GEISHA - A Chicken Embryo Gene Expression Database
Browse By
- Anatomical Location
- Stage
- Gene Name
- GEISHA ID
- Multiple Parameters
Search
- Quick Search
Data Class
Enter Text:
go
- Gene Family QuickSearch
Transcription Factors
Growth Factors
Receptors
MicroRNAs
- Human Disease Gene Search
Documents
- Downloads
- Protocols
- About GEISHA
- Contact Us
Resources
- Transgenic Birds
- Model Organism Databases
- Gene Expression Databases
- Genomic Resources
- Anatomical Atlases
- Chicken Stage Series
_

SIX1
SIX homeobox 1

The human orthologue of this gene is associated
with the following human diseases:
Gene
Official SymbolSIX1
Official Full NameSIX homeobox 1
CGNC ID54357
also known ashomeobox protein SIX1|sine oculis homeobox homolog 1
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_001044685
PolypeptideNP_001038150
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.20089
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human6495MIM:608389MIM:601205
Mouse20471ENSMUSG00000051367All phenotypic alleles (5):Chemically induced(1) Targeted, knock-out(2) Targeted, other(2) MGI:102780
Xenopus100101784, 373734, 100101702, 398185480716, 481503
Zebrafish404627, 494168ENSDARG00000039304ZDB-GENE-040426-2308, ZDB-GENE-040718-155ZFIN:ZDB-GENE-040426-2308, ZFIN:ZDB-GENE-040718-155
Gene Ontology
Molecular Function
Biological Process
Cellular Component
Links to other databases
Entrez Gene693262
Ensembl Gene
KEGGgga:693262

Entry 1

GEISHA IdSIX1.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerGGAGAACACGGAGAACAACAACG
Reverse cDNA Template PrimerAATTAACCCTCACTAAAGGGAGGCAGACAGAGAGAGACGCcDNA Template Length944
Forward cDNA Template Probeshow
CCCANNCCCCNCCNNNCCCCCCCGCCCTCTCCCTTCATTTTATTTCTGCTGCTGTAATTCCCCCTCACTTGAACTCAAA
AGGCCAAGGGCTTTCTGCCCCTCTCTGCTTTTGGCTCCTTGAAAATTATTATTACCATTATTATTATTATTATTAAAAA
AACCACCGTTGAAAAAGGAGGGTGGGGGGGGACCCACCCTGCTTTTAACACCTTGAAAAAAAACCAACTTCTTTTTCAT
GACCACCCCCCCTTTTTTACAACCAAAATTCGTTTCCCACCACCTCCTTTTATAACCCAACCCCCCCCAGCCTGGAGGT
AAGCGCCCCCCCCACCAATTCTTGAATTTAATGCCCCGCCAGGTTTTCCTTCCCCGGGGGGGCGGCCAGGAACCCCACC
GGTTACCAAAACCTCCTCCCTGAAGGAAGTTTCCCCCCCAAAAGAAGAACGAATTTATAAATAA
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 5
stage 6
Early Endoderm
Early Mesoderm
Headfold
 
7-12
stage 8
stage 8
stage 8
stage 9
stage 10
stage 11
Ear/Otic Placode
Endoderm
Forebrain
Head Mesenchyme
Neural Plate/Tube
Somatic Mesoderm
Somites
Splanchnic Mesoderm
 
13-18
stage 13
stage 17
stage 18
Ear/Otic Placode
Foregut
Head Mesenchyme
Leg Mesenchyme
Nasal Placode/Nerve
Pharyngeal Arches and Clefts
Pharynx
Somites
Wing Mesenchyme
 
19-24
stage 21
stage 23
stage 24
Head Mesenchyme
Leg Mesenchyme
Nasal Placode/Nerve
Pharyngeal Arches and Clefts
Somites
Wing Mesenchyme
 

