| |
 | TBX20
T-box 20 | The human orthologue of this gene is associated
with the following human disease: |
| Gene | | Official Symbol | TBX20 | | Official Full Name | T-box 20 | | CGNC ID | 9220 | | also known as | T-box transcription factor TBX20|T-box protein 20|cTbx20, T-box transcription factor TBX20, T-box protein 20, cTbx20, T-box 20 | | gene type | protein-coding |
| | Genomic Map | | | Sequence Information | | | Gene Expression | | | Orthology | | | Gene Ontology | | Molecular Function | RNA polymerase II activating transcription factor binding, more...RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription coactivator activity, sequence-specific DNA binding transcription factor activity | | Biological Process | aortic valve morphogenesis, atrial septum morphogenesis, blood circulation, cardiac chamber formation, more...cardiac muscle tissue morphogenesis, cardiac right ventricle morphogenesis, cell proliferation, dorsal/ventral pattern formation, embryonic heart tube elongation, endocardial cushion formation, foramen ovale closure, heart looping, muscle contraction, negative regulation of SMAD protein complex assembly, negative regulation of transcription from RNA polymerase II promoter, neuron migration, outflow tract septum morphogenesis, patterning of blood vessels, pericardium morphogenesis, positive regulation of cardiac muscle cell proliferation, pulmonary valve formation, pulmonary vein morphogenesis, tricuspid valve development, visceral motor neuron differentiation | | Cellular Component | cytoplasm, nucleus |
| | Links to other databases | |
Entry 1| GEISHA Id | TBX20.UAlinear | Data Source | GEISHA ISH Analysis | | Complete cDNA Template Probe | show ATGGAGTACACACCGCCCCCGAAGCCGCAGCTCTCGTCGCGGGCCAACGCCTTCTCCATCGCCGCCCTCATGTCGAGCG
GCAGCTCCAAGGACAAGGAGGCCGCCGAGAGCACCATCAAGCCTCTGGAGCAATTCGTTGAGAAGTCCTCCTGCGCGCA
GCCTCTGAGCGATCTGTCCGGCCTGGAGCCCCACGGGGACTTCAGCGGCAGCCCCTCGGCCCTGTGTACCGAGCCCCTC
ATCCCCACCACACCCATCATCCCCAGCGAGGAGATGGCCAAAATCTCCTGCAGCCTGGAGACCAAGGAGCTGTGGGACA
AGTTTCACGAGCTGGGCACCGAGATGATCATCACCAAGTCCGGCAGGAGGATGTTTCCCACGATCAGGGTTTCTTTCTC
GGGAGTGGATCCTGAAGCCAAGTACATCGTGCTAATGGATATCGTTCCGGTGGACAATAAGAGATACAGATATGCCTAC
CACCGCTCCTCCTGGCTGGTGGCTGGCAAAGCCGACCCTCCTCTCCCAGCAAGGCTCTACGTGCACCCCGACTCCCCGT
TCACGGGTGAGCAGTTGATGAAGCAGATGGTGTCGTTCGAGAAAGTGAAGCTCACGAACAACGAGCTGGATCAGCATGG
CCACATCATTTTAAACTCCATGCACAAGTACCAGCCAAGAGTCCACATCATTAAGAAGAAAGATCACACGGCTTCTTTG
TTAAATCTGAAATCTGAAGAGTTCAGGACGTTTATCTTTCCAGAGACAGTTTTTACTGCTGTCACAGCCTACCAGAATC
AATTGATAACCAAGTTGAAAATTGACAGCAACCCTTTTGCCAAAGGATTCCGCGACTCTTCCAGACTCACTGATATCGA
GAGGGAAAGTGTGGAGAGCCTTATCCAAAAGCATTCCTACGCCCGATCCCCGATTCGAACCTATGGTGGAGAAGATGAT
CTTGGAGATGACAGCCAGGCAACGCAAAGCAGAGGATCAGCTTTTACAACATCTGATAACCTGTCCCTCAGTTCCTGGG
TATCCTCTTCAACCAGTTTTCCTGGATTTCAGCATCCCCAGTCTTTGAGTGCCCTGGGTACCAGCACTGCATCCATTGC
TACACCTATTCCTCATCCAATCCAAGGATCCTTGCCTCCATACAGCCGCTTGGGAATGCCTCTTACGCCCTCTGCAATA
GCCAGCTCCATGCAAGGTACTGGCCCCACTTTCCCTTCTTTCCACATGCCAAGGTACCATCATTATTTTCAGCAGGGTC
CTTATGCAGCCATCCAGGGACTGCGTCACTCCTCCGCAGTAATGACACCATTCGTATAG |
Entry 2| GEISHA Id | Tbx20.Plageman.2005 | Data Source | Publication | | Complete cDNA Template Probe | show ATGGAGTACACACCGCCCCCGAAGCCGCAGCTCTCGTCGCGGGCCAACGCCTTCTCCATCGCCGCCCTCATGTCGAGCG
GCAGCTCCAAGGACAAGGAGGCCGCCGAGAGCACCATCAAGCCTCTGGAGCAATTCGTTGAGAAGTCCTCCTGCGCGCA
GCCTCTGAGCGATCTGTCCGGCCTGGAGCCCCACGGGGACTTCAGCGGCAGCCCCTCGGCCCTGTGTACCGAGCCCCTC
ATCCCCACCACACCCATCATCCCCAGCGAGGAGATGGCCAAAATCTCCTGCAGCCTGGAGACCAAGGAGCTGTGGGACA
AGTTTCACGAGCTGGGCACCGAGATGATCATCACCAAGTCCGGCAGGAGGATGTTTCCCACGATCAGGGTTTCTTTCTC
GGGAGTGGATCCTGAAGCCAAGTACATCGTGCTAATGGATATCGTTCCGGTGGACAATAAGAGATACAGATATGCCTAC
CACCGCTCCTCCTGGCTGGTGGCTGGCAAAGCCGACCCTCCTCTCCCAGCAAGGCTCTACGTGCACCCCGACTCCCCGT
TCACGGGTGAGCAGTTGATGAAGCAGATGGTGTCGTTCGAGAAAGTGAAGCTCACGAACAACGAGCTGGATCAGCATGG
CCACATCATTTTAAACTCCATGCACAAGTACCAGCCAAGAGTCCACATCATTAAGAAGAAAGATCACACGGCTTCTTTG
TTAAATCTGAAATCTGAAGAGTTCAGGACGTTTATCTTTCCAGAGACAGTTTTTACTGCTGTCACAGCCTACCAGAATC
AATTGATAACCAAGTTGAAAATTGACAGCAACCCTTTTGCCAAAGGATTCCGCGACTCTTCCAGACTCACTGATATCGA
GAGGGAAAGTGTGGAGAGCCTTATCCAAAAGCATTCCTACGCCCGATCCCCGATTCGAACCTATGGTGGAGAAGATGAT
CTTGGAGATGACAGCCAGGCAACGCAAAGCAGAGGATCAGCTTTTACAACATCTGATAACCTGTCCCTCAGTTCCTGGG
TATCCTCTTCAACCAGTTTTCCTGGATTTCAGCATCCCCAGTCTTTGAGTGCCCTGGGTACCAGCACTGCATCCATTGC
TACACCTATTCCTCATCCAATCCAAGGATCCTTGCCTCCATACAGCCGCTTGGGAATGCCTCTTACGCCCTCTGCAATA
GCCAGCTCCATGCAAGGTACTGGCCCCACTTTCCCTTCTTTCCACATGCCAAGGTACCATCATTATTTTCAGCAGGGTC
CTTATGCAGCCATCCAGGGACTGCGTCACTCCTCCGCAGTAATGACACCATTCGTATAG | | Citation | Plageman TF, Yutzey KE. T-Box genes and heart development: Putting the "T" in HearT. Dev Dyn. 2005 Jan;232(1):11-20. | | Copyright | Copyright © 2005 Wiley-Liss, Inc. |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 31-36 |  | | stage 36 |
| Atria
Heart
|
Entry 3| GEISHA Id | Tbx20.Yamagishi.2004 | Data Source | Publication | | Complete cDNA Template Probe | show ATGGAGTACACACCGCCCCCGAAGCCGCAGCTCTCGTCGCGGGCCAACGCCTTCTCCATCGCCGCCCTCATGTCGAGCG
GCAGCTCCAAGGACAAGGAGGCCGCCGAGAGCACCATCAAGCCTCTGGAGCAATTCGTTGAGAAGTCCTCCTGCGCGCA
GCCTCTGAGCGATCTGTCCGGCCTGGAGCCCCACGGGGACTTCAGCGGCAGCCCCTCGGCCCTGTGTACCGAGCCCCTC
ATCCCCACCACACCCATCATCCCCAGCGAGGAGATGGCCAAAATCTCCTGCAGCCTGGAGACCAAGGAGCTGTGGGACA
AGTTTCACGAGCTGGGCACCGAGATGATCATCACCAAGTCCGGCAGGAGGATGTTTCCCACGATCAGGGTTTCTTTCTC
GGGAGTGGATCCTGAAGCCAAGTACATCGTGCTAATGGATATCGTTCCGGTGGACAATAAGAGATACAGATATGCCTAC
CACCGCTCCTCCTGGCTGGTGGCTGGCAAAGCCGACCCTCCTCTCCCAGCAAGGCTCTACGTGCACCCCGACTCCCCGT
TCACGGGTGAGCAGTTGATGAAGCAGATGGTGTCGTTCGAGAAAGTGAAGCTCACGAACAACGAGCTGGATCAGCATGG
CCACATCATTTTAAACTCCATGCACAAGTACCAGCCAAGAGTCCACATCATTAAGAAGAAAGATCACACGGCTTCTTTG
TTAAATCTGAAATCTGAAGAGTTCAGGACGTTTATCTTTCCAGAGACAGTTTTTACTGCTGTCACAGCCTACCAGAATC
AATTGATAACCAAGTTGAAAATTGACAGCAACCCTTTTGCCAAAGGATTCCGCGACTCTTCCAGACTCACTGATATCGA
GAGGGAAAGTGTGGAGAGCCTTATCCAAAAGCATTCCTACGCCCGATCCCCGATTCGAACCTATGGTGGAGAAGATGAT
CTTGGAGATGACAGCCAGGCAACGCAAAGCAGAGGATCAGCTTTTACAACATCTGATAACCTGTCCCTCAGTTCCTGGG
TATCCTCTTCAACCAGTTTTCCTGGATTTCAGCATCCCCAGTCTTTGAGTGCCCTGGGTACCAGCACTGCATCCATTGC
TACACCTATTCCTCATCCAATCCAAGGATCCTTGCCTCCATACAGCCGCTTGGGAATGCCTCTTACGCCCTCTGCAATA
GCCAGCTCCATGCAAGGTACTGGCCCCACTTTCCCTTCTTTCCACATGCCAAGGTACCATCATTATTTTCAGCAGGGTC
CTTATGCAGCCATCCAGGGACTGCGTCACTCCTCCGCAGTAATGACACCATTCGTATAG | | Citation | Yamagishi T, Nakajima Y, Nishimatsu S, Nohno T, Ando K, Nakamura H. Expression of tbx20 RNA During Chick Heart Development. Dev Dyn. 2004 Jul;230(3):576-80. | | Copyright | Copyright © 2004 Wiley-Liss, Inc., A Wiley Company |
Entry 4| GEISHA Id | Tbx20.Lincoln.2004 | Data Source | Publication | | Complete cDNA Template Probe | show GTGGACAATAAGAGATACAGATATGCCTACCACCGCTCCTCCTGGCTGGTGGCTGGCAAAGCCGACCCTCCTCTCCCAG
CAAGGCTCTACGTGCACCCCGACTCCCCGTTCACGGGTGAGCAGTTGATGAAGCAGATGGTGTCGTTCGAGAAAGTGAA
GCTCACGAACAACGAGCTGGATCAGCATGGCCACATCATTTTAAACTCCATGCACAAGTACCAGCCAAGAGTCCACATC
ATTAAGAAGAAAGATCACACGGCTTCTTTGTTAAATCTGAAATCTGAAGAGTTCAGGACGTTTATCTTTCCAGAGACAG
TTTTTACTGCTGTCACAGCCTACCAGAATCAATTGATAACCAAGTTGAAAATTGACAGCAACCCTTTTGCCAAAGGATT
CCGCGACTCTTCCAGACTCACTGATATCGAGAGGGAAAGTGTGGAGAGCCTTATCCAAAAGCATTCCTACGCCCGATCC
