGCAGCTTTTGTTGGCCTGTAT
ACAAGCGAGAACAAAATGGTTATTCAGGAGAACGCTTTCGATTTTTATTGTGTGTAGTATGCACAAAGAGCAGTGTTAT
TGTATTAAAAAGAACCATCTGTAGCAGAAACAATGGCATCAAATTATCTTTGAATACCCACTGCAAAAATATAAAGCTT
TTTTATTATTCTTCTGCTGTACGGTGGGGGACAGAGAAGTGACTTTTTTGTTGTCGCGGGTGCATTCTTATAACACACA
CAAAATCAGCCATTTGGATTTTTTAAGCCATAAACGATTTTTTCCCCTCTTGTTCCAGGGACCGCAGTTAAAAGCTAGG
GCTAGGACTTGGAGGACGTGTAGGCAAACGGAAGGAGAGCCGGGGGAAGAAAAGCCGAAATGGATTCATTCTCCGTCCT
GGCTGGAGGAGGAGAGGAGCGGGGACGTGCGGGCTGCCTGCAGCTGCCTCTGTCCGGTGAGAAGTGCTCCCAGCCCCGC
GGCTGACTCGGGCTCGGGAGTCCGCGCGGACTTTCGCTCGAAGCTGCCAATCAAACCGCTAACCGCCACCACCCTGCGC
TGGCACCGACATGTGAGTACTGCACCACAACTTTGACATTCACGGGTTTCCCCCTTCCTCCCCCGTGACCTTTAAAACG
ACGGAGAAATACCGCTGTCGCTTAGCGCCCGCCGCTCCGAGCTGGACGGCGTTACACTGAGGGACTCGCGCGCGGGTTT
GGGTTTGCCTGCAACTGCGCGGCAGCCGCTTTGCGACCGGAGCGCCGAGCAGGAGCGGAGCCGCCCGAGGCCGCCCCGC
GCTGCCGGCCCCGCGCTGCCCGCCCCTACGCCGGCGCGCACGGACCGAGGGGTCCCCGCGGGCCGCCTCGGCCGGGGCC
GCAATTTCGGCGGTGCCAGGTTCCGCTGCGGGGCGGCGGTCGTTTGAGTCACGCCGGCGCTGCGCTGCGCTGTCCGGGG
AACGGCGGAGGCGCTCCGCGGGGGCTGGGGGCGGCCGCGCTGCGGGGGTTACCTGGGCGCGCAACGGGCGCGCAGCAGC
GCTGGCGCGGCGCCCGCGGCGCCTGCGCTTTGGCGCCCCCTACCGGCGGCCCGCGGCCCGCACCCTCCCGCCGCTCCCC
TTCTGCGCGGCGGCTCCGGGGGCGCTCCCGAGGAAAGGAGGGACGCTGGGGGGTCTGCGGCCGCGCGGGGATCCGCGCA
GAGCCGTGCGCTGGGAAACGGGGTACACGTACACGAGAGGAAACGCGGGGCGTCCCTGGGCAGAGCCCTCGCTGGGCGA
AGAGGCCGTGCCCGGGGAAGTTGCGAGTCAATCGATGCGTGTCACTGCCTGCGCCTAACGCTGCCTCCCGGTGCACTGC
AATTTGGGCTGGAAATGATCGATTTTGACATTTTGGTTCATTATAATGCCACTTAAAGGGAGGCTCTTTTTAGTTACAG
TTAGCAAAGTTATGGTTGGGTTTTCCCCCTCTTCCCTCCTCCGTCCTCCCCCCCTCCCCCCCCCCCCCCCTCTGTTTTT
TGGGGTAAGAATTTGGTAGATAAAGGTTAATCTTGGGCTGAATTATAGAGCTGTGATTGACAAGAGAAAAGGTGTTGAG
GGCAGGTCGAGCTGTCTTATTTACAGCCCACTGCTTGCTATAGAGCCTTTGTTAGGACTGGAAAGCTAATTTAGTGCTG
ATCAAAAGCACCACGGAGTTAAAGGACTGGTAATGACTGCTAATTTCATTTCAGCCTCATACATCCCCAACCGCTGTAA
TTAAAGACGTGCTATTTAAATACAGGTGAAGAGTTTTTGTAGCAGGGGGAAAGTGGGCAGCCGGGTACCATTTTATTTC
TGCTTAATGTGGTCAGAGAGCACCGTGTGCCGCGGGGCGAGCGCTGCTTTGTGCGGCCCCGAGGGGACAGCCCCGACCC
GCCGGGTTATGTGGGTTTAATTCCTCCCATGCAGCGGCATCGGGAGCGCTGGGAGAGACGAGACGGAGGGTACGTGTCA
GCCGTTAAGTGCCTCAGCGGAAGCTCGGGTCCTCGTATTATGATTATTTTTAATTAAATTATTTTCCCACTCCACGGCC
GGCTCCGAAACGATGTAATTTCACAACTGATGTAACAGTTTCTTTCTGAGACACATCAAAGGATAAAAGCTCTGCGTTT
TCGTGGTTGGTTAAAATTGCTACCAAAAAAAAAAAAAAAAAGGAAAAAAAAAAAGAGAGAGAGGGAATTTAGCCTTTAA
TCTCTTTTATCTGCCGAGCCTGAAGATCCGCACTCGACCCCGCTCCTCTCCGGGCTCTCCCCCTCTTCCGGGGCCGCGC
CGGGCGGGAGGCGGCGCTGAGCGCGGGTTGCGGCGCCCCCTGTCGGCCGCGCCCGGAGCCGCCCGCGGGGACCTGGCGG
AGGAACCGCGGCTCGGCGGCGAGCGGGGCGCGGAGCGGAGCGGTGCTGGGTGTGAGCGTGGGGAGGTGGGGGGTGAGAG
AGAGCCCGGAAATCACGGGAAGGGAAAGCGCCTCCAGATCGAGCTCTGTGGCTGCACAGACATTAAACATAATGGCACC
GATGTATGTGTGAGCAGAGCTGCCTAAAGCCCCGTCCTTGGCGAAGCGTCCGCGTATGCCGCTGTCGCCCGGCCAATGT
GCCGCTGCGGGACCGCGCCGCGGTAGTGGGTGGCAGTGGGCAAATCCCTCGTCCCCCACTGCCGCTGCTGTCGGGACAC
TGCAGCCTTCCGGATGCTGTGGTTGTGATTTCCCCCCGAGGCGCTGGAGCTAAGTCGCACTGACAGGTGTTACTTGCGA
GCAGAGCTCGGCGGTTCCGTTTCATGTTTCATTAAGGCAAAATGTTCGCAAATGTCATATTTTAAGGCGAAGCGATGAA
GTCGTCTTCCTCCTCCCTTCCAAAAAAAAAAAAAAAAAAGAGAGCAAAATAACCCCCCCTCCCCCGATTCCTGGAAAAG
GAGAAGCGTTATCTTCAGTGAATGCGTGGAGTGGGGGGTTTCTTCCTCTCTGTTGACAGATTTAAAGGACAGCTGCGTG
TTACAAAACCATCAGCCAAAATATGCGAAGTGCCGCATTGTCACCAACTTTTACATGAATTCACCGCTTATTTTATAGG
CATCTGCACGGTGTTTGCGAGGTGCGGTGTTAACTGACCGCGATTTGTGCGTCCTGCGTGCGGGGCGGAACGCTAATGG
GAACCAAATGATTTCTGCTAAAGCGGGGTGATTTTGTATCTCCTGGTAGCAGCCTGTTTGAAAGCCGTAATGCCGCATT
TCTTCTATGAAATGATTCCCATGGCCGTGCGTCTCACAGTAAACTTTTCGCTTTCGACATTAAGTACGAATTGGTGTTT
TTAAGGATCATTGTTTGTCGCGCAGAGTATGCGCGCTCCGTTCTCTCGGTTTGATCTCCGCTTGAGACTCCCAATGTGT
CCCAAAATAAAGACATCGCATTTTCTATAAATAATAGCAAGAGCCCTGCGCAGATTTCTGCACAACGGAATTCCCAGAT
TTCCTTTACTGTTTCTTTCCTCGGTGCACGTTGGGTATATATAACTCTGAAATTAAGCAAAAATATACATCTGTATGAA
TCTGTCAAGCAGGCTATAAACAGAGATATTATATGTCAATTACCACAGGAAACGGAAAAAATACCGAGCGGTTGGTACA
CACGTTGTAACGTCAGGAAGCGCTTTGCAAAAAACGCAGTGACTCCTGCAGCAGTGTGAATGATTAACCCGGACCCGGA
GCGGGGCTGCTGGGGCTCCCCTGGAAACAGCAGTGCTGAGGGGGCTGTAAAGGGCTCGTAAAGTCTCCCCTCCGAGGGG
CAGAAGTTGGCGGATAGAGTGAGGCTGTAACCACAACAGGAGCGCTTCCCGGGCTCGCTCGGTGCCAGCTGCGGGTCGA
TCCTAAAGCCGGGAGGGAGCCGGGGGTGGCACGCACCTGGCAGCGGGGGGTGGGGGGCCGCTCCGTGCTTGTCCTCTTT
CGTCCCCACTTGGCGGTAAAGTGCGGTTTTACTTTACGTATGTCTTTTGGAAGTAGGCTTTATGGATGTCCACATTTCC
TCCAGCTCTCGAGGAGCAGAAGAGTGAAGGAAACAAACCCTAAAAGCAACCGGGATGCGGGGCAGATTTGCTCACTCTA
CCTTTCCTTTCTCCTCCCCATCCCCAGGCACGGCTGCTGCAAGCCCGTCTTGGGCAGAGGGGTGCTGGGAGCAGCCCCA
TTCCCCTGTGACATCACACCGCAACCCAACCCGGGGGTTCAGATTTTTCATGTGCCCTTAAGGTTCTCCTTGTCCCCAC
ACACAGGCCTAAGCCCTACGAGGGATGCCGGGGAGCAGCCGGGCTCCCTCCTGAAAAGGCTCTCTCGGGTCATCCTGGG
GCAGAGGACAGCAGATAGACACATGGGAAGCGCTGATGGTATTATTTATAGCACCATCTCTCTGCTCCGATTAAGCGCC
GTCTAAATATGAATTCACAATATAGACAGCTAGTCTATAATTTGAATTAAAACCCCCCCAACGAGCCCGTCACTTGAGA
ATTCTGAAATCACAAGCCTAAGTTGTCACAATGAGCCCATGGTGTCAATAAACCATGGACGAGATGGAGAGATTGTCAC
TCCAGACCATAACAGTTCTGAAAGTGTCATTACCGTCTGTCCTGTCAATGAGCTCCAAATTAAGGACTATGAGGAACAG
CGAGATAAAAGTCACCGTCTTGGCTCCATTATGGGCGATCGTGTCAGTGATCTGAGAGTCACTGGAAAGACATTGCTTT
TTTTCTTTCTTTCTTTTTCTTTATTATTTTTTTTAATGTACTTTTCAAACCGTGCCTCGGGATTCCAGGGTTTGAGGTG
CAACCTTGAAGCACCCCGGGCTGTGCCTCAGGCGTTCCCATTGAATCCGCGAGAGCTTCTTTGGGAAACGTCGCGAATT
CAATGCGGGAGTCGGAATAATTCCATCAAAACTGCTCCGGGGCCAAAGAGGACTTCATTTGATTTGGGCGACACGTGTG
ATCCCATGCACAGACGCGTTTCTACACCTTTTTTTTCTCTTCAGTCAATAGAAAGATGGTGAGGGGGAACGAGGGAAAT
AAAATAGAAACCTCAGCTTTGGCAAAAGACAATGGATTTCTGTGCGAGATGGCCCCTTCCAGGCATGAAAACTTTCAGA
AAAAGGTCCCAATCTCTCCTTCCTGCGCGCCTGAGAGAGCTGAGGGGACTTATTCAGAAACTGGAAACCTTCAGCTCTG
GATTTTTGTGCCTTTGTGGGTTTAGGCAAAGCAGTTAGCGTTCTTCAGGAGGGGTTTTGTGTTTAATATACATGAGTTC
ATTCAACTACAATGGGAAAAGAAAACTCATTTGTTCTTATAAAACTAGGAAGGAAAGATAACTTGAAATAGAGTGCCCA
GAAGGGCCGCGCTCAGGGGGTGCCGTGCCGGCCTGCGCCCGGCGGCCGTCTCACCCCATGGCACGCAGCAATTCCCGAC
CTCATCCTCACCGCTGCTGCTTGGTTTTCTGTTTTATTTTTAAGGTCACGTAAAATAATAATAATAACGGCTTCCATTC
TGCTCTGCTCCGGGATGGAGGGCTGGGGAGGGGTGTTCGAGATGCGGGGAAGAGTCACCCAGAGTCGGAGGGCTGTTTC
TGGAGCCCTGGGAGCAGAGCAGGTTTGGACACACGGCCTCTCCGCTCGCTGGAAGCCTTCTGAAAGCGGCTTGGAGCGC
TGGTGTGTGTGCGTGAGCCGGCTTTGCTGATGTTTATTGTGTACCTTCAACCCGTCCCATCATCTCAGCTTTATGAGTA
TATTTTTAAATTTCTCTTATGGCCCCACAGAAGAAAGGTGGGGCCGCTCCCTCTTATTTCCTTTTCGATTTTTTTTTTC
TTTAACGCTGTGTTGATGCCTTTTTTTTTTCCTTAACGCCGCTCAAAGTAGCAGCACAGCTGCTGGAGGCGGTGGTCGC
GGGGCGGGCGGTGCCCGAGGGGCGGCTCGGAGCGGACAGCCGGCAGGCACAGCCGGGCCCGGAGCGCGGCGCGGGGCGG
TTGCGGGGCCACGGGCCGCCCGCACGTGTGCTCGCCCGGCGGTTCCATTGGGAAGAAGGGGGATGAAAGGGGACGCCGG
