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WNT11 Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol WNT11 Official Full Name Wnt family member 11 CGNC ID 546 also known as protein Wnt-11|Wnt-11 protein|wingless-type MMTV integration site family, member 11, Wnt-11 protein precursor, wingless-type MMTV integration site family, member 11 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Entrez Gene Ensembl Gene Genetic Phenotypes MOD Fruit Fly Human 7481 ENSG00000085741 MIM:603699 Mouse 22411 ENSMUSG00000015957 All phenotypic alleles (6 ):Targeted, knock-out(2 ) Targeted, other(4 ) MGI:101948 Xenopus 100158655 , 446915 , 549489 , 399441 854157 , 5858980 Zebrafish 30283 , 791595 ENSDARG00000014796 , ENSDARG00000004256 ZDB-GENE-980526-249 , ZDB-GENE-990603-12 ZFIN:ZDB-GENE-980526-249 , ZFIN:ZDB-GENE-990603-12
Gene Ontology Molecular Function frizzled binding , protein kinase activator activity , Ras GTPase activator activity , more... transcription regulatory region DNA binding Biological Process cell fate commitment , negative regulation of apoptotic process , more... negative regulation of canonical Wnt signaling pathway , negative regulation of cell death , negative regulation of cell growth , negative regulation of cell migration , negative regulation of transcription, DNA-templated , neuroendocrine cell differentiation , neuron differentiation , palate development , positive regulation of cell migration , positive regulation of gene expression , positive regulation of protein kinase activity , positive regulation of protein kinase C signaling , positive regulation of Ras GTPase activity , positive regulation of stress fiber assembly , positive regulation of transcription, DNA-templated , protein localization to cell surface , protein phosphorylation , Wnt signaling pathway Cellular Component cytoplasm , extracellular space , proteinaceous extracellular matrix
Links to other databases
Entry 1 GEISHA Id WNT11.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATAATGAGAAAGTGGGGTCGCAC Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGGCTGTGTGTGAAAATCCATCAAGC cDNA Template Length 860 Forward cDNA Template Probe show TTAAACATNGGGCTAATAGCCANACACCTAGGAGACACGATTTTCCTGATATGAAAGTCCCATTGGAGGTCACAGAGGT
Entry 2 GEISHA Id Wnt11 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Entry 3 GEISHA Id Wnt11.Chapman.2004 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 4
stage 4
stage 5
Hensen's Node Mesoderm, early
Entry 4 GEISHA Id Wnt11.Rhodes.2006 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Rhodes LSS, Merzdorf CS. The zic1 gene is expressed in chick somites but not in migratory neural crest. Gene Expr Patterns. 2006 Jun;6(5):539-45. Epub 2006 Jan 31. Copyright Reprinted with permission from Elsevier.
Copyright © 2005 Elsevier B.V. All rights reserved.
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204784).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
stage 18
Dermomyotome
Entry 5 GEISHA Id Wnt11.Cheng.2004 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Cheng L, Alvares LE, Ahmed MU, El-Hanfy AS, Dietrich S. The epaxial-hypaxial subdivision of the avian somite. Dev Biol. 2004 Oct 15;274(2):348-69. Copyright Reprinted from Developmental Biology, Volume 274, Issue 2, Louise Cheng, Lúcia E. Alvares, Mohi U. Ahmend, Amira S. El-Hanfy, and Susanne Dietrich, The epaxial-hypaxial subdivision of the avian somite, Pages 348-369, Copyright 2004, with permission from Elsevier.
Copyright © 2004 Elsevier B.V. All rights reserved. Comments Authors indicate probe is from Tanda et al., 1995 who indicate their probe has Genbank Acc# D31901.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7 stage 7
Dermomyotome
Entry 6 GEISHA Id Wnt11.Sakiyama.2000 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Sakiyama J, Yokouchi Y, Kuroiwa A. Coordinated expression of Hoxb genes and signaling molecules during development of the chick respiratory tract. Dev Biol. 2000 Nov 1;227(1):12-27. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204784).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 24
Lung 25-29 stage 27
stage 29
stage 29
Lung
Entry 7 GEISHA Id Wnt11.Hardy.2008 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Hardy KM, Garriock RJ, Yatskievych TA, D'Agostino SL, Antin PB, Krieg PA. Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene, Wnt11b, regulates cell migration during avian gastrulation. Dev Biol. 2008 Aug 15;320(2):391-401. Epub 2008 May 29. Copyright "Reprinted from Developmental Biology, 320, Hardy, KM, Garriock, RJ, Yatskievych, TA, D'Agostino, SL, Antin, PB, Krieg, PA. Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene, Wnt11b, regulates cell migration during avian gastrulation., Pages No., Copyright (2008), with permission from Elsevier".
