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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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MEIS2
Meis homeobox 2

Gene

Official Symbol	MEIS2
Official Full Name	Meis homeobox 2
CGNC ID	49388
also known as	Meis2a.1, Meis2a.2, homeobox protein Meis2\|Meis1, myeloid ecotropic viral integration site 1 homolog 2\|homeoprotein Meis2a.1\|homeoprotein Meis2a.2\|myeloid ecotropic viral insertion site-2a protein
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204803
Polypeptide	NP_990134
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.4046

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	4212	ENSG00000134138		MIM:601740
Mouse	17536	ENSMUSG00000027210	All phenotypic alleles (1):Targeted, knock-out(1)	MGI:108564
Xenopus	100036664, 398167			487674
Zebrafish	170454, 30066	ENSDARG00000077840	ZDB-GENE-020122-2, ZDB-GENE-000210-23	ZFIN:ZDB-GENE-020122-2, ZFIN:ZDB-GENE-000210-23

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395588
Ensembl Gene
KEGG	gga:395588

Entry 1

GEISHA Id	MEIS2.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	TCCGCTGTCAACGACGCTC
Reverse cDNA Template Primer	ATTAACCCTCACTAAAGGAAGTCCTGTGTCTTGGGCTAACTG	cDNA Template Length	756
Forward cDNA Template Probe	show TTTCCCCCTTTTTCGCTCTCGAAGGAATGGATGTGTGAGAGCTGGAAAACCATGCTCTCATGATATTTGTTGCTACTTT GGGGAAAATGCCTCTTTTCTTCTGTCGCTTTTTGTCCTTGTCTGGGTCATCATCATCCCCAGTACCAGGTGAGGCTACA CTGTTGTCTAAACCATCCCCTTGCTCGCTGCTGTTGTCTCCACTCTGGGAAGCATGGCCCCCACTGGAGGGCCCCGGTG TGCCTGCCGAGTGCGTTGAGGTTGCATCATCGTGGTCTCTCCAAGATGAAGGATTATGGTCGGCTAAATTTGTGGAAGA TCCTGAGAGTTCCTCGTGGTCTGACTTGGAGCTGCCATCCCTTTCATCGATAACGAGGTCTATTGGCATTTTTCCTTTC AAACAACTAATGTACCGATGGCAGAAGTTATCGCACAATTCGTGAACCTTCTCTAACTCCAGGAGGTGGAACCTTAGTA CTTGTATTGCTTGGATCATCAAATTGTCCAACTCTGGGTTTGAAGAAAAAAGTGGTTTTTCAGCGCGGACCTGCTTGGC GAAGACGGCGATGTCCTCGTTGAAGGAGTCGGAGGAGCAGACGTCCCCGCCGGCCACGCCGGGCTCCCGGGGCGTGCAG GTCGCCAGCTCGCACTTCTCAAAGACCAGGGCGAGGAGGGGAAACANCGGGTGCCCGTAAATCGCATCCTTGTCCCGCT TCAAAGCGTCGTTGACAGCAGAAAAAC

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 5

stage 6

Early Mesoderm
Endoderm
Epiblast
Germinal Crescent
Lateral Plate Mesoderm
Primitive Streak

7-12

stage 10

Anterior Intestinal Portal
Forebrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Neural Plate/Tube
Somites

13-18

stage 17

stage 18

Endoderm
Eye
Heart
Hindbrain
Limb Buds
Mesencephalon
Nasal Placode/Nerve
Neural Plate/Tube
Pharyngeal Arches and Clefts
Somatic Mesoderm
Somites
Telencephalon
Trunk Mesenchyme

19-24

stage 20

stage 21

stage 23

stage 24

Endoderm
Eye
Heart
Hindbrain
Leg
Mesencephalon
Nasal Placode/Nerve
Neural Plate/Tube
Pharyngeal Arches and Clefts
Somatic Mesoderm
Somites
Telencephalon
Trunk Mesenchyme
Wing