CCGATTCGAACCTATGGTGGAGAAGATGATCTTGGAGATGACAGCCAGGCAACGCAAAGCAGAGGATCAGCTTTTACAA
CATCTGATAACCTGTCCCTCAGTTCCTGGGTATCCTCTTCAACCAGTTTTCCTGGATTTCAGCATCCCCAGTCTTTGAG
TGCCCTGGGTACCAGCACTGCATCCATTGCTACACCTATTCCTCATCCAATCCAAGGATCCTTGCCTCCATACAGCCGC
TTGGGAATGCCTCTTACGCCCTCTGCAATAGCCAGCTCCATGCAAGGTACTGGCCCCACTTTCCCTTCTTTCCACATGC
CAAGGTACCATCATTATTTTCAGCA | | Citation | Lincoln J, Alfieri CM, Yutzey KE. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn. 2004 Jun;230(2):239-50. | | Copyright | Wiley-Liss, Inc. 2004 |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 25-30 |  | | stage 29 |
| Heart
| | 31-36 |  | | stage 36 |
| Heart
|
Entry 5| GEISHA Id | Tbx20.Shelton.2007 | Data Source | Publication | | Complete cDNA Template Probe | show ATGGAGTACACACCGCCCCCGAAGCCGCAGCTCTCGTCGCGGGCCAACGCCTTCTCCATCGCCGCCCTCATGTCGAGCG
GCAGCTCCAAGGACAAGGAGGCCGCCGAGAGCACCATCAAGCCTCTGGAGCAATTCGTTGAGAAGTCCTCCTGCGCGCA
GCCTCTGAGCGATCTGTCCGGCCTGGAGCCCCACGGGGACTTCAGCGGCAGCCCCTCGGCCCTGTGTACCGAGCCCCTC
ATCCCCACCACACCCATCATCCCCAGCGAGGAGATGGCCAAAATCTCCTGCAGCCTGGAGACCAAGGAGCTGTGGGACA
AGTTTCACGAGCTGGGCACCGAGATGATCATCACCAAGTCCGGCAGGAGGATGTTTCCCACGATCAGGGTTTCTTTCTC
GGGAGTGGATCCTGAAGCCAAGTACATCGTGCTAATGGATATCGTTCCGGTGGACAATAAGAGATACAGATATGCCTAC
CACCGCTCCTCCTGGCTGGTGGCTGGCAAAGCCGACCCTCCTCTCCCAGCAAGGCTCTACGTGCACCCCGACTCCCCGT
TCACGGGTGAGCAGTTGATGAAGCAGATGGTGTCGTTCGAGAAAGTGAAGCTCACGAACAACGAGCTGGATCAGCATGG
CCACATCATTTTAAACTCCATGCACAAGTACCAGCCAAGAGTCCACATCATTAAGAAGAAAGATCACACGGCTTCTTTG
TTAAATCTGAAATCTGAAGAGTTCAGGACGTTTATCTTTCCAGAGACAGTTTTTACTGCTGTCACAGCCTACCAGAATC
AATTGATAACCAAGTTGAAAATTGACAGCAACCCTTTTGCCAAAGGATTCCGCGACTCTTCCAGACTCACTGATATCGA
GAGGGAAAGTGTGGAGAGCCTTATCCAAAAGCATTCCTACGCCCGATCCCCGATTCGAACCTATGGTGGAGAAGATGAT
CTTGGAGATGACAGCCAGGCAACGCAAAGCAGAGGATCAGCTTTTACAACATCTGATAACCTGTCCCTCAGTTCCTGGG
TATCCTCTTCAACCAGTTTTCCTGGATTTCAGCATCCCCAGTCTTTGAGTGCCCTGGGTACCAGCACTGCATCCATTGC
TACACCTATTCCTCATCCAATCCAAGGATCCTTGCCTCCATACAGCCGCTTGGGAATGCCTCTTACGCCCTCTGCAATA
GCCAGCTCCATGCAAGGTACTGGCCCCACTTTCCCTTCTTTCCACATGCCAAGGTACCATCATTATTTTCAGCAGGGTC
CTTATGCAGCCATCCAGGGACTGCGTCACTCCTCCGCAGTAATGACACCATTCGTATAG | | Citation | Shelton EL, Yutzey KE. Tbx20 regulation of endocardial cushion cell proliferation and extrcellular matrix gene epression. Dev Biol. 2007 Feb 1;302(1):267-80. | | Copyright | Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. | | Comments | Authors said: The chicken Tbx20 sequence (GenBank accession number AB070544) was amplified from HH stage 20 heart cDNA using previously reported degenerate primers 5′-TGCTGRAAGTARTGRTG-3′ and 5′-GTGGAYAAYAAGAGATA-3′ where R represents purine and Y represents pyrimidine (see paper for refs). |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 25-30 |  | | stage 25 |
| Endocardium
| | 31-34 |  | | stage 34 |
| Endocardium
|
Entry 6| GEISHA Id | TBX20.Hasan.2010 | Data Source | Publication | | Complete cDNA Template Probe | show ATGGAGTACACACCGCCCCCGAAGCCGCAGCTCTCGTCGCGGGCCAACGCCTTCTCCATCGCCGCCCTCATGTCGAGCG
GCAGCTCCAAGGACAAGGAGGCCGCCGAGAGCACCATCAAGCCTCTGGAGCAATTCGTTGAGAAGTCCTCCTGCGCGCA
GCCTCTGAGCGATCTGTCCGGCCTGGAGCCCCACGGGGACTTCAGCGGCAGCCCCTCGGCCCTGTGTACCGAGCCCCTC
ATCCCCACCACACCCATCATCCCCAGCGAGGAGATGGCCAAAATCTCCTGCAGCCTGGAGACCAAGGAGCTGTGGGACA
AGTTTCACGAGCTGGGCACCGAGATGATCATCACCAAGTCCGGCAGGAGGATGTTTCCCACGATCAGGGTTTCTTTCTC
GGGAGTGGATCCTGAAGCCAAGTACATCGTGCTAATGGATATCGTTCCGGTGGACAATAAGAGATACAGATATGCCTAC
CACCGCTCCTCCTGGCTGGTGGCTGGCAAAGCCGACCCTCCTCTCCCAGCAAGGCTCTACGTGCACCCCGACTCCCCGT
TCACGGGTGAGCAGTTGATGAAGCAGATGGTGTCGTTCGAGAAAGTGAAGCTCACGAACAACGAGCTGGATCAGCATGG
CCACATCATTTTAAACTCCATGCACAAGTACCAGCCAAGAGTCCACATCATTAAGAAGAAAGATCACACGGCTTCTTTG
TTAAATCTGAAATCTGAAGAGTTCAGGACGTTTATCTTTCCAGAGACAGTTTTTACTGCTGTCACAGCCTACCAGAATC
AATTGATAACCAAGTTGAAAATTGACAGCAACCCTTTTGCCAAAGGATTCCGCGACTCTTCCAGACTCACTGATATCGA
GAGGGAAAGTGTGGAGAGCCTTATCCAAAAGCATTCCTACGCCCGATCCCCGATTCGAACCTATGGTGGAGAAGATGAT
CTTGGAGATGACAGCCAGGCAACGCAAAGCAGAGGATCAGCTTTTACAACATCTGATAACCTGTCCCTCAGTTCCTGGG
TATCCTCTTCAACCAGTTTTCCTGGATTTCAGCATCCCCAGTCTTTGAGTGCCCTGGGTACCAGCACTGCATCCATTGC
TACACCTATTCCTCATCCAATCCAAGGATCCTTGCCTCCATACAGCCGCTTGGGAATGCCTCTTACGCCCTCTGCAATA
GCCAGCTCCATGCAAGGTACTGGCCCCACTTTCCCTTCTTTCCACATGCCAAGGTACCATCATTATTTTCAGCAGGGTC
CTTATGCAGCCATCCAGGGACTGCGTCACTCCTCCGCAGTAATGACACCATTCGTATAG | | Citation | Hasan KB, Agarwala S, Ragsdale CW. PHOX2A regulation of oculomotor complex nucleogenesis. Development. 2010 Apr;137(7):1205-13. | | Copyright | Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Ragsdale. | | Comments | As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204144). |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 31-38 |  | | stage 38 |
 | | stage 38 |
| Midbrain
Spinal Cord
|
Entry 7| GEISHA Id | TBX20.Nathan.2008 | Data Source | Publication | | Complete cDNA Template Probe | show TTAATGTGAGCAGGGCCGGATTTTCACCTCTGCGCGCCAGCAGTGACCAGCGTGGCTTTTGGGAATGCGTTACTGCCGT
GGTTCCAGGTGGGCTGGTTTCCATGCTCCGATGGAAGCAATGGGAGCAGGCTGGGCTGTGTTGCAGAGCCGGCGGCCGG
GGCAGGAAGCACACAGCTTGTACACTTGTCTTCACACCGCTGAAATGAAAACGGTGCGGGCGCCAAGCTGCCAGCAGAG
CTTGTGCAGAGAGCTGCACAAACTTGGGAACTGCCTTCCCCCAGCATTATTTACGACCAGCTTATTCCAAATAAGCCCT
GTTTCACCCAACAAGCTCAGCCGTTGCCAGATAAATCAGCAGTATGTTATGGGTACTGAAATATGTTTTCCAAGCCCTA
ATCCCGAATACTTTTGAAACAGCAGGCCTTAGCACTGCACACTTTAAACAAAATCATTTTCATTCCAGAACACCCCATT
GGAGCTCCCCATACTGTTAACAGAGCAGCAGTGCTGCCTCTCACTGTGCTGCAGGAATGCTCTCCTCATGTCCCCACGT
GAAATCACACCAGTTGTGCCTGGCCATGCTCTGGCCGTGCCCTCTGTGCTGGGGCTGCAGTCACCACTGTGGTGCTTTG
GGCAGCGGATGGGGCTTCTCCCTGCATCTCTATGCTTTCTTACTCTTTATATTTTGGAAACTAACAAACGTTTTCTTTT
GCCTCTCCCAGATGACATCCGGGACACAAAGTGAGTGTAGTGCATCACTGTGTGAAAACCAGAAAGTTTTGAAGAAATA
GCCGATAGTCTCTTCTTAATTCCTTCTACTGCCAGCCCTCGAAGCAAAACCCGTTGTCTTTGGGTGTGCTCCTGCTGCT
GTGCGTTTGCAGAGGGAAAATGTGCAGGGGTCAGCAGTTTCAGAGGCAGGCTCTAATTTTAGGTTCTCAGCTTTAGATA
TTTTGGGACGGAACTTGGGACACAGCAAAAGAAGTGTTGAGGAGCCATAAATCTGGATGAAGTAAGCAACACCCAGCAC
CTCGCGAGCCGAAGACCTAAAACCAGAGACGCTTCTATTTAGAAGGGGAAAAAAAAAAAAAAGTCCTAGCATTTGCCAG
ATGCTGTTTTTCTTAGTTCTTGAGGTTTCTATCCTTCGCCACACTTCCCGCTATTCCTATTTTCGTATCGCCGTCACTC
ACAGCACTGACATTCACCAACCAATCCATGGCCTGCAGAAGCCAGGGGAGAAAAACTGCCTCTTCTCTGAGCGTGCACG
GGACCATGGCAAGAGTGGTTCTGAGTAAAGGCTGATGCTTGTTTCTGAAGAAAACACGCTCCTTGAGATGGCACCAAAC
TGAGTTTGTTCCGATGCTTTTAATTGGCAACATGTCGCTTGTTAATGTGTTTTAAATATGCAATTTATTAAAACAAAAA
CAAAGTAAACAAAATATTTATATGCCTGTCACGCAATACAGTTTTAAAGTGTTTGTTAAATAATTCTTAAGTTTAAAAT
GAAATACGAAGATATGAAGATACGAACATACGAAGATACGAAAGTACGAAAATACGACATTCTGAAAATACGAAATAGC
CAAGAAAGCTTGAAAAGCGTAATTCCGAGGTTTCCCATCGAATAGCTGTTGCTGTCAGCAGAAAACAAGAACAAGCCCG
AATAATCGGTCGCTGCTGGGAGCGTTGGAGCACCGCTCAGGCAGCCCCGCGTCCGTCCGCGGCGCGCAGCAGCCCGGTG
CCGGCTCGCCCCGCTCCGCCGCAGGATCGAGACACGGCCGGGGCAGGGGGAGCTGCCCCATTTTTAAGTCTTTAAGATG
AGTTCTGAAATGCAGGAGTGATGTCTGTTTTGCAGGCAAACGGTGGTGCGAAGGGGCGGTTTCAGTGCGCAGGGACCCT
CGGGCTGCGCTCCGCGGAACGTAACTAAGAGAGGGAGTATCGTCGGGCAAGCTCTGTTGTAGGGCGCAGCTGTGTGCAT
ACAGATGAACGGACGGATATATCCGTAGATGGACAGATGATGTATCTATAGTTACGTATATAGTTGTGTTTGTTTGTTT
GTTTGTTTGTTTGTTTGTTTTTCACGTCGAATGCTATTCCCATCCGCTAAGTGAGCGAGCCACGTTTTGTGTTTCTGAA
GGACGTTTCTCACTGCTTTTTTGTGTCAAAAAAATGGAGAACGCTTTATTTTGTGCAAAGAAATCACGCGACAGTCCTC
CCGGAGAACGCCAAAGCCCACTCCCTGTCCCCGAAGCAATTGGGACCGCGCACATACAGTGCGGCGCACTGAGTTCTTT
GGGAGCCCTTCGCCGGGTTCCGCCGCAGCGCGGTGCGTCCCGGGGGGGCGGGAGCGGTGCGGGGCCGGGGAAACGCGGA