Entry 2

GEISHA IdSix1.Barembaum.2007Data SourcePublication
Complete cDNA Template Probeshow
GCCGAGCATCCCCCGCTCCGCCGCCGCGGCCGCCTCCGCGCCTCCCCGCTCTGGGGACGGGACCGGGCCCGGGGCTCTC
CCCGCCCCTCCGCCGCCTCCCGGTGCCGCACGCAGCCCCGAGCCGCCCCTCGGCGCCCGGCCCCGGCCATGTCGATGCT
GCCGTCGTTCGGCTTCACGCAGGAGCAGGTCGCCTGCGTGTGCGAGGTGCTGCAGCAGGGGGGGAACCTGGAGCGCCTG
GGCCGCTTCCTCTGGTCGCTGCCGGCGTGCGACCACCTGCACAAGAACGAGAGCGTCCTCAAGGCCAAAGCGGTGGTGG
CCTTCCACCGGGGCAACTTCCGCGAGCTCTACAAGATCCTGGAGAGCCACCAGTTCTCGCCCCACAACCACCCCAAGCT
GCAGCAGCTCTGGCTCAAGGCGCACTACGTGGAAGCCGAGAAGCTGCGCGGGCGGCCGCTGGGCGCCGTGGGCAAATAC
CGGGTGCGCCGAAAGTTCCCCCTGCCCCGCACCATCTGGGACGGCGAGGAGACGAGCTACTGCTTCAAGGAGAAGTCGC
GGGGGGTGCTGCGGGAGTGGTACGCGCACAACCCCTACCCCTCGCCCCGCGAGAAGCGGGAGCTGGCCGAGGCCACCGG
GCTCACCACCACGCAGGTCAGCAACTGGTTCAAGAACCGGCGGCAGCGGGACCGGGCGGCGGAGGCCAAGGAGAGGGAG
AACACGGAGAACAACAACGCGGCCACCAACAAACCCAACCAGCTCTCCCCCCTGGACGGGAGCAAACCCCTCATGTCCA
GCTCCGAGGAAGAATTTTCACCCCCGCAGAGCCCGGATCAGAACTCGGTCCTCCTGTTGCAGGGGAACCTCGCTCACGG
CAGGAGCTCCGCGTACCCGCTGGGCTCCCTGCCCGCCCCCCCGGGCACGCACAGCCTCCCGGGCCATCAGCTCCAGGAC
TCGCTGCTGGGGCCGCTCACCTCCAGCCTGGTGGACCTGGGCTCCTAAAGGGAGCTCGTGGACACGGACTCTCGGTTGT
ACATAGCGGACGGTGATCCTGAACGTGACTCGGCTCTCTCCACGGTCTCAGCTGCAGGTCCGGTCCCCCCCCACCTCCC
TTCTCCACTGTCGTTATTTTTATTATTATTATTCATTATTGTTATTATTATTTTTCACGTAGCCAAATGCAGAGAGCGG
CAGAAAGCCCTCGGCCTTTCGAGTTCAAGTGAGCGGGAATTACAGCAGCAGAAATAGAAATAGAAGGGGAGAGGGTGAG
GGGAAAAAAAACCCAACCCCGAACCCCGGATCCCATTGCGCCCCATAAATCCCGGCTGTTGCGGCCCAGAGGCAGAGGG
AGCGCGGGGCCCTTTGCGGCAGCGGGAGGAGGGAGGGGAACTTTTTCGTTTACATTTCTTTTTTTTCATATTTAGCTTC
ACCGGAAGGATTTCGATGTAGTTTAAAATTAAAAAAAAAAAAAAAAAGAGGGGAAAAAAAAATAGATAATTAGGAAGCG
GCAGTCTGAGTGCCTCTGTCTTAACGCGGCGGTGCTGCTCCCCGGCCGGGACACGCAGCGATGCGGCTGCACTTTAGGA
CAGTAACAACAGCGATAATAAATGCGGATGGCCCTTTCCTTCCGCAGGAGCGTCTCTCTCTGTCTGCCTCCCCCAACCC
CCAGCTCTGCCTCGCAGTGAGCCCGCAGCTGTCTGTCTCGAGTCTGTGTTACCGACCTCGCGTGTGCTTTCAGGTTTCT
TTTCTATTGTACCCGAACAGCCGAAATTAAACACTGCTGATGGCAGAAAAAAAAAAAAAAAAAAAAAAAAAA
CitationBarembaum M, Bronner-Fraser M. Spalt4 mediates invagination and otic placode gene expression in cranial ectoderm. Development. 2007 Nov;134(21):3805-14.
CopyrightPublished by The Company of Biologists 2007
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001044685).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 5
stage 5
Ectoderm
Preplacode Ectoderm
13
stage 13
Ear/Otic Placcode
 