Entry 2

GEISHA Id	MEIS2.Sanchez-Guardado.2011	Data Source	Publication
Complete cDNA Template Probe	show TACACGCCGGACAGCACTACGGCGCCCACGCCCCGCACCCCAACGTCATGCCGGCCAGCATGGGCTCCGCTGTCAACGA CGCTCTGAAGCGGGACAAGGATGCGATCTACGGGCACCCGCTGTTTCCCCTCCTCGCCCTGGTCTTTGAGAAGTGCGAG CTGGCGACCTGCACGCCCCGGGAGCCCGGCGTGGCCGGCGGGGACGTCTGCTCCTTCGACTCCTTCAACGAGGACATCG CCGTCTTCGCCAAGCAGGTCCGCGCTGAAAAACCACTTTTTTCTTCAAACCCAGAGTTGGACAATTTGATGATCCAAGC AATACAAGTACTAAGGTTCCACCTCCTGGAGTTAGAGAAGGTTCACGAATTGTGCGATAACTTCTGCCATCGGTACATT AGTTGTTTGAAAGGGAAAATGCCAATAGACCTCGTGATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAAC TCTCAGGATCTTCCACAAATTTAGCCGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTC GGCAGGCACACCGGGGCCCTCCAGTGGGGGCCATGCTTCCCA
Citation	Sánchez-Guardado LÓ, Ferran JL, Rodríguez-Gallardo L, Puelles L, Hidalgo-Sánchez M. Meis gene expression patterns in the developing chicken inner ear. J Comp Neurol. 2011 Jan 1;519(1):125-47.
Copyright	© 2010 Wiley-Liss, Inc.
Comments	The sequence below was obtained from NCBI (acc. #: AF199011) using the information provided in the publication.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

7-12

stage 12

Ear/Otic Placode
Head Mesenchyme
Neural Plate/Tube
Splanchnic Mesoderm
Unlabeled

caudal level
intermediate level
rostral level

13-18

stage 14

Ear/Otic Placode
Head Mesenchyme
Neural Plate/Tube

19-24

stage 20

stage 24

Ear/Otic Placode
Neural Plate/Tube

vp, vertical pouch
vp, vertical pouch; hp, horizonatal pouch
vp, vertical pouch; hp, horizontal pouch

25-30

stage 27

Ear/Otic Placode
Neural Plate/Tube
Unlabeled

31-34

stage 34

Ear/Otic Placode

Entry 3

GEISHA Id	MEIS2.Merchan.2011	Data Source	Publication
Complete cDNA Template Probe	show ATGGCGCAAAGGTACGATGAGCTGCCCCACTACGGCGGGATGGACGGCGTAGGGGTGCCGGCGTCCATGTACGGGGACC CGCACGCCCCCCGGCCGATCCCCCCGGTGCACCACCTCAACCATGGGCCGCCGCTACACGCCGGACAGCACTACGGCGC CCACGCCCCGCACCCCAACGTCATGCCGGCCAGCATGGGCTCCGCTGTCAACGACGCTCTGAAGCGGGACAAGGATGCG ATCTACGGGCACCCGCTGTTTCCCCTCCTCGCCCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACGCCCCGGGAGC CCGGCGTGGCCGGCGGGGACGTCTGCTCCTTCGACTCCTTCAACGAGGACATCGCCGTCTTCGCCAAGCAGGTCCGCGC TGAAAAACCACTTTTTTCTTCAAACCCAGAGTTGGACAATTTGATGATCCAAGCAATACAAGTACTAAGGTTCCACCTC CTGGAGTTAGAGAAGGTTCACGAATTGTGCGATAACTTCTGCCATCGGTACATTAGTTGTTTGAAAGGGAAAATGCCAA TAGACCTCGTGATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAACTCTCAGGATCTTCCACAAATTTAGC CGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTCGGCAGGCACACCGGGGCCCTCCAGT GGGGGCCATGCTTCCCAGAGTGGAGACAACAGCAGCGAGCAAGGGGATGGTTTAGACAACAGTGTAGCCTCACCTGGTA CTGGGGATGATGATGACCCAGACAAGGACAAAAAGCGACAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATAT CATGAGAGCATGGCTTTTCCAGCATCTCACACATCCATATCCTTCAGAGGAGCAGAAGAAACAGTTAGCCCAAGACACA GGACTTACAATTCTACAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCTATGATTGACCAGTCAA ATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTT TGTATTGGATGGTCAGCAGCACATGGGAATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAT GGGCAATGGCACTACATGTAACCTTCATCTTGTAAATCAGTCGCAAA
Citation	Merchán,P, Bardet, SM, Puelles, L, Ferran, JL, Comparison of Pretectal Genoarchitectonic Pattern between Quail and Chicken Embryos. Front Neuroanat. 2011; 5: 23. Prepublished online 2010 December 29. Published online 2011 April 5
Copyright	Copyright © 2011 Merchán, Bardet, Puelles and Ferran.
Comments	Primers: Forward: 5′-ATGGCGCAAAGGTACGATGAG-3′; Reverse: 5′-TTGCGACTGATTTACAAGAT-3′.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

