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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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TBX4
T-box 4

The human orthologue of this gene is associated
with the following human disease:

Small patella syndrome

Gene

Official Symbol	TBX4
Official Full Name	T-box 4
CGNC ID	48992
also known as	T-box transcription factor TBX4\|T-Box protein 4
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001030537
Polypeptide	NP_001025708
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.489

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	9496	ENSG00000121075	MIM:147891	MIM:601719
Mouse	21387	ENSMUSG00000000094	All phenotypic alleles (9):Targeted, knock-out(1) Targeted, other(8)	MGI:102556
Xenopus	100488041, 373555			951381
Zebrafish	100333554, 30070	ENSDARG00000030058	ZDB-GENE-991124-5	ZFIN:ZDB-GENE-991124-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	373989
Ensembl Gene
KEGG	gga:373989

Entry 1

GEISHA Id	TBX4.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	GTGACCTCCTACCAGAACCACAAG
Reverse cDNA Template Primer	ATTAACCCTCACTAAAGGGGAACTCATTGGCAGCGTTG	cDNA Template Length	889
Forward cDNA Template Probe	show AAAAGTGTGGGGAGGGCTTCTCTCCACACGGACGGATGCACTCTTTCCCTTGGGAAAGATGATGGGGGGACACGCTCCC GAACCTGAGACTGGGCCAGCTGGTTGTAGACGCTGAAGTGGCTGTTCCCTGGGGGCTGCGAGCCCTGCCCTGCGATAGA AGGGAGCCGCGGCATCATGGTGGTGGCTGTGAAATGGGCTGGGAAGGGCTGGTAGGGCACAGTTTCCATTGTCTGAACA CTGTAGCTGGTGTAAGGTGCGACTGAAGTCCACATATTGCAGCTCAGCGGGGGAGGCGGAGGTGGCAAGTCATCCACTG CCGGCACACCCGCGATCTCAGCCCCTGACCCAGAGTACATGCAGGCTTCCCGCGGGGCCACCTCACTGCAGTAGGACGG GCTCAGCATCTGCTGCTCGTAGGGTGGTGGGGAGCGGAAGTAGTGATCGTCACCCACCGATGAGGAGGCCTCCAGGTAG GAGCGCTTGCAGGGCAGGTCCAGGTGCCGCGCGCTTTCTCTTCTCTTCAGGCAGTGATAGAAGAGCCCTGAATCTCTCT GTGCTGTGAAGGTGTTGAGTGACAGGTCTTGAGTATCTGAGGCTGCAAACTGCATGTGAGCACCATTCTCATACTGATA GTGTTGTAGGGTCTGGTGACTGCCATGGAGCGGGTTAACATCTGGCTTGGTCGAGAGCTGGCCATGGCTGGACACCAAT CTCTGCCTCATGATGCTTTTGGAAATCACTGGGTATTCTTTGCTTTGGAGCCGTGCCACGCGCAAGTCGCTGTCGTCAC TTCCCCTGAATCCCTTTGCAAAGGGGTTGTTCTCAATTTTCANCTGAATTATCTTGTGGTTCTGGTAGGAAGTCACAA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 13

stage 15

stage 17

Foregut
Lateral Plate Mesoderm
Leg
Limb Buds
Lung

Low level expression observed in the lung.

19-24

stage 19

stage 20

Allantois
Hindbrain
Leg
Lung
Outflow Tract

25-26

stage 25

stage 26

Leg Mesenchyme
Lung
Outflow Tract

Left side.
Right side.
Ventral view with the heart removed.