GAGCAACGCGGAGCTCCCTCCGCATTCCCCGGCTTTCAAGGGTCCTTAGAGCCCTTGAATGAAATTATTGGGCGAAATT
GGGGCTGGACGCAGGTTTGCGCCTCACCCCCCTCGATCGTTTGTACGTGTAATGCCACTTCTGAGAGCGACAATCGGGC
TACTTGCTGGACAGGCAGGGACAAAAAGCAGATTAAACCGTTTTAAATAATAATAAAATATCCCAAACGCAAGCAGAGT
GGATTACACTTGCTCCAGCGCCTCGCTCCCCACCGCGTTCCCCCAGCGGCTGCCCTCGCCCTCCGGGCCGCGCCGAGAG
GGTGGCCCCGTGCCGGCGGGGTGCGGGGCCCGACGGGGTGCGGGCCGGCTCTGAGCACGGCCCCAACTTCTAAAGTTTG
GTGGAGCTTTTTTTCTTCTTCTTCTTTTTTGTCCCCCCTTTTAAGTGCCCCCAGGTTGTCGCTGCGTCTGTCCGTCACC
GTCGTGGAATTGTTTGCTGGAGAAAATGTGGCGTTTTCGTCATTTGGGGAGCGTGCAGGAGGCTGAAGGCCCCCCCTGC
CCTGCCCTTCCATGGGCCCGGACCCACTCGAAATGGTTTCAGTGAATTGCGGGGACCACTCGGGGTGTTTCTCCCCACC
CTCGATAGCTGAAGTCCCCCGGGATTGGGGCGTGGGGTCGTGTGAGGAACTTCCCGGGGAACTTCGGCTCTGCGGAGGG
AGAGGGGGGAGAGGAAATTTCTCTGTACGTTTTCGTCTTCGGCTTTTTTTTTTTTAACGTAATGAAATTAAAACTTTTG
GAGCTCAGAGTTGACATTTTGCGGAAAATTGAGTTATCAAGGCAGTAATTATTTCACAGGGAGATAAAACTCTCATAGC
CCTAACTGTCAAATAGGGCCCTTTTCAGATTTTAATTACAAAATAAAATTAGTCTGCTCTTCCTCGGAAGGGTTTGTGA
GTGGCTAAACAGAGCTTTCCCCAATACTGGTGGTCGTCAAACTCTGCTAATTAGCAATGCTGAGAAATTCCAGTTAACA
AGGACATTCTCTAAGTCTCTGCAGGTTCCCTGCCGTTCGCCTTCATTTCCATAAGAAGATTAAGAGTGGAGGGGAACAC
ACTCAAATGCAGATGCAGAAAAGAAGCGTTTTTAACAAGCATCATAATAGTAAGATGCTTGGCTAGTTCTCACCTAATT
ACTGCAAGTTAAACCTCTATTTGCAGCTAAGGACAAAAAATGGAGCTGCAATCTTCCATCTCCACAAGACCGCTTAATA
GTTTGCTTAGATTGGTTACTGGCAGGTTCGGAAAAATAATATGAAAATGCGTATATTCTTTCCGATACAGTTAACCCGA
TAGGCTGTATCCTCGGGGCTCAGAGAGAATCGGCGATTATTAGCACAATAAATACGCAAAATCCAAGTCGTTAACGTTC
ATTTTCTTTTAAAGAAACGCATAACCTGGAAATAAGAGTGCGTGTGCCGCAGAGCCCATCGCCGAGGACGTTTGCGGAC
TATTTGCTTAATGCGACCGCTTTGCATTTCCATAAATTACACCGAAGGGAGCGGGTTTATAAATCCGCTCGGACCGAAG
CATCCCCGCGCGGCTCCCCCAGCGCCGTGCGGCCGTGCGCGGAGCCGCGGGGTCCGGCCGTGTTCCTCCGCGCACCCAC
CGCCCCCAGCGCAGGAGGCGGCTCCTCGGGGAGCCGGACGGCCCTCACCTCGTTTTCTAGAGCGCGTTACGATGTAGAT
ACGCCAGATACAGTTGATTGCGTCGATAATTAAAGCAGTTAGTTCAAACGAAGCTGTAAATACCGCCCGATAACGCACT
CGCTGGGCAATTCCCACCCTTTATGGGTGCGATAAACGCGGTGAGGAAGGGGCCCGGCCCCGCGCAGAGCCGCGCTCCG
GTATCCGTTTGTTACAGCACCGCCGCCCACTCCTCCCCGCTTTTCAAACTTAATTATCCCCGAGATTGCATTATTATCA
TTATGATTTGGAATGTTGTTATCAACCGCGGGCCCCGGGCACGACCAATAAGAGAGCTTTCAGCGGCCGTGGGAGCGCG
GGGGCAGTCGGGTCGCGCAGAAATCGCGCATCACCGCGGTGTGCGCATCCCGCTACGCGCGCCCGTTTTCCGACGCTTT
CAACCCGTCACATCTCTCCAGGTTATATATACACCTTAGAATTACACGCGTTAAAGCCGATAGCGTTTATTTGCATAAT
CCAGAGATGCACCCTCGCCCGCCTCACTTTTTCTGCGCGTTACCCGGACGGGGGGGGGCACGGCCGCTCCCTTCCCCCC
GCCCCGGCTCCCGCCGCTCCGCACCGTGCCGGCAGGGGGCGCCGCAGTGCCGCGGCTGAGCCCTCGCGGGGCGCCCGGG
CGCTGCCCCGGCCCCAACCCGCCCCTGCGCGGGGCCGCGCTTCTCGGGGGGCCCTTCTCGGGGGGCCTCGGCGCTGCCG
GGGAGCGCGGCCGCGGGCAAAACAGCGCCGTCGGGGCGCGGCAGCGCGTAGAGCGGGGCCGGGAAGCGCCCCCCCCCCC
CGCCCCCCTTTCTCTCCCCTCCTTCCTTTGTCGTCAAGTGCGTTTTAGCAACAAAGATCCCAACAAGAGAGTGGAAGTA
AACTTAGCCGGGGCTTTGTGCGGCCCCGTGTAGCGACAACAAGAGAAACAAAACTACCTATTTGTTCCTGCGGGCCGCC
CCCCCGCCCGGCGCGCCCACCCAGCGTCGCACAGGGGGCGCGTCCCGGGGCTGCAGGCCGCGCACCGCGTTCTGCGGGG
AGGGCCGTCGGGGGACCTCCGCTCCCGCTTCCAGCGGGCACCTCCGGGTTGGAAGGAAGGAGAGAGAAGGGCACGGCCC
GGCCCCGTTCTGCGCGGGGCCCGCTCGGCTCCTTTCGGCGGGGCGGCCCCGGGTCAGGGGCTCCGCTCCCCGCGGACGG
GGCGAGCGCTGCGCACGCAGCCGGACGGCTCAGGGGACACTTCGCAACGGGGCGCGGGGTCGAGGGGAAGCCGTTCCCG
CTCCCCCTATGGCTTCTCCCGACATCAACTTAAAAAACAACAACAACAAAAAACCAACAACGTAGCAACAATGCTGTTT
ACCCACTTCCTCCAAAAGGCGTGTGTGACCTGTTGCTGGAAGGGGAGATACAAAGGCTTCCCAGTGGCTGCCTGGGCCG
GCCCTGGGCCCGCCCCCCCCGCCGCGCCGTCCCGGCGGCTGAGAGCCCCCGCCCCGTTTCATGCAAAACCAGGGGTAGA
GACTTGTCCTCAGTGGCGGAGCCGCCGAGCGCTGATTGGCCGGGGCGAACGCATTTATTCCCTGACAAGCCCCCATCAC
ATGGATGGTTGTCTATTAACTTGTTCAAAAAAGTATCAGGAGTTGTCAAGGCAGAGAGAGAGAGTGTGTGTGTTTGCAA
AAGGGGGTAAAGTAGTTTGCTGGCTCTTTAAGACCGAGGTGGAGAGAGAGAGAGAGAGGGAGAGAGAGAGGGCGGCAGG
CAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATTATT
AATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATACCCC
TCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCGCTTCTCCGCTCCGGGCTGGT
TCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGGG
AGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTTC
ATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGGC
TCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGATGAAGCCAAACGGCTCCGAGCTCTGCA
CATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTTG
CCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTGA
ACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCTA
CCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCAG
TACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACCC
CGGGCATGGCCCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTAGTCACCTCCTCGTC
TCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGAA
CCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACAC
TCCCTCTATCACATATGTAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAAACAAAACAAAA
CAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGAGAAAACGGGGCGGGGGGGGGGGAGGGGAGGGGGGCGGGGGGGCAGAAATAAAGCCGACAAAGGAACC
TGTATAGATCTCGGAGGGGAAGCGACTACACAAAACTTTTTAAAAGTTCTAGTGAGAACGGTGGGAACTTTGCAGGAAG
TTTGCAAAAGTCTTTACCGGTAATATTTAGAGCTAGACTCAAAGAGCGGAGAGGAGAACGTTTTAATATTTGCAGGCAA
CTTTTGTACAGTATTTATCAAACTCAACATGGCAATCAGAATGTCCATCGGTCATAGGGAGAGGGGACAAATCAAACCC
GAGAATTCGCGAGTGGTTTTTTACACACAGACTCTCCGTGGAGCACCGTGGCCGTGGCAGCTCCGCTGACGGCAGCTGC
GGGAGGAGAGGGAATTATTTTGCAGCATTTGGACGTTGAAATTGTTTTAGAAATTGTACAAAAGGCAAAAGCGGTAGGA
AGAAGACTGGCGAACCGTGGGCTTGGTTTGCTGGGCGAGGGCAAACGCTTCGATGTACGACGTTTTTATTTTATTTTAT
TTTATTTTACTTTATTTTATTTTATTTTATTTTTTACTTCTTGTTAAAAAGCAAAAAAAAATGCCATGAAGGTTCACAC
GCCGTTTGTTAATTTATAATAACTTTTTTGTTTCCAGACTTCATCCCATTCAGAGAAAAGGAAAAAAAAAAACAAAAAC
AAAAACAAAAAAACCCCAACCTGAAATTACTGTGTTTGAAAGATTTTCCTCTGGTTTGTAATATTTCTGTACATTTATT
GTGATGATATTTTAAGTTCTTTTTTTTTTTTTCCTCATTTTCCGTAGTTGTATTTTAAAGATTCGGCTCTGTATTATTT
GCAATCAGTCTGCCGACAGTCCATGTATATATTTGAACTAATACCATCCTTATAACAGGTACATATTCAAGTTAAGTTT
TTACTCCATTATGCACAGTTTGAGATAAATAAATTTTTGACATATGGACACTGAAGTTCCGTTTGAGTGTTGGATTTAT
TTTTGTACCGCAAGCTGGCTTTTTGGTTTTGGTTTTTTTATTTTTCAATAATTCATCAGAGGAAGGTATCCCCGCGGCC
GACAGACTGTTATAAATAATGCAGCCGTATACCGAGGCATGAATATTTTTATACGTATGGATAGAGAGGGACCCAGCGC
GATACGCTTTACCGGAACGACCGTCCTCGGGGCACGGCGGTGCGGAGCGGAGGCCCCGGTCCCGTCCGGTCCCGTCCCG
TGGGCCACTTGTTGCCGGGGCATCCGCGCTCCCTCCGCGCCCGGCGGTGCCGCTCGGAGCCGTGCGGGCCTTCGGGGCG
CGGCGCGGGGCTGCAGTGCGGCTGCGGGGCCCGAGCGCTGCCTTTGTTCCGCACTTGCCAAAGTTTCCGCTCCTCGCTC
CGGGGCAGCGCAGGAGGAGGTGAGAGGTGGGGGCGGGGGGGGCTCGGCCGGGCAAAGGTAAGGAACGAGAAAAGCGGCG