Entry 3

GEISHA IdSIX1.Sato.2012Data SourcePublication
Complete cDNA Template Probeshow
GCCGAGCATCCCCCGCTCCGCCGCCGCGGCCGCCTCCGCGCCTCCCCGCTCTGGGGACGGGACCGGGCCCGGGGCTCTC
CCCGCCCCTCCGCCGCCTCCCGGTGCCGCACGCAGCCCCGAGCCGCCCCTCGGCGCCCGGCCCCGGCCATGTCGATGCT
GCCGTCGTTCGGCTTCACGCAGGAGCAGGTCGCCTGCGTGTGCGAGGTGCTGCAGCAGGGGGGGAACCTGGAGCGCCTG
GGCCGCTTCCTCTGGTCGCTGCCGGCGTGCGACCACCTGCACAAGAACGAGAGCGTCCTCAAGGCCAAAGCGGTGGTGG
CCTTCCACCGGGGCAACTTCCGCGAGCTCTACAAGATCCTGGAGAGCCACCAGTTCTCGCCCCACAACCACCCCAAGCT
GCAGCAGCTCTGGCTCAAGGCGCACTACGTGGAAGCCGAGAAGCTGCGCGGGCGGCCGCTGGGCGCCGTGGGCAAATAC
CGGGTGCGCCGAAAGTTCCCCCTGCCCCGCACCATCTGGGACGGCGAGGAGACGAGCTACTGCTTCAAGGAGAAGTCGC
GGGGGGTGCTGCGGGAGTGGTACGCGCACAACCCCTACCCCTCGCCCCGCGAGAAGCGGGAGCTGGCCGAGGCCACCGG
GCTCACCACCACGCAGGTCAGCAACTGGTTCAAGAACCGGCGGCAGCGGGACCGGGCGGCGGAGGCCAAGGAGAGGGAG
AACACGGAGAACAACAACGCGGCCACCAACAAACCCAACCAGCTCTCCCCCCTGGACGGGAGCAAACCCCTCATGTCCA
GCTCCGAGGAAGAATTTTCACCCCCGCAGAGCCCGGATCAGAACTCGGTCCTCCTGTTGCAGGGGAACCTCGCTCACGG
CAGGAGCTCCGCGTACCCGCTGGGCTCCCTGCCCGCCCCCCCGGGCACGCACAGCCTCCCGGGCCATCAGCTCCAGGAC
TCGCTGCTGGGGCCGCTCACCTCCAGCCTGGTGGACCTGGGCTCCTAAAGGGAGCTCGTGGACACGGACTCTCGGTTGT
ACATAGCGGACGGTGATCCTGAACGTGACTCGGCTCTCTCCACGGTCTCAGCTGCAGGTCCGGTCCCCCCCCACCTCCC
TTCTCCACTGTCGTTATTTTTATTATTATTATTCATTATTGTTATTATTATTTTTCACGTAGCCAAATGCAGAGAGCGG
CAGAAAGCCCTCGGCCTTTCGAGTTCAAGTGAGCGGGAATTACAGCAGCAGAAATAGAAATAGAAGGGGAGAGGGTGAG