Copyright © 2008 Elsevier B.V. All rights reserved. Comments Authors said: The Wnt11 probe was derived from a clone in the GEISHA database that encompasses the entire open reading frame. Below we show NM_204784.1.
Entry 8 GEISHA Id Wnt11.Tonegawa.2003 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Tonegawa A, Kasai T, Takahashi Y. Systematic screening for signaling molecules expressed during somitogenesis by the signal sequence trap method. Dev Biol. 2003 Oct 1;262(1):32-50. Copyright "Reprinted from DEVELOPMENTAL BIOLOGY, 262, Tonegawa A, Kasai T, Takahashi Y. Systematic screening for signaling molecules expressed during somitogenesis by the signal sequence trap method. 32-50, Copyright (2003), with permission from Elsevier".
Copyright © 2003 Elsevier B.V. All rights reserved. Comments Accession number was given in the paper.
Entry 9 GEISHA Id Wnt11.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Comments Images Provided by Susan Chapman.
Entry 10 GEISHA Id Wnt11.Agarwala.2005 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments According to the authors, "Digoxigenin
(DIG)- and fluorescein-labeled riboprobes were synthesized from chick cDNA plasmids..." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (NM_204784).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-26 stage 26
Neural Plate/Tube Spinal Cord
Entry 11 GEISHA Id Wnt11.Theodosiou.2005 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Theodosiou NA, Tabin CJ (2005). Sox9 and Nkx2.5 determine the pyloric sphincter epithelium under the control of BMP signaling. Dev Biol. 2005 Mar 15;279(2):481-90. Copyright Copyright © 2004 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204784).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 26
Gizzard 31-32 stage 32
Entry 12 GEISHA Id Wnt11.Skromne.2001 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Skromne I, Stern CD. Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo. Development. 2001 Aug;128(15):2915-27
Copyright Printed in Great Britain © The Company of Biologists Limited 2001 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204784).
Entry 13 GEISHA Id Wnt11.Theodosiou.2003 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Theodosiou NA, Tabin CJ. Wnt signaling during development of the gastrointestinal tract. Dev Biol. 2003 Jul 15;259(2):258-71. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments Authors said: Probe derived from 1827 bp ORF. This is the full length of the mRNA (NCBI acc# NM_204784).
Entry 14 GEISHA Id WNT11.Geetha-Loganathan.2009 Data Source Publication Complete cDNA Template Probe show AGCCGAGCCCGCAATTTTTCTTAGCTGCTTTTCTGTCCTTGATTCTGCAGACGGGGATTTGCTACGGGATAAAATGGAT
Citation Geetha-Loganathan, P, Nimmagadda, S, Antoni, L, Fu, K, Whiting, C, Francis-West, P and Richman, J. Expression of WNT signalling pathway genes during chicken craniofacial development. DEVELOPMENTAL DYNAMICS
Volume 238, Issue 5, May 2009, Pages: 11501165. Copyright Dev. Dyn Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved. Comments "(inner primers: 5'CCATGGAGCCGAGCCCGCAATTTTTC;
3'GAATTCATTTGCAGACGTATCTCTC.
Outer primers: 5¢CTTTCTGAAAGTGGGGGACG; 3¢:
ATCTCAGCTCAGCAGACGAG)."