Entry 2

GEISHA Id	Tbx4.Krause.2004	Data Source	Publication
Complete cDNA Template Probe	show GCGCCCCGCGCAGCCCCGCGCTGCCCCGTGCTCCCTTCATGCCGCAGCCGCCCCGAGACGAAGCCAGGAGCCCCCCGCT GCGCCCGCTGCCCCCCGGCCGGCAGTGAAATGCTCCAGGAGAAAAGCCTGTCTGAAACCGAGGAAGGGTTTCCAACAGC CCCCGCACCCGGCCATGCGGACTCCTCCGCGGGCTCCCCCGTCCTCGGCGTAGCCGGGGGCAGCAGCACTCCGCTCAGC AGCCCGCAGCTCCCCGACCCCGAGCAGACGATAGAAAACATCAAAGTCTATCTCCACGAGAAGGAGCTATGGAAGAAGT TCCATGAAGCGGGCACCGAAATGATCATAACCAAAGCAGGCAGGAGGATGTTTCCGAGCTACAAGGTCAAGGTGACTGG AATGAACCCCAAGACCAAGTACATTCTGTTGATTGACATTGTCCCAGCTGATGACCACCGGTATAAATTCTGTGACAAT AAATGGATGGTGGCTGGGAAGGCAGAACCCGCCATGCCGGGCCGGCTGTATGTGCACCCTGACTCGCCTGCCACTGGAG CGCACTGGATGCGGCAGCTCGTGTCCTTCCAGAAGCTGAAGCTCACCAACAACCACCTGGATCCCTTCGGGCATATCAT CCTCAATTCAATGCACAAATACCAGCCGCGGCTGCACATTGTGAAGGCAGATGAGAACAATGCTTTTGGCTCAAAGAAC ACGGCCTTCTGCACCCACGTGTTTCCAGAGACGTCCTTTATCTCGGTGACCTCCTACCAGAACCACAAGATAACTCAGC TGAAAATTGAGAACAACCCCTTTGCAAAGGGATTCAGGGGAAGTGACGACAGCGACCTGCGCGTGGCACGGCTCCAAAG CAAAGAATACCCAGTGATTTCCAAAAGCATCATGAGGCAGAGATTGGTGTCCAGCCATGGCCAGCTCTCGACCAAGCCA GATGTTAACCCGCTCCATGGCAGTCACCAGACCCTACAACACTATCAGTATGAGAATGGTGCTCACATGCAGTTTGCAG CCTCAGATACTCAAGACCTGTCACTCAACACCTTCACAGCACAGAGAGATTCAGGGCTCTTCTATCACTGCCTGAAGAG AAGAGAAAGTGCGCGGCACCTGGACCTGCCCTGCAAGCGCTCCTACCTGGAGGCCTCCTCATCGGTGGGTGACGATCAC TACTTCCGCTCCCCACCACCCTACGAGCAGCAGATGCTGAGCCCGTCCTACTGCAGTGAGGTGGCCCCGCGGGAAGCCT GCATGTACTCTGGGTCAGGGGCTGAGATCGCGGGTGTGCCGGCAGTGGATGACTTGCCACCTCCGCCTCCCCCGCTGAG CTGCAATATGTGGACTTCAGTCGCACCTTACACCAGCTACAGTGTTCAGACAATGGAAACTGTGCCCTACCAGCCCTTC CCAGCCCATTTCACAGCCACCACCATGATGCCGCGGCTCCCTTCTATCGCAGGGCAGGGCTCGCAGCCCCCAGGGAACA GCCACTTCAGCGTCTACAACCAGCTGGCCCAGTCTCAGGTTCGGGAGCGTGTCCCCCCATCATCTTTCCCAAGGGAAAG AGTGCATCCGTCCGTGTGTGAGAGGAAGCCACCTTCCCCACACCTCAACGCTGCCAATGAGTTCCTCTACTCCCAAAGC TTCTCCTTGTCACGAGAGTCCTCGCTGCAGTACCATTCAGGAATGGGGACGGTGGAGAACTGGACGGACGGGTGACTCC GCGGGCCCAGCGGTGCCGCAGCTCGCATTACCGCTCCGGGACGGTGCTAAGGCAGCGTTATACCTGTGGGTAACTTGCA CTTGGGTGAGACGAGCATGCATTTCCCAGGGGCGCCGTGTGTGTGGGGAGCGCCCATCTCTGGGCACACTGAGAATTAC GGCTCCTGGATCCATCAGCCTCTGACTGACTTCCGAATGAATTAATTCTCACGTCTTCGTTACCGATCTGGTAGAAACC ATCTTCTAGACTAATGAGTGAAGTTGTCTGTCATTCGCTTTTGCCTGTAACAGTAAGCATCCGTGAGCAAATTTCGACT TTTTGGGAAAAGCACGAGCTTCACTTATATGGTACTCAGTTCGTGAAGTCACAGAATCCCCCAAACCAAAGGAAGAAGT GATCTGTTGGGCTGTGTAGCTCCAGGACTGCTGTAGCAGCACGTGTTAGGCTCTGTCCACCTGCAGAAATTCCCTTTCC TCTGAGGCCAGTGGTGAGGTGCCATTCCAAACTCCAGGCGCAGCGCAGAGAGGAGAAGCTCCGGTGCGCAAATGTCCCT TCTTCCCCCATTGACCGTGGCTGTGGGAGACCGAGAAGTGAAGCATTACGCCCCGGGCCAAA
Citation	Krause A, Zacharias W, Camarata T, Linkhart B, Law E, Lischke A, Miljan E, Simon HG. Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Dev Biol. 2004 Sep 1;273(1):106-20.
Copyright	Reprinted from Developmental Biology, Volume 273, Issue 1, Ange Krause, William Zacharias, Troy Camarata, Barbara Linkhart, Evelyn Law, Antje Lischke, Erik Miljan, and Hans-Georg Simon, Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development, Pages 106-120, Copyright 2004, with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence is from GenBank Entry NM_001030537.1

