GEISHA - A Chicken Embryo Gene Expression Database
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CFC1
cripto, FRL-1, cryptic family 1

Gene
Official SymbolCFC1
Official Full Namecripto, FRL-1, cryptic family 1
CGNC ID49319
also known asCFC1B, cryptic protein|CRIPTO-related factor 1|chick-cripto|cripto, FRL-1, cryptic family 1B, Cryptic protein precursor, Cripto-related factor 1
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_204700
PolypeptideNP_990031
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.2640
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human653275, 55997ENSG00000152093, ENSG00000136698MIM:605194
Mouse
Xenopus
Zebrafish30304ENSDARG00000035095ZDB-GENE-990415-198ZFIN:ZDB-GENE-990415-198
Gene Ontology
Molecular Functionactivin receptor binding
Biological Processanterior/posterior pattern specification, atrial septum morphogenesis, BMP signaling pathway, more...canonical Wnt signaling pathway, digestive tract morphogenesis, endoderm development, gastrulation, heart looping, left lung morphogenesis, liver development, nodal signaling pathway, post-embryonic development, spleen development
Cellular Componentanchored component of membrane, extracellular region, plasma membrane
Links to other databases
Entrez Gene395437
Ensembl Gene
KEGGgga:395437

Entry 1

GEISHA IdCFC1.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerTTATAAAAGCTTGCGGCCGCAGAATATGCCTTCAGTGAGGGACTTTGGAC
Reverse cDNA Template PrimerGCTCTAGAAATTAACCCTCACTAAAGGCGCAGACATTGTTTGCTGTAATCTCcDNA Template Length605
Forward cDNA Template Probeshow
TTTTNTTTTGCTCTTCTGCTCAGCTTTCCGAAGGAAACACAGTATTTCAGGCTGCAGGAAGATGTTCTGGCGAAAACAT
GTTAGAATTCTTTTCACTGTGACTCTGATTTGGCAGGCCATTCATTTAGGAAAAGGCCGTGAAAAAGAACATGAAAAAG
ATGTGAAAAATTTCAACGACACAGCGCAAAAGCAATCGCCTAAGAATTCAGTGACAATTATAGATGCTTTCAGTGACAT
GAATCAGAGTTACCAAAGCAGAAAGCAACAGAATTCCAGAGAATTTGTACCTTTCACCGGGATTACAGAGAGTAAAAAT
CTGAACAGAAACTGCTGCCAAAACGGGGGCACCTGCATCCTAGGGGCTTTCTGTGCATGCCCAAAGCATTTTAGTGGCC
GACACTGTGAACTAAGAAAGTGCGGCAGCATCATCCATGGCGACTGGGTGATGAAGGGCTGCTGGCTGTGTCGGTGTCT
CTATGGCACTCTGAAGTGTCTCTCTCAAAACACACAAGACGGCTGTGAACTGAGAAGGGAAGAGGAAATTATCAGATTA
TATTCTAATGGCTTGAGATTACAGCAAACAATGTCTGCGCCTTTAGTGAGGGTTAATTTCTAGAGCAAA
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 6
Early Mesoderm
Hensen's Node
Lateral Plate Mesoderm
Primitive Streak
 
7-12
stage 7
stage 8
stage 9
stage 11
Anterior Intestinal Portal
Heart Tube
Lateral Plate Mesoderm
Notochord
Primitive Streak
Tail
 
19-24
stage 20
stage 20
Heart
Nephric Ducts
 
25-26
stage 26
stage 26
Nephric Ducts
Proepicardium
Staining observed in the head may be due to trapping.