CAAACGAGCAGGACAAAACGAGACGGGCGGACGGCGGAGACTCGCACGCGAAATCACAGCTCTTTCTTGAATCCTATTT
CTTAAATTGCCAGCGCGGTGTAGCCCCAATTCGGACAATCTCTGCAGCCGGTCGCAAGCCCCAAAGAGAAGCGCTGGCG
CCCGCCAGATAGGAGGAGAGCTCCGCCGTCGGTGCCAGGTAGAGTTCCACTTCGTGCGCTCGGAACCGCCGCCGCCGAG
GGCCGCTCGTTGCTGGCCGGGCCCGGCCCGGCCCGGCGGGGGCGGCGGGAGGGGAACGGCGGCGCAGCCCCTCGGCCCC
CGGGCGGCCCCGCGTGGGTCCGCGCTGCCAACGCGCCTGCGGCCGCCTCGGGACTGCGCGTGGGGAGGTGCGGATAGGC
ACGGGAGGAATACGGCGCCCGAGGAAGTGGGGGGCTGTGATTGCGAAGCGGTCGCGTGTCCTGCTCGTGGCTGTTGTGC
TTGGAGGCACGGACGTGGCGGTTTGCTTAGGCACAGGCCGGGTACGAGTGTGGCTCAGCTTTTCTTTCTCGTGTTTCTG
GTCGGTCGCCGGATTGCGATTTAGCTCAGGGAGAGACAAAAAAAAAGCGGGCAGAAATGACAAAAGAAGAGTTAGTTGG
CTCGCTGTGGTTTGTGTCGTCGTGCTGTTCGCCAGGTTCGGCTCTGGCCTCCGTACTTGGGGCCGGGTGCCCGGAGAGC
TCCCGTTGCCGGGCTGTGGGCTGTGGGGTTCTGCTCACTGTGGTGCAGCTCAGCTCCCTTTGTCCCTTTTATTTCCGCG
CCGTCGCGGTGTTTGGGCACACGGCAATTACTGCACATTCCCAACCTATTCTGTTTCTTTTGCATTAATGCAACGAGTA
AAATATTTTTTTTTCTCAGAGCTGTGCGGCGTTTGTAATGCATCTGGGGATTATTCACGTGGCAGTGAGCGCTCAGCCC
CGCTCCGCTCACCTCGCTGAGAAAAGGGGACTGGGGAGAAAAGCCCAATCGATATCTCGATTCCATTTTTTTAGAGCGA
ATCTTAGCCAATTAACAGCAATAAAACCGGGCCCCTTTTTGAAGTGCTAACTGAAATAGTCGAGGGGGGTAGCTGGAAT
CGTTGGTGCTTTTACGATTCGCATAAAGAAGGCGAGGTAATACCATTAAACAAAGGCACTAAACCACATATTCAGGCTT
AGTGTTTTCAGCAACTTTTTATATGGGCAGTTTGTTTGAGCTTAGATTTCGGACTGTGATGTAAAATATATGTTGGTGA
AACCTGATCTCCCTTGGGCAGATTCCTCCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCA
TCCATTTATCCGTTTACTGAGGATAACCCAAAGCATTTTCTAGGTCCAGCTGAACGCTTTTATTTTTAAAGTGCGACTT
GGAAGAACGCCATTGTCCCTGCTAATTTTCAATGCAAAGCATTAAGTAACCCCATTCACACCTCAGCCATTATCCCGGG
CGTTTATTGCAGCTGAGATGGGGATAGCGGAGCCCGTGGCTGCGGTTTTATTCTGTTTTCGGAGCCCTTTCGGGTATCC
CCTCGGAACTGCTGCGCGTTCCATCCCAGGGCGATGCGCGGTCCATGAGCTTCGGTGTAACATTTCGCCAACGTTGTGC
AGAGCCGCAGTGAACCCGAGGATGAGATTAGAGTTTCCCCTGTGATTTTTGTACGGCTGTTTAAGGGCCGGGGTGTTAA
AATATTTTGCGGAACTGGAGAGGTAGATTAGCGGGGTTTCTTGCCAAAGCCGGGAAGCTGGTATTACAGCTCGTCCCAG
GGGGACATCGCTCACATTAACCACTAAATGAATATTTGACAAGGGCTCATTCGGGGGTATTATTACTACAAACGGGTCC
CTACTGGACTTTCCGAGGGTCAAAGAGCAATGGTTCAATTAATTATTTAGACTGTTAGGAGATGCGATTGTAATAGCGG
CGCTTATTTCTGCAACCGACGGTTCTCGAGGGGGGAAGCGGGGAGAGGCTCCGCTCGGCCCCGCGGCCGGCAGCGGCTT
CAGAGGGCACCTCGGGCCCCGGAGCGCGGGGCTGTGCCGGCCCGGGGAGGTGGCGGTGCCGGGAGACCCCCGCGGCGGC
CCGGGCCCTCTGGGTGAGCCCCTTCTGGGCCCCGACGTGCAGCAGAGCGAAGCGTGCGCTCCGCAGAGCGGGCGGGTAG
CTCCGCGATTGCAGCAGTATATAACGCGGGTCCAGCCGAGGGAAGGAGGCCCGTTGCTGATAGGTGTGATTAGATACAC
TTCAGTTATTTAAATCCCGATCTAACTCAAATATTAAAATCTAAAATGCGTGCGGGATTCCCGAACGGAGCGCTGAGCC
CCGGTCCGCGCCTTGGCCCCCGCCGGGTCCTGACACCGCGGTTCAGCCTTTGGGTCGGTGGGGGGGGTGGGGGGGGAGC
AGAAGGAGGGTTATTTTGTTTAATTTCTACAACAAACATGTCCGCAGTAGTAGATACTAAAAAAAAAAAAAATGTTGGG
AGTGTGCGATTAGGTGACAATAATATATGTTGAATGAATAAGAGATAAGCTGCAAGGGGGGAGAGGGAAGCAGTAATTA
CAAACCCAATTCATTCAGCTTTTCAGGACTTTTGTTGTGGGAGCTCCATTGACGGGCTTCGAGCTGCCAGTTTTCTCAC
ATTAAAAAGAACTGATCAGCGCCTCAGGGGGACAAGCAACACCGCTTAACTGCATAGTGATGGGGTCCTCATTTAGAGC
CATTACAACGAGAAAATTAAACAGAGCCTTTGTGTGCACCGGGTTTACTTTTCAATTGCTGACAGTTTATAGCTAACTG
CTCAGAGATTGAAGTTTGATTGCGGTTTGATCGCCCGCTAGTTAGCACCGCCGCTAGTTGGGTTTTGGTAATTAAAAGC
AGTTTTCTGACGCTCGCCCGGGGGATGCGAGAAGTTTGGTCCTGTTTTGCTTTTGAGGAATCGAGTTCACTTGGCGAGG
ATGTCCGGCGCTGAAGTGAGTGCGGAGGCTTTTTCGCTTACAAACTTGGGGGGGTGAAGAAGCGGGAGGGGGGAGGGGG
GAAGAAAAAGAAAGAAAAATAAGGAACACAGAAATGGAAATTCTCGGAGTTGTAAATGTGGCTGAGAACGCGGTGAGAA
GCGGAGAGGCGCGGAGCGGGCCGAGCTCGGAGCCCCGTTTGGGCGCAGGCCCCGCTCAGTGCCGCACTGCGGGGGGAGC
GGGGAAACGAACGGGGCCGGAGTGCGGGGCGGGGGGCACTGCGCTGCTGGGGGGAGTGTGGCTGAGCCGTGGGAGTGCG
CGCTGAGTGCGTGTCAGCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGCGCGTGCATGTGCGTATC
TGCCCGTGTGCGCCTGTGCGTGCAGGAGGAGGGGGCGTCCAAAAGAGCCGTGATTTTTCCTTCCCACTTGCAGAAGTTC
AGGAGGAGATGGGCTCGGCCGCACCGCACGGGGCGTTCCGCGCTGGGGGTCCCGCGCGCCCGTGGAGCGCCGTGGGCGC
AGCCGGGGCACAGCAGGGCCGTACCGGGGCAGTCCGTGCCCCAGTCGGGCTGCGGTTGCCGCCGTCCCGCGCCTCGCAG
GGCCGTAGCTCGGTGCACCAGCTCCTTTATAGCGCCTTTATATTTCTTCTGTTTTCTCGTCATTTCTTTTTCTTCTTCT
AAGCTTTTTATTTATTTTGTTTGCATCCCCTCCCCGGTCCGAACAGGAGGAAAAAAAAAAAAAAAAAAAGAGCCTCTCC
TTCCTTCCAAGTGCCCCTCGGCCTCGAGTAACCGAGCGGTTATTTCAAGGCTGTTGACTCCTTCAGGAGAGCCAGGGGA
TGGGGGGGCCGCCCCGTCGGGCGGAGCTCGGTGGGCCATAGCGGCGGTCCCCGGGGGGCTCTGGGGGCTGCGGAGCCGG
GCTGCGTCCCCACGGGTCCCCACAGCGCGTCCCTCCCCGCTGAGCAGAGGGGGGGCTCGGGGCAAGCCCGGCCCCCGCC
GCCCCCCCGCCCCGGGACCTCGGTGACCCCATCATCGCTCAGCGGTTAGGGCTGCTGACGTCACGAGGGCGCTTTTTGC
AGACAGACGTGATGAATGGTGTGTGTGTTGGGGGGGGGGGGGGAACCCCACCGGTCTGTGGAGAGGAGCGGGCCTCTGC
CCTACGCTGGGGGGGACCGGGCTGGGACCCCCCCAGATGGGGATGCTCGGGGCTGGGAATGAGCCCCCGGAACCAGGCG
GGAGAGGGCTGCAGCCCGTCCTCCAGGAGCGATGGGTCCTTTAAGCCCTTACAAATTGCCAAACTTGCGGAAGACAGAG
AAATAATTAATGTATTAAAACAAGCGGCGAATTCCTCAGGAGGCACCTTATCAACTCCAGCCACACTGCTTCATCCCTC
CTCGTATGCTAATGCTCCGTGACGTCACCGGCGCCAGATTGAATGGGAATCAGTTATGAAATTATTAGTTTTAGCTCAA
AAAGCAATCTGCCGCTCCGCGAGTGGGGCCGTCGCTCCGCGGCCTTCGCCCCCGTTCTCCCCACGTTACGCACACGCTG
CGCTCGAGGCTTTTCCCATCGCAGCGGTCCGTGGTCCCAAAGCACGCACCCGAGCGGGGTTTGGTGTAAAGAAACCGAT
AGGTTCGCGGGGTCCCGAGCGTGAGCCGGCAGCGCCTTATCGGTACCCGCGGTACACCCGACAGCAGGCAGTCGGATTT
CCTCCTGCTGGTCAGGTAGGAGAGAGCTCCTCGGGATTTATGGCCGCTCGGTCCCACGGAGGGGCTGCGCCAGGGTGTG
AGGAGCGGCAGCCAGGAGCGTGCATTGTGGTCGGAGAGAAGCAAAACGGGCCGCAAAGAGGGGAGAAATGTATATATTT
ATACCGTCGGTTTAAAATAAAAAGATTTCTTCTCTCGCGTTTGAAAAGGAGCGTAACCCAGCGGTGCAGGGCCACGAGA
GCCGAGCGGGGAACAATGGGAATTAACACCGTTCCAATCGCTGAGGCCACTCTAATTAGATGTCTGGATCCGGCGAGAT
CAAATGCCTGAATCTAAAACCCCGGGCTCGGTTTCTTTCGCTTGCAAATGCTTCTGAAAAACGATTTGGGAAGAAACAA
ACCCGACCGTTTCCCAGACCCCCCCCCCACCCCCCGCCCCGAAGAGTTCCGCCGGCCCCAACTTTGCCCCCCGCTGTCC
CCGGCCGCGCTGTGTCCCCCCGGGTGGCCGCGGTCCCCGAGCTGTGCCCCGCGGCGACACGGGGACGGGAATTGCCGGC
AGCGCTCCGGGACGCTTTGCTCTCTTGGGCCCTTTCTTCCCGTCTCCCGAGAGCTCCTCTGCCATGAATTATGGATCAG
CCCCGGGATCGGCCCCGCGCTCCCGGCCCGGGGCTCCGGGGGGCACCGAGGCGGCACTGCTGCGGCACTCCCCCCATCC
CCGTCCTCCTGCCGTCCCCTCAGCGCACGGGGACGGGAAGGAGAAAGGGAAAAAGTTGTGACTGGCTGAGTGAGGAGTG
AGCTTTCTGACTAATGAAATCCGAAATGAGTTGCGAATATCAAGTATTGTAAGATTTCTTCCCTGCCCCCCCGGCACTG
ATTGGCAATACTCTTCGTTTTTTTTTTCTTCTTTTTTTTTTTTCTTGTGTGTTGGTTTGAAAAGCAGGAAGAAATGTAA
TGAATTGAGTGCTGTCAGAGATGTCTTCTGTGTTGATGTGGTGAATGGCAGTAGCTCCCTGATCCAGTGCAGGTGCAGT
AGAGCTGGGGAATAAAAGAGGGGGGCTCTCTGTTCAGTGGAAAAAGCACATTCCCTACAATAGACCACACACTGCCAGC
CAGCACGGCATCAGCTCACACACAGACTTTTTTCGCCTCTTTCCACAGTCCCGAGCTCACAAAATGGCTATACATTAGC
CCTAGTTAGAGTTTGCTTTTAATGAACAGTTGTGACTCCTTTTGACCAACATTTAAATCTGCTGTGCTCGCTCTGAAGA
CAGGTCTGTTTTGATCACAGGTTTTACAGACTGGCCCGGTGCCTTCCAAGGCGGCTCAGACCGGGCCATCAGCCGCGTC