GGGAAAAAAAACCCAACCCCGAACCCCGGATCCCATTGCGCCCCATAAATCCCGGCTGTTGCGGCCCAGAGGCAGAGGG
AGCGCGGGGCCCTTTGCGGCAGCGGGAGGAGGGAGGGGAACTTTTTCGTTTACATTTCTTTTTTTTCATATTTAGCTTC
ACCGGAAGGATTTCGATGTAGTTTAAAATTAAAAAAAAAAAAAAAAAGAGGGGAAAAAAAAATAGATAATTAGGAAGCG
GCAGTCTGAGTGCCTCTGTCTTAACGCGGCGGTGCTGCTCCCCGGCCGGGACACGCAGCGATGCGGCTGCACTTTAGGA
CAGTAACAACAGCGATAATAAATGCGGATGGCCCTTTCCTTCCGCAGGAGCGTCTCTCTCTGTCTGCCTCCCCCAACCC
CCAGCTCTGCCTCGCAGTGAGCCCGCAGCTGTCTGTCTCGAGTCTGTGTTACCGACCTCGCGTGTGCTTTCAGGTTTCT
TTTCTATTGTACCCGAACAGCCGAAATTAAACACTGCTGATGGCAGAAAAAAAAAAAAAAAAAAAAAAAAAA
CitationSato S, Ikeda K, Shioi G, Nakao K, Yajima H, Kawakami K. Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods. Dev Biol. 2012 Aug 1;368(1):95-108. doi: 10.1016/j.ydbio.2012.05.023. Epub 2012 May 30.
CopyrightCopyright © 2012 Elsevier Inc.
CommentsThe sequence below was obtained from NCBI (acc # AB199734.1) using the information provided in the publication as described in Sato et al.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 5
stage 5
Ectoderm
Head Process
Preplacode ectoderm
7-12
stage 7
stage 8
stage 10
stage 11
Ear/Otic Placode
Ectoderm
Neural Plate/Tube
Somites
HH8+ embryo
preplacode ectoderm
13-18
stage 14
stage 15
stage 15
stage 18
Ear/Otic Placode
Nasal Placode/Nerve
Neural Plate/Tube
Pharyngeal Arches and Clefts
Somites
 