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 15

stage 18

Leg
Limb Buds

19-24

stage 21

Heart
Outflow Tract

25-30

stage 25

stage 29

Heart
Leg
Limb Buds
Outflow Tract
Ventricles

31-32

stage 32

Leg

Entry 3

GEISHA Id	Tbx4.Gibson-Brown.1998	Data Source	Publication
Complete cDNA Template Probe	show GCGCCCCGCGCAGCCCCGCGCTGCCCCGTGCTCCCTTCATGCCGCAGCCGCCCCGAGACGAAGCCAGGAGCCCCCCGCT GCGCCCGCTGCCCCCCGGCCGGCAGTGAAATGCTCCAGGAGAAAAGCCTGTCTGAAACCGAGGAAGGGTTTCCAACAGC CCCCGCACCCGGCCATGCGGACTCCTCCGCGGGCTCCCCCGTCCTCGGCGTAGCCGGGGGCAGCAGCACTCCGCTCAGC AGCCCGCAGCTCCCCGACCCCGAGCAGACGATAGAAAACATCAAAGTCTATCTCCACGAGAAGGAGCTATGGAAGAAGT TCCATGAAGCGGGCACCGAAATGATCATAACCAAAGCAGGCAGGAGGATGTTTCCGAGCTACAAGGTCAAGGTGACTGG AATGAACCCCAAGACCAAGTACATTCTGTTGATTGACATTGTCCCAGCTGATGACCACCGGTATAAATTCTGTGACAAT AAATGGATGGTGGCTGGGAAGGCAGAACCCGCCATGCCGGGCCGGCTGTATGTGCACCCTGACTCGCCTGCCACTGGAG CGCACTGGATGCGGCAGCTCGTGTCCTTCCAGAAGCTGAAGCTCACCAACAACCACCTGGATCCCTTCGGGCATATCAT CCTCAATTCAATGCACAAATACCAGCCGCGGCTGCACATTGTGAAGGCAGATGAGAACAATGCTTTTGGCTCAAAGAAC ACGGCCTTCTGCACCCACGTGTTTCCAGAGACGTCCTTTATCTCGGTGACCTCCTACCAGAACCACAAGATAACTCAGC TGAAAATTGAGAACAACCCCTTTGCAAAGGGATTCAGGGGAAGTGACGACAGCGACCTGCGCGTGGCACGGCTCCAAAG CAAAGAATACCCAGTGATTTCCAAAAGCATCATGAGGCAGAGATTGGTGTCCAGCCATGGCCAGCTCTCGACCAAGCCA GATGTTAACCCGCTCCATGGCAGTCACCAGACCCTACAACACTATCAGTATGAGAATGGTGCTCACATGCAGTTTGCAG CCTCAGATACTCAAGACCTGTCACTCAACACCTTCACAGCACAGAGAGATTCAGGGCTCTTCTATCACTGCCTGAAGAG AAGAGAAAGTGCGCGGCACCTGGACCTGCCCTGCAAGCGCTCCTACCTGGAGGCCTCCTCATCGGTGGGTGACGATCAC