Entry 2

GEISHA IdCfc.Schlueter.2006Data SourceGEISHA ISH Analysis
Reverse cDNA Template Probeshow
GGCTGTGAGCTGGACAGAAAGAGAAAGCTTTCCTCCGTCAACTTTTCTGCCTGTCTTGGTACTGTATATGGTGCGAGAA
CAACTGCACGTAGCAGCCTTCAGTGAGGGACTTTGGACTTCTGCTCAAGCTTTCCCGAAGGAATACACAGTATTTCAGG
CTGCAGGAAGATGTTCTGGCGAAAACATGTTAGAATTCTTTTCACTGTGACTCTGATTTGGCAGGCCATTCATTTAGGA
AAAGGCCGTGAAAAAGAACATGAAAAAGATGTGAAAAATTTCAACGACACAGCGCAAAAGCAATCGCCTAAGAATTCAG
TGACAATTATAGATGCTTTCAGTGACATGAATCAGAGTTACCAAAGTAGAAAGCAACAGAATTCCAGAGAATTTGTACC
TTTCACCGGGATTACAGAGAGTAAAAATCTGAACAGAAACTGCTGCCAAAACGGGGGCACCTGCATCCTAGGGGCTTTC
TGTGCATGCCCAAAGCATTTTAGTGGCCGACACTGTGAACTAAGAAAGTGCGGCAGCATCATCCATGGCGACTGGGTGA
TGAAGGGCTGCTGGCTGTGTCGGTGTCTCTATGGCACTCTGAAGTGTCTCTCTCAAAACACACAAGACGGCTGTGAACT
GAGAAGGGAAGAGGAAATTATCAGATTATATTCTAATGGCTTGAGATTACAGCAAACAATGTCTGCGCTGATTTGCCTT
CTCACCTTCCTCCTGGAGCTTTGCTGCTGGCAGTTGTGAAGCTGAACAAAAAGACTATACTAGGGTTCCTGTAGCATTT
AACTACAGGAATGAGCTGTGTGACTTCTTTCTTTAGTAAACTGCAGAAGACACTTGTACTTACATATCTGAAGCAGATT
ACAATGTCTTAGGTAATGATGAAATGCTTGGTTTATTATAAATACAGATTATATAAACGTGAAGTATTTATTATTTTAT
TATTATTATATTGCTACTACCAGTGTCCATTCGCTGGACAATTCCAACGCTTCTTTAGTTTTAAAATACTGTTCTTTCA
GTGGAAGAACTAAAAATGAATTATCTATGCCTTAAGTATTGAATTTTCATTGTACATGATAAAATTACTTTAAATAAAT
AACAGCGTTTTTCTTTGTTTCTGAAAAAAAAAAAAAAAAAAAAAAAA
CommentsAccording to the authors, "For expression analysis of Cfc, a 1-kb full-length cDNA was used (Schlange et al., 2000). The sequence below was obtained from NCBI (acc # NM_204700)
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 11
stage 11
Proepicardium
 
13-18
stage 13
stage 13
stage 17
stage 17
Proepicardium
Anatomy.
19-22
stage 22
stage 22
stage 22
stage 22
Proepicardium
epicardial and pericardial mesothelium

Entry 3

GEISHA IdCFC1.Ishii.2007Data SourcePublication
Complete cDNA Template Probeshow
GTCTGCGCTGATTTGCCTTCTCACCTTCCTCCTGGAGCTTTGCTGCTGGCAGTTGTGAAGCTGAACAAAAAGACTATAC
TAGGGTTCCTGTAGCATTTAACTACAGGAATGAGCTGTGTGACTTCTTTCTTTAGTAAACTGCAGAAGACACTTGTACT
TACATATCTGAAGCAGATTACAATGTCTTAGGTAATGATGAAATGCTTGGTTTATTATAAATACAGATTATATAAACGT
GAAGTATTTATTATTTTATTATTATTATATTGCTACTACCAGTGTCCATTCGCTGGACAATTCCAACGCTTCTTTAGTT
TTAAAATACTGTTCTTTCAGTGGAAGAACTAAAAATGAATTATCTATGCCTTAAGTATTGAATTTTCATTGT
CitationIshii Y, Langberg JD, Hurtado R, Lee S, Mikawa T. Induction of proepicardial marker gene expression by the liver bud. Development. 2007 Oct;134(20):3627-37. Epub 2007 Sep 12.
CopyrightPublished by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by T. Mikawa.
CommentsSequence below was obtained from NCBI (NM_204700) using the primers given in the publication: chick Cfc1 (cCfc1) forward primer, 5'-GTCTGCGCTGATTTGCCTTCTCAC-3' and reverse primer 5'-ACAATGAAAATTCAATACTTAAGGCATAG-3'.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 11
Lateral Plate Mesoderm
Myocardium
Proepicardium
 
