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WNT8A Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol WNT8A Official Full Name Wnt family member 8A CGNC ID 4563 also known as CWNT-8C, Wnt8c, protein Wnt-8c|CWnt-8|Wnt-8C|wingless-type MMTV integration site family, member 8A, CWnt-8, Wnt8a, Wnt-8c protein precursor gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id WNT8A.UApcr Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CATCACAAACAAAATCGGGAACTTGTGTAAAGCCCGATGAAGGAGCTCAAGTCCATGGGGTTCAGGCAGTTGCAGATCC
Entry 2 GEISHA Id Wnt8c.Mikawa.2004 Data Source Publication Complete cDNA Template Probe show ATGAGGGGCAGCACCTTCCTCCTCCTCTCCATCGTGGGCATCTACGGTGCTATTCTCAATGCAGCAGCATGGTCGGTGA
Citation Mikawa, T, Poh, A, Kelly, K, Ishii, Y, Reese, D. Induction and Patterning of the Primitive Streak, an Organizing Center of Gastrulation in the Amniote. Dev Dyn. 2004 Mar;229(3):422-32. Copyright Copyright © 2004 Wiley-Liss, Inc.
Entry 3 GEISHA Id Wnt8c.Chapman.2004 Data Source Publication Complete cDNA Template Probe show ATGAGGGGCAGCACCTTCCTCCTCCTCTCCATCGTGGGCATCTACGGTGCTATTCTCAATGCAGCAGCATGGTCGGTGA
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 4
stage 5
stage 5
Primitive Streak
Entry 4 GEISHA Id Wnt8c.Ehrman.2001 Data Source Publication Complete cDNA Template Probe show GCTCCGCTGGTGTTATGTACACCCTGACCAGGAACTGCAGCTTAGGAGACTTCGAGAGCTGCGGCTGTGATGACTCCAG
Citation Ehrman LA, Yutzey KE. Anterior expression of the caudal homologue cCdx-B activates a posterior genetic program in avian embryos. Dev Dyn. 2001 Aug;221(4):412-21. Copyright 2001 Wiley-Liss, Inc.
Entry 5 GEISHA Id Wnt8b.Garcia-Calero.2006 Data Source Publication Complete cDNA Template Probe show ATGGGGCGGGGCAGGGCAGGCAGACAGGACCCCAATAGGTGTAGGCAGGAGAACGTGCTGAGGGACCAGAGGTCAGTGA
Citation García-Calero E, Garda AL, Marín F, Puelles L. Expression of Lrrn1 marks the prospective site of the zona limitans thalami in the early embryonic chicken diencephalon. Gene Expr Patterns. 2006 Oct;6(8):879-85. Epub 2006 Feb 28. Copyright Reprinted with permission from Elsevier. Copyright © 2006 Elsevier B.V. All rights reserved. Comments According to the authors, "Digoxigenin-labeled RNA probes were prepared from plasmids kindly provided by ... A. McMahon(Wnt8b)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (XM_426508).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 20
Forebrain Telencephalon
Entry 6 GEISHA Id Wnt8c.Ladher.2000 Data Source Publication Complete cDNA Template Probe show ATGAGGGGCAGCACCTTCCTCCTCCTCTCCATCGTGGGCATCTACGGTGCTATTCTCAATGCAGCAGCATGGTCGGTGA
Citation Ladher RK, Church VL, Allen S, Robson L, Abdelfattah A, Brown NA, Hattersley G, Rosen V, Luyten FP, Dale L, Francis-West PH. Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev Biol. 2000 Feb 15;218(2):183-98. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
Comments According to the authors, "... Wnt-8c
(Hume and Dodd, 1993) were used as previously described." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (AB193181).
Entry 7 GEISHA Id Wnt8c.Baranski.2000 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation Baranski M, Berdougo E, Sandler JS, Darnell DK, Burrus LW. The dynamic expression pattern of frzb-1 suggests multiple roles in chick development. Dev Biol. 2000 Jan 1;217(1):25-41. Copyright Copyright © 2000 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205531).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
stage 4
Primitive Streak
Entry 8 GEISHA Id Wnt8c.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show ATGAGGGGCAGCACCTTCCTCCTCCTCTCCATCGTGGGCATCTACGGTGCTATTCTCAATGCAGCAGCATGGTCGGTGA
Comments Insufficient information provided to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # AB193181). Images Provided by Susan Chapman.
