GEISHA - A Chicken Embryo Gene Expression Database
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TIMP2
TIMP metallopeptidase inhibitor 2

Gene
Official SymbolTIMP2
Official Full NameTIMP metallopeptidase inhibitor 2
CGNC ID49073
also known asmetalloproteinase inhibitor 2|TIMP-2|tissue inhibitor of metalloproteinase 2|tissue inhibitor of metalloproteinases 2
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_204298
PolypeptideNP_989629
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.2965
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human
Mouse
Xenopus
Zebrafish
Gene Ontology
Molecular Functionmetal ion binding, metalloendopeptidase inhibitor activity
Biological Process
Cellular Componentextracellular region
Links to other databases
Entrez Gene374178
Ensembl GeneENSGALG00000027070
KEGGgga:374178

Entry 1

GEISHA IdTIMP2.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerGGAACCCCATCAAGCGAATC
Reverse cDNA Template PrimerATTAACCCTCACTAAAGGTGTCGGCGTGGACCAGTCTAACcDNA Template Length544
Forward cDNA Template Probeshow
TCTGCTGGCTTTCTACTGGCTACTGGAATGCGCTCGGTCGGCTTAGGGGTCCTCGATGTCGAGAAACTCCTGCTTCGGG
GGGGCCATGCCGCGGTACCAGGCGCACGAGCCGTCGCTCCTCTTGATGCAGGCGTAGTGCTTGGCCTGCCGCCCGCCCA
CGATCTTCTCCATCGCCCAGTCTGTCCAGAGGCACTCATCCGAGGAGGAGACGAAGCAGGGGATGGAGAGGCAGCGCGA
GATCTTGCACTCGCAGCCCATCTGGTACCGCTGGTTGAGGCTCTTCTTCTGGGTGGGGCTCAGCGAGTCCCAGGTGGCA
ACCAGGTCACACAGCGTGATGTGCATCTTGCCATCGCCCTCGGATTTGCCTGCAATCAGGTACTCCTTCTTGCCTCCTG
TGTCCAGAGGCTGCCCACACACTGCCGTGGACGGCGCCGTGTAGATGAATTCGATGTCCTGGTCGGGGCCCTTAAACAT
CTTGATCTGCTTCACTTCGTACTGGATTCNCTTGAGGGGG
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 5
stage 6
stage 6
Area Opaca
Epiblast
Hensen's Node
Notochord
Primitive Streak
 
7-12
stage 9
Area Opaca
Blood Vessels
Forebrain
Neural Plate/Tube
Sinus Venosus
 
13-18
stage 13
stage 13
stage 13
stage 13
stage 13
stage 14
stage 18
stage 18
Amnion
Extraembryonic Blood Vessels
Eye
Forebrain
Heart
Heart Tube
Intermediate Mesoderm
Midbrain
Neural Crest
Neural Plate/Tube
Proepicardium
Rhombomeres
Sclerotome
Somites
extraembryonic endoderm
 
19-20
stage 20
stage 20
Aorta
Ectoderm
Eye
Leg Mesenchyme
Myotome
Notochord
Sclerotome
Wing Mesenchyme
 