TCCCGCGGGCACAGCGTGGGTGCTGCCGAGCTCGGGCCGGGAAAAGGGGTTTGCAGCCGTTCCTGGCGGCTCTCACAAC
GCGAAGCTATCCCGCAGCGCCCGAATTGAATTAAACGAAGGTGCCCGTGCCCCCGCGCCGGCCGCTGCCGCTCCGGGTT
ACGGCGGCGGAGCGCTGCGAGGGCAACGCCGGGTGCGCGTCAGCTCGGTGTGCAGAGACGGCTTCACCCCGACCTGAAA
TCGACGGGAGCTGCACACGGACGGAGGTTTAACTCCTTGAGAAAGCGTCGTCTCTCTCGTTAGGAGCGAGCGCTGCGCG
GCCGCGGGCTGCACGGATCGCTTCCACTCGTGGGGCTGCCCCAGGAGCGGGTCTGCTAAGCGGGTCGGGGTCGGGATGA
GGGGAGTTTCGGTGGTCCTCCCGCTTGGGAGACCTCGGGTGTGTGTGTGTGTGTGTGTGTCCCCGTGCCCGCTCCCCGC
GCGCAAAGCCGCTCCCGTCCGCCGCCTGCGATGTGCGAATAATTTTCGTCGGGGAGTTACACGGAGCGGGAGAGCTTTT
AGCACATTATCCGCCGGCAATTGGGCTCTAATCTCATTGCCAGCCCTCGGGTATTAATAGAGCCTTTCTCTTTGCGGCG
TTGGATTTGCATCGGGGAGATACCGAACCGGCCGCCTCTCTCGGTGGCGGCCGTGTTTTCCACGGCAAAAGGCAGCGAG
GGGTCTTCGTGGAATGGAGGGGAGGAGGTGGAAGTGTTCTTAAAGCTCGGGGCAGGGAGGGGGGAAGTATAATGAAATG
GCTCTGCCGTGCCCGAGGGACGCCAGCGGCAAACCCCTGCGCTGCGGTGCGCGTTTCGTGCGCTTTGCGGCACTGAAGG
ATTTCGTTCAAACGGGTTCGCGGAAGGCGAAGCGCTCCGTCCCGCTCGGGCGAAGCGGCGCTGCGAGAGGGGCAGCGGC
AACGAGCGGTGACATCCCCGGGGAGCGGGGCGCGGCGGGCACCTCCACCCCGACACCCCCAGCCTCGGCCCCGGGGGCC
CCGCTCCGCGCGCGTCTCCGCCAGGCCCGGGTGGGGAGGCCGGAGCCGGACCCCCGTTCGTTGCCCCGGGGAGCGCGGG
GCCAGACGGGCCTCGTTCCCTCATTCTCGTCAAAACCGAGAAACGAAAGGTTCTCGGCGGACGGAACGAAACCTTGCCC
AGCTCGCAGAGCCGCTTTCTCTCTCGCGGGGACGGACCCCGTTTGAAACAAAACGAAGCCCCACTCCGCGCACGCCCCG
CGTTGTACCGGCGGGGTCCCGGCCCCGGCTCCGCAGGAAGGCGCGGGTAGGGCCCGGTCAACCCCACGACGTGAGCCGC
ACCTGCACGGCAGCCCCCGCCGGGCCGGGCGCGTTACCGCCCCGCTGCCCTGGACGGAGCGGAGGGGACGGCCGGCAGT
GCCGCTGCTGCCGTGCGGCGGGCGCTGGGCTCTCCGTTCGCCCCATCCGTGCGGGCGGCGGCCCAGAGAGCTGCCGGAT
CTCCTTCGGGGCAAAGCGAGATCTCCTCTGTACACTTATTTTATTTCATTTTATTTTCGTATTGAATACGCGTTTGTCA
CGCAGCGTGTATATATGCACTGACCGAGTGCCGCTGATGCACGGGCAGCTCCGCGGGTGCTCTTCAGTGATCCCAGCAG
CGCGCTGCCGCCCCTGCAGCGCTCCCGGACCCCGTTTTGAGTTTAGAAGCTTTAGAGACAAATTCGCTCCTGCCCTTGG
GTCGGTTCGGGGAGCAAACCCGTTCGGTTTCTTTTATTCGAAGGACTTCGGTTACGTTCCCGCTTCTTTATTTACGCTC
ACACGGTGGGGCGGTGCTGTGCGGAGCCGGGAGCTGCGCTCCACGGTCCTCGTGGGCCCCTTCCAGCCTGGGACACCCT
GTGGTTCTGTGACTCTGAGAGCTGAAGGGAACACGGGGCACAGCCCGTTCCCATCGCTCCCCCGGAGCACCCCTCAGCT
GTGTCTCTCGTGGATCTCCGCGCCCTGCGCGCTCCACCAGCAGCACTCGGTGCTCTGGGACTCCGCGGGACCGCCACAA
AGCACGAGGGGTTTCGCTGCGTGAAAACCAACGCCGAGCGCGGGGCGGCCCGGGGGAGCTCAGCGCCCGCGGAAGGAGC
GCGGGGGCGGCCGCCCCCTGCCCACCCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCCGCATCCTCCTCCGG
CTCCATCCTCCTCCTCCTCCCGCCTCCGCCCCCTCCTCCGCGGCCGCGCCGAGCCCGGGGCCCTTGACGTGTCCCGCCG
CCGATTGGCCGCCGGCCGATAGCATCTCGGCGGCCGCGCGTTAAGGCGGGGGAGAGCGCGGGCCCGGCCGCAGAGAGCC
GCTGCGACGGGACGGGACGGGACGGGACGGGACGGGACGGGACGGGACGGGACGGGACGGAGAGGAGCATAGCGGAGCC
GAGCCGAGCCGAGCCGCCCCAGCGGGGCTCGCCATGGAGTACACACCGCCCCCGAAGCCGCAGCTCTCGTCGCGGGCCA
ACGCCTTCTCCATCGCCGCCCTCATGTCGAGCGGCAGCTCCAAGGACAAGGAGGCCGCCGAGAGCACCATCAAGCCTCT
GGGTGAGCGCGGGTGGGCGGGCGGCGGGCGCAGGTGGGCGGCGTGGGCGGTGTGGGGACGGGGCCCGGCCCACGCTCCG
GCCCGGCTCTGCCTCTCCCCGCTCCCCCCGCGGAACCGCTCCGCCAAAGCCGCTCCGGTCTTTTTTTCGTCGCTTTCGG
GAGAGGCTGCTCGGAGCGTAACCCCTTTCGTGGGTCCCTCCGGGTTCCGTTCCGCCGTTTCTTTATCGGGCTTCGCCAT
TCGTAGAATAATCTCACGCCCCGAGGTAGCCGCGTTTCTCTCTTCTGCTGCGACATAAAGCGCTGAAATACGCGAAGCG
AATCACCCGTGGTTCTCAAAGTCAAAGAAAAGAAGCCCCGGGGTACACGGGGGAGGACAGAACTGCCCGCAGCCCCGCA
GCCCCGCAGCCCCTCACTCCAAGCGCTCGCTGCGGGCTCCGAGCGGCAGCCCGCGGCATCCGGGCCGGCGGGTGGGGGT
ATTTCTGGCCATTCCGGGTGACTTTCGGGTGAGCGATTTGCCTTCTTTTCGATCTCCCGCGTTCCCGTTCCCGAAGGAT
ATTAAAAAGACGCCCTGCACCCCCATCGCCAATCCGTGTGCCTTGCGTTCCTTGCGCGTACCCAAGAGTGCAGAGCTCT
ACAAGAAATCAGCACCGCGCTCACGGGGCCACCGCCCGACGTGACCCTGGGCTGGGGGGACGGGAAGGGCCGCTCTCTG
CGCGTTCCCTCCGAGCCCCCCGCCAGGGTATTCCGGGGGTCCATCGCCAACTTTATTTCTTTGCTGAGGCACCGTGCAG
GCCGGCTGTGTCACAGTGAGCCTGGTGGGCACATTTACGCGGGCTAAGCTTGGCTATTTCTCTCGTTCTCTCTCTCTCT
CTCTTTATGACTACTATTATTTTATTTTTTTTATTTTTAGAAACGCTCGCTTAATCGATTTTCCAATATTATTTTTTTT
TTGACCCATTTCCCCACGCCATTCACTTAGAAATCCAAACGAAACGACTGCCTGCACCCCTGCTTCTATTATCTGGAGA
TCTGGGGGAAATCCCCTTTCCAGTCTCTCCCCTCAGCCACCCCCAGCCCCCAGCCGCCGCGTCCCGCAGCCGGGGTCGG
CTCCGGGCATCCCTCCCGTCTTTTGGGGATGAAGGGCTGGAGCCAGGCTCCCCATATTCTCGCTCAAATCACCGGCCGG
AGGAGCAGCGCGGCTCTGAGGGAGCGCTGGAAGGAGGGGCCCGACCGAGCGAGAAATGCCTCATTTTTGGAAAGCGCTT
TTTGCCGGCAGCCCGCCCCGGCTCAACGTCCCCTCTCTGTCTCCTCTCCCCCGAACCCCGCAGAGCAATTCGTTGAGAA
GTCCTCCTGCGCGCAGCCTCTGAGCGATCTGTCCGGCCTGGAGCCCCACGGGGACTTCAGCGGCAGCCCCTCGGCCCTG
TGTACCGAGCCCCTCATCCCCACCACACCCATCATCCCCAGCGAGGAGATGGCCAAAATCTCCTGCAGCCTGGAGACCA
AGGAGCTGTGGGACAAGTTTCACGAGCTGGGCACCGAGATGATCATCACCAAGTCCGGCAGGTACGGCTGGCGGCGGCC
CGATGGCAGCGCCGGGGAAAGGGGAGGGTTGCGGTAGCGAAAGCAAGAAAAAGAGAGAAATTTTTAAAAATAAAGGGGT
GTACGGCGGAAATAGAGACGAAAAAAAGTCCCAGCTGCCGGCTGTGACCCGGGAGCGCAGCGCGGACAGGGTTGGGAGC
AGCCCGCGTACGGTGCGCGCTGCGCTGCGCGGGGCGCGCAGGGGAGAGCCGTGCAGTGGAGCTGTGGTTGTGCTCGGAG
CTGCCCGCACTCAGCGGCGCGGGCTCCCGGCTGTGAGCTCGGGGCTGTGCCGGCACGGACGCCGGGCGGAAAGCGGAGA
TTATCGCTGCTCTCGTTTGTAAATAGCGCGCAGAAGGACTCCAGGCTTTGCTGTCGCCTCAGACCGTTCCGTTTTTCCA
GGGAGGTTTTTGGGTTGGGGTCGGTAACGCGCAGCCCGGACGAGCCGAGCGTCTGCTCGGGGTTTGTCCCGAAGTGACT
CGCTGGGAACGCAGTTTGCTGACTGTTTCTCTAAGGAACGGCTCCGGCAGTATCTGTTAAAAAATAACCCCAACGGATG
TACAAAATCTGGAATTTGGAGCTCATTAAAAATAACAACAACAGTAATAATCTCTTTAAAGTGGCTTAGAGCTATTTCT
GGTCTACGGCAGAAAAAGCTTACGCTTTAAAACTGTGAAATTTGTCAAAATGTTAATGCTGAAGGGAGGGCTGAATTCT
CAGAATGCCCCTCAGCAACACTGTAGGAATGCATCTGAGGTCGGTGAGCGTGTTTGCTGAATTAACCGCTGCGTTATTG
CTGTAGCTCCAGCACGTATCCCATTAAAAATAGACTTATCTCCGTGTTTCTTTGGCACAACGACTTTCCGGAAGCTCTG
CGTGCTGCTCGTAACCCGGCAAGACTCGTTGTCTCCTTTACTCTTTCACTTTTGCCATTTCTCTTTTTGCTTTAAAGAA
ATCGTTTGAGCTTCGAGCAGCGCTTCTGTGTATATTGTAGAGGTGCACAGGATGCGATTTCTGTCGCACTGAAGCAGTA
TTGGTCGATGCCTTCATTTATTTCATCTTTTTTTTCAGGAGGTTTGGATAGAAATTCCCTTTCTAGCAGCTTTTCCTCA
GCTCTTCTTTCTATCCCCCGTCCCCGTATTTATTTCCTGCTTTCCTCTGTTCCAGGAGGATGTTTCCCACGATCAGGGT
TTCTTTCTCGGGAGTGGATCCTGAAGCCAAGTACATCGTGCTAATGGATATCGTTCCGGTGGACAATAAGAGATACAGA
TATGCCTACCACCGCTCCTCCTGGCTGGTGGCTGGCAAAGCCGACCCTCCTCTCCCAGCAAGGTTTGTGGGCTCCACAG
CTGGATTTTTTCCCCTTCCCTTTATTTTTTTATTCCCCCCCCCCACCTTCCTGAAATACCTCCTATTAATCTTTGATGC
CGTTTGCAAACAGCGCTCTGAGAGCTCGAGTCCGCGCCCGACAAACCCGATCTCAGAGCTCGGATTAATTTCTATGGTG
CGGAGCGGGGCCTCAGATCTCCGTTTGAGGGCTGATTTATACCGAGAGTTCGAGGGCGAACGGGGTTTGGCCGAAGGCT
CTTGCTTATGTGCGAGCGTTTCTAAAGGAAGCTGCTGGCTGAAGGCTCTTTTCTGTCCGTCTGTATTTTGAAATGAAGT
TTACCTCAGTTCAGATCGGAAAAAAAATTCAAAAACCCATTGCTTTGTCCCTGGGTTTGTTCTGCCCTCCCCGCTACGT
CTGACCTTATAATTTAACGCAATCCAAATCTGGCAGAAATGCCACGTTACAGTGCAGTGCTGCTTATGCTGAACGTTAT
ATTAGTTCTTAAAAACATGCCCAGTGCTTACTGACCGATACTTTGATTCTTGCCTTTAGTTGTCCCTTATGTGATGAGT
GAGTGAAGTGTAGGTCAGTCCTATGGCACAGAGGGTTTCTTGTTGAGGAACTCTGGCAGATCTTGAGATTTTAGGGGGA
AAAAAAACAAACCCAAAACCCACCGACAAGCAAAGCTATTTTCTCTGCAGCAACACCTCTTCTGTACAGGAGCAAAACG
CTGTAGGAAACGAACGTCTATGAGCATTCCCTTACCGCCGTTGATGAGCACGGCTCCTCCCGGCACGGGGAAGCCGCGG
CTCCGGGCAGAGTGCAGCGGTTCCGCGGCGCAGCCTCCGCACGGCACTGCGATGCGTTGCGCGCTGCTGTCCCCGAACC
CCGCGGGACGGGACCACAACGCGACCGGCGCTGCTCAGCCGGAGCTGCGGGTGGACGGGGGTAGCGCCGGCGGAGGGCT
CCGCGCAGGCATCGCGGGCAGCGCCAGGTGCCTTAGCCCGGGGCTGAGATCTTGCTTATTAGAGAGAGAGAGAGAGACG
TTAGGAGAGAAGCAAGGAGTGGCAGCGCTTTGTTTTGATGGGTTTGTTTGGGGACCGAACGCTGAGAGATTTCCTCGTC
GGAGCAGAGCTCCGCTGAAATCCTGCTGACTGCTCGTCTCTGAAGGCGGCTCGGGGAAGTACGCAGGAGGAGTGCACGG
AGAAGCTGTTATTAAAGCAGCAACCCAGGAGTTATGGCAGCTTTGTTTTCGTGGCCAAAAGCTCCTTCCTGCAGCGTGG
TTGGCGTCAGAGGGCTTCATTTGGGGTATCGTAATGGGCACTGATCAAACCCCACAGCAAATAGATGGGTCCTGCTCCA
AAGGAGTCAGCACCGAAAGAAAAAAATAGGGGAAGGACAGAAATAGTTTCAGGGCAGGCTTCTCCCTTTAGCATTTGTT
