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Human Disease Gene Search
WNT1 Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol WNT1 Official Full Name Wnt family member 1 CGNC ID 49678 also known as WNT-1, protein Wnt-1|wingless-type MMTV integration site family member 1 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Entrez Gene Ensembl Gene Genetic Phenotypes MOD Fruit Fly Human Mouse Xenopus Zebrafish
Gene Ontology Links to other databases
Entry 1 GEISHA Id Wnt1.Chapman.2004 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation Chapman, S, Brown, R, Lees, L, Schoenwolf, G, Lumsden, A. Expression Analysis of Chick Wnt and Frizzled Genes and Selected Inhibitors in Early Chick Patterning. Dev Dyn. 2004 Mar;229(3):668-76. Copyright Wiley-Liss, Inc. 2004
Entry 2 GEISHA Id Wnt1.Ohuchi.2007 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation Ohuchi H, Hayashibara Y, Matsuda H, Onoi M, Mitsumori M, Tanaka M, Aoki J, Arai H, Noji S. Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development. Dev Dyn. 2007 Apr;236(4):1134-43. Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (AY753286).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-15 stage 15
Diencephalon Midbrain
Entry 3 GEISHA Id Wnt1.Badde.2005 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation Badde A, Bumsted-O'Brien KM, Schulte D. Chick receptor protein tyrosine phosphatase lambda/psi (cRPTPlambda/cRPTPpsi) is dynamically expressed at the midbrain-hindbrain boundary and in the embryonic neural retina. Gene Expr Patterns. 2005 Aug;5(6):786-91. Copyright Copyright © 2005 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # AY753286).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-16 stage 15
stage 15
stage 15
stage 16
Eye Isthmus/MHB
Entry 4 GEISHA Id Wnt1.Chesnutt.2004 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show TGGTGGGGCATAGTGAACGTGGCCTCATCCACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCG
Comments The following in situ probes were used: Wnt1, Wnt3a, Wnt4 (Hollyday et al., 1995), who indicated: cDNA was amplified using 200 ng of each
of the following degenerate oligonucleotide primers [5-
ATAAGATCTGGTGGGG(A/G/C/T)AT(A/C/T)GT- 3] (encompassing WWGIV in Wnt-1) and [5-TATGGATCCCCA(A/G)TGCCA(A/G)CT-3] (encompassing DWHWG in Wnt-1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-14 stage 14
Neural Plate/Tube Spinal Cord
Entry 5 GEISHA Id Wnt1.Ladher.2000 Data Source Publication Complete cDNA Template Probe show TGGTGGGGCATAGTGAACGTGGCCTCATCCACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCG
Citation Ladher RK, Church VL, Allen S, Robson L, Abdelfattah A, Brown NA, Hattersley G, Rosen V, Luyten FP, Dale L, Francis-West PH. Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev Biol. 2000 Feb 15;218(2):183-98. Copyright Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
Comments According to the authors, "... Wnt-1 (Hollyday et al., 1995), were used as previously described." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (AY655699).
Entry 6 GEISHA Id Wnt1.Baranski.2000 Data Source Publication Complete cDNA Template Probe show TGGTGGGGCATAGTGAACGTGGCCTCATCCACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCG
Citation Baranski M, Berdougo E, Sandler JS, Darnell DK, Burrus LW. The dynamic expression pattern of frzb-1 suggests multiple roles in chick development. Dev Biol. 2000 Jan 1;217(1):25-41. Copyright Copyright © 2000 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (AY655699).
Entry 7 GEISHA Id Wnt1.Chapman.2008 Data Source Direct Submission Complete cDNA Template Probe show TGGTGGGGCATAGTGAACGTGGCCTCATCCACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCG
Comments Images Provided by Susan Chapman.
