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Human Disease Gene Search
VEGFA The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol VEGFA Official Full Name vascular endothelial growth factor A CGNC ID 7830 also known as VEGF, vascular endothelial growth factor A|VEGF-A|VPF|vascular permeability factor, Vascular endothelial growth factor A precursor , VEGF-A, Vascular permeability factor, VPF gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function chemoattractant activity , fibronectin binding , growth factor activity , heparin binding , more... identical protein binding , platelet-derived growth factor receptor binding , protein heterodimerization activity , receptor agonist activity , vascular endothelial growth factor receptor 1 binding , vascular endothelial growth factor receptor 2 binding Biological Process activation of protein kinase activity , basophil chemotaxis , blood vessel maturation , more... cardiac vascular smooth muscle cell development , cell migration involved in sprouting angiogenesis , commissural neuron axon guidance , coronary artery morphogenesis , coronary vein morphogenesis , endothelial cell chemotaxis , epicardial cell to mesenchymal cell transition , lymph vessel morphogenesis , macrophage differentiation , monocyte differentiation , negative regulation of cysteine-type endopeptidase activity involved in apoptotic process , negative regulation of extrinsic apoptotic signaling pathway , negative regulation of neuron apoptotic process , negative regulation of transcription from RNA polymerase II promoter , outflow tract morphogenesis , positive regulation of angiogenesis , positive regulation of axon extension involved in axon guidance , positive regulation of branching involved in ureteric bud morphogenesis , positive regulation of cell division , positive regulation of cell migration involved in sprouting angiogenesis , positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway , positive regulation of CREB transcription factor activity , positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway , positive regulation of endothelial cell proliferation , positive regulation of ERK1 and ERK2 cascade , positive regulation of focal adhesion assembly , positive regulation of histone deacetylase activity , positive regulation of MAP kinase activity , positive regulation of mast cell chemotaxis , positive regulation of p38MAPK cascade , positive regulation of peptidyl-serine phosphorylation , positive regulation of peptidyl-tyrosine autophosphorylation , positive regulation of peptidyl-tyrosine phosphorylation , positive regulation of positive chemotaxis , positive regulation of protein complex assembly , positive regulation of protein kinase B signaling , positive regulation of protein kinase C signaling , positive regulation of receptor internalization , positive regulation of retinal ganglion cell axon guidance , positive regulation of transcription from RNA polymerase II promoter in response to hypoxia , positive regulation of vascular endothelial growth factor receptor signaling pathway , positive regulation of vascular permeability , regulation of cell shape , tube formation Cellular Component cell surface , membrane , secretory granule
Links to other databases
Entry 1 GEISHA Id VEGFA.UAlinear Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CCGCCACCGCCACCCCGACGTGCGGAGCGGGCTCGGGCTCAGCCCCTTCCTTCCCCCGGGGGAGGCGACCCCGGCTCGC
Entry 2 GEISHA Id VEGF.Nanka.2006 Data Source Publication Complete cDNA Template Probe show CAGGCCATCCTGTGTGCCTCTGATGAGATGTGCGGGTTGCTGCGGCGATGAGGGCCTAGAATGTGTCCCTGTGGATGTG
Citation Nanka O, Valásek P, Dvoráková M, Grim M. Experimental hypoxia and embryonic angiogenesis. Dev Dyn. 2006 Mar;235(3):723-33. Copyright Copyright © 2006 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (S79680) using primers provided by I. Flamme (quail VEGF, 310-bp probe; Flamme et al., [1995]).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 22
Entry 3 GEISHA Id VEGFA.Moran.2011 Data Source Publication Complete cDNA Template Probe show CCGCCACCGCCACCCCGACGTGCGGAGCGGGCTCGGGCTCAGCCCCTTCCTTCCCCCGGGGGAGGCGACCCCGGCTCGC
Citation Moran CM, Salanga MC, Krieg PA. Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development. Dev Dyn. 2011 Jun;240(6):1354-64.
Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205042).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Neural Plate/Tube Somites
Entry 4 GEISHA Id VEGF.Loscertales.2008 Data Source Publication Complete cDNA Template Probe show CAACCATGAACTTTCTGCTCACTTGGATCCACTGGGGGCTGGCGGCGCTGCTCTATCTGCAGAGCGCGGAGTTGTCGAA
Citation Loscertales M, Mikels AJ, Hu JK, Donahoe PK, Roberts DJ. Chick pulmonary Wnt5a directs airway and vascular tubulogenesis. Development. 2008 Apr;135(7):1365-76. Epub 2008 Feb 27. Copyright copyright 2008 The authors. Published by the Company of Biologists Ltd.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-40 stage 40
stage 40
Lung
Entry 5 GEISHA Id VEGFA.Moran.2012 Data Source Publication Complete cDNA Template Probe show GCGGCTCGAGAACAAATGGCCCTGCCAGGAAAGGAATCTCCTTCCAACTTGGTGCGTCTGCTAGGGGAAGACTGGGAAC
Citation Moran CM, Myers CT, Lewis CM, Krieg PA. Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway. Dev Dyn. 2012 Jun;241(6):1034-42. Comments The cDNA template for the probe was obtained from BBSRC - VEGFA (ChEST820k21) as described in the publication.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
stage 10
Neural Plate/Tube Somites
Entry 6 GEISHA Id VEGF‐A.Ivnitski-Steele.2004 Data Source Publication Complete cDNA Template Probe show CCGCCACCGCCACCCCGACGTGCGGAGCGGGCTCGGGCTCAGCCCCTTCCTTCCCCCGGGGGAGGCGACCCCGGCTCGC
Citation Ivnitski-Steele ID, Sanchez A, Walker MK. 2,3,7,8-tetrachlorodibenzo-p-dioxin reduces myocardial hypoxia and vascular endothelial growth factor expression during chick embryo development. Birth Defects Res A Clin Mol Teratol. 2004 Feb;70(2):51-8. Copyright Copyright © 2004 Wiley‐Liss, Inc. Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Ivnitski-Steele et al. 2004. VEGF‐A is also known as VEGF in NCBI.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44 stage 36
stage 44
Ventricles
Data from NCBI Unigene EST ProfileGga.537
Mouse Frog Fruit Fly Zebra Finch Zebrafish