Entry 2

GEISHA IdTIMP-2.Linask.2005Data SourcePublication
Complete cDNA Template Probeshow
AATTCCGCGCCGCACGATGCCCGGGGCCGCGCTGCCCAGCCTGCTGGCCTGGCTGGCGGTGCTGCTGCTCGGCAGGGCC
CGCCCGGCCGACGCGTGCAGCTGCTCGCCCATCCACCCGCAGCAGGCCTTCTGCAACGCCGACGTAGTGATCCGAGCAA
AGCGCGTCTCGGCGAAGGAGGTGGATTCAGGGAATGACATTTATGGGAACCCCATCAAGCGAATCCAGTACGAAGTGAA
GCAGATCAAGATGTTTAAGGGCCCCGACCAGGACATCGAATTCATCTACACGGCGCCGTCCACCGAGGTGTGTGGGCAG
CCTCTGGACACAGGAGGTAAGAAGGAGTACCTGATTGCAGGCAAATCCGAGGGCGATGGCAAGATGCACATCACGCTGT
GTGACCTGGTTGCCACCTGGGACTCGGTGAGCCCCACCCAGAAGAAGAGCCTCAACCAGCGGTACCAGATGGGCTGCGA
GTGCAAGATCTCGCGCTGCCTCTCCATCCCCTGCTTCGTCTCCTCCTCGGATGAGTGCCTCTGGACAGACTGGGCGATG
GAGAAGATCGTGGGCGGGCGGCAGGCCAAGCACTACGCCTGCATCAAGAGGAGCGACGGCTCGTGCGCCTGGTACCGCG
GCATGGCCCCCCCGAAGCAGGAGTTTCTCGACATCGAGGACCCCTAAGCCGACCGAGCGCATTCCAGTAGCCAGTAGGA
AAGCCCAGCGAGATGTTAGACTGGTCCACGCCGACATCGGGGCCTGGAAAGCATGAAAACCCACACACGCCGAGGGGCC
GCAGGGCACGGAGCTGCCGGAATT
CitationLinask K, Han M, Cai D, Brauer P, Manisastry, S. Cardiac Morphogenesis: Matrix Metalloproteinase Coordination of Cellular Mechanisms Underlying Heart Tube Formation and Directionality of Looping. Dev Dyn. 2005 Jul;233(3):739-53.
CopyrightCopyright © 2005 Wiley-Liss, Inc.
CommentsAccording to the authors: "Digoxigenin-labeled antisense and sense riboprobes for chicken MMP-2 and TIMP-2 were generated and the hybridization carried out as described in Cai et al. (2000)." Cai does not mention TIMP-2, therefore insufficient information is provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204298).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1
stage 1
stage 1
Endocardium
Heart
Myocardium
Splanchnic Mesoderm
dorsal mesentery

Entry 3

GEISHA IdTIMP-2.Brauer.2002Data SourcePublication
Complete cDNA Template Probeshow
AATTCCGCGCCGCACGATGCCCGGGGCCGCGCTGCCCAGCCTGCTGGCCTGGCTGGCGGTGCTGCTGCTCGGCAGGGCC
CGCCCGGCCGACGCGTGCAGCTGCTCGCCCATCCACCCGCAGCAGGCCTTCTGCAACGCCGACGTAGTGATCCGAGCAA
AGCGCGTCTCGGCGAAGGAGGTGGATTCAGGGAATGACATTTATGGGAACCCCATCAAGCGAATCCAGTACGAAGTGAA
GCAGATCAAGATGTTTAAGGGCCCCGACCAGGACATCGAATTCATCTACACGGCGCCGTCCACCGAGGTGTGTGGGCAG
CCTCTGGACACAGGAGGTAAGAAGGAGTACCTGATTGCAGGCAAATCCGAGGGCGATGGCAAGATGCACATCACGCTGT
GTGACCTGGTTGCCACCTGGGACTCGGTGAGCCCCACCCAGAAGAAGAGCCTCAACCAGCGGTACCAGATGGGCTGCGA
GTGCAAGATCTCGCGCTGCCTCTCCATCCCCTGCTTCGTCTCCTCCTCGGATGAGTGCCTCTGGACAGACTGGGCGATG
GAGAAGATCGTGGGCGGGCGGCAGGCCAAGCACTACGCCTGCATCAAGAGGAGCGACGGCTCGTGCGCCTGGTACCGCG
GCATGGCCCCCCCGAAGCAGGAGTTTCTCGACATCGAGGACCCCTAAGCCGACCGAGCGCATTCCAGTAGCCAGTAGGA
AAGCCCAGCGAGATGTTAGACTGGTCCACGCCGACATCGGGGCCTGGAAAGCATGAAAACCCACACACGCCGAGGGGCC
GCAGGGCACGGAGCTGCCGGAATT
CitationBrauer PR, Cai DH. Expression of tissue inhibitor of metalloproteinases (TIMPs) during early cardiac development. Mech Dev. 2002 May;113(2):175-9.
CopyrightCopyright © 2002 Elsevier Science Ireland Ltd.
CommentsThe complete cDNA template sequence was obtained from the information in the publication as described in Brauer et al. 2002.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 12
Endocardium
 
13-18
stage 15
Aorta
Endocardium
Myocardium
 
19-24
stage 19
Endocardium
Epicardium
Sinus Venosus
Ventricles
 
25-30
stage 25
stage 25
stage 25
Aorta
Endocardium
Epicardium
 
31-44
stage 44
  
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.2965

Mouse

Emage
Eurexpress
MGI GXD

Frog

Xenbase

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFIN
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