TATGCGCCTTTTGGGGTACCCTTAGGTAGGCTGCTGATCGGCACATCGGCTAGCTCAACGGGGAAACATTCACAATATA
AGATAAGAGACCGATCCTTTGAAATAATGAGCAGCTCCTCTCCTGTTAGCTGCTACAGGGCTGGGGTCAAACCTTGCTG
GAATTTAACATTAATTACCACTGTCTGGTGGCAGCTCTCTAAGGTTCCTGTTGGGTCAGTGCTCCTGTGTGCAAACGTG
TACCTCTGCTGCACATCTCATTTCCTTTTCGAGTTGTTCAGCCAACAGACTGACAGCAGACACAGGTTACATCTCCTCT
GTACGCACGGTGATGCGTACATGCGCTTTCTGCTCCTATAATTATTGGGTAAGGAAAGGTTGGCAAGAGGAGGAGCGTG
CCGCTGTTTGCGTCGCCGATGCTGTTGGCAGAGCGTTGGTACTTTTGACACAGGAGGCCTCCATCCTGCCCGAGCAGAA
AGCAGCACCGTTCCCATCCTGAATGGATCTGCTCCTGCTCTGCTGAGAGGAGCCCTTCCGGCAGCACTCTCTCACACCC
CTTCCTCCCCAGGCGCACGGCTGTGTCTCTCCTCACCTGAGCAGGTCCCGAGGCGCTGCCTCCCCATGCACCTCTCTGC
CCTCATCCGTGTGGGTACCACCGCAACCTGAGGATTGCTCAGGAGTCCCCTTATGCCTACACGTAAGGCTTTGCAGAAT
CAAACCCGTGAGTTTCTCTGCCCTTTCTTATTATAAAACCAACTTTCAGCGCTAAGCCAACCTTCCTCAGAATTGAACG
GTAAGCTGTGATTCCCTCTGAAAGATGAGCCCTTCAGGGAACTTGCTGCGAGAAGCAGTAATATCCCTGTCTTCCTGCT
GTCAGACAAGTTTGTGCTGCAGCGAACACTTGCATAAAGCTACTTTTCAAGAGAGTGCTTTGTCAATCTGCTAGGGTGC
TATCTGGAAATAGAATTCCTGTGTGATACTTCGTGTTTGTTCTTCCAAATTGCTAAGGCTGTGAGAAAGAATCAGTTTC
AGCATGTACATTTGTTTGCCCCTCTTCTTTTTCATCTCCTTTCTTTCACTCATTAAGTCCCCCCCCCCTCCCACTCCCC
TCCACATACACATTTTATGTGGCTGCAGTCAGATGCCCATCATCATTTATTTAATGGAATTGTAGTGCTCGCGCACTTA
CGGAGGAAACTTTTTAAAGGCATTGTACTTTGAAAATTATCTGTTTGGGATGCAAAGGTAATCAAAAGCAGCATGTGTA
GAAGCTTTAGGGCTTGTAGGACCAGAACAGCTGCTAAACTAAACATAAGCAGAGCACTGCAGCACTCCCAACTATGCAT
GAAGGAAACCGTACCCAAACCTGGGCTGTATCATGAAACACCGTGGAGCAAATTCACAACCAAATAAGGCTCCCGAAGC
TGCAGTGAGCTCGGGCAAATGATCCCCGCATCCGGCCGTGGGCAGCAGAGCTCGCGCAGCTCCGGGGCTGTTTTGTGTG
CAACGCAGGAATGCGCGCGTTTATTTCTCTAATCCACTCACATCAGCTTTCCCAGCCTCGGAGGGCAATGCATTTAGCT
CTGAGCCCTCTGCTGCAGGGTCAGGCTGCAGGAGAAGCGTGCGGGGAGGTGCGGTCAGCCAGGTGGGGCCACGCGTGCA
GCGGGATTGGAGGCATGCGGTGCATCAGCATGGAAAAGCCAGGTTTATTACACGTGTGCCTAACCACTGTTTGGGTGCC
AATCCTTCTGCGTCTTCCCTGCTAGCTCGCTGCTAACTCATTCACAGCATGAGTGCTGTGCCAGCCATTAACCGCATAT
GGCATAAAACAATGGTGCTCGGCTTGTAGGCACACAAAGATCCTTACTCGCTCCCCAAGTGCATATTTGAAATAGTTTG
GCTTTTTGGTCCCAATTAGCCAAACCTTGCTGAGCCTGATGCTCTCTGATCACAGTAAACAGCATTAGCTATCCAGACA
TGCAAAACTAGGAGTCAGGCTCCAAAAAAATCATGAGACTGGCTGCAGAGATGCAGGGGCTGGAAGCGATATGGTCAGG
ATTGTTTTTTCTTTGCCTTCTGTAATTTGAGGCTTCGAAAATCCACGTTTTTACTGTTTTATACAGGAAAGCGAAGTGG
ATTTTGATAAAAGATCTTAGGTTTTCAGGCACACTGTTATTTCCTCGCGAGCCTTGCTCTACAGCTGGGAGCAGGGAGA
ACCCTGTGTGTTGGGCTCGCTGGCGCAGCATCCCTCCCATGGGTGCAGCTGCACCAGCCAAGCGGTGCTGCGGATCAAG
AGAAGGAAAACATCCTGCCCGCCTGGAGTGAGCTGTGCCAGTAAAGCTTCAGTTTCACCAGCAGGACTGTGCCTTGTGG
ATTCTGTTGGCAAAACAGAGAGCCCACGATCACATCTCTTTCCTCTTGGAGCAGCAGAGCGGTGCCTCAGGGGGCTTTA
GCTCAGCTGTTTCTTGATTAGGGACCTGCGTGGTCCGTCAAGCAGTTATGCCTCATTGTTTTGTGGGTTTTCCATTCTC
CTTTTGCTTAACTAGAACCATGGCTCAGTGAGAAAAAAAGAAAAGCAAACAAATTCTCTCTCTCAGCCAGCATCTCAGC
CTTGCGTGATGGAGGGAATCTCTTGGAGTGGCCAAAAACCTTGTCTGTAGAGAGCCAGGCCCTCTGCAAGTGATAACGC
GCACCGACAGCAGCAGAACCAGCCTGGTTTGCACTGGCTGAAGCTCTAATTCAGCCCTTAATTTGCTATCCCAAAAGCA
CTTTCAAGTGAAATCATTTTTATCACTATATTATTCGTATAAAATCATTGTTTTTAAATAGCCCGGCACTTGCACTGAG
TCCAGTCATAACGTATATATCATTCTATCTACATGTCTTCCTTACTTCCTTTTCTTCTGCTTAATTTCCTAGGTTGTGG
GCTGTTAATTACAGCGTTGCAATTAATTACTTTCATGTCAGACCACTGTCCTGGACTGCAGCCCTCAACCTCTTATAAA
CACACGTCACCACAGCCAACGTGTGATCGAATGCAGGTTAAAATCATTATCACGGCTTAATGTTACATATAAAGAAAAA
TGCATTTTTATCTGCATTCCCCCATTATCTCCCTAATGACACTGTGTTTTTTCTCTTGGAGCTGTAGTCATTGTTATTT
TAAGTGCTTGTTAGTACAGCTGTGGGGAAAGACGATCAATTTTTCATTTGGGAAAAGAAGCAACAGTGACCGTTAGTTA
ATGTCTCCATTTTAGATAACTAGATAAAATAATAGCTATGGCCAGGGAGCACTCTAGCACTTGGTCACAGAATTCTTCA
TTATGTCCCTGTGAACTAAACAACTTCAGGAATCTGCTTTACTGTCTTTCATTAATGGCATTCATTCATCTGGGCAGAT
TGCATGCTTCTTGCTGTACTAGCAGATCTGTATTGCCCAGAGCTCTCAGGAAACCCACTGCTGTGAAACCACGGCACAT
CTTGAAAGCAAAATTTTGCTTTGCATTTTCCTATGGAGTTGGTACCTATTTGAGTCGAGTTTTCACGCAGAGGCCTTTT
CACCGTGTCTTTTAGGCTGTACGTGCACCCCGACTCCCCGTTCACGGGTGAGCAGTTGATGAAGCAGATGGTGTCGTTC
GAGAAAGTGAAGCTCACGAACAACGAGCTGGATCAGCATGGCCACGTGAGTAGCCCTTCTTGGGGGAAAGGACCAGGAG
AAACAGCACTCTGACACTGCATCCGTTGGGGATGGGGAAACACTTGGGGTGGAGCTGAGCATTTCAGTGAGGGAGAAAA
GGGAGGACTGAGCTCTGTGCTGTGCTCCTGCATTTGCCTTGCTGTGACTTGGCAGCAGGCTTAGTGACCCACCCTGGCT
TGCAGGCTTGCATGCTTGTCCCTGTGTGCTTGGAAGATGCCTCTCATTGCAGGCCATCTCTTAGGTTTGGGTTCTTCCA
CAAGAACTCTTTTACCTCGAGACTCAACACAAGTTGGGCATGGAGTTAGCAGAAAAGACACCACAAGAAGGGATATGGT
AATATGAAATGTGCCTCAACAGCTCTTGAAATAACTATGGGATGCCTGAAAATCAGCGTACCACGGCATTCACTTGATG
CGCTGGAGAAAACCGGCCCCAAAAGAAATTTGGTCTTGTCGGTACCAGCCTGATGTCAGGAGACCTAGCTGGAACCCGG
TGGATAGGCTTATTGGCTGAGAATGGGGAAGTTGAAAGGAAAGAGCCTAAATGCAGGGTCAGTAAATGAAGTGTCAGGA
TGAGGGGGCTCATTATGAGCTCTGACGCGTGCCAGGGGGTAAATGACCGGTAATGCAGAGCAATAGTGGTGTCCGTGGT
GTCAGCAAGGCCCCCACAGAGTGCTGCTTGTTGCTTTTGCAGGCTGGCTGAGGTGGCAGCTGACCACCTGAGCTGCACT
TGGTGCTAAAGCTTCTCATCTGAGAGAGCATTTGTGATCATTTCAAGACCTAAAAATTGAACCACAGTCATTTGCATTT
AAAAATCCTTCTAGAAACAAACAATCAAAAAAATAGTTCCTTTAAAACCATGCTCAGCTAGATGCCTACGTGTTGTTCT
TTGTTAAGCTCTGTGTGTGGATATATTTTTCTTGAATCCAGTTTCCAGCACTGCTCCCTTCCTAGCAGAGGGACTAGCA
GAGGCTGTCTTTTTTTCCCCCTCTTATTTCATAGTCTGTAGAAGGGCAAAGCTGAAGATTTGTGGGCTCTTTCACCGAG
TGATGATAGAGCAGTATAAGTGCGCATTTAAAAAGAAGCATTTTTCATCATAACAGGGGCCATGTGTGCCTGTAATAAT
GGGCTTGCAGCAGTATATCGCACACTAGTTAGGAGCGGTGCAGTTCCCAGAAGCCCAGACGAGTATAAAGAAGAAGTCG
GTCTGTGAAGCTGTCGGGAATAGGGACACATAACAGAGCAAGATGTCAGTGTTTTGCAGGCAGGCAGCGGGGAAACATG
GCCCGCAGCGGGTGAGGTGTGGCCAGTGGTTCACTTTCCAAGTGGCGGAGGTGGAACGCTTTCTTTACACAAAGGCTTT
GGATGGCTGAAGTTAATGGAAAGTTTTGCACATTTGGTTAAGAATAAGCCTGGAAGGCTTGATCCAGGGTTGAGATTTG
TGTGACACGTATTATGCTATCGTGGAGCACTCCCTTTTTTGTGTTTCTTCATGTTCTATATTCCAAATGAGGGTGTCAG
GTTTTACGTGCTGCCTTATGAAGCCGTGTAAATATCATGTCTGGATGCTCTATAGAATGAAGGAGTGAATTCCTCCTCC
GAAGCCTTTAAAGGGTGTTAGCTGTGGCATGGCCAATGGGTCTGCTGAGGTCCAAGAGAAGGGAGGAATGGAAATGCCT
CTCAAAGATTCCCTTTTTGTTTGAAAGAGCTGTGCTTTGCTGAGGAGATCTTTTTAATTATCCTGATAAAATGTTAATT
ACATTTGATAAGGCGTGTTACTTCCTGAGGAAGCTTTAATGACCTAAAACCTGTCTTTAGATACTAGTTATGGGTGCAG
CAGTTAGAACCAGCTTAATTTCAGTTTGTTCTAGTGGCTTGCTTTCTCCATCATCCAGAAGACAGTTTTGGTTGTTAAG
GTAATTGCGGTGTTTTATTTGTAGAGTGGTTAGTTTCCTGAAAAGGAATCTGAAGAAAAGAGAGGCATTTGTTTGCCTT
ACCATTTGTTTGTTTTCTCTTATTCTGAGACTTCTGGAGTTGGCAAGCGTTGCTGCTGTGTATCTTCAGCAGCACACAT
AACCCCATAGCTATGAACATTTTCTCCCCAAGCATCAAGCAGAAGTCTTATCTCTGTGTGCATGACATACAGTTTGCAC
CATGGAAACACTTGCAGATATCCTTACCAGAGAAAGGAAATGGCTCTCGCCTCTGGATTTCTGCAGCAGAGCAAGTAAT
TCCTCTTCCTTTTTTTTCTGCTTGTGATACACTGATGAGCAGGATATTTTCCAGATTTCTGGTGATGTTTTTCACACTG
GCTGTTCTTCCTGGGACTTTTGGTTGCACTCAGTTGTGGTGGCATTATTTCTTGTTTATGGTGAGGTGAATCATGAGTG
TACACATTATCATAATTGCTTTTCTGGCATTTATGATAGCAAAACTTAAACAGATGAACGTTTGCAAAAGCAAACATGG
AGGTGTGAACACAGGCAACTGTGAAAGCTGGGATTTCAGAATAGCCACAGGCGGTTACGCCCAGGTGTTTCTTAAAGTT
AACCTGGCAGAAGTTAGGAATCTACAGGCTTTTAAAAAGCAAACCTGGCCCAGCAACTCTCTTCCTGAGCTAATGTGGA
AGCTGAATTCCCAGCACAGTTCCCAAATTCTAAGCCACCTCAGGGATTTCGCATCTGGCATCCAGATTGCTTCTGGTGA
CTGGCCTGCCATTGGTGGGAGCCAGTTGCCCACAAGGCCCACCGGGCCCCTGCTAATCCTAGAAGGACCTGTTCTGGCC
ACCTCCCTGCCTGAGGTGTCAGTCTGGGGGCAGATGGGATGGCCAGAGGCCTGTGGTCATGCTAAATGACCAGTGAGCA
CCTGATGTAGCCAGATCCTCCAGGTTGTTTCCATAGCCCTGACACCCAACAGTGAATTAAGGTGGTAGCTTTGTGCAGT
CTCCAGTGAGTGCAGCCTGTGTGGGGATGCAGGCGAAGCACCGCATGCAGAGAATCTTAACAAGGGCCCTCCACCTTGG
CCATGGGTCTCCTGTCACTTCCGGGCTGCATTCAGTTGTTTTGGTCCTGATTTGCTTCTGGGGGGAATGTGTGGTGTAG
AAAATGGCGGCAGAGGTTGTTACTTGTGTGCTTTTGGATTTGGAAAGCTCTCAAAGAATTACATGGTGTTGTTTGGGAA
ACAGAGTTTTTTTCTCATGACTGATGGTCACAGAGGAATGAGGGGAAGGGGAATGTGTGGGGCTGCTGTGTCACAACCT
GCTCCTCCTCCTGCTTGGCTGCTACTCAGATGTGGTGCTGGAGCCTGGATATTGCGGCCATGACAGACCATGGTCTGTG