"Authors indicated the probe could be found in another publication (see text). The indicated probe sequence is included here"
Entry 15 GEISHA Id WNT11.Sienknecht.2009 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Sienknecht UJ, Fekete DM. Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordium. J Comp Neurol. 2009 Dec 20;517(6):751-64. Copyright Copyright © (2002 Wiley-Liss); This material is used by permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204784.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-23 stage 20
stage 20
stage 23
stage 23
Ear/Otic Placode
Entry 16 GEISHA Id Wnt11.Brauner.2010 Data Source Publication Complete cDNA Template Probe show GTGGAAAAAATGAAGCCGAGCCCGCAATTTTTCTTAGCTGCTTTTCTGTCCTTGATTCTGCAGACGGGGATTTGCTACG
Citation Brauner I, Spicer DB, Krull CE, Venuti JM. Identification of responsive cells in the developing somite supports a role for beta-catenin-dependent Wnt signaling in maintaining the DML myogenic progenitor pool. Dev Dyn. 2010 Jan;239(1):222-36. Copyright Copyright © 2010 John Wiley & Sons, Inc. All Rights Reserved. Comments Text from citation in paper: We have isolated the full coding sequence of the chick Wnt-11 by RTPCR, using 2- to 3-day-old chick total RNA as template. We chose
two sets of nested oligonucleotide primers within the published Wnt-
11 sequence (citation) to amplify the gene (inner primers: 5′CCATGGAGCCGAGCCCGCAATTTTTC; 3′GAATTCATTTGCAGACGTATCTCTC. Outer primers: 5′CTTTCTGAAAGTGGGGGACG; 3′:
ATCTCAGCTCAGCAGACGAG)
In situ probes were generated from a 1-kb chicken Wnt11 clone encompassing the entire coding region
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13 stage 13
stage 13
stage 13
stage 13
Dermomyotome Somites
Entry 17 GEISHA Id WNT11.Bond.2003 Data Source Publication Complete cDNA Template Probe show GAGCTGCGAGACATTGCACTGGACCTCAAAAACAAGTATCTGTCAGCCACCAAGGTCGTTCATCGGCCCATGGGCACAC
Citation Bond J, Sedmera D, Jourdan J, Zhang Y, Eisenberg CA, Eisenberg LM, Gourdie RG. Wnt11 and Wnt7a are up-regulated in association with differentiation of cardiac conduction cells in vitro and in vivo. Dev Dyn. 2003 Aug;227(4):536-43. Copyright Copyright © 2003 Wiley-Liss, Inc. Comments The probe was amplified by PCR using the following primers:
5';-GAGCTGCGAGAC-3'; and 5';-TACCACTGGTGCTGC-3'; and was partially extracted here from NCBI Acc# NM_204784.1
Entry 18 GEISHA Id Wnt-11.Cauthen.2001 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Cauthen CA, Berdougo E, Sandler J, Burrus LW. Comparative analysis of the expression patterns of Wnts and Frizzleds during early myogenesis in chick embryos. Mech Dev. 2001 Jun;104(1-2):133-8. Copyright Copyright © 2001 Elsevier Science Ireland Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204784.1).
Entry 19 GEISHA Id Wnt11.Loganathan.2005 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Loganathan PG, Nimmagadda S, Huang R, Scaal M, Christ B. Comparative analysis of the expression patterns of Wnts during chick limb development. Histochem Cell Biol. 2005 Feb;123(2):195-201. Copyright Copyright © Springer-Verlag 2005 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204784.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 17
Wing 19-24 stage 20
stage 23
Wing 25-30 stage 26
stage 26
stage 29
Limb Buds Wing 31-44 stage 31
stage 34
stage 44
stage 44
Wing
Entry 20 GEISHA Id Wnt-11.Stark.2000 Data Source Publication Complete cDNA Template Probe show TCCCCAGCGCACGGGCTGAAGGAAATACATTGCACGGGAGATTCAGAAGCCTCCTATTTTCCCCTCGGAGCAGCTGATT
Citation Stark MR, Rao MS, Schoenwolf GC, Yang G, Smith D, Mauch TJ. Frizzled-4 expression during chick kidney development. Mech Dev. 2000 Nov;98(1-2):121-5. Copyright Copyright © 2000 Elsevier Science Ireland Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204784).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-44 stage 40
stage 40
stage 44
Renal
Data from NCBI Unigene EST ProfileGga.306
Mouse Frog Fruit Fly Zebra Finch Zebrafish