CGATTGCAACAAGAAAAGGAGAAAAAGAACAAAAGGCTCCCGATTAATAAATGCCTCCTCCGAGAGCTCCGAGCAGGGA
AAGGGTTTTTTGGTGTTTTTTTTTTTTTTTTAAATATATATAATAAAATGGCGTGGGGAGGAGGAGAGACACTGTTTTT
AAATGGATGAGATGGTCTAATCCTATACACGAACGCATATTAATCCTGTTTAGAGATAACCTGTCTCCTTTTTGGCTTA
ATGTATTATCCTTATACACGGATAGAAACTTTGCGGTCCTACTAATTCGGCGCAGATTGGTTTTTCTCGGCTTCTTTCC
GTCACTTTATCATGATTATTATTATCGGTTTTTTATTCCCGGCGATCTGTTCGGAGGAAGCCCGATGTTACACACTCGG
TTCCTCGACTTTTATTCCGAGTGACTCGCACGGTGAGGGCTGACCGCACAGCCCGGGGCCTCTGGCTGTACCCCCCCCT
TCCTTCCCCCCCCGTCCTACCGCGGCCCCGCACCGCGCCGACTCCTCAGGGCGGCCCGGAGCAGCCCCCGCGCCCGCTG
CTTCCTCGCACCCGTCCTGCAAGAAGCACGTTAAGCTCTTTTGGCTGTAGCTGCTGATGCATTGCGCCGGGGAAAATTG
CTCTGTGTTTGCTTCTAAAGAGCCACGTTAGTGTGAAAGTTCTTTTTTCCCCCCCTAATCGTGGTAACAAATAGCGTCA
GCTTCTGGAACGGTTTGGCAGAGGCACTCTTTGCCTGATCACCGCTAAACGGGAGAGGCTGACAGCGAACCTGACCCCC
CTCACACACGCTGTAACGCGACGTGGTCGCGGCAGATGACGGTGGAAATGAGGCAGATTCCGGTGGGTGCTGCAGCGCG
TTCGCAGGGGTCAGCTCTCGTCACCCCGAGCACAAAAGAGCGGATCTTGGCGAGGCGTAAGGGAAAAGATAATATTGAT
ACGAAAAGAAAAAAAAAACAAAACAAAACAACCAAAAAAATACGGACGGTTCTCACTTTGTTTTCGGGACGTTTCCAAC
GGGTCTCTGCCGCCGGAGCATCACCCGGCAGCGGAGGTGGGAGCCAACAAGTGGGAGCCCCCCCGGCAGCCGCCCCCGG
TCCCGCTGCGTTGCGCAGCGCCGCGCGGTGCCCTCCGGGCGGTGCCGTACCGGGGGCGGCCGCTCCCACCGCAGCCCCC
GCGCCGCTCACAGCCTTTGTGTCCCGGCGCTGCGCACACCCGTAATTAATCCTCCTGCTTACCGCTTACATCCCGGACC
CAAGGGGCAACTCAAACCTATTTAGATCGCCTTGGTTGGTTGCACAAATTTAAGTGGCAAATGAGTTATAAACCTAATA
ACCGCTTTAATAAAAATAATTATTTGATTATGGCGGAGTACGTTTGGCGGAGTGCAAGGATGGGTCTGGGTCCGCGTTT
GGGTGGCGCTGAGATTCGTCTTCGGGTTGAAATCTTTTAAAAACACCGTTCCAAATAGCGACAGTAGTAACAATAATAA
TAACAACAAACCTAACCCAACCCCAGAAGCCCTCAAAATGCCAATCCGAAACCCAACTTCGCACCGACCAAACGGCGCC
CGATCCGCCGAGCGCTGTGCAACGTTTTCTGCGATATTATGTAGGACGGATTTGTAAACACAAAACCAGTCCGAGGTTT
GGGTTGGTCTGAATTCGCTGCAAAGCGCCGACACGGGGGCCCGGCCCGCCGGCACCTCGCTCACTTCTCTCCCGTGGAG
GACGAAGTTTGCGCCTCTCGCAGTGTTTGTGCGCTCCGGTTTTACCAGCACAAGTGAGGATGCGACAAGCCCGCTCGCG
CTGTCCGCTCTATACTTTTAACGCTAGCATATTGTTTGATTACTAATTCGAGTTAATATGATCTTTATGGCAACATAAC
AGTGGATAATTGGCCCTTTTTCTGAACAACAATGTAAATCACAATCGCTTTATTATTTAATAACGTCAAACGCTTCGTT
GGATTGGCCCCGACAGAGAAGACCTTTTCTTTCTAGGCAGTGTTGTTGAGAAAGAACAATGCAGATCTAATTGTGGAGA
TTTCAGAAGTTGGCTCCTGTAAATGAACAGCTTAGATATGGAAGTTCCAGCAGATGTCTGCACTTTTCCCTGTGACAAA
CCTTGTAACCCCCCTTCCTCCCCCACTGCCCCGTCCTCCCCCCTCCCCGACTTATTGAAGATTTTTTGTTCTCACATCC
TAGCAACAACCTAAATCTTCCCGCAGCAATACCCCCTCTCCCCTGGTTGCTACCCAGCCCTCAGCTGGCAGCCTCCGAG
CTCCAAATTAGCGCCTGGCCCGAGGAGCGTTCGCTGCTCGCCCCGTGCTCCCCCCGGGCAGCTGCGGGCGTTTTTCGGC
TCGGCGGAGGGGAGGGGAGGGGGGCCCGGGGGGGTTTGGTGTCTCGTCACCCTCCTGCCAGCCCCGCGGACGTGCCCGG
GGCTGAGTTTGCAACAGTTTGGAGGTGGCTGCGAGTTGCGCAGGGAATACGGCGGGGCCTGTCCGGCCCGGGGGTGTAC
GATGGGACGGAGCCCCCGGAGCCCACCTGGGGGCTGCCCCCGCAGCTCTGCGGGGCCCATCAGCTTGGCCTGCCCCCAA
CACCGGCCCAAACTCTTCCGGCTGCACTCGCGGTGCCTCTTCTCCGGGGGAGGAGTCGGGGACCTCGCGGGACGGCTCC
GAGGGGAAGTTGCGCTGTTCCTTGCGCGGCTCTGCGCGTAGCCCCGATCCCCTCCGAACCCGCCGGGCTGCGCGCTTTG
GGCGCTGCGCGGAATTTTCCCTCGCGCTTGAGGCTGGGACGAGCCCTGCGCGGCAGAGCCCTCTCCCTACCGCCCCGCC
CGCTTCTCAGAGGGCAGTTCTGCTGGGAAGAGTGATCTGGAAAACTTTGGCCGAGGGGAGCTGGCAGCAGTGCCGAGCC
CCTGCCCCGTCCCGTTGCCCCCCCGGGCGCCGAACAATGCGCGCTTTGTCGCGCGCGGGGCACCATCAGAGAGAGATTA
GGGCGATGTGTGCCGGCCCTCCGCGCAAGCAGGGGTGTCAGGAGATGGGGCAGAGATACAAATACGGCAGGTTCTCTCT
CTCTCTCTCTCTCTCTCTCTCTCTCTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGACACGAAGAGGCCGGGAAAACAG
TGCCTCGATCCCCTTCTGCAGCGCCTCCGGTGCGTTCCCACCGCCGTGTCCGAAGCTCCCGTTTTCAGCCCCAGGAACG
CGGGCCCGCAGCCCCCCTGCCCTGCCCCGGGGCGGTTCGGGTTTGTTTGGTTACGAGAACCCACTCGAGGGAAGTGGTG
AAACAGATCGCTGAGATTCCCCGCAACGAATACGGTGAATCGGACTCACAATCCCTGCCTACAGCCGTGGGAAGGGACT
CCTCGGTGCCTATTGACCTTTGGAAGGGAAATCTTGATTTTTTTTTTATTTAGTTGTTTGTTTAGTTTTACCTTTCCCG
GCTTGTTGGTTTAGTTAGCAACTTTGTCATCACCTGACGCGGGCAGCAGCGCGCCCGCCGGGTGCTGCCATGGGAGCGG
GTGGGGGCCGCGGGGTCGGGGGGGGGGGGGTCTGCGGGGCTCTCCTGGATGGCAGCGGCGTGCCAGGGGTTAAAGGCTC
CCGCTGTGGGGCCGTGGGTGAAACTTCCCCGAATAACGGCAACGGGACGGAGCCGCCCCCGAGCCCCCGGGCTGCACTG
GGCCGGGTCGGGCCGGGCCGAGCCGGGCCGGGGGCGGGGAGGGCTTCTGCTGCCGCCACTCCTCCCCGTAATGAGCTCA
TTTCCATGTCTGCACCTCCCGCAACTGTGAGAAAATCCGCCGGACCAGGCAGCGTGCCGATGCGGCCGGGGCTGCCCCG
GTCTCCCCGGTGACAGCGGCCGCCCGGGAGAGCCGCGCCGGCGGGTGGGAACAAAATAAAGAAAATAAATAAAGAAAAA
GAAATGCCCCCCCTCCCCACTTCGGCCCTCCGCGGCTCCTCGCGGGGCGCTGCTTCCCGCAGGGAGGGGGGATGCGTGG
GAGGACGGGGACGCGGCCACGCGTGGCTTCCGTGGGGTGCGCCCCGAAAGCCGGAGCCCGGGGCGGGGGTACCGGGACG
GCGGGGAAGGGGGAAGGGAGCCCAGAGCCCCGCACTTATCAATAACAAGATGTATAAATATCAAAGTGAAGGAGCCCGA
GTAAGTCTTTCTAGAAGCGAGGAGGAAGCTTAAGCAGCTTTCTTTAATGGTGATTTGTAGCTCTGTAAGGGGCACGGAT
AGCAAATACCCTGCAGGTGCATGTTGTAACACTGCCATCCGGACTTTAATGTAGATTACTCTCCAACTCGTTTGATCGG
TCCTTTGAAACCCTTTACAATTGCCTGTGACGAACCGCCAGTCTCAGTTTTTTTTCTTTGAATAATGCCTTAAGGGTAA
GTCCTCGGGGCTTTTAAAGATCTCCAGCACATAGAAAAAAAATCACGTTAGATTTCACTTTAGAGCGTGGGTCCGCGTC
TCTCAACTCAGAGCTGTTAACAGGCATCTTTTAAATCATTAATCGTTTAATCACCACCAACTTTACTCGGGAAGGGCGA
TGCTCGCGGGGATCTTCTAAAGCCCTCCGCACATCTGCATCGCTGCGGCTTTGGGAGGCGGCCGCCCCGAGCTGCGGTC
CCCCCCCCCACCCCCCCCGCAAACGCGTGCCGGGGGCTGAGCCCGGGGAGAGAACTCGAAGGGAGGGCCGGGGGGGTCC
GCTCCGCTCCTTCCTCCCCCCCCCCCCGCTCCCAGCAAACAGCGGCCGGGGGTGGGGGGCAGAAGGGACGAATCGCAGA
GAGGGGACGCGCCGAATCCCGCAGACGTTTCAGCTCTCCCTGCACGTAGCGTTTAACCTTTCATATTTATTCGTTACTA
CGAATTAAAAAAAAAAAAATGATTACTGAACTTTTGGCCCTTCCGCTTCCACAAGCGGCGCTTTGTTTCTACAAAATAA
ACTCGGGAGAACCAATCCCTCCCGTATCAAACCGGGGCTCTGAATTAAAGGCCCATTTGGGACACTCGAGACTACAAAG
GGTTACACATAAATAAATGCCACATTTGCCTATTGCAAAAGTTTTCTCTGTCCTTTCTCAGTCGCAACAGGGGAGGAAA
AAGCCGTCGTTTATTATCTCGCGCCGGGCAGGAGCAGCCCCTCCAGAATGTGCTCCGGCAGAAGAGGCACTCTTTTTCC
CCCCCCTCAACAGCAGCTCCTTTTGTTCTCCAGATCTCTTTCCCAATTTCAAGCTTCACTTGCGGATCCGAAGTTTGTT
TGTTAATGACGCTATTACCATCTGGCTCGTCCTACTTTCCAAAAGATATAAATCTCCCCGGTTTCATTGCCCACATTAT
CATTTAAGTGCCACCATCGCTGGAAGAAAAATACGCTTTCAAGGCAGCGGGTTCTCCCGCACGCCCAGCGCCGGCCCCG
AACGCGCTTCCCCTCCCAGCGCCGCTCGGAGCGGGGCACCGCCGCGCCTTCGGTTCGCCACCGTCGGCTTAAGTGAAGC
TCTCCCCCCGATGTGGGGCTGCTGAGTGCATCTGGCTGCCGGGAACCGTTATCTGGGGCGGGACGGGTCCTGCCCCGGG
CCGCCCCCGCCCCGCACCGGCTCACGTCCCGTACAGACGCGGGGAAACCTTTCCCACCGGCGCCGCGCAGTGATGGGGA
GAAAAGTTTGGGCTCCTCCCGGAGCGTAGCGGTCGCGGATTCGTGTGCGCTTGGGCATAAAGGGCCGGGGGGAGGGCGA
GAGGGGATGGGGGAGGGAGCCGGATCGGTTTGTGGATGGGCTCCACAATGACTCTATTTATTCGCTGCGACCAGCCCGG
GCAGGCTGAATAGGCGAGAGAGGCACCCGGCCTTCCCAGCGCGTGGGCCCGGGGCGACCGACTCCCCGCGTTCCCATGA
CGGGGGTCTGCGGGACGGCCGCGCCCGCACTGCCCGAACGGCCCGCACGGCCCCGGCCCCTCTGCTCAGTGCATTCAAT