TACTTCCGCTCCCCACCACCCTACGAGCAGCAGATGCTGAGCCCGTCCTACTGCAGTGAGGTGGCCCCGCGGGAAGCCT GCATGTACTCTGGGTCAGGGGCTGAGATCGCGGGTGTGCCGGCAGTGGATGACTTGCCACCTCCGCCTCCCCCGCTGAG CTGCAATATGTGGACTTCAGTCGCACCTTACACCAGCTACAGTGTTCAGACAATGGAAACTGTGCCCTACCAGCCCTTC CCAGCCCATTTCACAGCCACCACCATGATGCCGCGGCTCCCTTCTATCGCAGGGCAGGGCTCGCAGCCCCCAGGGAACA GCCACTTCAGCGTCTACAACCAGCTGGCCCAGTCTCAGGTTCGGGAGCGTGTCCCCCCATCATCTTTCCCAAGGGAAAG AGTGCATCCGTCCGTGTGTGAGAGGAAGCCACCTTCCCCACACCTCAACGCTGCCAATGAGTTCCTCTACTCCCAAAGC TTCTCCTTGTCACGAGAGTCCTCGCTGCAGTACCATTCAGGAATGGGGACGGTGGAGAACTGGACGGACGGGTGACTCC GCGGGCCCAGCGGTGCCGCAGCTCGCATTACCGCTCCGGGACGGTGCTAAGGCAGCGTTATACCTGTGGGTAACTTGCA CTTGGGTGAGACGAGCATGCATTTCCCAGGGGCGCCGTGTGTGTGGGGAGCGCCCATCTCTGGGCACACTGAGAATTAC GGCTCCTGGATCCATCAGCCTCTGACTGACTTCCGAATGAATTAATTCTCACGTCTTCGTTACCGATCTGGTAGAAACC ATCTTCTAGACTAATGAGTGAAGTTGTCTGTCATTCGCTTTTGCCTGTAACAGTAAGCATCCGTGAGCAAATTTCGACT TTTTGGGAAAAGCACGAGCTTCACTTATATGGTACTCAGTTCGTGAAGTCACAGAATCCCCCAAACCAAAGGAAGAAGT GATCTGTTGGGCTGTGTAGCTCCAGGACTGCTGTAGCAGCACGTGTTAGGCTCTGTCCACCTGCAGAAATTCCCTTTCC TCTGAGGCCAGTGGTGAGGTGCCATTCCAAACTCCAGGCGCAGCGCAGAGAGGAGAAGCTCCGGTGCGCAAATGTCCCT TCTTCCCCCATTGACCGTGGCTGTGGGAGACCGAGAAGTGAAGCATTACGCCCCGGGCCAAA
Citation	Gibson-Brown JJ, I Agulnik S, Silver LM, Papaioannou VE. Expression of T-box genes Tbx2-Tbx5 during chick organogenesis. Mech Dev. 1998 Jun;74(1-2):165-9.
Copyright	Copyright © 1998 Elsevier Science Ireland Ltd.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_001030537).