19-21
stage 21
Leg
Nasal Placode/Nerve
Pharyngeal Arches and Clefts
Somites
Wing
 

Entry 4

GEISHA IdSIX1.Litsiou.2005Data SourcePublication
Complete cDNA Template Probeshow
GCCGAGCATCCCCCGCTCCGCCGCCGCGGCCGCCTCCGCGCCTCCCCGCTCTGGGGACGGGACCGGGCCCGGGGCTCTC
CCCGCCCCTCCGCCGCCTCCCGGTGCCGCACGCAGCCCCGAGCCGCCCCTCGGCGCCCGGCCCCGGCCATGTCGATGCT
GCCGTCGTTCGGCTTCACGCAGGAGCAGGTCGCCTGCGTGTGCGAGGTGCTGCAGCAGGGGGGGAACCTGGAGCGCCTG
GGCCGCTTCCTCTGGTCGCTGCCGGCGTGCGACCACCTGCACAAGAACGAGAGCGTCCTCAAGGCCAAAGCGGTGGTGG
CCTTCCACCGGGGCAACTTCCGCGAGCTCTACAAGATCCTGGAGAGCCACCAGTTCTCGCCCCACAACCACCCCAAGCT
GCAGCAGCTCTGGCTCAAGGCGCACTACGTGGAAGCCGAGAAGCTGCGCGGGCGGCCGCTGGGCGCCGTGGGCAAATAC
CGGGTGCGCCGAAAGTTCCCCCTGCCCCGCACCATCTGGGACGGCGAGGAGACGAGCTACTGCTTCAAGGAGAAGTCGC
GGGGGGTGCTGCGGGAGTGGTACGCGCACAACCCCTACCCCTCGCCCCGCGAGAAGCGGGAGCTGGCCGAGGCCACCGG
GCTCACCACCACGCAGGTCAGCAACTGGTTCAAGAACCGGCGGCAGCGGGACCGGGCGGCGGAGGCCAAGGAGAGGGAG
AACACGGAGAACAACAACGCGGCCACCAACAAACCCAACCAGCTCTCCCCCCTGGACGGGAGCAAACCCCTCATGTCCA
GCTCCGAGGAAGAATTTTCACCCCCGCAGAGCCCGGATCAGAACTCGGTCCTCCTGTTGCAGGGGAACCTCGCTCACGG
CAGGAGCTCCGCGTACCCGCTGGGCTCCCTGCCCGCCCCCCCGGGCACGCACAGCCTCCCGGGCCATCAGCTCCAGGAC
TCGCTGCTGGGGCCGCTCACCTCCAGCCTGGTGGACCTGGGCTCCTAAAGGGAGCTCGTGGACACGGACTCTCGGTTGT
ACATAGCGGACGGTGATCCTGAACGTGACTCGGCTCTCTCCACGGTCTCAGCTGCAGGTCCGGTCCCCCCCCACCTCCC
TTCTCCACTGTCGTTATTTTTATTATTATTATTCATTATTGTTATTATTATTTTTCACGTAGCCAAATGCAGAGAGCGG
CAGAAAGCCCTCGGCCTTTCGAGTTCAAGTGAGCGGGAATTACAGCAGCAGAAATAGAAATAGAAGGGGAGAGGGTGAG
GGGAAAAAAAACCCAACCCCGAACCCCGGATCCCATTGCGCCCCATAAATCCCGGCTGTTGCGGCCCAGAGGCAGAGGG
AGCGCGGGGCCCTTTGCGGCAGCGGGAGGAGGGAGGGGAACTTTTTCGTTTACATTTCTTTTTTTTCATATTTAGCTTC
ACCGGAAGGATTTCGATGTAGTTTAAAATTAAAAAAAAAAAAAAAAAGAGGGGAAAAAAAAATAGATAATTAGGAAGCG
GCAGTCTGAGTGCCTCTGTCTTAACGCGGCGGTGCTGCTCCCCGGCCGGGACACGCAGCGATGCGGCTGCACTTTAGGA
CAGTAACAACAGCGATAATAAATGCGGATGGCCCTTTCCTTCCGCAGGAGCGTCTCTCTCTGTCTGCCTCCCCCAACCC
CCAGCTCTGCCTCGCAGTGAGCCCGCAGCTGTCTGTCTCGAGTCTGTGTTACCGACCTCGCGTGTGCTTTCAGGTTTCT
TTTCTATTGTACCCGAACAGCCGAAATTAAACACTGCTGATGGCAGAAAAAAAAAAAAAAAAAAAAAAAAAA
CitationLitsiou A, Hanson S, Streit A. A balance of FGF, BMP and WNT signalling positions the future placode territory in the head. Development. 2005 Sep;132(18):4051-62. Epub 2005 Aug 10
CopyrightAuthors hold the copyright. Published by the Company of Biologists Ltd.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_001044685.1
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 6
Early Endoderm
Early Mesoderm
Neural Crest
 
7-8
stage 7
stage 7
stage 8
stage 8
Early Endoderm
Epiblast
Head Mesenchyme
Neural Crest
 