GTCCAAGCCCTTGGTAAGCTCACACCATCTCCACACTGTCCTTTCAAAGGTCTCTTCTGGCTGCCTAGAATGGTCTGAG
ACAAGGCTGGTAAGACAAAATCTTACAGAGATATAGAAATGTGCTGAGGATAGTAGCAGTCATGTCAATGACCCATGTC
AATGACCATTGTGTGTGTATGATAAAATGGTGGAAGTGATCAGAAAAAGGATCTTAGTTGGTAGGGGCTGACATGAATC
ACTTTAATGGACAATGGCTCCTGAAGTGACTTCTGCGATGTGCATCCCTCACCCCTAGAGTCACAGTGCATGTCATAGC
AATATTTGGCCCCAGAGGAAAAACAAAGACATGCAACCTTTCCTATTCACTGAGCTAGCACAAAGTACTGCCCTGCTTC
TGCTGTGTTTCAGCTGAAGTTAACGCTTCCCAAGGAATGCACATTAGCTATTCCAGATGTACAGAGCTGGCTGCAGTGT
AGTTATGGCCCCTGTAAAATAGAACCACCCACTCCTTTGCCAATTTAGTCTTGTGACTGTGATTATATCCAAAACAAGG
ACTGGTGCAAGCCGAACTCTGTATTTAATTCTTATATTGTAATGCTGTGGTTAGAGGCAGCCAAAAAGACCTCCATCCC
ATGGTAATTCAAGCAAATGGGAATCGCTGTTTGACGCCAGTGAACATTGGAATTAGTTAGTTGGTATGCTAAGTTTAGA
ATTATTTTGGGGGCCCACAAACAAGAATTAATGAGACAAAATGGAAAAACTTGGTCATTTGGGGTTTCTGTTTCTCTTC
TTTCATTTTTGGTAGTTTATGGTGAAGAACATCTATCATGTAGGTTGCTTTAAAGGCTTGCTATCATATAAAGGTCTGG
GAAGTTTTATTTTTTGGTCAGACAGTTTGTGCTGGCATTGGTGGGTTTTTTTTTTTTGGTTTTTTTTTTTTTTTGGAGG
GGGGTGATTCTTGGCTTTCTACATTCTGCACCTGCATGATTTCGTAAATGTTAGGCCTTGGTCATACACTTTCAAGAAT
AAAATACCCACATTTGCAGGTGAAACCCGCAAACTAGGTCCTGTACAAGCAATAATGTCATGTAGGTAACACACCTCGT
CTGTAAGAATAGGTACTTATGCTCCAAAAATGGATGCTTACCAGTAACATAGGAGGCAGAGGAAACCAGCTCTTGAACT
GACTCCTTCTACGGCTTCATTTTCTGAAGTCAGGATCTTCTCAAAAGATCTGAAGAGCTCATTGCCAGAATCAGCCCCT
GACCAGTTTTATAGTCTTTAAGGGTCTTGTTAATCTTCCTCTCAGGACAGTGCCTTGTAATTCTTTCTTGCAGATCATT
TTAAACTCCATGCACAAGTACCAGCCAAGAGTCCACATCATTAAGAAGAAAGATCACACGGCTTCTTTGTTAAATCTGA
AATCTGAAGAGTTCAGGACGTTTATCTTTCCAGAGACAGTTTTTACTGCTGTCACAGCCTACCAGAATCAATTGGTGAG
TACGGTTGCTAATTTGCACAGATATGGTTAAATTCCACCCTGCTAAAAATTCCTTTTTCCCCCAGTCTTGTCTAGCAAA
GTTTCTGATACAACCTACCTTTGCATTCTAATGTTTGTAGTGGCTTTGGCTGGCTTCATTCATATTCACAAGTCATTCT
TATGTATATGGATAGTTCAGCTAACTTCAAAGGGACATAAGAATTATTCACAGGAATAAAGATGACATGAAAGTAGCTT
TCATTTTTTTCCCCTTCTTTCTATACAAGGCAGTTTGCGTATTATCATTTTGTCCTTTTCTAATTCAAGTTCATTAAGG
AACCGTTCTTATTTGAAGTGATCTTTCATGCCATGAGCAATTAGCTGTGCAATACTCTGGTTTGCACATCATGATTTCA
TGGGTTTAAAAAGTTGACTGATTAAGCTGTTAGGCTCAAATGTAAGGGAATCACTCTGAGATACACTTTTCAGAGGCTG
CCCAGATTACATCCAGATGTTTGAATTTCAATTTGCATGCCAGTGAATAATGTACACAAAACGGAGGAGATCAAAACAA
TGGATTGCTAATGAGTAATTTTAGGAAGTATATAAACAATTGGAAAGAAGAGGCTTTGCTTAATAGTGGGCAGAGCTTT
AATTTTTAAGTCAGTAGAAATATGTTGTTGGCTTCATTGCGATTCAAAATGTATTTAAAAGGATTAATGTCTTCTGCAT
TTCAAAAAGGCAACCCTTTCCATCTCTAATTCCCCCAAGTTAAGAAAAATTTAAGAAGTACTGTCCAAACATGTGGGCA
GGCAGCATCCTAGAGTCAAAGAACCTACTGTTTTCTTAAAGAAATCTGCTTTTCTTAATATAAAGCAAAACTAACTCAT
TTCCAAATGCCACAAATAAAATAAAACTACAGCATGAGGGTTCAAATAAGCCATGGTTGCAGTAGTAGCAGTGTTAAGT
TAGTTCCTGCGACAGACCCCACCTCCAGCTTTAAGGCTCAACATCTGATGTCTTGATGTAGACTCAGGTTCAGCACATG
AAAATCTCAAAAAACCATGTAGTTTGAACATTTGGTTAGATTTTTTCCTTTTAACTTTCTGTAGAAACTAGTAGAACAC
AGGAGGCACTAAACTAGCTAAACCTGGCATTTATTTCTATAGGATGGATTTATGTTTACTGATGATATTTATATCAGAG
ATGTTTCCAAACTAACCTTCTCAAAGCACATGCAACAAGTCCTGGAAAATTTCTCAATGGAACATCTCCGGAACCCCTG
GAGGTTGATGCTGTCATTTTATTTATGACTAATGAAAATGGAGCCTTTTTTCATTTTTGCCATTTCTTTCAGAACTGTT
TTAAGGAGGGGTTGATTACATTTCTGGAGGTTATTAGATAAAAGCTAAATACATTACACTTTCAACAAACTATCTCATA
ATTTAAGATTTAAAGGGCATGCATTTATTTAAACAGTCAAACCACTGCCACAGAGTTGAATTGTAGGTCAAATTTCATT
TTAAAATGCTTTCTAGCAGATGTTCTCTGATTGTTTGTGAGACAGTCTCTCAGGAAAAATATGGCCATAAATGATTGTG
AGTCTCATCTGGCTTTGGTGAATACAAAAAGTTTCTCTTGTGATGTCATACCAAATCTTTAATATTAGGAAAATGGAAG
TTTGATTGGTGAAAATACACTCAAGAGATGAATAGAAATCCTCATGATTCTGCAGTACACTTGGCTCAGTGTGCTGGTG
ATCTAAGTCACTCAAACTAGTTAGGGCTTGTCTTTTTGCAAGGTAGCTTTCAAGTGCTGCCACAAAAATGTTCCCCATA
CGTGAGGCACCAACCTGCTGCTCTTCCCAGCATTGCTGCAAATCTGGCACGTAGACTTCTCAGGAGATGGAGGACACTG
CACCTGGCTTGCTGAGCTGTTGTAAAGCTAGTGTTGAGGATGGTTGTCACTGTGTGTGTTTGCAAGGCAGGACAGCCCC
AAAACCTCAGCCAACTCTGAGGTGCTATTTGACCAGCCTCCACTGACAACCGTGGGCTTGATGACAATGTGATTGTCTA
AGGATTTGGAAAAGACCCCTTTCCTTTCTGAGTCTGTAGGGCCATCCTTTAAAAAAATGAAGACTTTTTTTTTTTTTCT
TAATGTGAGGAAAGTCAGACTGAAACCACTGCTCAGTAGGCAATGTTGACTTTCGTCAGTTGTAGCTGAAGTTGGTGGC
AATCGCTGCCCTTCAGGACAGACCCCATGTTGTCCCTCTGTTCCAAGAAAAACTCTAACTCTCACGTGCTGTTTAGCAT
AATTAGTAAATCCGAATATTGTTTTGATTGTCTCAGGTGTTACTCACTAAACTGTTTTTAACTGGACAGCTAGAAAACT
GCTAAGGGCAACAGCGTGTTTTCCTGCTCCCAGAAACACAGTGGAAGCCCCCATCTCTTCCAGGGAAGTTTCACTGCAA
AGTTCAGTGCATCCCTGGTGCCACAGGGTGTCCTAGTTTGTGGTTACTCTGGCAAAAAGTAAAGGCTGACAAAGTGTAC
AAAGTTGTAGGGCTGCATTTGAAGATGGGAAAAGAGTTTTTCTTACAAGAGATCTGGCTTTCTAGGACTGACTGTTTCA
ACGGGGTTTACTATTTTAGCCCTTCCCTTCCCTTCCCTTACCTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCCTTCCATCTTTCCATGCAAAAACAGCTAAACTG
CCCCTGTGTGCTGGAAGGTAAATCTGGCTGAGAATATTTGCATGGCAGTTAAAAAAAACTGAAAAAAAAATGGGACTGA
AGTTTGCAGGCAGCCATTCACGGTTTGGACATAGCTGATGTGCAGCTCCACTGGAGAGGCTCAGATGTTTGCAGGGTGC
TGTGCTTTCTCATGATAAAAAACCTATCTATTTGTGTTTTCTGGAAGCAATAATGTCTTATGAGGGTGGGTTACTCCTG
CTCCGGGTAATGCAAAGCCTGAGCCCACTGTACCCTTTGGTCTTTCTGCTCCTGTATAGATAATATACGTGGCTTTGCA
GCACCTCAGGAGTTGTGCACACATATAAAGAACACGGATACAATTAGTGGTGAAGTCAGGAGAATGGATAGGCAAACAC
TTTGTACGCTGCCATACTTTAACACTATTTTCATGTTGCGTTGCTTTTTTCTGTGTTTCCAGATAACCAAGTTGAAAAT
TGACAGCAACCCTTTTGCCAAAGGATTCCGCGACTCTTCCAGACTCACTGATATCGAGAGGTAATGGGGACTTTCTGTT
TACTTTCCATGCAGATAAGATAAAGAGAAGGGAGAGTTTGTAGGAAAAGCATCCTTTCAACTCCTGAGAAGCTGTGCAT
TTTAAAGTTATCCTGTTGCATATAGTAAGCCCCCTGCACCTCCTTTAAAAATACTTACAAACTTTACGAAGAAAGAGCT
GTTTTGAGTTTTGACATCTGTTCCAGTTGGGGTCGATATATTCATCTTCCTGATGGGGCTTCTTGGAGGGAGAGACAGT
CGGTTTTAAACCTTTAGAATGAAAAGCTTTTTTCTTATCGTGCCATTTAATCCTATTGAGGGCTGTGAATTGGGTCACA
GAGAAACAAGGGCAGTGGTCCTGTGAAAAACATCTTTATAGCTCCTCACTGCTTCACACAGTGGAAAAGAGAGAGGGGA
GCTTCCCAAAATACACTTCAGCAGTCCCAGACACTGAAGTCAGCAATTATTGCCATCAGGACAAATCCCATAACTCCCA
CTCTGACGACAAAGATGCCATTTTTGTTTCACCAAAATTGTACTGCAGGCTTCATCAGGGGAAAGCTTTATCTGCAAAC
TGTGGAGTTTTGTGTGTACAGCTCATTATAAGCAACTGCTGCCATAGGGACGGAAGCATTAACCCACAGCTGAGTAGGA
AACAAACTTCGATCTCTTGGTAGCTTTCCAGTGCATCACATTTTTATGATATCTTGTCGAATGGTTTGGCAAATGAAGT
AAATTAAGCAGCCTGCGTCCTTTAGGCTGGAAGAGAACTTGATGGAGATGGATATAGCGCATCCAATTTTTCCTATGAG
TATATGATCATGAAAGTAAACTGGGAGAGGCCAAAACCCTCCAGGCTCCTATATGGGGATATCCAGATGTATCTGTGAT
TCATTTTCCATGGGTGCATATAGGGGACAAAACGGAATATGACTTTATTGAGCATAGAGCTAGAAAATCTCCTCACGGT
ACTGCAAAAGCATATAAATCCCAACAAATCTATGGCTGGAAAATGTTGATATAACTTATACCTTACTACTACTGGATCA
TTAGTGATCTGTTAAGTAGCTGGGTGAAAGAACAGTAATTCTGGGGGGGGAAAAAAAGCATGTGAACAATAATGCATGC
TTGCAAAGCTGTTAAAGATTTCACTCTAGATGAAGGTCTTAGACGAATATGGAGAAAAGTAACATAAAGTTAACTAAAA
TAGCATAGCCTGGTTTCTGGACAGAACACTAGAAAACAATGTACAAAGCTCAGACAGTAATGCAGTAAATAGTCAAGAA
AGGACCTGTAGGAAGAGAAGAAAAACTGAAAAACATTTCAGTTTCCTTGCTTTACAGACAGGCAACATCTAATGACACA
GTTTTGCAAAGGCTGAGGGAGTCTGAGTAGATAAGCGGGAAGAAAAACTGAGTTACCTTTGTGCTGATGAACTGACTAT
CGTGGTGCTGGGTATGAAGGGAATTTTTCCAGAGGACATCTTATTATAACAGCACATGGCACGAAGTCAGAAATGCTGA
GCATAAACCACAGTGCCCTTTTGTTTATTGATAAGAATAGAGCCTGAGACAGGCAGCTTAGCCCAGGCATGAGTGTTGC
CATGAAAGATAAAGTATCCAAATGTGAAACCTACAATAAATACAAAAACAGACTGTGGAAAAGTATTGAAATCCCATTA
AAACTCTGCATTTGAGAGTCTAGATTTGGATACAATCTTATTTTCACTTAAATGGGAGCATTTAGTTCTGATTAGGGCA
CAGTGGTGTTTAAGAAAAAAGATCTGCCGTACTGTTTATCAAGTGATAGGACAGTAAATGTGTGGTACACAAGGGGGCT
AGCTAATAGGAGATTGAGAATTTCTTAAGTTATCAGATGTAGTCCAGACATACCAAAGGTTTTATTTATTTCCAGCATT
AAATAATCAGGCACATAAGAATGTCATTTTCAAAGTGCCCACTGTTCTACAGCTTTCATCTTAGCACCAGCAATATTAC
TTAAATAAATCTGATGTGAAGCAGGAGAGATAGCAATGTGAGGTATGACACAGGAAGGGTTTCCGGGCTTATGTCCAAT
GAGGTGAGCATTACAAAATGCAGGGGATACACAGGATAGATCAGTGTGACTCTCACTCAGTCGAGTTGGAAATGTGGTA
CGTTTGGTAAGACAACTGTCTGATAAAAAATCCTTGTAGATACATACCATACGCATCTATGCCAGGGGAAAGTCTGTGT
