GEISHA - A Chicken Embryo Gene Expression Database
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VEGFA
vascular endothelial growth factor A

The human orthologue of this gene is associated
with the following human disease:
Gene
Official SymbolVEGFA
Official Full Namevascular endothelial growth factor A
CGNC ID7830
also known asVEGF, vascular endothelial growth factor A|VEGF-A|VPF|vascular permeability factor, Vascular endothelial growth factor A precursor , VEGF-A, Vascular permeability factor, VPF
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_001110355
PolypeptideNP_001103825
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.537
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human7422ENSG00000112715MIM:125853MIM:192240
Mouse22339ENSMUSG00000023951All phenotypic alleles (12):Targeted, knock-out(4) Targeted, other(8) MGI:103178
Xenopus100038089, 100037058, 373589485743
Zebrafish558154, 30682ENSDARG00000034700ZDB-GENE-030131-4605, ZDB-GENE-990415-273ZFIN:ZDB-GENE-030131-4605, ZFIN:ZDB-GENE-990415-273
Gene Ontology
Molecular Functionchemoattractant activity, fibronectin binding, growth factor activity, heparin binding, more...identical protein binding, platelet-derived growth factor receptor binding, protein heterodimerization activity, receptor agonist activity, vascular endothelial growth factor receptor 1 binding, vascular endothelial growth factor receptor 2 binding
Biological Processactivation of protein kinase activity, basophil chemotaxis, blood vessel maturation, more...cardiac vascular smooth muscle cell development, cell migration involved in sprouting angiogenesis, commissural neuron axon guidance, coronary artery morphogenesis, coronary vein morphogenesis, endothelial cell chemotaxis, epicardial cell to mesenchymal cell transition, lymph vessel morphogenesis, macrophage differentiation, monocyte differentiation, negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of neuron apoptotic process, negative regulation of transcription from RNA polymerase II promoter, outflow tract morphogenesis, positive regulation of angiogenesis, positive regulation of axon extension involved in axon guidance, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of cell division, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway, positive regulation of CREB transcription factor activity, positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway, positive regulation of endothelial cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of focal adhesion assembly, positive regulation of histone deacetylase activity, positive regulation of MAP kinase activity, positive regulation of mast cell chemotaxis, positive regulation of p38MAPK cascade, positive regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-tyrosine autophosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of positive chemotaxis, positive regulation of protein complex assembly, positive regulation of protein kinase B signaling, positive regulation of protein kinase C signaling, positive regulation of receptor internalization, positive regulation of retinal ganglion cell axon guidance, positive regulation of transcription from RNA polymerase II promoter in response to hypoxia, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of vascular permeability, regulation of cell shape, tube formation
Cellular Componentcell surface, membrane, secretory granule
Links to other databases
Entrez Gene395909
Ensembl GeneENSGALG00000010290
KEGGgga:395909

Entry 1

GEISHA IdVEGFA.UAlinearData SourceGEISHA ISH Analysis
Complete cDNA Template Probeshow
CCGCCACCGCCACCCCGACGTGCGGAGCGGGCTCGGGCTCAGCCCCTTCCTTCCCCCGGGGGAGGCGACCCCGGCTCGC
CGCGAAGAGGGGGCGCAGCGAAAGAGATGCATTGAAACTTTCCGCGCAAACTTCGTGGCGAGTGCGCGAAGCCGAGAGC
GAGCGCGGCGCGGGTGCCTGCCTGCCCCGGCGCCGGGAGAGCGGCCGCGCACGGGCGCCGCTGTGGAGCTCGGATTGCC
CGGCGGCGGGGGCCGGGCGGCGGCGGGGCGGCCGCGGAGCCTGCGCTCGGCCCTGCGGAGCGCCCACCGAGAGCGGCAG
CGGGGGCCGGCGGAGAGCCGGCCGTATGGAGGGGTGAAAGCGGAGACCCCGAAGAGGAGACCCCCTTCCGCCGGAGCCC
CTCGCAGCGCCCGGGAGGCGGCGGGCGCGGAGGAGGCGCGGGCGAGAGCGCGGCAGCGGGGCGGCGGCGGCGGCGGCGG
CGCGGCGGCGAGGCGGAGTGCGGCGGGCCCCGCTCCGCGGCGTGCGCCGGCAACCATGAACTTTCTGCTCACTTGGATC
CACTGGGGGCTGGCGGCGCTGCTCTATCTGCAGAGCGCGGAGTTGTCGAAGGCTGCTCCGGCCCTGGGGGATGGGGAGC
GGAAGCCCAACGAAGTTATCAAATTCCTGGAAGTCTACGAACGCAGCTTCTGCAGGACAATTGAGACCCTGGTGGACAT
TTTCCAGGAGTACCCTGATGAGGTGGAGTACATATTCAGGCCATCCTGTGTGCCTCTGATGAGATGTGCGGGTTGCTGC
GGCGATGAGGGCCTAGAATGTGTCCCTGTGGATGTGTACAACGTCACGATGGAGATCGCAAGAATTAAACCCCATCAGA
GTCAGCACATAGCGCACATGAGCTTCTTACAGCACAGTAAATGTGACTGCAGACCAAAGAAAGATGTCAAAAATAAACA
AGAAAAAAAATCAAAGCGAGGAAAGGGGAAGGGTCAAAAGAGAAAGCGCAAGAAAGGCCGGTACAAACCACCCAGCTTT
CACTGTGAGCCTTGCTCAGAGAGGAGAAAGCACTTGTTTGTACAAGATCCCCAGACCTGTAAATGTTCCTGCAAATTCA
CAGACTCACGTTGCAAGTCGAGGCAGCTTGAGTTAAACGAGCGCACTTGCAGATGTGAAAAACCGAGACGGTGAGCAGC
GGAAAAGAAGGGGGAACAGCCCTGTTTCTGGAGCCTGATTTCTCGCCTGGACAG
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
Area Pellucida
Epiblast
 
