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TIMP3
TIMP metallopeptidase inhibitor 3

The human orthologue of this gene is associated
with the following human disease:

Gene

Official Symbol	TIMP3
Official Full Name	TIMP metallopeptidase inhibitor 3
BirdBase ID	BB-GG18574
CGNC ID	9540
also known as	IMP-3, TIMP-3, metalloproteinase inhibitor 3\|21 kDa protein of extracellular matrix\|TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)\|tissue inhibitor of metalloproteinase 3\|tissue inhibitor of metalloproteinases 3
gene type	protein-coding

Genomic Map

Sequence Information

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.2827

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	7078	ENSG00000100234	MIM:136900	MIM:188826
Mouse	21859	ENSMUSG00000020044	All phenotypic alleles (9):Targeted, knock-out(4) Targeted, other(5)	MGI:98754
Xenopus	100489929, 373596			482399
Zebrafish			ZDB-GENE-070824-3	ZFIN:ZDB-GENE-070824-3

Gene Ontology

Molecular Function	metal ion binding, metalloendopeptidase inhibitor activity
Biological Process
Cellular Component	proteinaceous extracellular matrix

Links to other databases

GEISHA Id	TIMP-3.Brauer.2002	Data Source	Publication
Complete cDNA Template Probe	show CGAGAGAGAGGCGGTGTGAGGAGGGAGCGAGCGAGCAGCGAACAGGCGAGGCTCGAGTTAGGCGAACAGAACAGCGGCT GCAGCTCGAAGCGCACCCCGGGGCAGGCAGCATGACGGCGTGGCTCGGCTTCCTCGCCGTGTTCCTGTGCAGCTGGAGC CTGCGGGACCTGGTGGCGGAGGCGTGCACTTGCGTCCCCATCCACCCGCAGGACGCGTTCTGCAACTCCGACATCGTGA TCCGTGCTAAAGTTGTGGGGAAGAAGCTCATGAAAGATGGACCATTTGGAACAATGCGATACACAGTCAAGCAGATGAA GATGTACAGGGGCTTCCAGATAATGCCACACGTTCAGTACATCTACACAGAAGCCTCAGAGAGTCTTTGTGGTGTGAAA CTGGAGGTCAACAAATACCAGTATCTGATTACAGGCCGCGTGTACGAAGGGAAGGTTTACACTGGCCTGTGCAATTGGT ATGAGAAATGGGACCGACTGACTCTGTCCCAGCGTAAAGGACTGAATCATCGTTATCATCTGGGCTGTGGATGCAAGAT TCGGCCCTGCTACTATTTGCCCTGCTTTGCCACCTCCAAGAATGAGTGCATTTGGACAGACATGCTCTCCAACTTCGGC CACTCAGGACACCAAGCGAAGCACTATGCCTGCATCCAGAGGGTGGAAGGTTACTGCAGCTGGTATAGAGGATGGGCGC CTCCAGATAAAACGATCATCAATGCCACAGATCCCTGAGCACGCTGTACCTTCCTTATCTTCCCTCTCCCTTACTTGTG GCTGATCTTCCTTTGGACACTAACTCTTACCCGATCATGATGATGACAATGAAATTAGTGCCTGTTTTCTTGCAAATTC TAGCACTTCGAAC
Citation	Brauer PR, Cai DH. Expression of tissue inhibitor of metalloproteinases (TIMPs) during early cardiac development. Mech Dev. 2002 May;113(2):175-9.
Copyright	Copyright © 2002 Elsevier Science Ireland Ltd.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_205487.2).