AGTGGAACTGCACATTTGCCCAGCTCTTGAAAAATGAATACTTACCTAGAAGCTGTGAACCTATCTTCCATGCAATTCT
TCCTAAGACAGCTTGTGTTCAGCGTGTGCATGCATAATCTGCTATGTTGTGCCGTGATCTTAACGGTCTCCTGTAAAGC
TGCCTGTGATGTTAGGGCCAAGAGAGCGCTAATTTATCGCAAGTTCCAGCTTTTCAGAATGACCTAAGTAGTGTGAAAG
TGTACAGAGCTTTCTATTTCATTTCCAGGTATTTAAGCCTGCTTTTTCCTAAACAGCCTTTGGGGAGGGAAACAAATCA
GATCAATTGATCTTTAGAGACCTAAAGAAATTAAATTAGTCTGGAGTCAGTTACTGCACTAAACCATCCGGTAATTGGA
TTGCTCCTTGTAACTGATTGAAAACAGCCCCTATCTGTAACAATATAGGGAGCTTTCCTTTATAGTAGATCTGAGAGAA
AAACACATCTTTTTATGACATGATGACAGAAATTGCACTTTTTTAACCTAATTGAATATGATTTTATAAATATGTGACT
TTAACGATTTCAAGCTTCCCATTCTAGATTTACGATCTCTATGTAGGAAATTCAAGCTGCAAATGCCTTTAGGATTAGA
TTTGTTTGCATTATATGTGTTGGAGTTATAATATATGTAAAGGTAGTCAGGTTTGCAAAATGATAGAGGAGCTCGACAA
ATGCAAAGCTATTCAAGTTCCTGCGTTTTCTTTTGTTGTTGTCTAACTGCCTTACAGCCGTTTGCTAGTACTCATAGCT
ATCTATACAAAGCTTTTAACTGTTGAAAAAAATCTTATGTTAGTTTGGTATATATTGAATTTTCAGTAGGATGTGAGAT
TCCTTCCTTCCACAATCAACTCTTTCCATACGTTACTTGTGGTAATCTATTTATGGCAACGGGACAGGCTTTATCTGTG
GCTACTGTGATTTAGATAAGTTCTGACTCACCTTTTGATCTTTTTATGTGGTATTTGCTTTTTTTTCTATTATAAAGAA
AGCCTCTGCAGTGGTTGTGATTGAAAAAACAAACATTTAGCTGCAATTACCAGACTGTGGAACTTGATGTTCTATGGTG
TTGACTACAAGACGCCACACACAGTAATGCAGATGATGAGAAATCTTTTTTAATGGCAAACTTTGTTTAATAATAATAG
TTAAAAAAACAACAACAACAACAACAAAAAACAAACCTGAAAGTAATGCAAGCTTTATGAGTAGTTCACTCGGCTGTTA
TAAGGGCATGTCTTTATGCTTCTGCTTAAGTAGAACTGCCAAACTCATACAAGATGCAAAATGAAAATTCAAACAGAAG
AGATCCAGAATTTGTCCTCTGAGTTATGATAAAGAAGGTGGCCTCTCAAAAATAAGTAATTAAATGAAACTATTACAGT
TAAGTGTCATACAAACAATCCAGTGAAACGGGTGATCGTTTGAAGAGCGTGAGTTGACTGAACTACTGAATTGTAACCT
AATGATCAAACAAGAATTGACACAGTATAATTACGACTTGAACGCTGCTGGTTTATTTTCTCCAGCATATGATAGGCAA
GTTTGGGTTGTGAATCCAAGACTGTTAAAGACAACTAAGGGAGTATACTCATACATACAAGCCTTTCTGGGAGATAGGG
ACATGCTTTAAGGAGCCAATGTGAAAGTCTGGCTACACAACCAAGTGACTTCTAGGCAGAGAAAGCAAGGACTGGGGGC
TGGGGGAAGTAAGAGAGCCGCAACCCATCGTACCAGCTGGATTTGCGTAGTAATCAGATTCTGTATTTTCCCCTGAGGA
GCTTCATGTCTGAAACGTAGAGATACATTGTACTGCCTTACAAGGCTGCAAGTGAAATGGATGCTAATGCCCAGATAAA
GGTACTGTCTTGCTGAAGTAGCAGTCAAACCATATACTTAATGTGCTGTCAGCAGCTGTCTCTGCTCCCATCCCTTCCT
TGTTCACCCTACAGGGGCTACCTTCCTTCCTGCTCCCACTGGTTACTGATAATCTAGAGGAAAGGCCCCAGCCTGCTGC
CAGAAATCTGTACCCTCTGTCCATGTTTGAGTAGGGCTTTCCCATTGCTGTTGTTTAGGTGGGGTGAAGTGATGTTCTG
AGCTTTGGGGAGACACTGGGTACAGCAGTACCTAAACACCTGGTGACTCATACTGTTGCAGATGTGCTGAGGTTATTCC
AGCAACTGCTGCTGCGAAGGCATAAATTGATTATCTGTAGCTTCTATATCAACCTTTCCAGACCTTGCAGGAGGCTCGA
ATGGCTTAGGACATATAGCGAGCAGTACCGGCCTACATTTAGGCACCTGGAATAGCTGAAACTTGAAACATTCCCTTCA
AATTAGATTCCTCCAACTCTGCTTCCTGATAGCAGTCAACTCTTCCTTTTCTCCAGCATAAACCCTTCCTTGCCAGCTA
AGACCTCTTCATTTCCCAAGATTTTAAGCACTCATACCCTAACCTGTTTTCTAGTTAGGGTTGCTTTTCTGTTCTCTCC
TTCTTGTGCAAAGTTGTATAAAATATTTTAATTTGCTAGTGTATTTCACTTACCTCACATAGATGCAGTGCATGCTAAG
CGGGTGGGATGACGTCAAATCAGATCCACCATTTCTATCCCAGGGAAAATTTTCCAGGAGATTTCCCCAGATTTGTGTG
TCACGGTGCTGCTCTGTCTTTACCTTACATCCTCTGCCTGACAGCCAAAAAGAACTGGTAGCACTCACAGGTTGAAATG
GAGCTTTTTGGAGCTGCTTGTCTGTCGTTAAGTGTCACCATATTTTGCAGGGATAAAGATACAGAGAAGGAGCTTTGAT
ACGCATTTGTAGTGGTTATGCTTTTTGGCAAACCAGAGGAGGAAAAAAAAAGTTCTCCTTTTTTTTCATTCCTTGTATA
AAGATTTATTTATTTTTTTCAGCTGAGAGACGTAGAGTGGGTATATTTAATATCCTCATACTCCTCCTTCAGTTATTAC
TTTTCCCATGTCATGACTTCAGCCAAGCTAAAGCACCTCCATGTTATAGCTATTCCATAACTGCCATTGGTAATCAGAT
GTTTACTGTGAGGGTGCCAGTAAATACCACTTGGAGATGTACTCATTCTTTCTCTTTAAATCATCTAGAGCTAGGTGTT
CCATAATTTAATTTTCCTTTCACTTCTTTTTTAAAATTGCAGGTATTCTTGTAGAATTGCTTTCATCCAACACTTGCCT
GATAGTTTTGACTTTCAGTGAAAACGTGTGGTGCTTCTGTGCTACATTTTGGGCCAAATTATACTTCAGTTTATGTGAG
TCAATGTAGTTTGATGAGCCCTGGTTCGTAACTGGTTAGAGTTGGTTCAGCTGACACAAGCGGTGTAACAGTGCTGCTC
TGTTCTGGTTGAGGATTTGATCCATTCCCTGTAGTAGTTGAGTTACGTTGTTAGGTCAACCTGCAATATTTATCTACCA
GGGGAACAAGCAGGTTAATCTGTGTCTGTATGTTTGTACATGCTTAAGGTAACAGCTATAAGCCATGGAAACACGAAGG
CTGAGTGATAACTGAACAGTGCTTCTGACAGTTTTCATTGTTCAGTCCTAGCTGCTGTTATAGAAATGTATTTCTTCCT
CCTGTTGTTTTCCTTTTTTTTTCTTTTTTTTCTGTTTTGTTTATTTTTTTTAGGGCTTGTTTTTAGCACTTGCATCTTG
GACAAATTAGTCATATTTTCCCTTAAAAAAAGAAGTCTACTACAGTGCGACTTCCGACAAGTTTATTTTTATGCCTTCT
CAGCCCATTTATCCCATCTGTCTTCACCTCACCTCGCTTCTGATGTCTTCTGTTATCTGGGCTTTCTTCCAAACATACT
AACTGGCAGCTACAAAAAAAGGAAACCTTTGAAATGCAGAACTAAAGAAGTCATTCAGGCCGCAAACTGATAATTCATA
CACTTTATATCCTGTTCTGTATTTTTCTTTGCATTGAATGGAATGGCCAAGCAAAACATAGTTGTCAGGTTTTTTTATT
TTATTTTTTATAAATTCTCTTTAGCATTGCTTTTCTCATAAAGAAAAAAAGACAAAAACCACAACACCAGGAATAGGGA
GTGGATTCTGAGGATATCCTTATATTTTGCTTACCTATCACTTGGATAGTAAGGGCAAATAGAGAAAATGCTAACAGGT
TGCTGTACTCCGCTCTGAAATTTGATGCCCTACATAACTGAGATGATGACTTCTGAAGAGGATATGAGTCTGGAGTCCC
TGGATCTACCACTTGCTCTTTATCACTTTTGCATTTTGTCTCCAGTGGGTTTTGAACCTGCCTTGTGGTGGAATGGTAC
CTGAATATTATATCAACTCCATCCGCTCTGAAGCCATTGTATAGATTTAAGATGGATACCAACCCTGGCCTGGCTCCAG
CAAACTCATTCTGGATTAGATTTTCTAACACCTTCTGCCAAAACCAAAATATATTGCCCTTAGCCTCCTCATCCCAAAA
GGAAAAGGTAGACTTCCTGTCTCCATCTCCTTGGTGCTCTCTGTGCCAAACTGAGGAAAATCCATAGCTTCAGGCACAT
GTGGCAAGTGTTTATGGGGGGCGTTGTGTTTATGGGGCATTGTGGCCAAGTGAGCCCTCACTGATAACAGCAGGGCTCA
CGATCACACACCTCAGGATCAGGGTCATAGTAATCAGTAGGCTGTGAATGCACAGCTGAAACAGAGTAACAGCAAAAGC
AACAGAAAAAAATGATATTAAAAAAGCACCAAATAAATACCTGTTTCCATCTACGAAGAAGCAGTGTTCTTTTATCTTG
ATTAAAGATCCTTCTCAATGTGATCTGGGTCTCTATGGGCTCCAGAGAGAACTTATGTGATTTGGATTTGACAGCATTA
GAGAGTCAGCATCCTTACACAGGGCCTTGCTTCTCAGCTGATCCCCATGTATGCTTCCTGCAGTCTCTCTGTGAGTATC
CAGTACCATGGCAAGATCTTGGGTTTAATTTGTGAAGTGTTAGTGAATTATTTATCAGGCAGATCAAGGTCTTCCTCTC
TACTTTTCACCCTCTCAGAGTACTCTGTATGCAAAGTGCAATGCTAACTAAATGTAGGCAAAAACTTGGCATGTATTTA
AAAGGCATAAAATGTCCTGTCTATGTACCTTAAAACTATGCAAACTGATAATTTCTCCCAGTCCTTTACTTCCTTAGAT
TTCTGGTCCAGGACTTGCTGGTTTCTTTCTTGCTTTGTTCCTGGTAAGCACAGGCTTGTTAAAAGGACCAAGCTCAAGG
TGAGCTTCTGTCAGAAAGCAGATCGTTTGGATCAGCCTAAACTCCTTTTCCTTTTTACCTCTTCTTACATTTATCTTGC
CTCAGTATTTCCTCGGAGGGTGTGTTAGCCAATAAGTGCTTGTTCTTTTCCTTTCCATTTGGCACATGTTTTTCTTATT
TTTTCTTCACCTTCAGCTCCTAACTTGCTCTTCTCCAGCTTGTCATCTGCTATTATCCAATTGCACATGTAATGTAGCT
AAAATCACAGTAACATACTATGCCTGTATATTATTTTTTACCTCCTCTGAGTATTCATGAAGGAACTATGAGCTGAAGA
GGATCCTGGAAGAATGAAAATTGTTGGTAGATCACACAAAAGGGTTTGAGAGAAAGAACACATCCTTCTGGTATCCAGC
TGATAGGTTTTGGTTGCTCGAAAATCAAGGCTATTGCTCATAGAAGAAACTGTAGCATTTTAAGTTACATTAAAAGATG
CAAATTGTTAGGTCTAAGTATTAGATAATGAGGGATCACGAATTGAATAGACCAGGTAAAAAAATGGAGCACTGAGCAA
CTGGAAATCACTTTCCTCTTCAGGCAGATTAGTGTGGATCATGTCTGAAGACACCAAAGGAGAGCTCTAAAAATCTCCA
CCAAATCTCGTTTTTTCATCATCTTTGTTCATAAATTCACCTATCTTATCTTATCTATTTATTTATTTATTTTGAGTAG
AGCAAGAATAGCAAATAGTGATTTACTGCTCATTAACTTATAAATTATTTCTGTAAATCCTTTGAAATGTGCTGAAATA
TATGAAGATGTTGCATAGGGCACTATAAAGCCATAGGTTTAAATAAACGAGTCTTTTCATATAACTATAATTATTATTA
TTATGTTTTGGGACTTCTAAAAAATGTTTATTTTATTGGCCCACTCTAGAGGGCATCATATTCTGTATCTTCTAAGCAG
TACAAACTTTCATAAAAAGAATGCTTAGGAAGATTTCGTGATTTAAGTCCTTTTGGTCCAGACTGACAAAGTGATATAA
GTAGGAACCTGTAGTCAGGTTTTTTTGGTTTTTATTTTTTTTTATTTTTTTTATTTTTTGTGCATTCTGAACAAGATTT
CACAGCCACTTAAAACCTGCTGTATAAGTTTTGCTTTCTCTTACACATCTACTTCGGAGCAAGTAGTGCCTCTGTCTTA
AGTGAGTTGAAGAGGTTAATCTCCTCTTTCTAACCTCTGTGGGAAACTTGACGTGTTTCAACCACTTTCTTTTCTGAGG
TCTCTGAGTGGTGGTCTCTGAGCGTAAAACAGTTGAACCTCATGCAAATGTCACCACCTCTTTCCTTTGAAAGATGGAG
AGAAGCAAAGATTATCCCTTGATTTGGTAGTTAGGTCACTTGTGCAAGATGGGGAAAACCTGAGTGCAGATTTCAGGTC
TTGTTTTGCTAGATTGGAGAACTCAAATATAAGATTCATGAGTGGAAAAAATACAGCACTTCTTGCTTTGTTTTGTTTC
CTTTTGCACGCTTAGGTGTTCTCCTGATCATATTTTTGTATTTTGTTAGGTCTGTTTAGAGTTGTAAATGCAGCAGGTG
TGTGTGCAAAAGGAGAATGTCCACTTGAAAGCTGTGGGGGCCAGGTACCTAAATGCTGGTGTGAATCTCATGCACCCAT