4-6
stage 4
stage 5
Area Pellucida
Epiblast
 
7-12
stage 7
stage 9
stage 11
stage 12
Area Opaca
Area Pellucida
Blood Vessels
Heart
Lateral Plate Mesoderm
Somites
Widespread Expression
 
13-18
stage 17
  
19-22
stage 19
stage 22
  

Entry 2

GEISHA IdVEGF.Nanka.2006Data SourcePublication
Complete cDNA Template Probeshow
CAGGCCATCCTGTGTGCCTCTGATGAGATGTGCGGGTTGCTGCGGCGATGAGGGCCTAGAATGTGTCCCTGTGGATGTG
TACAACGTCACGATGGAGATCGCAAGAATTAAACCCCATCAGAGTCAGCACATAGCGCACATGAGCTTCTTACAGCACA
GTAAATGTGACTGCAGACCAAAGAAAGATGTCAAAAATAAGCAAGAAAAAAAATCAAAGCGAGGAAAGGGGAAGGGTCA
AAAGAGAAAGCGCAAGAAAGGNCGGTACAAACCACCCAGCTTTCACTGTGAGCCTTGCTCAGAG
CitationNanka O, Valásek P, Dvoráková M, Grim M. Experimental hypoxia and embryonic angiogenesis. Dev Dyn. 2006 Mar;235(3):723-33.
CopyrightCopyright © 2006 Wiley-Liss, Inc.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (S79680) using primers provided by I. Flamme (quail VEGF, 310-bp probe; Flamme et al., [1995]).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19-22
stage 22
  

Entry 3

GEISHA IdVEGFA.Moran.2011Data SourcePublication
Complete cDNA Template Probeshow
CCGCCACCGCCACCCCGACGTGCGGAGCGGGCTCGGGCTCAGCCCCTTCCTTCCCCCGGGGGAGGCGACCCCGGCTCGC
CGCGAAGAGGGGGCGCAGCGAAAGAGATGCATTGAAACTTTCCGCGCAAACTTCGTGGCGAGTGCGCGAAGCCGAGAGC
GAGCGCGGCGCGGGTGCCTGCCTGCCCCGGCGCCGGGAGAGCGGCCGCGCACGGGCGCCGCTGTGGAGCTCGGATTGCC
CGGCGGCGGGGGCCGGGCGGCGGCGGGGCGGCCGCGGAGCCTGCGCTCGGCCCTGCGGAGCGCCCACCGAGAGCGGCAG
CGGGGGCCGGCGGAGAGCCGGCCGTATGGAGGGGTGAAAGCGGAGACCCCGAAGAGGAGACCCCCTTCCGCCGGAGCCC
CTCGCAGCGCCCGGGAGGCGGCGGGCGCGGAGGAGGCGCGGGCGAGAGCGCGGCAGCGGGGCGGCGGCGGCGGCGGCGG
CGCGGCGGCGAGGCGGAGTGCGGCGGGCCCCGCTCCGCGGCGTGCGCCGGCAACCATGAACTTTCTGCTCACTTGGATC
CACTGGGGGCTGGCGGCGCTGCTCTATCTGCAGAGCGCGGAGTTGTCGAAGGCTGCTCCGGCCCTGGGGGATGGGGAGC
GGAAGCCCAACGAAGTTATCAAATTCCTGGAAGTCTACGAACGCAGCTTCTGCAGGACAATTGAGACCCTGGTGGACAT
TTTCCAGGAGTACCCTGATGAGGTGGAGTACATATTCAGGCCATCCTGTGTGCCTCTGATGAGATGTGCGGGTTGCTGC
GGCGATGAGGGCCTAGAATGTGTCCCTGTGGATGTGTACAACGTCACGATGGAGATCGCAAGAATTAAACCCCATCAGA
GTCAGCACATAGCGCACATGAGCTTCTTACAGCACAGTAAATGTGACTGCAGACCAAAGAAAGATGTCAAAAATAAACA
AGAAAAAAAATCAAAGCGAGGAAAGGGGAAGGGTCAAAAGAGAAAGCGCAAGAAAGGCCGGTACAAACCACCCAGCTTT
CACTGTGAGCCTTGCTCAGAGAGGAGAAAGCACTTGTTTGTACAAGATCCCCAGACCTGTAAATGTTCCTGCAAATTCA
CAGACTCACGTTGCAAGTCGAGGCAGCTTGAGTTAAACGAGCGCACTTGCAGATGTGAAAAACCGAGACGGTGAGCAGC
GGAAAAGAAGGGGGAACAGCCCTGTTTCTGGAGCCTGATTTCTCGCCTGGACAG
CitationMoran CM, Salanga MC, Krieg PA. Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development. Dev Dyn. 2011 Jun;240(6):1354-64.
CopyrightCopyright © 2011 Wiley-Liss, Inc.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205042).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-10
stage 10
stage 10
Neural Plate/Tube
Somites
 