13-16
stage 15
stage 16
stage 16
Myocardium
Proepicardium
 

Entry 4

GEISHA IdCFC1B.Hardy.2011Data SourceGEISHA ISH Analysis
Complete cDNA Template Probeshow
GGCTGTGAGCTGGACAGAAAGAGAAAGCTTTCCTCCGTCAACTTTTCTGCCTGTCTTGGTACTGTATATGGTGCGAGAA
CAACTGCACGTAGCAGCCTTCAGTGAGGGACTTTGGACTTCTGCTCAAGCTTTCCCGAAGGAATACACAGTATTTCAGG
CTGCAGGAAGATGTTCTGGCGAAAACATGTTAGAATTCTTTTCACTGTGACTCTGATTTGGCAGGCCATTCATTTAGGA
AAAGGCCGTGAAAAAGAACATGAAAAAGATGTGAAAAATTTCAACGACACAGCGCAAAAGCAATCGCCTAAGAATTCAG
TGACAATTATAGATGCTTTCAGTGACATGAATCAGAGTTACCAAAGTAGAAAGCAACAGAATTCCAGAGAATTTGTACC
TTTCACCGGGATTACAGAGAGTAAAAATCTGAACAGAAACTGCTGCCAAAACGGGGGCACCTGCATCCTAGGGGCTTTC
TGTGCATGCCCAAAGCATTTTAGTGGCCGACACTGTGAACTAAGAAAGTGCGGCAGCATCATCCATGGCGACTGGGTGA
TGAAGGGCTGCTGGCTGTGTCGGTGTCTCTATGGCACTCTGAAGTGTCTCTCTCAAAACACACAAGACGGCTGTGAACT
GAGAAGGGAAGAGGAAATTATCAGATTATATTCTAATGGCTTGAGATTACAGCAAACAATGTCTGCGCTGATTTGCCTT
CTCACCTTCCTCCTGGAGCTTTGCTGCTGGCAGTTGTGAAGCTGAACAAAAAGACTATACTAGGGTTCCTGTAGCATTT
AACTACAGGAATGAGCTGTGTGACTTCTTTCTTTAGTAAACTGCAGAAGACACTTGTACTTACATATCTGAAGCAGATT
ACAATGTCTTAGGTAATGATGAAATGCTTGGTTTATTATAAATACAGATTATATAAACGTGAAGTATTTATTATTTTAT
TATTATTATATTGCTACTACCAGTGTCCATTCGCTGGACAATTCCAACGCTTCTTTAGTTTTAAAATACTGTTCTTTCA
GTGGAAGAACTAAAAATGAATTATCTATGCCTTAAGTATTGAATTTTCATTGTACATGATAAAATTACTTTAAATAAAT
AACAGCGTTTTTCTTTGTTTCTGAAAAAAAAAAAAAAAAAAAAAAAA
CommentsImages provided by Katharine M. Hardy and Mary J.C. Hendrix, and funded by NIH award R01CA121205 Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204700.1).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
X-XIV
stage XIV
Area Pellucida
 
4-6
stage 4
stage 4
stage 4
stage 5
stage 5
stage 6
stage 6
Early Mesoderm
Lateral Plate Mesoderm
Notochord
Primitive Streak
 
7-12
stage 7
stage 7
stage 8
stage 8
stage 9
stage 10
stage 10
stage 11
Head Process
Heart
Heart Tube
Intermediate Mesoderm
Lateral Plate Mesoderm
Notochord
Paraxial Mesoderm
Primitive Streak
Tail
 