Entry 9 GEISHA Id Wnt8b.Vieira.2005 Data Source Publication Complete cDNA Template Probe show ATGGGGCGGGGCAGGGCAGGCAGACAGGACCCCAATAGGTGTAGGCAGGAGAACGTGCTGAGGGACCAGAGGTCAGTGA
Citation Vieira C, Garda AL, Shimamura K, Martinez S. Thalamic development induced by Shh in the chick embryo. Dev Biol. 2005 Aug 15;284(2):351-63. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments According to the authors, "Digoxigenin and fluorescein-labeled RNA probes were
prepared from plasmids kindly provided by A. McMahon." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (XM_426508).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25 stage 25
Forebrain Midbrain
Entry 10 GEISHA Id Wnt8c.Skromne.2001 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation Skromne I, Stern CD. Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo. Development. 2001 Aug;128(15):2915-27
Copyright Printed in Great Britain © The Company of Biologists Limited 2001 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205531).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) X-XIV stage XII
stage XII
Area Opaca
Entry 11 GEISHA Id Wnt8c.Joubin.1999 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation Joubin K, Stern CD. Molecular interactions continuously define the organizer during the cell movements of gastrulation. Cell. 1999 Sep 3;98(5):559-71. Copyright Copyright © 1999 Cell Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205531).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
Primitive Streak
Entry 12 GEISHA Id Wnt8b.Theodosiou.2003 Data Source Publication Complete cDNA Template Probe show ATGGGGCGGGGCAGGGCAGGCAGACAGGACCCCAATAGGTGTAGGCAGGAGAACGTGCTGAGGGACCAGAGGTCAGTGA
Citation Theodosiou NA, Tabin CJ. Wnt signaling during development of the gastrointestinal tract. Dev Biol. 2003 Jul 15;259(2):258-71. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_426508.2).
Entry 13 GEISHA Id Wnt8c.Garcia-Castro.2002 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation García-Castro MI, Marcelle C, Bronner-Fraser M. Ectodermal Wnt function as a neural crest inducer. Science. 2002 Aug 2;297(5582):848-51. Copyright Copyright © 2002, The American Association for the Advancement of Science Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc. #NM_205531.1)
Entry 14 GEISHA Id WNT8C.Olivera-Martinez.2007 Data Source Publication Complete cDNA Template Probe show ATGAGGGGCAGCACCTTCCTCCTCCTCTCCATCGTGGGCATCTACGGTGCTATTCTCAATGCAGCAGCATGGTCGGTGA
Citation Olivera-Martinez I, Storey KG., Wnt signals provide a timing mechanism for the FGF-retinoid differentiation switch during vertebrate body axis extension. Development. 2007 Jun;134(11):2125-35. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Storey. Comments Authors indicated they had the clone associated with NCBI Acc# AF181680, and we inferred this was used as their probe. Its sequence is shown here.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
stage 10
stage 10
Neural Plate/Tube
Entry 15 Entry 16 GEISHA Id WNT8C.Chapman.2007 Data Source Publication Complete cDNA Template Probe show ATGAGGGGCAGCACCTTCCTCCTCCTCTCCATCGTGGGCATCTACGGTGCTATTCTCAATGCAGCAGCATGGTCGGTGA
Citation Chapman SC, Matsumoto K, Cai Q, Schoenwolf GC.
Specification of germ layer identity in the chick gastrula. BMC Dev Biol. 2007 Jul 30;7:91.
Copyright © 2007 Chapman et al; licensee BioMed Central Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AB193181.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 1-3 stage 3
stage 3
Primitive Streak
Entry 17 GEISHA Id WNT8.Alev.2010 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation Alev C, Wu Y, Kasukawa T, Jakt LM, Ueda HR, Sheng G. Transcriptomic landscape of the primitive streak. Development. 2010 Sep 1;137(17):2863-74. Epub 2010 Jul 28. Copyright Published by The Company of Biologists 2010. This material is protected by a copyright retained by the authors. Permission granted by Dr. G Sheng. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205531.1).