Entry 8 GEISHA Id Wnt1.Canning.2007 Data Source Publication Forward cDNA Template Probe show TGGTGGGGCATAGTGAACGTGGCCTCATCCACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCG
Citation Canning CA, Lee L, Irving C, Mason I, Jones CM. Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity. Dev Biol. 2007 May 1;305(1):276-86. Epub 2007 Feb 16. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # AY655699.1)
Entry 9 GEISHA Id Wnt1.Jin.2001 Data Source Publication Complete cDNA Template Probe show TGGTGGGGCATAGTGAACGTGGCCTCATCCACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCG
Citation Jin EJ, Erickson CA, Takada S, Burrus LW (2001). Wnt and BMP signaling govern lineage segregation of melanocytes in the avian embryo. Dev Biol. 2001 May 1;233(1):22-37. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (AY655699).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13 stage 13
stage 13
Neural Plate/Tube
Entry 10 GEISHA Id Wnt1.Theodosiou.2003 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation Theodosiou NA, Tabin CJ. Wnt signaling during development of the gastrointestinal tract. Dev Biol. 2003 Jul 15;259(2):258-71. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments Authors indicated complete cDNA + poly(A) ~2.2 kb was used as a probe. No similar sequence is listed in NCBI so Acc# AY753286 is listed here instead. (length 960)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Duodenum Hindgut 31-32 stage 32
stage 32
Duodenum Hindgut
Entry 11 GEISHA Id WNT1.Agarwala.2002 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation Agarwala S, Ragsdale CW. A role for midbrain arcs in nucleogenesis. Development. 2002 Dec;129(24):5779-88. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Ragsdale. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # AY753286.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 38
stage 38
Isthmus/MHB
Entry 12 GEISHA Id WNT1.Golden.1999 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation Golden JA, Bracilovic A, McFadden KA, Beesley JS, Rubenstein JL, Grinspan JB. Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2439-44. Copyright Copyright © 2012 National Academy of Sciences. All rights reserved.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-23 stage 23
stage 23
Eye Mesencephalon Midbrain
Entry 13 GEISHA Id WNT1.Adams.2000 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation Adams KA, Maida JM, Golden JA, Riddle RD. The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer. Development. 2000 May;127(9):1857-67. Copyright Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Comments As insufficient information is provided in the publication to verify the exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (acc # AY753286.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 10
stage 12
stage 12
Isthmus/MHB Mesencephalon
Entry 14 GEISHA Id WNT1.Brugmann.2010 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation S.A. Brugmann, K.E. Powder, N.M. Young, L.H. Goodnough, S.M. Hahn, A.W. James, J.A. Helms, M. Lovett. Comparative gene expression analysis of avian embryonic facial structures reveals new candidates for human craniofacial disorders. Hum Mol Genet. 2010 March 1; 19(5): 920930. Copyright Copyright © The Author 2009. Published by Oxford University Press. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # AY753286.1).
Entry 15 GEISHA Id WNT1.Rossi.2007 Data Source Publication Complete cDNA Template Probe show CACCAACCTGCTGACGGATTCGGGCAGCGTGCAGTTGGTTCTGGAGCCCGGCCTGCAGCTGCTGAGCCGCAAACAGAGG
Citation Rossi E, Siwiec F, Yan CY. Pattern of Wnt ligand expression during chick eye development. Braz J Med Biol Res. 2007 Oct;40(10):1333-8. Epub 2007 Jul 31. Copyright copyright Creative Commons Attribution License
Entry 16 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-9 stage 9
stage 9
Neural Crest Neural Plate/Tube
Entry 17 GEISHA Id Wnt-1.Cauthen.2001 Data Source Publication Complete cDNA Template Probe show TCTCCCCCTCTCCATCCCAACCCGGTCCGACACCGACCCCCCGCCTCACTTTAAACCGACCCCCCCCCTTTAACACCGA
Citation Cauthen CA, Berdougo E, Sandler J, Burrus LW. Comparative analysis of the expression patterns of Wnts and Frizzleds during early myogenesis in chick embryos. Mech Dev. 2001 Jun;104(1-2):133-8. Copyright Copyright © 2001 Elsevier Science Ireland Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_015273182.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 10
Neural Plate/Tube 31-44 stage 44
Entry 18 GEISHA Id Wnt1.Jungbluth.2001 Data Source Publication Complete cDNA Template Probe show TCTCCCCCTCTCCATCCCAACCCGGTCCGACACCGACCCCCCGCCTCACTTTAAACCGACCCCCCCCCTTTAACACCGA
Citation Stefan Jungbluth, Chris Phelps, Andrew Lumsden. CEPU-1 expression in the early embryonic chick brain. Mech Dev. 2001 Mar;101(1-2):195-7. Copyright Copyright © 2001 Elsevier Science Ireland Ltd. Comments Authors indicated that Wnt1 probe was a gift of A. Graham. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession XM_015273182.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Isthmus/MHB Midbrain all
Entry 19 GEISHA Id Wnt1.Hidalgo-Sánchez.1999 Data Source Publication Complete cDNA Template Probe show TCTCCCCCTCTCCATCCCAACCCGGTCCGACACCGACCCCCCGCCTCACTTTAAACCGACCCCCCCCCTTTAACACCGA
Citation Hidalgo-Sánchez M, Millet S, Simeone A, Alvarado-Mallart RM. Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain. Mech Dev 1999 Mar;81(1-2):175-8. Copyright Copyright © 1999 Elsevier Science Ireland Ltd. Comments Authors indicated that Wnt1 probe was a gift of Drs. Marion Wassef and Gail Martin. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession XM_015273182.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-20 stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
stage 20
Midbrain all
Data from NCBI Unigene EST ProfileGga.683
Mouse Frog Fruit Fly Zebra Finch Zebrafish