Entry 4

GEISHA IdVEGF.Loscertales.2008Data SourcePublication
Complete cDNA Template Probeshow
CAACCATGAACTTTCTGCTCACTTGGATCCACTGGGGGCTGGCGGCGCTGCTCTATCTGCAGAGCGCGGAGTTGTCGAA
GGCTGCTCCGGCCCTGGGGGATGGGGAGCGGAAGCCCAACGAAGTTATCAAATTCCTGGAAGTCTACGAACGCAGCTTC
TGCAGGACAATTGAGACCCTGGTGGACATTTTCCAGGAGTACCCTGATGAGGTGGAGTACATATTCAGGCCATCCTGTG
TGCCTCTGATGAGATGTGCGGGTTGCTGCGGCGATGAGGGCCTAGAATGTGTCCCTGTGGATGTGTACAACGTCACGAT
GGAGATCGCAAGAATTAAACCCCATCAGAGTCAGCACATAGCGCACATGAGCTTCTTACAGCACAGTAAATGTGACTGC
AGACCAAAGAAAGATGTCAAAAATAAACAAGAAAAAAAATCAAAGCGAGGAAAGGGGAAGGGTCAAAAGAGAAAGCGCA
AGAAAGGCCGGTACAAACCACCCAGCTTTCACTGTGAGCCTTGCTCAGAGAGGAGAAAGCACTTGTTTGTACAAGATCC
CCAGACCTGTAAATGTTCCTGCAAATTCACAGACTCACGTTGCAAGTCGAGGCAGCTTGAGTTAAACGAGCGCACTTGC
AGATGTGAAAAACCGAGACGGTGAGCAGCGGAAAAGAAGGGGGAACAGCCCTGTTTCTGGAGCCTGATTTCTCGCCTGG
ACAG
CitationLoscertales M, Mikels AJ, Hu JK, Donahoe PK, Roberts DJ. Chick pulmonary Wnt5a directs airway and vascular tubulogenesis. Development. 2008 Apr;135(7):1365-76. Epub 2008 Feb 27.
Copyrightcopyright 2008 The authors. Published by the Company of Biologists Ltd.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
31-40
stage 40
stage 40
Lung
 

Entry 5

GEISHA IdVEGFA.Moran.2012Data SourcePublication
Complete cDNA Template Probeshow
GCGGCTCGAGAACAAATGGCCCTGCCAGGAAAGGAATCTCCTTCCAACTTGGTGCGTCTGCTAGGGGAAGACTGGGAAC
ACTGTGTTTTCTGCAGGGCCATCTGATGCTGTCTGCGATGCTGCACTTGTTTACTGCAGCGTGTTGTGGCTCTGGGAAT
TGCAGCACAGAAATGTCCAAAAGGTTTTATACTTGGCTTATTTCTCAGAAAGCTGTGACTTGGAAAACTCAGGCCGGCC
TAACCTTTCTTCCAAGTATTCAAACAATATGCTTGGTAATGTCATTCTGCAGACAGTTTTGATTTCTGATTTTTCCAAT
TAATTTTGGGAGAAAACAGAGGTCCTGGAATTTCCCACAAAGCAGAATTTCTGTTGTTCCACCAGCTTGACTCAGCAAG
AATTTCTCCCACAGGAATTTGGCCTTGTCGAAGGCTGCTCCGGCCCTGGGGGATGGGGAGCGGAAGCCCAACGAAGTTA
TCAAATTCCTGGAAGTCTACGAACGCAGCTTCTGCAGGACAATTGAGACCCTGGTGGACATTTTCCAGGAGTACCCTGA
TGAGGTGGAGTACATATTCAGGCCATCCTGTGTGCCTTTGATGAGATGTGCGGGTTGCTGCGGCGATGAGGGCCTAGAA
TGTGTCCCTGTGGATGTGTACAACGTCACGATGGAGATCGCAAGAAATTAAAGCCCCATCAAGAGTCAGCACATAAGCG
CACATTGAGGCTTCTTTACAGGCACCAGTAAATGTGACTGCAGACCCAAAGAAAGATGTTCAAAATAAACAAGAAAATC
ACTGTGAGCCTTGCTCCAGAGAGGAGAAAGCCACTTGTTTGGTCAAGATCCCA
CitationMoran CM, Myers CT, Lewis CM, Krieg PA. Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway. Dev Dyn. 2012 Jun;241(6):1034-42.
CommentsThe cDNA template for the probe was obtained from BBSRC - VEGFA (ChEST820k21) as described in the publication.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-10
stage 10
stage 10
stage 10
Neural Plate/Tube
Somites
control embryo