CCTTCAGTCGATCTCCATCGCTTCTTTGCTGGGTGTCCGGCAGCGCTTTGGCGAGGTTTTATTGAAATACAGCCGTACA
CACACGCCCTTAATATTGCCAAGTGAGGGAAAAGGTACTCCTCTAATACATGAAGGAAAGAAACGTGGGGATTTTTTTT
TTCCCCGAGGGATCTAATTGTTGTAAACAATTACGGATGAAAAGAAAACTCACTGCTGATGCACTTGCAGAGCTGTGAG
TGCCTGGGAGAGGACGGGGCCGAGGCAGGGACTCACAGCGCGCATCGCATCGCATCGCATCGTGTCGTGTTGGGCCCTT
CGCCGCCGCCACGCAGCCACGGCCCCGCACAGCCGAGTGCAGCTGGGAGGGATCTTGTTTATAAATTTATATGACGACC
TTTCCTTTGTGTCTGCTCTAAAGTTGATATGGACAAATTGCAGAGGTATACAATTTAAGTAGATGCACTTTTAATCACC
GATCATTAAAATGGTTATGTTAAATATACTCAATTACATGCATGACTTCACCCTAACAGTACTTTCTATTCTCCCAGCT
GCTCACGTATTCCTTAACTATAGTCAGCAGAAGAAACTCGATTATGCTGAATCCATACATTTCTATGGATTTCATCAGC
CTAATTAATGCTTCAGTGTGGTCCATGTGTCTGAATGGTCCCTTTGCTATTACTTGGGTAAGGAGACAGTGCAGGAATG
CAGAGGGGCTTTCTTTCAAAGGTACCCATGGGGGTCACTCTAGGACTCTAATGGCAAAGGTAGCAAGTGTTAAATGGCA
GAAACATGCAGAGAAAGGGAAGGCGACGATGTAAAAAGGACACATCGATACTGTAGGTATGCCCAACAGGTCAGTGATG
ATAATTAAAGTGCTTAAAGAAGAAAAGGTAAACGTAGGGTCTCCAAGACACGCAACGTGCCTGTTTGAAAGCAAACACA
TCAGCCCACATGGACACACCGTGATGGTCCTAGTGGGAAGAAAAAGTTGGCAGCAGATTTTTTGCTTAAATAACCACCA
GGGCAGTGTCTCCTGCCAGCACCAGGTTGGAGTGCCCTGGCTGTTCTCTCATTTTCTTGTTGTTGAAATGCAACGTGTC
CTGGAGATGCCTGTGCAGCCGGGAAGAGCTGGGTGTTCTCTCATGGCTGCATTGTGTGCAGTTGTGGTCCTGGCAGCGT
TTGGGGATGTTCCTGCAGCCTCTGAGGTTGGTGTGCTCAGGCAGTGCAGGTGCACACGGAGATGGTAGAAGTACCTCTC
CTCTCTCCCACCCTTCCTCAGCTTTCTTCCAGAATGAAGAAGCAATTCAAGTAAATGGAATGCACTGCAGCTTTAGCAC
AAGCAGCCAATGGCTGCTTTAATAACACATCTTCCTATCTCAGCATTTAGTTGCATCTCAAAAGCAAGTGCTGTCTGCT
CTTCAAGCAACCTGTTAATGAATGTGAAATTCATCAGGATGGATTTACATTGTGTTCCCACCTGTTGTGCCAGGAAACC
ATCAGATCAGCCCTTTCTCTGGCTGCTGGGAGCCATGATGGAAATGAGAGACCTTTCTTTCACCCACTGCCACGCCAAG
GAGCCCGCACCTCTCCCCTGTTCCCCATTTGTGCACCGTGGCTCAGTTGTCCTCACTAGTGTCCACGCCTCTCTGCAGC
CTTCATCCTTCAAGTGGAGAGAGAGAGAGCAGGAGAGATTTCAGATCCATAACCAAATTATAACCTAGGAACTTTGTGC
TTGTCATGCTAATTTAATGACTTTTATAGTAAGTGTAGACTTTCTGTCTTTTGAAATTAGCACTTCAAAATGCTTTGTG
TAATGACAGACACTAGACATAAGAGACAAATGCACAAGCAATAGTGGGATAATAATCTGGCAAACACTGTGCCATTTAA
TATGAAGATGGAGAAGGAAGTGAAGCACGTCTCAGCGGAGATGTTTGTCACTGCCCGGGGCTGTTGGTCCTCGTCTGTG
CTTCGGACTGACCCAAAATGAGGAGGTACTGAGCGTGATATGGCATTTCAGTGTGATGACCCTTTGCCTTCTGGTGGTA
CATACACGTGTTTGAGGGCTGTGAGCAGTCTGGTTTGACTGGGCTGTGCCTGGGCCCAGCCCCTTTGCTCGGATCCCAG
TGGGGCTGTATGTGTGGTGCTCACATGTGTGGCCCTGAATGTACGGATCACCTCCATTCTTCAGAGCACTTCGGTGCTC
CCATGTTGTGAGCGGTCCACAAAGCTGCCCAAGAGCTGGTCTTGATAACAAAGGGAGGGATAAACCCCAAGCTATAGGT
GTACTGCAGTCTGGGTAACTCTCTCATTGCCTATAATTGTAAATAAAGGAAGTTCACACGACGATCGAGTGACGGGGGA
ACAAGAGGCCCATTTTAATCAGGTGGTTATCTCTCCTTGGTGGAGATCAGAGCTCCATCGCTCCTGGCCTTCTCATTGT
GTCCCCCCTGCTGGAAATGACAGCTCCTTCAGAAATAAGCAACTTGGTCCCTGGATGGGATTTCAGCTCCTTTGCACTA
CACATGTACCAATTGTGATCTTACAGCTACAGCGAAACCTCTAAATTATATACGTGTATAAACTCGGCCTCATTAAATC
CCTCCGTTTGGATAGCCTCAAGGTTGGAGAGTATATTACTGTAAGCCAGAGAAGACTTAAATTATATCTAAATGGGGAT
TGAAATGTAGTGGTACTTAAGCACACTTCTTGTCTCAGCTACAGAGGTTTCATTTTTTCCCTTTAGAGTGTTATAATAT
TACAAACGCAACAGTTTCCTATGTCAAATCAAAGGATCTGAAATCCCGTTTCTTGATTCAGCCTGCAGGTCCCTTTGTG
GTGGGGACAAAAACACAAAGATACGATCAAACACTGCTGTCTGACCAAAGAGAACTTATCGCTCATCTGAGAGAGCTTC
CTAATTTGAAGCTAAAGCCTTCCCCTTCCCGAGTGCATGTGAGCTGTGTGCTGCCTGTGTTGTTGTCTCGCGTGTGTGC
GCAGCTAAACAGGGCTGTGCAGCACGGGATGGGGATTGAGAGCAGGGTTACCTCCCAGCTCCACATCCCCTGCCCGCAG
GTTGGTCCGTCCCATCAAAAAAAGGAAAGGTTTTAGTGGAATATCTCTGCGTGTGCGGCTGCCCTGTTTCTGCTGAGCC
TGTTTACAGTGGGTGCCTGGGGCACGGCGGGGGCTGAGGGGGCTCTGCCGACTGTCCCCTGCAGGTCAGCTCCGTGGTC
CCTCTGCCCGGCACTGCCCTCTCTGCCCGGCACTGCCCTCTCTGCCCGGTGACACTGATTTCCCCGCACAGCTCCAAAT
CCATCTCTCCGAAGTTGGGGTTGCTGGGAGGGGCTTGACCAACCCCCCCGCTCCCCCCAGTCCCTTTCCAGCGCTGGCA
GGAGGGTCAGTGGTTTAACCAGGCGTCACCAGGACTTCGTTTTATCCCCGGCCCACTGGAGCGTGTGGCTTTTAGTGAC
TGATGGTCACAGTTGCTCTCACGGTGCGTGCTCCAGATGGGCACGTCCTGGAGGCCGGGGGGGGGTGGGGGGCGGGCGG
AGGGAAGCTTGTGGGGGGGAGGACGACACGGGCGCTTCGGAGAGGCCACGATGACACCGGGATTTGTTCTGGGTCACCC
CCCCACCATAACGACAAAGTTGAGAAACTTCTACAGCAGTGCAGGAGCGAGTGCGTGTGTGGGGGGGAGGGGGGGGGAG
TGTTGGCGGAGCTGGGGTCGATGTGCCCCCCCCTCGCTTCGCCCTGCGCGTCATCCCCGCGCACAGCCAGCACGTTCCC
AAACTTTGAAATGCCAAATCACGTTATTGCTGCGGCGGGAGGCTGCTTTCGGATCTGTGACAGCTGAGTTTTTCCTATC
GATTATGTGACACTGCCGTTCATTTACACAGCTCAAAAGCTTAAAGCCACGGGAGGAGCCCCCAGTTGAACCCGAAATC
CTAACAGAAAGCGAATCAACTTTCTGGCCGCTGTTTCAACTGATAGATCAGAACTTAATTCGGAGAGACAGAAAGGGAG
AGAAACGACAGCACAGATTTATCTTGCCCGGCGTCTTCCGCTGAAACTTTAGAAACTGCGGCGTTGCAAACCCGGGGCC
GAGATGCTAATGAGCGGCAGCGCGTTGTGTCCCCGCTCGTCATTTATTGCCGAGAGCGGATCGCGGCGCTCGGGGACCC
GCGCGGGTGCGCGGGCGGAGCAGCGGCGCTGCCGGACCGGGGCCGCTCCGAGCTCATCCCGGCGTCTTTCGGGGAATGG
GGGACACTTTGCTCCCCCCCCCCCCCCGCCCCTTCCTTGCGATCCCTCCGTGCTGGGTCTGCTGGGGGCTGTCCAAGCG
GCGGCCCATCTCTGGGTTCTGCCGCTCCCTCCCCACCCCCCGTCTTCGCCGAGGTTTCATTACTTGCTGTTAGTGCCTG
GAAACAATAAAGGATGTCGGACTGGGCTTTTATTGATTATTTGTCACCCTGTATTTGTCAGTTTCAATAACTTTTCCTG
AAGTTTTACTTACGGGCACTTGAGCTTTCGGATTAGGCCAGCTCTGCGGATTGCAGCGAGGGGTAATTATCCGCCGGGC
TGCTTCGCCGCGGCCGGGGGGCGACGAACAGCAGCACGCTGAGCGGGCAGGATGCGGCCGGAGCCCCCCAGAGCGCTGC
GGGGCCGAGAGCCGCCCCCGCCGCCCCCCGCCCGCGGCCACCGCTCGCTGCCCGCTTTGAGGCCTCCGATTGAAGCCCG
GAGCCGGGGCTCGGTGCTGCGGGACGGGATGGGATGGGAGAGGGAGAAGGCTGAGCCTCCCCTCTGGCCGTCTTCCTCC
CCTAATAACTTTCCTACCCAAGCGATGCGCGCTGCTCCATACGTGCTCCAGCTCCGCTCATTTGTACACACGGAAGGCG
AGCTCGCATAATCGCTGCCGGGCTGGCAGGGTGCCTATCGCGTACAGTGCCGTGTTTGATGTGCTGTATCTCATAGCAC
GGCGAGCTCGGAGACAAGTGAACACAGAGTGCCCAGTTACACAGGATTTAATTACAGCGAAATGCATTCTCCATGCTGA
TTAGGAGAAAAATCAATCGGGGGCTTATTTGCCACAATGAACCAATAATAATAATAAAAAAACACCACCACCAACAAAA
AAACAAAAACAATTTATTAGAGCAATAATCTCAGTCCCAAATGGTCTAAATATTATTGTTTCTATTGCACTGAGGAAAT
TCATACTGAAAGTGTTACACAGGGAGCATCAGGGAGTCCTTTCCCAGAAATCCAGCAAGTTTCTAACTGATTTCCAGGG
GCCTGACGCTGGCTTAGAAACCCTGGGAACAGGGGTTGGGTCCCCCATTTCAGGTGCAAGTGTTGGCTTGCTGCATCAC
CTACAGGACGAGATGCTCTGTGGTCTGCAGCTGTCTGTGCCAAACCTAGCATGAGCTTCCCACCAGGGCTTGCAGATTT
CCTGCTTTCTAGTGATTTATACATGGAATTCCTAGAAGAGAGGAGGCCACACAAAAGATCCCCGAGCCACAGGCTGAGA
TAAATGCCTTGCTGTAACACAGCTAGCAAAACACCCCAAGATGTGCCAAAACCTTCCAGCTGGGACTGGGTGGGGAAGT
GACCCCTTGGAGGGTGCTGAGCTCTGAGGCCAGGCTGGGACATGGGGGGACAACGGGGGCAGCTGTGCCCTCATTTCTC
CTCTCCCACGCGGAGTTGCTCCCCGGTCTCAGCTGGACCTAAAGCTCCCGGGGGACTCCTGGAGAGACAGGGGGTGTAC
AGGGGGTGCAGGTGGGCCAGGAACCGTGGGGTCCTGGGAGCTGGAAGGCTGTGACTCAGGAGGTCCTGGTTTTGCTTTC
CAGCTTTCTGTAACTCCAGTCATCTCCGTCCCAAACCGGAGGGGACCTCATTTCCTGCTCAGCACTCTGCCAACCACAA
GGTCTTTTAATAAGGCTGCCAGGGGTGCCTGGCTGCGGGAAGGACAGTCAGTGTTTGTCACCAGGGAGTGAGCTGGCAT
CATAGCTCTAATCTGAGTCAACAACCTGGCGAGCCCTGAGCATGACTTCATAAATCATGCTATCTAATTGAAAAGCACA