Entry 5

GEISHA IdSIX1.Anderson.2019Data SourcePublication
Complete cDNA Template Probeshow
AAAGTTCCCCCCGGCGCTCCGCCGAGCATCCCCCGCTCCGCCGCCGCGGCCGCCTCCGCGCCTCCCCGCTCTGGGGACG
GGACCGGGCCCGGGGCTCTCCCCGCCCCTCCGCCGCCTCCCGGTGCCGCACGCAGCCCCGAGCCGCCCCTCGGCGCCCG
GCCCCGGCCATGTCGATGCTGCCGTCGTTCGGCTTCACGCAGGAGCAGGTCGCCTGCGTGTGCGAGGTGCTGCAGCAGG
GGGGGAACCTGGAGCGCCTGGGCCGCTTCCTCTGGTCGCTGCCGGCGTGCGACCACCTGCACAAGAACGAGAGCGTCCT
CAAGGCCAAAGCGGTGGTGGCCTTCCACCGGGGCAACTTCCGCGAGCTCTACAAGATCCTGGAGAGCCACCAGTTCTCG
CCCCACAACCACCCCAAGCTGCAGCAGCTCTGGCTCAAGGCGCACTACGTGGAAGCCGAGAAGCTGCGCGGGCGGCCGC
TGGGCGCCGTGGGCAAATACCGGGTGCGCCGAAAGTTCCCCCTGCCCCGCACCATCTGGGACGGCGAGGAGACGAGCTA
CTGCTTCAAGGAGAAGTCGCGGGGGGTGCTGCGGGAGTGGTACGCGCACAACCCCTACCCCTCGCCCCGCGAGAAGCGG
GAGCTGGCCGAGGCCACCGGGCTCACCACCACGCAGGTCAGCAACTGGTTCAAGAACCGGCGGCAGCGGGACCGGGCGG
CGGAGGCCAAGGAGAGGGAGAACACGGAGAACAACAACGCGGCCACCAACAAACCCAACCAGCTCTCCCCCCTGGACGG
GAGCAAACCCCTCATGTCCAGCTCCGAGGAAGAATTTTCACCCCCGCAGAGCCCGGATCAGAACTCGGTCCTCCTGTTG
CAGGGGAACCTCGCTCACGGCAGGAGCTCCGCGTACCCGCTGGGCTCCCTGCCCGCCCCCCCGGGCACGCACAGCCTCC
CGGGCCATCAGCTCCAGGACTCGCTGCTGGGGCCGCTCACCTCCAGCCTGGTGGACCTGGGCTCCTAAAGGGAGCTCGT
GGACACGGACTCTCGGTTGTACATAGCGGACGGTGATCCTGAACGTGACTTCGGCTCTTCTCCACGGTCTCAGCTCCAG
GTCCGGTCCCCCCCCACCTCCCTTCTCCACTGTCGTTATTTTTATTATTATTATTATTATTGTTATTATTATTTTTCAC
GTAGCCAAATGCAGAGAGCGGCAGAAAGCCCTCGGCCTTTCGAGTTCAAGTGAGCGGGAATTACAGCAGCAGAAATAGA
AATAGAAGGGGAGAGGGTGGGGGGGAAAAAAACCCAACCCCGAACCCCGGATCCCATTGCGCCCCATAAATCCCGGCTG
TTGCGGCCCAGAGGCAGAGGGAGCGCGGGGCCCTTTGCGGCAGCGGGAGGAGGGAGGGGAACTTTTTCGTTTACATTTC
TTTTTTTTTCATATTTAGCTTCACCGGAAGGATTTCGATGTAGTTTAAAATTAAAAAAAAAAAAAAAAAAGAGGGGAAA
AAAAAAATAGATAATTAGGAAGCGGCAGTCTGAGTGCCTCTGTCTTAACGCGGCGGTGCTGCTCCCCGGCCGGGACACG
CAGCGATGCGGCTGCACTTTAGGACAGTAACAACAGCGATAATAAATGCGGATGGCCCTTTCCTTCCGCAGGAGCGTCT
CTCTCTGTCTGCCTCCCCCAACCCCCAGCTCTGCCTCGCAGTGAGCCCGCAGCTGTCTGTCTCGAGTCTGTGTTACCGA
CCTCGCGTGTGCTTTCAGGTTTCTTTTCTATTGTACCCGAACAGCCGAAATTAAACACTGCTGATGGCAGAA
CitationAnderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
CopyrightCopyright © 2019 Elsevier Inc. All rights reserved.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001044685 ).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 12
stage 12
Heart
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.20089

Mouse

EmageMGI:102780
EurexpressMGI:102780
MGI GXDMGI:102780

Frog

Xenbase480716, 481503

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-040426-2308, ZDB-GENE-040718-155
Home | Contact
     
© 2008 Arizona Board of Regents
This website is hosted by the Biotechnology Computing Facility at the University of Arizona