Entry 6

GEISHA IdVEGF‐A.Ivnitski-Steele.2004Data SourcePublication
Complete cDNA Template Probeshow
CCGCCACCGCCACCCCGACGTGCGGAGCGGGCTCGGGCTCAGCCCCTTCCTTCCCCCGGGGGAGGCGACCCCGGCTCGC
CGCGAAGAGGGGGCGCAGCGAAAGAGATGCATTGAAACTTTCCGCGCAAACTTCGTGGCGAGTGCGCGAAGCCGAGAGC
GAGCGCGGCGCGGGTGCCTGCCTGCCCCGGCGCCGGGAGAGCGGCCGCGCACGGGCGCCGCTGTGGAGCTCGGATTGCC
CGGCGGCGGGGGCCGGGCGGCGGCGGGGCGGCCGCGGAGCCTGCGCTCGGCCCTGCGGAGCGCCCACCGAGAGCGGCAG
CGGGGGCCGGCGGAGAGCCGGCCGTATGGAGGGGTGAAAGCGGAGACCCCGAAGAGGAGACCCCCTTCCGCCGGAGCCC
CTCGCAGCGCCCGGGAGGCGGCGGGCGCGGAGGAGGCGCGGGCGAGAGCGCGGCAGCGGGGCGGCGGCGGCGGCGGCGG
CGCGGCGGCGAGGCGGAGTGCGGCGGGCCCCGCTCCGCGGCGTGCGCCGGCAACCATGAACTTTCTGCTCACTTGGATC
CACTGGGGGCTGGCGGCGCTGCTCTATCTGCAGAGCGCGGAGTTGTCGAAGGCTGCTCCGGCCCTGGGGGATGGGGAGC
GGAAGCCCAACGAAGTTATCAAATTCCTGGAAGTCTACGAACGCAGCTTCTGCAGGACAATTGAGACCCTGGTGGACAT
TTTCCAGGAGTACCCTGATGAGGTGGAGTACATATTCAGGCCATCCTGTGTGCCTCTGATGAGATGTGCGGGTTGCTGC
GGCGATGAGGGCCTAGAATGTGTCCCTGTGGATGTGTACAACGTCACGATGGAGATCGCAAGAATTAAACCCCATCAGA
GTCAGCACATAGCGCACATGAGCTTCTTACAGCACAGTAAATGTGACTGCAGACCAAAGAAAGATGTCAAAAATAAACA
AGAAAATCACTGTGAGCCTTGCTCAGAGAGGAGAAAGCACTTGTTTGTACAAGATCCCCAGACCTGTAAATGTTCCTGC
AAATTCACAGACTCACGTTGCAAGTCGAGGCAGCTTGAGTTAAACGAGCGCACTTGCAGATGTGAAAAACCGAGACGGT
GAGCAGCGGAAAAGAAGGGGGAACAGCCCTGTTTCTGGAGCCTGATTTCTCGCCTGGACAG
CitationIvnitski-Steele ID, Sanchez A, Walker MK. 2,3,7,8-tetrachlorodibenzo-p-dioxin reduces myocardial hypoxia and vascular endothelial growth factor expression during chick embryo development. Birth Defects Res A Clin Mol Teratol. 2004 Feb;70(2):51-8.
CopyrightCopyright © 2004 Wiley‐Liss, Inc.
CommentsThe complete cDNA template sequence was obtained from the information provided in the publication as described in Ivnitski-Steele et al. 2004. VEGF‐A is also known as VEGF in NCBI.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
31-44
stage 36
stage 44
Ventricles
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.537

Mouse

EmageMGI:103178
EurexpressMGI:103178
MGI GXDMGI:103178

Frog

Xenbase485743

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-030131-4605, ZDB-GENE-990415-273
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