GATATAAATCAAAGCCTCAATGTCCAAAATGAAAAATTACTAGGTGTGATGAGGTTATAGCTTAAATCACCAGCATAGT
TAGGCTAGATAAGTGCATTAAATGTTGAGCTTTAAATCCTAGATTCACAAAAGGAACTGCTTTTGCAAAGTGAATTCCT
TTCCCTTATCCAATATATTCATACCACTCCTTCTGCCATAAAAATCCCGGCTTCTTCTGCCAATAAATGAGATTAATCT
TCTAAAACTTTTAGCATATTATCTGCAACATTACAACATTAAATATAAATAAACAAACAAACCGTACACTTCTTAGTTT
TCAGACTTTACAGATACAGAGTTCACTAAGAAGTCATCTCTTTCCTTTAAAAGAAGACAACCATATAGAATAATAGAAT
TCTCTGTCTAGCATACAGACCCATCTGGAAAGAATTTAGTCTGCAATAATCATGGGCACTTGATTTAACTCTAAATCCC
TGTAGGTAATTCAAGCATAAATTTATTGGGGTGAATTTATCCCCCAACTGCTTTTGGATCCAATGAGGTTAGAGATGAA
CTTGGCCCACTGCACTTAAATTAGAGTATGTAGCCTTTCCATTGCATCCAAATATTGCAGGAATGCCTGTCATTATAAG
CAGACCCTTGCTAGAAATAAAGTCAATAGAGACAATACAGGCAATCACCTGAATTACAGTTATTTTTCCAATCTTTAAA
GACTAGTAATTATTTGGTTCTGAATATGTTTATAGACTGGTATCTAAATCAACTGGAAAACACTGGTCTAATTTGTTAT
TCGTTAATTCTGTATTCATCTGAGATAGTCTTTTTAGTTAAGTAAAATTTGTTGCGTTTCACATTATACTGCAAAAAAA
AAAAAGTTTCAAGAGGTATTCGGTACATAATGTAAACAATACCATCTGTCTTTTTCTTTGTAAAATCTTCTTTGAGATA
GCCCCGATATGCCTACTGTTTTCAATCACTTAAAAGGCAGTAATTTAATTATATCATCCTCTATGTAGGAACTGCCATT
GCTTTCAGTCCCCTTCCAGTCCTGACACAAGTAAATCACTTTGATAAGATCCACTTTTTATTTATATTTTTCCGAGGAG
ACTAGCATAAGTAATGATACCAGTGATAGACCAAGGACAAAATGACTATAATGGGCTTTTTGCAGAAGAGAAAAACATG
TGCCATTGTGATTTACCCTGTTACTTAGAAAATGTTTTTCCTTGGAATTTCTGCGACAGCCACTGTCTCATAGCAAAGG
GCATTAAGAAATATGAACAAATAAATGGTGAGTTCAACAAAATCTTCAAGGAGCAGCAGTTTTAAGCAGCTGTCACTAC
TTAAATTTCTTAAATGGGAACAGAAGTCAGACACGTTTTGAAAATGTGCCTAGGTTAGATTCATCTTTGGTAGAATGCC
ACCTACTTACATGGAAACATGCTGGGTATGTGGTTGGATCTTCCCTACAAACTGCTATGGCTTATCAGGCAGATATGCC
TTCCTTCTATTTAAAAAATTGTGTGGGTGACTTCAGTGTATTGTGCCATTGGCAAGGCATGGGCCTGGCAGACACTTCT
GCCCTCCCAGAATAGATGCTGCACGAGATCTGTAGTGTCTGTAGACTTCCTGCTGCAAATTGGCCTGGGTCCTGATGTT
CATGTACATGTTCAGAGGTGAGCTCTCTGGATACATCTTTTTCATGCCCCTAATTTCAGAAAAACAGAGGATGCCAGAT
GAAGTGGCTACATGTGACACAAAAACTTGTTTGAAAGGAACTGAGTTGTGTGTTTGAACCTCGACTGGTCACTGAGCAT
TAACACCTCCAGAGCACAGGTTTTATTGCTTGCATTTTCACACTGGTAAGGAGTTCTGGTCTTGTATTTGCTGTCTGAG
ACCTTCCTCAGGTATCGTAGCAAGAAGTTTACTCCAGTTTGGCTGCTGAAGAAGCAGTACCATGCAGTAAGAGGTGATC
AGCAATATTAAAACACCACAGGCCAAGTATGGTGCTTGTGTTTCCAGCAACATGCTGTGATGTAACCCTTTTGGTAAAT
TATTTTGGAGAGTTTGTGTGAGAAAGGTGTGATTTGGGCAGGAAAAAGGCAGCACGTTCACTGTTTTTAACCTAATTAA
CTATTTTCATATTCCAAGGGTTAAACTTCTGCTGCCAAACAGAGGCTGACGACTTGGGTTATCCTGTGAAACAGATAAG
AAGCTGTTAAGGATATTATTGATATAGTATGTTGTTTTCTTTCACAGGGAAAGTGTGGAGAGCCTTATCCAAAAGCATT
CCTACGCCCGATCCCCGATTCGAACCTATGGTGGAGAAGATGATCTTGGAGATGACAGCCAGGCAACGCAAAGCAGAGG
TAGGAAAATCTGCTCATGAGGTAAACTGTGCTTAAGAAAAGGAGGATCACGGCCAGTGCTGTGGTACTCTGAAGCATTT
CTCTGGTGTTTGTCTCTGCTATAAATCCACAAAGAAAAATACTTATTCCCGTATTGTTCTATTGGACATTTGATATGTC
TACGGCATTGGAGTGGGTGGCTCACTGAGGAGACAGCTCTAGAAATGCATATATATCTAAACTGCCATCAGAAGAAAAT
TATTGCTGTTTCCATTTCCATTTTACCCGAAAAACAGACAACTTCATTACTGTGGTGCTGAGTGCAATCTCAGATAACC
ATCCTTTGGTAGAACTTAAAAACTGTGGCTCAGCATCAGCTGTAAAGTACCACGCAGATGTGCCCTTTGCTGCCAACAA
AGGACTTGGTTCAGATCACTTTCAACCAGCCTGTGGTTAGCTTGCTTTGCCTCTACAGGGAGAGAAGTCCATAGCTGCC
TGGAGAACTGACATTTAATTACTTGTCTAGTGATCTCTGAAATGTGTCCTTACTGGTTGGGCATTTCACCTCAAATACT
TTAGGTTTGTCTGCTTTAGCAGTCAGAAAAGTAGTAGTAACACAAAGTTGTTCTTTGTGGGGTTATTTGCTGGAAAAAT
TGCATCTGCCATAATTTGCCACTGGAAATAGATCCATACTGTGAGATTGCTGACTAGCATAAACTTGTGCTACAATGTG
CTTTGCATGTTGACTTTGTGACCTGTCTGATATGCAACAGCCACTTGAGGTAAAGCAGTTCTACTTGCCTTCTGACTGG
CAGTGCCCTTGTCTTGTCCTCTAACTTCATACAGTGTTGCTAAGATAAGAGCATTATTTCTGGGCATAAACTATTTAGA
CTTGTGCAGGGAAAACACTTATTTTTAACTACAACTCACTCTTCAACAAAATGTGATTAGTTGGGTGTGTTCACACACA
TCTATTCTGAGAGTAGTTCCATAGATTGTGGAGTTCCTAGAGTAACTCCTTAGCTGGTACGACGCCATCCTTCCAAATT
CTTTTTGGGGACTACCTTGTGTTATGTCTCCTTAGATCCTAGGACAATTATTGTTGAATAAACATAAATTCTTTGCTCG
ACAAAAGTGCAGAGCAAGGCACCTTCCCTCCAAGATCTGTGTTTCTCCCTGGTCTGATTTATTTCTTTGAGACTGACAA
AGTGGGAAAGGTGAGTATTAGTGTGAGAGCTGGCAGTCAGAGCCTTTCTATTCTGAAGAGAATTGTGAAGGAAGGTATA
ACAGGAGGAAAGAATAGTTTATTAAAATTTATTTTTTGTAAAATATATTCAGGGCACACTTATGCATTTGCTTGCAACA
GGACATATATGTGAGGAAGACGATGAGTTGTCGCAACCAACTTTTTTCTGATGTGGGAGCCATATGCTAGGCCCCAAGT
CTTCTGAGGCACCCAGAACAGTTACACATGCTGCCTTTGCAGACAATTAACTTGTGCTGCCTTCACTCTTTATTTAGGT
CCAGTATCCTTAAAAAATAAAAAGTCCTCCAAGATATATAGAGAAATAGTTATTTCATTGAAACTCCTCAGACATTTTT
ATTTCTTCTGATGCAGTTTAAAACTACCTGGCACACAAAATGGAGGTGTGTCCTTCCAGACATGTGAGAATTGACAGCT
AAATACATGCATGCTGCTGGGTGGTGTGTGTAAGAAGCTCGCTGTAGACGTGTTGGAAAACATTTCTTCGGTGACAGCA
GATGTGATATGTGAGACTTTTTGGAATACTAAATTGCAGTTGGGGACCACTGTAGTTGGAGGAGGAAATGGCATTTCTG
GATGTTTCTCAGGAGAAGTAATTGTACACTTTGTTCTGTGTAGAAAGAAGAAAGTTTAACACTGCTATATATTTCTAAT
AACTTCAACACTCATCCAGAGCTTTCTCATCTCAGCCCATTTCAGCTGTCTAAAGATAGAAATGGCTAGCCTTCAATAG
TATATTTATCACAAGAAGTCTGTTTCCAAAGGAATTAACAGATACGAAATAAATCAAATTAAAACTCCTCAGTGCGCAG
TGTCTGGGTACCTGCACTCCAGCATTCACACTCAGAGTTGATGGTAGCCACCTGAACCAGAGCCAGATGTACAACTTCT
GCTGAAATCCGGATTTGCAGCCAGCTTTCCCAGTAGTGCAATAATACTCAGATACTCCTTGATTTGTAAAGGGTTTTGC
TCTGGCCTGTGAGTGTGTTCTTATCTGTACAGTTTGGCTCTGGATCCTAATTTCCCAGCAGTTACGATTTGGTTCTGTG
GTGGGTTCAGGATCTGGTTCAAGTCCATTCCTATTGCTGAATTGACACAATTTCTGCTTCCTGTTACTGTGCTGTTTCA
CTTGTTCCATTAGGCAGAGAAGGAATTAATCAAAAGCAGCGCTCTTTCTGATTTGAAAATCAATCTCTGAAGAGATCTA
TCATTTTGCTTTTTTTTTTTAAATCGCAGTATTATGTCTTTTCTTTCTATTGTTCTTTGCTACAGTTTTGAGTACATGG
CCATGATTGCTAGACAGGCATCTTAAAAAATGGATGTCTTCATATTCTTTCATTTTACTATTTGAATGAACCTGTCTTC
TAAAAACCAGATTTATGAAGCTAATACCTGTAATAACAACTGCAAAAATTCTTCTCTGGACGTTTTGTGTTATTGGCTT
GAAATTATGTTTTGGCAAAAAAATAAAAAATAATAAAAAAAATTGCCAGTACATTTATTTTTAAAGTAAGAAACATTTT
CTCAATGGAGGCAGTTGGACAAGAAATAAAATACAGAAGGGACATAAGTTGAACTTTTGTTTGTATAGGAATAAAATTA
AGAGTGTATTTATAGGATTTTGTTTTATCCCCCCATCTCTAGAAGCCAGACATCTGATGATAACCAGATGCTCAGAAGA
ACTGCAGAAGTGAGGGGCAATATCTTCATCAGATTATTTGAAAATGACCGTGTATAATTATTAAAACAAATTATTCATT
GGTTCCCCTCCCCCTTCCAAAGGAAAAAAAAATATATATGTATTACTGTCAAAATAAATAAGATTCTGCCACCTTTGGA
TAAAAAGTTTTAGAGGGGGAAAATTTGTGTAAATAGAAATTTTTGGAACTTTTCAGATGGAAAAAAATATCAAAGAAAC
CGCATTCACTGGATCAAAAGTTGATATTTATCTTGGGAATAAGCTTATCATATTTTTATGTACTTCGCTTAAAAAACAG
CATCTCAATATAATTCAGTATTGCTGCTGTTCCTTAGAGCACTACACACAGTTGGAAAAATAAGAAGAACGTTTTGACA
TTTTAGAGCTATTTGGAACACGTAAATTCGAGTGAAAAGATGCAGTGTTGACGTGCTTTCCTGGTGTTAAAGGAAAAAA
AAGAGCCACTAAAACTAACAAAACAAAACCTGAAAAGCTGTAATGCAAATGATATTTTCTTATGCTTTTACCAGACTGA
AACTTTAGAAAAATTTAATTGGTTCTACTGAAGGTCTGTTGTAAAAAGCTACAAGCATGTTTTCACCACAGGGATCGGA
TGCAGGGTGATTCCACGTCAGAGTAGGTGTGTCAGTGTTTGTTCATGCCAGCACCGCACGGTGTCTCATACAAAAAATG
TCCCATGTATAAAAATGATTTTACTGTTCAAGCCAACTGCAACCAGCTTCCTGTAACTTAAGTTTGTCTAAGATTTAGG
GATAAAGGAGACCAAATGGCAAATAATTATATAGAGAAAGATGCAATGAAGAGATAAAAGTATTTTGGAAAGTATCTCC
AATGGCAACTCGTAATTAAATTCAGCTTTACTGTGAAAAATCATTTTCCTCTTTTTGCTCTTCTACCAGCTTTGTACGT
TGCAGTGCAAATGTCAGGCATTCTTTCTCTTCATTTGCAGGATCAGCTTTTACAACATCTGATAACCTGTCCCTCAGTT
CCTGGGTATCCTCTTCAACCAGTTTTCCTGGATTTCAGCATCCCCAGTCTTTGAGTGCCCTGGGTACCAGCACTGCATC
CATTGCTACACCTATTCCTCATCCAATCCAAGGATCCTTGCCTCCATACAGCCGCTTGGGAATGCCTCTTACGCCCTCT
GCAATAGCCAGCTCCATGCAAGGTACTGGCCCCACTTTCCCTTCTTTCCACATGCCAAGGTACCATCATTATTTTCAGC
AGGGTCCTTATGCAGCCATCCAGGGACTGCGTCACTCCTCCGCAGTGATGACACCATTTGTATGACTGATGTAAGATGA
CAGAAACATAAGATTTTAAACGTGCAAGCATGGTATGAAAAAATACAAGGGACCTTCTCAAAAGGCCTGTGGTGGGAGA
CTGCTGAACTCAAACCAGCTAAGAAAACGCATTGTGGAGATTGATTCCTCCATTGAGGGATCACAAGAAGAGAGCATGC
AGCTTGGAGCTGCTCACAGACCTATGTGTAACACAGTCAAAACAGATCCCAGAGTTCCCAGGATTTCTGGTCACGTGCA
GGTTGTTCCAAAGGTTTGTTCTGCCTAGTGGAAAGAGACTATGTTTATGCAGCAGTGTACAAATTAATTGTGTATGTCT
TTTTCTGTATGCTAGAAGGATTCTGAAAAAGGCAATACTTTTATTCATCCTCACCTCTTCTTGTGACTAATGGGCATCT