TGCTTGTATGTACAGGGCTGTTGAAAAAGAGTGCAAAAAATAAAATGTAACAGACACTTCTGTTCTTCCCACTGGCCTA
TTAATCAGTCACCTGATTGTTTCAACTTAGATTATTTCATGCGGAAAAAAAAAGGGGAAAACATAAAACCACCTTGTTT
AGCCACAATAAAAGCACAAATGAAAAAATTCATCTCTTAAGGAGAGGCTTAGCCTTTTTCTAATAATAGGAAAACAATC
TCTAAGTGTTTTTAATTGAAGTTGTTTTCACGGTTAATTCTAAACTGCTGAATAATATTACCACATGTCTATGTATCCA
TTTGGCACTGAGGCATATGATGTTTCAGGGCAATTTAACCAGTTCTGGGTGGAGGAAAAGTCCTTTGCAGTTTCCGTAT
TCACTTGTTTAAAATGTTGGTTGGTGCATACATGCTGGCCTTCCTTGTTCCCTTCCTTCTAGTGGAAATGAAAAATGAA
TCTGTGACGAAATAGCAGATCTGTGCGGTTTGCTTCTCACACACAAACCTGCATTATTTTCCACCCACAGGAGCTGAGG
GATCGTGTTGTGCCAGAGCCACCTCTGCAGCCCCCTCGGCCACCTCAGCCCTGGGCAGAGGCTGAGCACATCTGAATAT
TTCTATTCAACTCTGCAAACAGACGGAGATACTCCAAGGTTGTGCGTGAGTCCAGATGACGTGAAACTTTCAACCCCTA
AACCCCTGTTCAGCTGTAGTCCAGAAGCAGGCAGCCCATAGCGGCCTGGGGACGCTGATGGAAGGTTGGCCATCGGAAG
CCCTAAGCAGGTTTTTCCCCACTAACACCGCATGCTGGTCTGTGCTCCCTTTCATAAGGTGCTCTTTAAGTATAGGAAC
ACCCAAAAAATTTGCATAAAAGCTTCATCTATTCTACAAGATTGCTTGTAAATTAAGCAGCAGTTTTCCCCTATTGTAT
TAGGAAGAGAGTGCACTTTGTTTTCTTGTTTACTCAGTGCAATTCCTGACCCCTTGGTGCATTTCTGTCAGCATCATGG
GACCTTGCTTACCTGGGACATGTCATAAGTGTGAAATGGGTCATGTTCAAAGTACCTGAAAAAAACAACAGTAATGGTG
TCTGACAACTTTTCTTTTTCTTTTCTTTTTTTTTTTTTTTGGCTCTTGTTAAATAATATTTCATGGTGCATTAAGTGGG
TTACGCAGCCTCTTCTGAAGAGACCACAGCAGCATATTGCTGCATGCTCAGTGCTGTCGTCAGGCTGTTAGTTCTTAAC
TGGAGAAAAGCTGAAGGCAGCTGGAATCCCTTCCTGAGCCTTTCCTCAGTTCGTTCTGAATTCGATAAAAAATGGCAAT
AATTTGGAGACAGATATAGAAAGAAGAAATAAAAGTGATTTCACAGTAAGCCCCTTGGCTTGCCACTCGTGACCACAGG
CAGATATTAGAAGTGCTAAATCCATTAAATGTTGCTTTTCCAGAAGCCGAAATGTTTTCAGCCAAACCGCTCTCTTGCC
GGCAGCTTCGGATGCTGTAGCGGGAACCAGAGCAGCCCAAGGAGAGAAGCAAACAATTAAAACATTTACATGTTTGCTT
CCTGATAGACATCTCTACAAGGTAGGTTTTAACGTTTTTGTTTTTTTTTTTTTCCCTCTTAATTTTTTTTTTTTCCTGT
GGTAAGAAGGATAAGCTTGGAGTGCCCAGTCACCGTGGTAACTGCCAGAAAAATTCTCCTGAAGTTTGAAGGGGTCAGC
GCGCGGGGTCAACAACTCTGGCCTCTCCCCGCGCCGGGGCTGCAGGCTCCGTCCCGTGGCCGGGCCTTAGCGCGGGCTC
AGCCCTGGGAGGTGGGCCGCTCCCGCTCTGATATAAATTTTTTGAGTCAGTTCACGGCCTGGGCTCTCCAGGTGGCCTC
CAAAATCGATCGTGACCTCATGACCCTGTCTAACGGAGGCATAGCATCCAACCTAAGTAAGGATTTAGGCAGGAGCGAC
AGCTTTCCGCTGAGTGTTATTGGGGACAGTGCAAACAGTTTTGGAAGCGAGGAGGTAGGTATGAGGAGCTGAGGTCATT
AAAGGCATATTAAAAAACAATTTTAAACAACCTCGTTAGTGGAAAGTTTGTATTAGCATTAACCATTCCTCAAGTAAAC
TGTTCTGTCAAGGACCCTTTTTCTCTCCCTAACAATATCAAATCGAGCATGAATGCAGGAAAAAATTAGCACTTCATAT
ATTCCAAACCAAACTCATATTTTGATTTTTAACTTATAAACCAAAGTGGCTGACATGTGGTGAGACGGGCTCCCAGGAA
GCACGCTTTTGCTTTAATGTCCTAAAACCCAGGAGATGGCTTATTAAAGCAATATGGTTATTTTAGGGAGGAATATCTC
TGATGTATGTATTCTTTTTAGATTCCTGGAGCTCTTAAGTGGGGTAAATTTATTTTTAAACTGGGAAATTAAGTCACAC
TCAGAATGGAATGAAAGTAGGAGAGTTTCGCAGGCTTCCTTTGCTGATCTGTAATTCAAATGGACAAGCTTTGGGTATG
CATGTTTTTGCAGAAGAAAATTTTCATCTCGCTAAAAGAGAATAGAGAAAATTACAGTTTTCCTGTGAGATTTTAAACA
ACAAACCATTGGGGTGGGGACAAGGGTAGGCTGCTGCAGAGGTCTGATTTTGTTAAAACAAATCTATAAACTTGTCCTC
TGAGCAAGAGGATTTGCTGTCCTGTTTGATTACCATCCCTGCAAGCCCCCAGCTCTGCACACCGTGCCCACAATCACAG
TCACCAGGTGAGTAAGTGGAACTGCACGGAGGAGCAAAGTCCAGTCTCCAAGGAGGAAAATGCTCTCAAACTCTGAGTG
ACTTTAAAACTGCTCTGAAGGAAGAAAATTGCGTTAATGTTTGTTCCCAGTCTTGGAAAAATTACACAAACTTATCCCA
GTGGGAATCCTGCCCAAAGGCTTCTTTCGCTCCCTGTGCTAAACGGCATTGCCCTGCCAGGCAGTGCCATCCGCTGCAA
CAGTGGGAGCCTCTCGCTTGGACTGGAGCAGAGCCTGGCTCTGCAGAAAGCCCAGAACCCAGGGCCGCCTGTTGGCCGA
GGTTCTGCCTCTTAGGGCTGCCATAATCTGCCCATGGGGGTTATCTGAAGAGCAGGAAATGAATTGGTACTAATAAGAG
GGGCAGAACTGTGCCCTAAATAATGTGAGGCCCAGACCTGCACGTGCAGTATCAGTGACAACACTCACTCTAATTCCAT
CCTCACTACTGCCCATAGTTTGTTGCTGTTGGTTTTTGGTAGAACTGTACTAAAACCAATTTATTTGCATTAGCAAGCG
TGTTGGTTCAGGGAAGTGCCCTCTATGACTAAGCTTGGCAAGGCAGAGCTCACAGTCCTTGATGAGGATCAGCATCAGC
GTATTTGCTTGGTTTTCAGAAAAAGCATTTAAAAATAGGAATTGCGAGCAGCTGCAAGGTGAATCCTCAGTGGTTTCAA
AAGCAACTGCAGAATATTTAGCAGCTTTCTTTCTCTCTCTCTCTCTCTCTTTTTTTTTTTTTTTTTTAATATTCATATC
TCCTTTGTAAAGTAAGCATACAGTGTCCCAGTTCCACCTGACAAGCAGGGTGGATGATCCAACCATCTAAAGCAGAGGA
TCCAACCATTGCACTGGAACTTTGGACAAAATTACCCCAAACTTTCTCAAAAGACTTGGGAGGAGGAATCATTAACAGA
GGCAGTGACGGGGGGGTCTCAGGATCTTTTACTTGCTGCAAATTCTTTTGAGTTGAACATTGTAGATCCTGTCCACTTT
ATAATCAACCGCAGGTCTACAAATGCCCCCTGATACAGGCCCCTGGGTTTGCATCTTTTGTAACTCTTTGCCTTTTTTT
TTAATTGTTCATCTCATACAGCTGGGATGTGGTGTGTGTTGGCAGTTGCTACAGTGGGTCTGCTCATCTTCCTTGGCCC
CTCCAGATCTGGGAAGTTCTCACTCCCAATCATTTGATTCCATGAAATACCTTCTGAAGTGCAGGCTGCTTTCATTTGA
ACGGAACGATATACATGAATGGGCTTAACACAGCGTTAGAGACGAGCAGTCGGAATCAGCAAGGGCTCTGGGCTGGTGG
TTCCCAGCCTCTATCATATGGATCACTGCTAATCCATGGGGCCTTGGTGAGTTTGCTGCAGGTGGTCTGTGGAACTGTA
TTAAATAATAACGCTCATGGTCTTCAATTAAAATTTTGATGAGAAGAGTGTGTGGCAGCCCGCACTCAAGTCTGAGAGC
TGAGAGTGATCTGCCGGCCTGAAAGGTCTGAGGATGTCTGCTTCGCAGGACTGTGTCTCAGCCTGTGGTCCACCAGGCA
GCAGAAAATATTTTCAGATTAATTACATGTGCAGCAAATGAGCACGCTTTCTCACTCAGGCAAGCAAGCAAGCAAAAGA
AAAACAAAACAACAACCAAAAAAAGCACTTCAAAACAAAATGAAGAAAATAAAAGCTACAAATTAACACTGAAGCCCGA
GCCTAGCTGGTGTTTGTTCCCACTCAGCACCACATTTCCAGTGGTGCTGAGTGGGAAGCACTGCTCAGCCCAGAGCAGG
GCTGGAGAAGCTCTGCACTCACCGGAGGAAGCAGTGAAGGCAAGTGGGCAGCCGGGCTGACAGGTGTGCTGCCAGGAGG
TGCCAAACAAATGCTGTACTTCCTTCTCCTTTTCTTCGCCTCTCCTCTCTGCTTTAAGTGTGTGCATGGCTGGCGTGCA
GAGGAAAAGTCAAACTAATTCTGATGCTTTTCCCTATTCTAGGCAGACTAAGTCAGAGAAAGCACTTAGGGCAGCCTTT
GCAGAAGGGTTACAATGTAGGTTGATACTTTAGGAGCTATAGGAAGTTCTTAATCCTTCACTGCCTACGGGACTGTCAT
TTATAGACCTGCTATTGTCTCATCTTTTATAAGGATGTTTCCTTACATTAAGGCTCCAAAAGCAACCAGACTTGGCCAT
TGTTCGCAGCTTTCAGCTTGTGGCTTAATGCACATCTAATATTTTGCTTCTGCTTTCACTACTCTCCTACACAGCAGAC
TGTACCTACACACTGGTTTAGGTGACATCATTCTGAAAATATTCATTCCAGCGTTTCATTTCTTTCTTTTTTTTTTCCT
CCTGATTTGTCTGCACATCTTAATTTTGCATTAGCCTCATTTATTACAGGTAACGTGGTAAAGCATGAGGAACTTCATG
TGATTTGCTTCTCATTTCATGTTTAGTTCTCAGTTGAAGAATAGCCACACAAACACACGTCCTTCTTACAACAAAAACT
TGTAAGTGCTAAATTTCCACCAGGTCAAATGCTTTATTTATAATCCAAATTTAAGTATTTCTTACCATATAATGGGAAT
GAAGTTGGACATGAGCAAACAAAATGGAAATGCAGATTATTTTGGCTTTGTACAAGTTTGCCTGAGATTAGCTGAAATA
AAGCAGGTGATCTGGTGACAGGATGATGTTCTGCCTTCCTGCTCTGCCTTGTGTGTGTTACAGACCTTCTTTGGAGCTC
AGAACTGTGTCTATAAAATAATAATAATTTCACAAAGTACTTTTTTATGCCTGAAAGTTTTGCTGTCTGCAGTCACTGG
TGGGCAGAGCACACAGGAACGTGTGATGCGCTCCTTCCTGATCCCGAGTTGCGCCCTGCTTAGCAGTTCCTCTTGCTGT
TTAGTTGCTCGTGTAGTTTCCAGTTATGTAACCCATCTCATTTTGTGAATATGTGAATTTAACAGCTGTCATTGTCAGC
AGTGCTGGTGTGGTTTCTTTTTTTTTGTTTCTTTTTTTTTTTTTTTTTTTTTGGCAAGCTGGCATTACTCATCAGTCTC
ATGGCAGTTTTGTTTGAAAAATGCTTGTGCTAGAAAAAGTGGATTTATCAGCTCAGCACTGTATGGTGCTAGCATGCAG
CACAACAAAAGACAAGTGCTCATTTCAGTAACGCTTGCAGCATTTCATGGGGCCCCCAAATAGGCTGAACAAGGCTTCT
CTGGCAGCTACACTGAAGTACAGTGGGAAACTGTTAAAGTGGCAGTGTCACTGCCTGGAAAACGGCCTCTGTTTTCTCC