Entry 18 GEISHA Id WNT8B.Sienknecht.2009 Data Source Publication Complete cDNA Template Probe show ATGGGGCGGGGCAGGGCAGGCAGACAGGACCCCAATAGGTGTAGGCAGGAGAACGTGCTGAGGGACCAGAGGTCAGTGA
Citation Sienknecht UJ, Fekete DM. Mapping of Wnt, frizzled, and Wnt inhibitor gene expression domains in the avian otic primordium. J Comp Neurol. 2009 Dec 20;517(6):751-64. Copyright Copyright © (2002 Wiley-Liss); This material is used by permission of Wiley-Liss, Inc., a subsidiary of John Wiley & Sons, Inc.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 20
stage 20
Ear/Otic Placode Hindbrain
Entry 19 GEISHA Id WNT8C.Stuhlmiller.2012 Data Source Publication Complete cDNA Template Probe show ATGAGGGGCAGCACCTTCCTCCTCCTCTCCATCGTGGGCATCTACGGTGCTATTCTCAATGCAGCAGCATGGTCGGTGA
Citation Stuhlmiller TJ, García-Castro MI. FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction. Development. 2012 Jan;139(2):289-300. Copyright © 2012. Published by The Company of Biologists Ltd Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AB193181.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 5
stage 5
Primitive Streak
Entry 20 GEISHA Id WNT8C.Vasiev.2010 Data Source Publication Complete cDNA Template Probe show ATGAGGGGCAGCACCTTCCTCCTCCTCTCCATCGTGGGCATCTACGGTGCTATTCTCAATGCAGCAGCATGGTCGGTGA
Citation Vasiev B, Balter A, Chaplain M, Glazier JA, Weijer CJ. Modeling Gastrulation in the Chick Embryo: Formation of the Primitive Streak. PLoS One. 2010; 5(5): e10571. Copyright Copyright Vasiev et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #AB193181.1).
Entry 21 GEISHA Id WNT8C.Litsiou.2005 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation Litsiou A, Hanson S, Streit A. A balance of FGF, BMP and WNT signalling positions the future placode territory in the head. Development. 2005 Sep;132(18):4051-62. Epub 2005 Aug 10 Copyright Authors hold the copyright. Published by the Company of Biologists Ltd. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_205531.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7 stage 7
Entry 22 GEISHA Id cWnt-8c.Wittler.2008 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation Wittler L, Saborowski M, Kessel M. Expression of the chick Sizzled gene in progenitors of the cardiac outflow tract. Gene Expr Patterns. 2008 Jul;8(6):471-6. Epub 2008 Feb 29. Copyright Copyright © 2008 Elsevier B.V. Comments The complete cDNA template sequence was obtained from the information from the publication as described in Wittler et al. 2008.
Entry 23 GEISHA Id WNT8C.Lee.2020 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation Hyung Chul Lee, Hui-Chun Lu, Mark Turmaine, Nidia M. M. Oliveira, Youwen Yang† , Irene De Almeida and Claudio D. Stern. Molecular anatomy of the pre-primitive streak chick embryo Open Biol. null. 10.1098/rsob.190299. Copyright Copyright © 2020 The Authors. Comments The complete cDNA template sequence was obtained from the information provided in the publication as described in Lee et al., 2020. CWNT-8C is also known as Wnt8c and WNT8A.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) X-XIV stage X
stage XII
stage XII
stage XII
stage XIV
Area Opaca Epiblast Hypoblast all
Entry 24 GEISHA Id WNT8A.Olivera-Martinez.2014 Data Source Publication Complete cDNA Template Probe show AATATCTGGAGATACGGCGTCAGTGCGGCAGCCCTGCCAGGGACCTGTGGGATCAGCAAAGGGAGCCAAGTTCCACGCT
Citation Isabel Olivera-Martinez, Nick Schurch, Roman A Li, Junfang Song, Pamela A Halley, Raman M Das, Dave W Burt, Geoffrey J Barton, Kate G Storey. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development 2014 Aug;141(16):3266-76. Epub 2014 Jul 25. DOI: 10.1242/dev.112623. Copyright Copyright © 2014. Published by The Company of Biologists Ltd. Comments Authors indicated the probe was made from gene construct provided by J. Dodd. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205531.1).
Data from NCBI Unigene EST ProfileGga.886
Mouse Frog Fruit Fly Zebra Finch Zebrafish