AAGCAGAAAAATGTATCATTGTAACTTTGAGCATGTTTTAGGCTATCTCAGCGTGCATTTGCTGGGAATGGGACAAAGT
GGTGAAAGCCACTGTCCTTTTTAAAGTCTAGCTTATACTCGCCAAGAGCAGTATTTCATAATTGCTACTATAATCTCAT
AGAGAAAATCATTAGCAAGTCTTTCTTTCTTTTATCTTTTGTTTCTTTCACAAAACACTTAACAGTTCCGAGAAGAACT
GTGTTACAGGACGGTAGCTGTAATGATGTATTCTGTTCTGCTTGTCTCATATCCTAGGAGGAGCAATTTAGCAGTCCAT
TAAGATATGGTGAAGGAAAACATAGAGTTTTAGAAAATCTGTTGCTTTTAAACTCAGAAACTCAAGACACTAAATTTTT
AAGCCAAAGCTACTGTTTGCTGCTGTGCTTGCCATCTGTGTCCAGCTGCAAATGGGTACCATTAGTTAACAGAATTTCA
GGTTAGATCAGTCTATATCTAGACTCTAGATCACACTATAATCAATAGATTCATATACAAATAACAGTATCTTGGAGTG
TCTTTCTACTTATTCTGTTTTCTTGGATTTGGTCATAAGTGTTACTAGACAAGCTGTTTGGCCAGGACACGAGAGTTGT
ACTGTTGAGTTTTTCAAGTCCCAGTTTCCTCGGGGAAATATCGATGAGATTTGCCTGTAATTTTTTTATTTTATTTTTT
TTTTAATTCATATCTGCCTTATTTTAGTTAGTAAGAAGAGTTCTCATCGAAAATACTGTCCACTTTTTGTAGTACATTG
TGTCTGATGCAACAGAGGATCCGTGGATTCATAGGAAAAAATGAGCTCTGCAGAGAGCTAGCATGAATCCTTTGCACTG
TTGAAAAGAGAACTGGTGTGATGCTGGTTTTCCGCCTGGTGGAAACTACGATTTCACTGTAAATAAGAAGTCAAAACAG
ATTTTCTGTGTGTTGTTGCATCCAAGTTATAGACGGTAAGACATCTATTGGTAAAAAAAGGACTTGCAATCCAATCTTA
TATATTAGAAGATTTGTGTAGAGCTGGAACAGATTGAAAAACAGACATTTTGGCACTATTCTCCTCTACTCTTGACCAA
TGGATGTTGGCAACATAAAATGAGAAGTACAGCGCAGTACACTGAGTGAAGTGCAGGGCAAGTCACCAGCTTTTGTTGT
TGTCCCAGTGCCTCATCATACCAGCCTGGTCACAGACAGCAGTGACAACATTCCAGACTTTTCCCAGCTTCTATTATAG
GCCAATGCATACACTCAAAGATAAGGACCATCTGTGTATTTTCCAGTAGTTGAATTTAAGATCTTGCAAATTGGCCATT
ACAATCACCTTAGTCATGTGCAGTATCATCCTAATTTCCCTTTACTCATTGTTGGGCATGCTAATAAAAAATGACCTGG
GAAAATCTGCAGCTGTTTTGCTCTGCATGTGAATGAAACCAAACCTCTTTTTGCAGTCTCTGGGTTTAGCACTACTACA
AGCAGGTCTGTGAAAACATATAACGAGCCAAACTCTGCAGTTTTAAAGTGGTTTAGAATCAGACACTGACTAAATTGTC
TTGATATGTCTAAACATTAAAATTTGCTCTAGGTTATAGATTCATCTGGAAAGTGCATATTGCAAGGTTGTGCATACTC
ATGACCTGTTCTAACATAAAAATACTAGTTTTCATGAAATCATATGATAGATATATGATTCTCACCCTTCTGTGGGCAG
CAAGAGAGCAGTTCCAAGATGAAATTCCTGCTCATCTTAAGACAGTGGTAAATTTCTTGACTGTAAACAAGACAGGATT
TCATTCAAATTTACATTCTTTCCCCAAAATAAAGTCTATCTGTATGGATGGTGGTTATGACAGCAGCAATATGGGAACT
TTGCAGAACAGACTGAAAAACAGCTATTAATCAACTTCAGCACTGACTGCATAACTGGAAGAACATTAATGTAAATGTG
TAATTAATTGGTTAAGGAACAAAATTGTTTTGTTTAAAATTGTACTACTTTGAAAATAACTCAGTAATTTATTTAAGGA
GTTGCTGTACCGCTGTCACAATTCTATCACTTTCAGGATAGAACATCTGTTGCTGGTAGATGTTCTAGGAATGCCAAAT
GTAATCTAGAGTTTATTTTCCAATATAATTCACATTTTATATCCCACGAGAAGTGCTCTTCATGTTTATGAGCTATCTT
GGCTGAGCAAACTTGGTGCTGCTTAGTGTTTTTTTTTTTTATTGTTTTATTGAAGAAGGGTGGAGAGAACATGCCTGAA
TGTGCTTTTCAAAAAGAATGATAAGATTATTTTCCAAAGTGTTAAAAGTACTTTTGGGTGTTTTCTGGATTACCCTTTT
ATCCTTAGACAGTTAACAGCCTTAGGTCTTTTATCCAACAAAAGCAACCCAGGACTAACAAAACTGACATAAATACGCT
TGTATGTATATATTTTTTTCTTCTAGTTTTGGAGCCCTGAGACAAGCTAGTATCAAAAAGCATTTTAAATTTGGCTGTT
GTTTTTGTGATGTTGGTTTACATGGCCTGAGGAACTCTCAAAGATAAAAATTCAGTCTCGCTGGTTTCAGGGTACTCTC
CAGACAGAAACAGGCAAACACTAAGTGGATAAAGGTGCAGTTTTTAATGGAAATGCTTCTCTGTGAGTTCAACTATAGT
GTGCTGTATGATAACTAACATCCTTGTAGTGGAGCCTAAAAAATGCAGTGGAAAATTTTTCCCCAGAAGGCTTTATTCT
TGGATAAAAGGATACACACATGCAGCGTGCACCTGAAGGTTGTGACACTGTATGAACATGTACACGCATGAAGATGGTG
CAGCTTCCAACATCCAACAAATACTAACTGGTATTTGAAAACGAACCTCTTCCAAATTGAAAAAAGTCTGGGCTGGCAA
CTTGACTATATGCTACATCCTCTGTATGCGCACGTATGTTATAAAGAGACAGAAATATCAGTGAAAATTATTGCAAAAA
CATGGGGAGCTTTCCAAAATTGGAAGGTAATGAAGCTGTGGTAATTCCTTCCTGGATAAGAGGCAAAGAGACAGTGAGA
TCAGTGTAACACTTCGGGCTCCTTATGTGGAAGGAAGCCTTGGCCTCAGAGCTTATGCTCATCATCTGCAGAGAGGTGA
TGTCCACTCACTGCAAGATTGTGTTTCATTTTGCTGAGAAGTTTTTCTCACCATTCCCTACAGAGTGCTTTCTGCTGCA
GAAGATGTGGTTTCTGTACTATTTACTTGCTGGCCAGAGGATTTATGCATTACTCTGTGATACACTGTCCCCAAATATA
GTCTTTAGTTTATAAAATAACAACTTCTTTTCCTTTATTTTATCTTTCTAAAAGAAACTAAGCAGTGATTTAAGTAAAC
TTTGAATTAACTTTTTATAATACTTTAAGGACAAAAAATACAGTTTGCTGTATTTTACCTTTAGCACATATAAACAACA
TTTTTTTTTTCAATTGTACCTTCAGAAACATGAGGAAAGATTTGGTTTAACAATAAGGAAGGTAAAAACTGGATGTAAT
CTCTTTAACAGAATGTACCACAGTTCTGCTGTTTGCTGTGTTGACTTTGTTGTTTATAATGCATTGCGTGAGCACATTC
ACCATGTACTGAAGTGTGTGTTTGTGTGTACGGGGTGGGCAGGGGGAAATCTTTTTATGGAAAAAGAAGTTATGAACAT
AAACTATGAAGCAACATCTAATGAAAAGTTTCTTTTTAAGTGCAATATATTTATTTCTGCTAGAAATATAATATCAACA
TTATGTAATATTTGAAGCATTAAATGTTATTTGTAAACAGCTTAAAATTATATATATATATCACAAAATTGTACAGAAG
TGCAAATGTGTGGATATTCAGTTTCTTTCATTAAAATATTGGGTGTTTTGATATATCATTCTTATTTAGCCAAAGCTTT
CTGCCTTTGTTGTTTTTCCTCTAACTGAGACACTAAGCGCAGTGGAACAAACAACAGATTTTCTACACAAAATTCAGAA
GGTCGCAAAAGGTTGTCTAAATCCTAAATCCAACACGTGGAGTATTAGTTGTGCAGTAGTTAACTATATTTGTAGCTTG
CATATCATTATATAAATAGCTCTTTCAAAGGGCTCTGTGATTATATTCAGAGAAATTGCTATTTTGGCCACTGGAGTAT
AACTAAATAGTTGAAATATGGGGTTCCCAGGATTCCCAAGATAATAGACAGAGACCTAGAAAACACGCTCTAAAAAGAA
AATTGAGAAGCATTTGGTCTATTTAGCCTGGAAAAGTTAAGATAACAGGAAGATACAATAAAGTTTTCAACTGTACATA
GAATATAAAGAAGGAAGGAAAGAATTCTCCATATCTACTGCAGGTTTTAAATAGGCTTTTATTCAGTAGGATTTTATTT
CTATTTAAATAACCT | | Citation | Nathan E, Monovich A, Tirosh-Finkel L, Harrelson Z, Rousso T, Rinon A, Harel I, Evans SM, Tzahor E. The contribution of Islet1-expressing splanchnic mesoderm cells to distinct branchiomeric muscles reveals significant heterogeneity in head muscle development. Development. 2008 Feb;135(4):647-57. doi: 10.1242/dev.007989. Epub 2008 Jan 9. | | Copyright | Copyright held by the authors. Published by the Company of Biologists Ltd. | | Comments | As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NC_006089.3 |
Entry 8| GEISHA Id | Tbx‐20.Afrakhte.2004 | Data Source | Publication | | Complete cDNA Template Probe | show ATGGAGTACACACCGCCCCCGAAGCCGCAGCTCTCGTCGCGGGCCAACGCCTTCTCCATCGCCGCCCTCATGTCGAGCG
GCAGCTCCAAGGACAAGGAGGCCGCCGAGAGCACCATCAAGCCTCTGGAGCAATTCGTTGAGAAGTCCTCCTGCGCGCA
GCCTCTGAGCGATCTGTCCGGCCTGGAGCCCCACGGGGACTTCAGCGGCAGCCCCTCGGCCCTGTGTACCGAGCCCCTC
ATCCCCACCACACCCATCATCCCCAGCGAGGAGATGGCCAAAATCTCCTGCAGCCTGGAGACCAAGGAGCTGTGGGACA
AGTTTCACGAGCTGGGCACCGAGATGATCATCACCAAGTCCGGCAGGAGGATGTTTCCCACGATCAGGGTTTCTTTCTC
GGGAGTGGATCCTGAAGCCAAGTACATCGTGCTAATGGATATCGTTCCGGTGGACAATAAGAGATACAGATATGCCTAC
CACCGCTCCTCCTGGCTGGTGGCTGGCAAAGCCGACCCTCCTCTCCCAGCAAGGCTCTACGTGCACCCCGACTCCCCGT
TCACGGGTGAGCAGTTGATGAAGCAGATGGTGTCGTTCGAGAAAGTGAAGCTCACGAACAACGAGCTGGATCAGCATGG
CCACATCATTTTAAACTCCATGCACAAGTACCAGCCAAGAGTCCACATCATTAAGAAGAAAGATCACACGGCTTCTTTG
TTAAATCTGAAATCTGAAGAGTTCAGGACGTTTATCTTTCCAGAGACAGTTTTTACTGCTGTCACAGCCTACCAGAATC
AATTGATAACCAAGTTGAAAATTGACAGCAACCCTTTTGCCAAAGGATTCCGCGACTCTTCCAGACTCACTGATATCGA
GAGGGAAAGTGTGGAGAGCCTTATCCAAAAGCATTCCTACGCCCGATCCCCGATTCGAACCTATGGTGGAGAAGATGAT
CTTGGAGATGACAGCCAGGCAACGCAAAGCAGAGGATCAGCTTTTACAACATCTGATAACCTGTCCCTCAGTTCCTGGG
TATCCTCTTCAACCAGTTTTCCTGGATTTCAGCATCCCCAGTCTTTGAGTGCCCTGGGTACCAGCACTGCATCCATTGC
TACACCTATTCCTCATCCAATCCAAGGATCCTTGCCTCCATACAGCCGCTTGGGAATGCCTCTTACGCCCTCTGCAATA
GCCAGCTCCATGCAAGGTACTGGCCCCACTTTCCCTTCTTTCCACATGCCAAGGTACCATCATTATTTTCAGCAGGGTC
CTTATGCAGCCATCCAGGGACTGCGTCACTCCTCCGCAGTAATGACACCATTCGTATAG | | Citation | Afrakhte M, Schultheiss TM. Construction and analysis of a subtracted library and microarray of cDNAs expressed specifically in chicken heart progenitor cells. Dev Dyn. 2004 Jun;230(2):290-8. | | Copyright | Copyright © 2004 Wiley‐Liss, Inc. | | Comments | The complete cDNA template sequence was obtained from the information in the publication as described in Afrakhte et al. 2004. |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 4-6 |  | | stage 6 |
| Early Mesoderm
Headfold
| | 31-44 |  | | stage 44 |
| |
MouseFrogFruit FlyZebra FinchZebrafish |
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