CATCAGTTATTGCTGCTTTCTGTGTTGTTTGTTTGTTTAAAGACTATTTACCAAAGTAAGAATTTCATTGAATATTGGA
GAAAAGGACACCAAGAAGTGTCTTTTTCTCACTGTTTCTTGGAGCACAGACCAAGCTGTCAGTCTGTCCTTCTCAAAGT
GGCTCTGTCATGTGAGAAAAAATAAGACACTTGTGGCTTTTACAAGTAAGTCAGCCCTGCTGCAGCCCATCAGGGAGAT
CTCATTCCCTGTTTAAAGCAGTTTTTTTTCAGAATTTTTGCCACACTTCCAGTTTCTTTCAGAGCTGCTCTTCCAGAAT
GCAAATGCAACTTGGGTAGTGTTCTGTATTTAATTGAATGTGTCAGGTGGTTAGAGTCATGTTTTAAAAACAGTATTGC
ATACTGCAAATATGCCAGACCCTTTGTTCGCAGGCATTTAAAACAAATGCATTTTTCAGTATTTATTTATTCTGTCTGA
TTGCATTCCATACAGATGGAGAAGATAAACAAGTGAGTTCCATTCTGGCTTATAAATTGTCTTTTACTTTTTCAGGCAA
GATTCTTCAGAGCCTGAGCGACTTCAGAAGGAGAAACTTATTAGAAGAAATCTTTGCCATTATATGTATAGTAAGTTCA
CCTCCCATGTGTGCTTGTGCTCCATACAGAGCTGGGATGCATGGGAGGAATGGGCACATGCGGTTTGATCTCATTTTGC
TCACCATGGAAAGGGACAGCTGCAGTGAGCTGCCTGTTTTCTGAGGTATCAGCTGCCAGACAGCCTGTAACACCTCAGC
CAGAGGCACAGGGACCTCACCATAAGTGCATGCTGGCCTAAGGCCATACCTGCACATGCAAGGTGCAGATCCTTTGGAC
TCCACACCTGTAGCATGGCATCCACAAAGCAGCAGCAGCAAAGCAGTTACCACTCTGTGCAAACAGCTTGCTGTGATTA
ACCTATCAGGGCTCATGCTTGTCTGAGGACAGCTGGAGCTGGTAAGATGTTTGCCTTGCAGTACCCAGAAAGCTGGATA
TCTCTTGGAGTGGTTCTGGATGGTTACACACAAATTGGAGACATTGGTCTCCTGCCAGACCAGGCAGAAATAACACAGC
AAGATGCCTCAGGGAAGCAAGGAAGTTGTTCAGGACTTCCTCTTCCCTCAACAACAGCAAACCTGAAAGCCATAGAGGG
GCAGGCTGGAGAACTGAGCTTGGCTGAAGACCTCTTGTCACTGACACTCCCATGCTCCCATCTTGGGCTGCTGGAGAGT
GGCATGTCCTTCATGACTCACTGTACCCTCACAGTCATAGCTCATCTTCTGTGCCTGGCTGAGCACAGAGGGCCAATCA
TGCTGCAGGACCTCAGTGTAAGATGTCGTCACAACAAGCAATTGGAAAAGCCAAAGAAGGCTGAAATCCATGGCTGTGA
AGATGGAGTTGGCTGTTTCACTATGAGATGTGGAGGAAATATTTATCCTACACCTACCGCAGCCAGACTGCAGTTGTTG
AGTTGAGTGACAAGGAAACGGGAGCCTGGGATGTCTCAGCACAAGCTTCCCTAAGCCTTGACTTGGTGGGTGAGCACCT
GAACACAGCCAGAGCCTGTTACATTAAAGGCTTTATAAAAGCAACAGTGCCAGGCTGACATCCACCTCCCACGTTACCG
GCAGCCCCAGCAGGTGTAATGCGATCCGGCAGGCGCAGCTAGCAGATAAACAAACGGCCTTTCTGCACAGGTTGTGCCA
GAGAGCCTCTCCCAGCAGGGAATTGGGTTGGATGTTGTACTAGGTCAGTGAGCTGCTATGGAAAGAGCTGTGACAATGG
ACAATATTGTCCTTTTTCCACACAGGATTTTCCCTCAACACTTAAGGCAAGGCAGCAGAAAAACCGTTGGGGAAAGTTT
CTCTACCAGGCCTCAGAAGTTTAGTGGGATTGGGCCCTCAATGGGGGCCTACTGCTGGATTTCCCTAGGCCGTCACTTC
AATGCCGCCAGGCCAGCCAGCAGCGCTGAGGGCTGCCTGCCAGAGCTGCTTGCTTGCTCTGCCATTGGGGCTCATCTCT
AGTGAGTAATATTAACCAAAGGCCTTCCTACTTGGCTACAACATATCTTCCTTCTTCATTAAGGAGCTAAGCTAAGCTG
CCCAGCTGTGGTAAATTTCCCTTGCTCCACAGCTGAGGTAATAATGATGCATTCCCAGGAGCAGGGCCTGCACCCTGTG
TGCCACATTGGGCCTGGTGGTGTGTGGGCACATTGCTCCACACCACACCAAAATGGCGTCCGTCTGGTACTGCCCCACA
GCGTGTGGGCGCACCATACCACTCCAAAATGGTGTCCATCCTGCACTTCTCTGCAGCTTAAGGGCACTCCACAACAAAA
TGGTGGCTGTTCAGCACTGCCCAGCAGTGTGTGGCACTCCACAACAAAATGGCGGCTGTCCAGCACTGCCCTGCAGTGT
GTGGCACTCCACAACAAAATGGCGGCTGTCCAGCACTGCCCTGCAGTGTGTGGCACTCCACACCACACCAAAATGGTGT
CTGTCCTGCGCTGCCCTGTAACTTGTGGGTGTACTAGAGCAAAATTGTGGGTGAATTGCAGTGCTGCTGTAGCATATGG
ACACACCACACCTAAATGGTGGCTGTCCAGCATTGCCCCACAGCATTTGGCACACCACACCAAAATGGCGGCCATCCAG
TGCTGCTCCCCTGTCCCTGTATCCCAGCTGGGTCCCATCTTGCCTCCAAAATTTCCCCCTCCCTGCCGTTGCTCCAGTT
CCTCATGAGTTATGATAACATATAAGCAGCTTAGAGAATTCTTATCGGAATGAGTTGAACACAATGCGACGTTTAACTC
TTAATGACAGCCACCTCTGACTGAGTGACACATTATAAATTATGTTTGAACTGGGTGTTTTTTTTCAGAGGCAGATATC
CCCCTGCCACCCAGCCAGCCCTGCGAAGTTGCACTTGTGGCCTTAATCCCACTTGGATGTGTGCCCCGCTGCCTCCACT
CTCCGTCACTCGGGTGCTTTAGTGTTCTTGAACAAGTGAACAATCTTTGTTTCTGTACCTTATTAGGCCAGAGACCATA
GCAGCGAGCGATGGCATCAGCAGGCCCCGCAGGCAGGATTCTCTGCAGACACAGCCAACCTCCAACAAACCCCTTTTTA
TCCTCCTGTTTCTAGGAAGAATTATGATGGTGGTGCCCTGCTGTTGATCAGTCAAATCTGTGGTGGGCCTAGAGATAAG
TCCTGTAAGTGTGGTGTACTGTAAAACAGCGGCTCCCATTCATTAGTGGCTTGTGTGTAATAAACCACCCAACAGAGGG
GGTTGGGGAAGAGAGGGAAAGAGCAGCTGCAGTGTGCAGGAACAAACAACACAACTCATTCTTGGGAGCCAAAACTTTC
TAATTTGCTGCTGGGCTGCTGGGAGCACTCAAATTCTTTCTGATAATGTGCTCGTGCCCTCGGTGTCTCTCCCTGCGTT
TCTGCTCTCCAGAATCTGGAATAGTTTCACTCTGAACAACAAACGTGGACGCTGCTCAACGGGGAGGAGGAGGGGAACA
CAGCCACCCAGTGTTTGCAGACTCCAGCACAGCAAAGTGGTGGACTTGAGGCAAGTTCTGCCGTGGAATGGCTGCTGCA
CGTATCTGCTTGTGCAGTGGGTAAACAAAGCATCACATGGGCTGCAGGCTGAGCACGAGGCGCGTGGCTGACCTATACG
TGTATGAGGCATGCAGGAGGAACAGCATATTCCAAACATTAGAGCCTGGTGGGATATTCAGGAACTTCTCTCAAAAAAC
TCAAACAAACGAAACAAAACCACAAATTGATTATAACTGAAAAATTATTTGGCTTGATTTCTCCTGTTTTTCCACAAGT
TTCAGTGAGTATTTACATAAGCGTATTTCTACATTGCCTTGCATTGGAAACAGCTTGTAAGTATGTTCATCAAAATGTC
AGTCGATTATAATGTAACTCATTGCACCTGTTTGGACCTCAGTAGTTGCTAATTGTAACTGTGCATTTACAGCTGTGAC
TGTGCTGGTGCTCAGCCTCAGACCTGACTGCCCATAGGACATTTCAAACTAGAAATTAAAATCACTGCGTGTGTTTCAG
AACTGCTCTCATAGACGAAACCTTTGCGCTAAAGCTTGTACTGTCACGAGAAAGGGAAATTAATTTTGGATTGATGCTA
CTCAGAAGGACCATTATACCCTCGCAGGATCACAGTGACTGCTTTTTCAGTGATGTGCCAGGCTGTGATGGTGCTTGGA
CTGTCTCCTAACATTTCTATAGACAAGAGCTACTTAAACAGCAAGTCCAGGCTTGGGCCAAACTGCAAGTACTCTTTAT
GTAGACAGGCAAAGTGTCAGACACAAAGTTTTCCACTTTAGAGCAGGCGATCTGCTTGCTTCCTCTTCCCTGACCTGGA
GACCTGTTCCAGGCATTGCCTGAGTCTTAACCCTTCAATGAGAGGTGCCTCTCTGAGCTGCCCCTTGGCCATGGTACCT
AATGGGTGGAGGTATGAATTCTTCATTCAGACCTGGCCAAATCCAGTGCTAGACCTGGATGCAAATCAGTTCTACCGAA
GGTTTAGGTAGTGAAGGAACTGAAACTTGCTGCTTACCTGCCATGCTGCACAGGGCCAGCATGAGACCCAGCCCTACAA
GCTCTGCTTGTAGGGTTTTGGTATTTTTGACACAGTCATTTGGCATTTTGATTTCCCTATGGTACAAACAGGGGGACAA
TCTAAAAATAAGAAATAGCTTTCCTGCACGAATACCTTGAATCATTAGAAACTGATGCTTTGTGAGTTTTCTGGGAATC
TGTTACTGTTTTTATATTTTCATAGGGATGTAGTCATCCAACATTGTTGGACAGAGGTAAACATGAGTAACCCAATTTT
GTTCTTACACTTGGAACACTGCAAATAGCTATATAGTCCTGAAGTTTTTGTATCTAACCAGATGACACTGGGGGAAGTG
AAATATTTCTTATTAAACTGAGGCAAAATATGCCTTTGTGATCTATAAGGAAGTCTAATAATTTTGGGTTCAAAGATGT
CTAATGTTGAATTATTAAATGACTCAATGTAGCTTTCTTTTAGAAGGGGTGATACTCATCCATCAGCTGGATCCAAGCT
ATTACAAAAACTCTGCTAGAAATAGAATGAGAAATAGACCAAAAACTCAGAGCTCAGGCTTGCAAATAAAATAAATTGT
TGTGACTGGTTGTTCACTAATATATGTGAAAGAGGGGCTACGTGTTACGTGTCTTTTATTATTGACAGTGTGCCCAATG
CTGTATGGTAAATGTTTGAACAGTGTCACCTTCTGTTCTGCCTCCTTCACCTACAGGAGCAGCTCTGGTGGCGAAGGGG
CAGCGTGAGGCACTGCTGGCCCCAGCTTCCCGCAGGTGTCCATCCGGCACCCGAGGCCTCGAGCAGCACCGTGTCTGTG
TCCTGTGCCATACCCACAGCCCTGGAACCATGGAAGGAGAATGAAGTTTGTTCTAAACGTGAATTTAATATGCTTTCAG
ATTTGACAGCCTCTTTTAAAAGGAAACGTTTAAGTTGAGCGAAAGGCACATTTGCTTCTCCAAATAAATGGAATTATAG
TTCAAAGATC
CitationWakamatsu Y, Maynard TM, Weston JA. Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis. Development. 2000 Jul;127(13):2811-21.
CopyrightPublished by The Company of Biologists 2000. This material is protected by a copyright retained by the authors.
CommentsAs insufficient information is provided in the publication to verify the exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (acc # NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19-24
stage 23
Spinal Ganglia and Nerves
 