13-18
stage 18
Heart
 

Entry 5

GEISHA IdCFC1B.Colas.2000BData SourcePublication
Complete cDNA Template Probeshow
GGCTGTGAGCTGGACAGAAAGAGAAAGCTTTCCTCCGTCAACTTTTCTGCCTGTCTTGGTACTGTATATGGTGCGAGAA
CAACTGCACGTAGCAGCCTTCAGTGAGGGACTTTGGACTTCTGCTCAAGCTTTCCCGAAGGAATACACAGTATTTCAGG
CTGCAGGAAGATGTTCTGGCGAAAACATGTTAGAATTCTTTTCACTGTGACTCTGATTTGGCAGGCCATTCATTTAGGA
AAAGGCCGTGAAAAAGAACATGAAAAAGATGTGAAAAATTTCAACGACACAGCGCAAAAGCAATCGCCTAAGAATTCAG
TGACAATTATAGATGCTTTCAGTGACATGAATCAGAGTTACCAAAGTAGAAAGCAACAGAATTCCAGAGAATTTGTACC
TTTCACCGGGATTACAGAGAGTAAAAATCTGAACAGAAACTGCTGCCAAAACGGGGGCACCTGCATCCTAGGGGCTTTC
TGTGCATGCCCAAAGCATTTTAGTGGCCGACACTGTGAACTAAGAAAGTGCGGCAGCATCATCCATGGCGACTGGGTGA
TGAAGGGCTGCTGGCTGTGTCGGTGTCTCTATGGCACTCTGAAGTGTCTCTCTCAAAACACACAAGACGGCTGTGAACT
GAGAAGGGAAGAGGAAATTATCAGATTATATTCTAATGGCTTGAGATTACAGCAAACAATGTCTGCGCTGATTTGCCTT
CTCACCTTCCTCCTGGAGCTTTGCTGCTGGCAGTTGTGAAGCTGAACAAAAAGACTATACTAGGGTTCCTGTAGCATTT
AACTACAGGAATGAGCTGTGTGACTTCTTTCTTTAGTAAACTGCAGAAGACACTTGTACTTACATATCTGAAGCAGATT
ACAATGTCTTAGGTAATGATGAAATGCTTGGTTTATTATAAATACAGATTATATAAACGTGAAGTATTTATTATTTTAT
TATTATTATATTGCTACTACCAGTGTCCATTCGCTGGACAATTCCAACGCTTCTTTAGTTTTAAAATACTGTTCTTTCA
GTGGAAGAACTAAAAATGAATTATCTATGCCTTAAGTATTGAATTTTCATTGTACATGATAAAATTACTTTAAATAAAT
AACAGCGTTTTTCTTTGTTTCTG
CitationColas JF, Schoenwolf GC. Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis. Gene. 2000 Sep 19;255(2):205-17.
CopyrightCopyright © 2000 Elsevier Science B.V. All rights reserved.
CommentsThe cDNA template used to generate the probe was obtained from NCBI acc. # (NM_204700.1) using the information provided in the publication.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 3
stage 3
stage 3
stage 3
Early Endoderm
Epiblast
Hensen's Node
Primitive Streak
HH st 3a
HH st 3d
4-6
stage 4
stage 4
stage 6
Early Mesoderm
Epiblast
Hensen's Node
Lateral Plate Mesoderm
Notochord
Primitive Streak
 
7-11
stage 7
stage 7
stage 7
stage 7
stage 7
stage 7
stage 7
stage 9
stage 9
stage 9
stage 10
stage 10
stage 11
Anterior Intestinal Portal
Early Endoderm
Endoderm
Endothelial Cells
Forebrain
Heart
Hensen's Node
Lateral Plate Mesoderm
Mesoderm
Myocardium
Notochord
Somatic Mesoderm
Splanchnic Mesoderm
Tail
HH st 7+
mc: myocardial cells
pc: pericardial coelom

Entry 6

GEISHA IdCFC1.Anderson.2020Data SourceGEISHA ISH Analysis
Complete cDNA Template Probeshow
AAGCTTTCCCGAAGGAATACACAGTATTTCAGGCTGCAGGAAGATGTTCTGGCGAAAACATGTTAGAATTCTTTTCACT
GTGACTCTGATTTGGCAGGCCATTCATTTAGGAAAAGGCCGTGAAAAAGAACATGAAAAAGATGTGAAAAATTTCAACG
ACACAGCGCAAAAGCAATCGCCTAAGAATTCAGTGACAATTATAGATGCTTTCAGTGACATGAATCAGAGTTACCAAAG
CAGAAAGCAACAGAATTCCAGAGAATTTGTACCTTTCACCGGGATTACAGAGAGTAAAAATCTGAACAGAAACTGCTGC
CAAAACGGGGGCACCTGCATCCTAGGGGCTTTCTGTGCATGCCCAAAGCATTTTAGTGGCCGACACTGTGAACTAAGAA
AGTGCGGCAGCATCATCCATGGCGACTGGGTGATGAAGGGCTGCTGGCTGTGTCGGTGTCTCTATGGCACTCTGAAGTG
TCTCTCTCAAAACACACAAGACGGCTGTGAACTGAGAA
CommentsImages provided by Claire Anderson; Complete cDNA template sequence was provided by Bertrand Pain.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
X-XIV
stage XIII
Epiblast
 
7-12
stage 7
stage 8
stage 8
stage 11
stage 12
stage 12
stage 12
stage 12
stage 12
Amnion
Anterior Intestinal Portal
Atria
Endoderm
Headfold
Lateral Plate Mesoderm
Myelencephalon
Neural Plate/Tube
Notochord
Outflow Tract
Pharynx
Primitive Streak
Proepicardium
Somatic Mesoderm
Splanchnic Mesoderm
Ventricles
extraembryonic ectoderm
extraembryonic endoderm
extraembryonic mesoderm
section 25
section 51
section 64
stage 12+
stage 8-
ventral
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.2640

Mouse

Emage
Eurexpress
MGI GXD

Frog

Xenbase

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-990415-198
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