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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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TIMP3
TIMP metallopeptidase inhibitor 3

The human orthologue of this gene is associated
with the following human disease:

Sorsby fundus dystrophy

Gene

Official Symbol	TIMP3
Official Full Name	TIMP metallopeptidase inhibitor 3
CGNC ID	9540
also known as	IMP-3, TIMP-3, metalloproteinase inhibitor 3\|21 kDa protein of extracellular matrix\|TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)\|tissue inhibitor of metalloproteinase 3\|tissue inhibitor of metalloproteinases 3
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_205487
Polypeptide	NP_990818

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	7078	ENSG00000100234	MIM:136900	MIM:188826
Mouse	21859	ENSMUSG00000020044	All phenotypic alleles (9):Targeted, knock-out(4) Targeted, other(5)	MGI:98754
Xenopus	100489929, 373596			482399
Zebrafish			ZDB-GENE-070824-3	ZFIN:ZDB-GENE-070824-3

Gene Ontology

Molecular Function	metal ion binding, metalloendopeptidase inhibitor activity
Biological Process
Cellular Component	proteinaceous extracellular matrix

Links to other databases

Entrez Gene	396483
Ensembl Gene
KEGG	gga:396483

Entry 1

GEISHA Id	TIMP-3.Brauer.2002	Data Source	Publication
Complete cDNA Template Probe	show CGAGAGAGAGGCGGTGTGAGGAGGGAGCGAGCGAGCAGCGAACAGGCGAGGCTCGAGTTAGGCGAACAGAACAGCGGCT GCAGCTCGAAGCGCACCCCGGGGCAGGCAGCATGACGGCGTGGCTCGGCTTCCTCGCCGTGTTCCTGTGCAGCTGGAGC CTGCGGGACCTGGTGGCGGAGGCGTGCACTTGCGTCCCCATCCACCCGCAGGACGCGTTCTGCAACTCCGACATCGTGA TCCGTGCTAAAGTTGTGGGGAAGAAGCTCATGAAAGATGGACCATTTGGAACAATGCGATACACAGTCAAGCAGATGAA GATGTACAGGGGCTTCCAGATAATGCCACACGTTCAGTACATCTACACAGAAGCCTCAGAGAGTCTTTGTGGTGTGAAA CTGGAGGTCAACAAATACCAGTATCTGATTACAGGCCGCGTGTACGAAGGGAAGGTTTACACTGGCCTGTGCAATTGGT ATGAGAAATGGGACCGACTGACTCTGTCCCAGCGTAAAGGACTGAATCATCGTTATCATCTGGGCTGTGGATGCAAGAT TCGGCCCTGCTACTATTTGCCCTGCTTTGCCACCTCCAAGAATGAGTGCATTTGGACAGACATGCTCTCCAACTTCGGC CACTCAGGACACCAAGCGAAGCACTATGCCTGCATCCAGAGGGTGGAAGGTTACTGCAGCTGGTATAGAGGATGGGCGC CTCCAGATAAAACGATCATCAATGCCACAGATCCCTGAGCACGCTGTACCTTCCTTATCTTCCCTCTCCCTTACTTGTG GCTGATCTTCCTTTGGACACTAACTCTTACCCGATCATGATGATGACAATGAAATTAGTGCCTGTTTTCTTGCAAATTC TAGCACTTCGAAC
Citation	Brauer PR, Cai DH. Expression of tissue inhibitor of metalloproteinases (TIMPs) during early cardiac development. Mech Dev. 2002 May;113(2):175-9.
Copyright	Copyright © 2002 Elsevier Science Ireland Ltd.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_205487.2).

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 11

stage 12

Myocardium
Notochord

13-18

stage 13

stage 17

Atria
Endocardium
Ventricles

19-24

stage 19

stage 23

Endocardium
Myocardium

25-30

stage 25

Cardiovascular
Endocardium
Ventricles

31-44

stage 44

Entry 2

GEISHA Id	TIMP3.Anderson.2019	Data Source	Publication
Complete cDNA Template Probe	show TTCCGCTTCAGCCCCGCTCGGTCCTGTAGCGCTGCTCACTCGGGCTTGCTCCGTGCCGCCGAGCGAGGGCTGCGCTGCT GAGGCCGAGAGAGAGGCGGTGTGAGGAGGGAGCGAGCGAGCAGCGAGCAGGCGAGGCTCGAGTTAGGCGAACAGAACAG CGGCTGCAGCTCGAAGCGCACCCCGGGGCAGGCAGCATGACGGCGTGGCTCGGCTTCCTCGCCGTGTTCCTGTGCAGCT GGAGCCTGCGGGACCTGGTGGCGGAGGCGTGCACTTGCGTCCCCATCCACCCGCAGGACGCGTTCTGCAACTCCGACAT CGTGATCCGTGCTAAAGTTGTGGGGAAGAAGCTCATGAAAGATGGACCATTTGGAACAATGCGATACACAGTCAAGCAG ATGAAGATGTACAGGGGCTTCCAGATAATGCCACACGTTCAGTACATCTACACAGAAGCCTCAGAGAGTCTTTGTGGTG TGAAACTGGAGGTCAACAAATACCAGTATCTGATTACAGGCCGCGTGTACGAAGGGAAGGTTTACACTGGCCTGTGCAA TTGGTATGAGAAATGGGACCGGCTGACTCTGTCCCAGCGTAAAGGACTGAATCATCGTTATCATCTGGGCTGTGGATGC AAGATTCGGCCCTGCTACTATTTGCCCTGCTTTGCCACCTCCAAGAATGAGTGCATTTGGACAGACATGCTCTCCAACT TCGGCCACTCAGGACACCAAGCGAAGCACTATGCCTGCATCCAGAGGGTTGGAAGGTTACTGCAGCTGGGTATAGAGGA TGGGGCGCCTCCAGATAAAACATCATCAATGCCACAGATCCCTGAGCACGCTGTACCTTCCTTATCTTCCCTCTCCCTT ACTTGTGGGTGATCTTCCCTTTGGACACTAACTCTTACCCGA
Citation	Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
Copyright	Copyright © 2019 Elsevier Inc. All rights reserved.
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Anderson et al. 2019.