25-30
stage 30
stage 30
stage 30
Spinal Ganglia and Nerves
 

Entry 14

GEISHA IdSOX2.Sanchez-Arrones.2012Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationSanchez-Arrones L, Stern CD, Bovolenta P, Puelles L. Sharpening of the anterior neural border in the chick by rostral endoderm signaling. Development. 2012 Mar;139(5):1034-44.
CopyrightPublished by The Company of Biologists © 2012.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_205188.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 4
stage 5
Mesencephalon
Neural Plate/Tube
SP, secondary prosencephalon
STAGE 5+ embryo
7
stage 7
Neural Plate/Tube
STAGE 7+ embryo

Entry 15

GEISHA IdSOX2.Psychoyos.2008Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationPsychoyos D, Finnell R. Double Whole Mount in situ Hybridization of Early Chick Embryos. J Vis Exp. 2008; (20): 904.
CopyrightCopyright © 2008, Journal of Visualized Experiments
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205188.1 ).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7
stage 7
stage 7
Neural Plate/Tube
 

Entry 16

GEISHA IdSox2.Daudet.2007Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationDaudet N, Ariza-McNaughton L, Lewis J. Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development. 2007 Jun;134(12):2369-78.
CopyrightCopyright 2007 the authors. Published by the Company of Biologists Ltd.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205188.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 12
stage 12
Ear/Otic Placode
Neural Plate/Tube
 

Entry 17

GEISHA IdSox2.Reza.2002Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationReza HM, Ogino H, Yasuda K. L-Maf, a downstream target of Pax6, is essential for chick lens development. Mech Dev. 2002 Aug;116(1-2):61-73.
CopyrightCopyright © 2002 Elsevier Science Ireland Ltd. All rights reserved.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205188).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-17
stage 17
stage 17
Eye
 

Entry 18

GEISHA IdSOX-2.Dady.2012Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationDady A, Blavet C, Duband JL Timing and kinetics of E- to N-cadherin switch during neurulation in the avian embryo DEVELOPMENTAL DYNAMICS. Volume 241, Issue 8, August 2012, Pages: 1333–1349.
CopyrightCopyright © 2012 Wiley-Liss, Inc.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_205188.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 4
Neural Plate/Tube
 
7-12
stage 7
stage 7
stage 8
stage 8
stage 8
stage 8
stage 8
stage 9
stage 10
stage 10
stage 10
stage 11
stage 11
Central Nervous System
Mesencephalon
Neural Plate/Tube
Notochord
Paraxial Mesoderm
 
13-14
stage 14
stage 14
stage 14
stage 14
stage 14
stage 14
Neural Plate/Tube
Notochord
Paraxial Mesoderm
Primitive Streak
21 somite embryo
22 somite embryo

Entry 19

GEISHA IdSOX2.Qiao.2012Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationQiao Y, Zhu Y, Sheng N, Chen J, Tao R, Zhu Q, Zhang T, Qian C, Jing N. AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning. Cell Res. 2012 Nov;22(11):1546-61.
Copyright© 2012 Shanghai Institutes for Biological Sciences
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_205188.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 4
stage 4
stage 4
stage 5
stage 6
Ectoderm
Epiblast
Hensen's Node
Neural Plate/Tube
Stage HH4+
Stage HH4-

Entry 20

GEISHA IdSOX2.Christophorou.2009Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationChristophorou NA, Bailey AP, Hanson S, Streit A. Activation of Six1 target genes is required for sensory placode formation. Dev Biol. 2009 Dec 15;336(2):327-36. doi: 10.1016/j.ydbio.2009.09.025. Epub 2009 Sep 23.
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205188.1
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4
stage 4
stage 4
Neural Plate/Tube
 

Entry 21

GEISHA IdSOX2.Acloque.2008Data SourcePublication
Complete cDNA Template Probeshow
AGGCAGAGAAAAGGGAAAAAGGAGGAAGAAGTTTTTTAAATCCGAGGCTCCGGCGGTAATAATAGCAGTTATTAGCATT
ATTAATCCATCAGCGAAGAGGAAGATTCTGATCTCGATCCAAGTGTGGTTTTGGGGAGTCCCCCTCCCCCCTTTCATAC
CCCTCCCTAGGAAAAAAAAAAAAAAAAAAAGTCCGGCTTGGGACTTCGCCGCCGCCGCTCCTTCTCCGCTCCGGGCTGG
TTCCAGGCTAAAGTAGTTTGAATGTACAACATGATGGAAACCGAGCTGAAACCTCCCGCCCCCCAGCAAACTTCGGGGG
GAGGCACAGGCAACTCCAACTCGGCCGCGAACAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTT
CATGGTGTGGTCCCGCGGGCAGCGGCGGAAAATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGG
CTCGGGGCCGAGTGGAAACTTTTATCCGAGGCGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGC
ACATGAAGGAGCACCCGGATTATAAATACCGACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTT
GCCAGGGGGCTTACTGGCGCCGGGCACCAATACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTG
AACCAGAGGATGGACAGTTACGCGCACATGAACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCT
ACCCGCAGCACCCGGGCTTGAACGCGCACAACGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCA
GTACAACTCCATGACCAGCTCGCAGACGTACATGAACGGATCGCCTACCTACAGCATGTCGTACTCCCAGCAAGGGACC
CCGGGCATGGCGCTGGGCTCCATGGGCTCGGTGGTCAAGACGGAATCCAGCTCCAGTCCCCCCGTGGTCACCTCCTCGT
CTCATTCGAGGGCTCCTTGCCAAGCCGGGGACCTTCGGGACATGATCAGCATGTATCTACCAGGTGCTGAAGTACCAGA
ACCAGCTGCCCCAAGCAGACTTCATATGTCCCAACACTACCAGAGTGCACCTGTTCCTGGCACAGCCATTAATGGCACA
CTCCCTCTATCACATATGTGAAGACAAAGGGGCCGGGGGGGGCGGGGGTGGGGGGGGGAAGGAGAACTAACAAAACAAA
ACAAACAACAACAACAAAAAACTTTTATTAGAAATTCTGACCTTTTTTTTTTTCTTTTTTTTCTTTTTTTTTTGGACTA
TTTTTGTACAGA
CitationAcloque H, Wilkinson DG, Nieto MA. In situ hybridization analysis of chick embryos in whole-mount and tissue sections. Methods Cell Biol. 2008;87:169-85. doi: 10.1016/S0091-679X(08)00209-4.
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205188.1
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-9
stage 9
stage 9
stage 9
Neural Plate/Tube
Red

Entry 22

GEISHA IdSOX2.Uchikawa.2011Data SourcePublication
Complete cDNA Template Probeshow
CAACCAGAAGAACAGCCCGGACCGGGTCAAGCGCCCCATGAACGCCTTCATGGTGTGGTCCCGCGGGCAGCGGCGGAAA
ATGGCCCAGGAGAACCCGAAGATGCACAACTCGGAGATCAGCAAACGGCTCGGGGCCGAGTGGAAACTTTTATCCGAGG
CGGAGAAGAGACCCTTCATTGACGAAGCCAAACGGCTCCGAGCTCTGCACATGAAGGAGCACCCGGATTATAAATACCG
ACCCCGGAGGAAAACCAAGACCCTGATGAAGAAGGATAAGTACACGTTGCCAGGGGGCTTACTGGCGCCGGGCACCAAT
ACCATGACGACCGGGGTAGGGGTTGGGGCCACCTTGGGAGCTGGGGTGAACCAGAGGATGGACAGTTACGCGCACATGA
ACGGCTGGACCAACGGAGGCTATGGGATGATGCAAGAGCAGCTCGGCTACCCGCAGCACCCGGGCTTGAACGCGCACAA
CGCGGCGCAGATGCAGCCCATGCACCGCTACGACGTGAGCGCCCTGCAGTACAACTCCATGACCAGCTCGCAGACGTA
CitationUchikawa M,Yoshida M, Iwafuchi-Doi M, Matsuda K, Ishida Y, Takemoto T, Kondoh H. B1 and B2 Sox gene expression during neural plate development in chicken and mouse embryos: universal versus species-dependent features. Cell Growth Differ 2011 Aug;53(6):761-71.. null.
Copyright© 2011 Japanese Society of Developmental Biologists.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
  
4-6
stage 4
stage 5
Neural Plate/Tube
Neural Ectoderm
7-12
stage 7
stage 8
stage 9
stage 9
stage 10
stage 11
stage 12
Ear/Otic Placode
Neural Plate/Tube
Peripheral Nervous System
Posterior Neural Plate
13-18
stage 13
Neural Plate/Tube
 
19
stage 19
stage 19
stage 19
  
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.601

Mouse

EmageMGI:98364
EurexpressMGI:98364
MGI GXDMGI:98364

Frog

Xenbase484552

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-030909-1
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