25-28

stage 26

stage 28

Midbrain

CoP commissural pretectum,
Double Label
Double label
Hab habenular region
JcP juxtacommissural pretectum,
OT optic tectum
PcP precommissural pretectum,
Quail
Th Thalamus,
mes mesencephalon,

Entry 4

GEISHA Id	MEIS2.Sanchez-Guardado.2011B	Data Source	Publication
Complete cDNA Template Probe	show ATGGCGCAAAGGTACGATGAGCTGCCCCACTACGGCGGGATGGACGGCGTAGGGGTGCCGGCGTCCATGTACGGGGACC CGCACGCCCCCCGGCCGATCCCCCCGGTGCACCACCTCAACCATGGGCCGCCGCTACACGCCGGACAGCACTACGGCGC CCACGCCCCGCACCCCAACGTCATGCCGGCCAGCATGGGCTCCGCTGTCAACGACGCTCTGAAGCGGGACAAGGATGCG ATCTACGGGCACCCGCTGTTTCCCCTCCTCGCCCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACGCCCCGGGAGC CCGGCGTGGCCGGCGGGGACGTCTGCTCCTTCGACTCCTTCAACGAGGACATCGCCGTCTTCGCCAAGCAGGTCCGCGC TGAAAAACCACTTTTTTCTTCAAACCCAGAGTTGGACAATTTGATGATCCAAGCAATACAAGTACTAAGGTTCCACCTC CTGGAGTTAGAGAAGGTTCACGAATTGTGCGATAACTTCTGCCATCGGTACATTAGTTGTTTGAAAGGGAAAATGCCAA TAGACCTCGTGATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAACTCTCAGGATCTTCCACAAATTTAGC CGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTCGGCAGGCACACCGGGGCCCTCCAGT GGGGGCCATGCTTCCCAGAGTGGAGACAACAGCAGCGAGCAAGGGGATGGTTTAGACAACAGTGTAGCCTCACCTGGTA CTGGGGATGATGATGACCCAGACAAGGACAAAAAGCGACAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATAT CATGAGAGCATGGCTTTTCCAGCATCTCACACATCCATATCCTTCAGAGGAGCAGAAGAAACAGTTAGCCCAAGACACA GGACTTACAATTCTACAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCTATGATTGACCAGTCAA ATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTT TGTATTGGATGGTCAGCAGCACATGGGAATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAT GGGCAATGGCACTACATGTAACCTTCATCTTGTAAATCAGTCGCAAA
Citation	Sánchez-Guardado LÓ, Irimia M, Sánchez-Arrones L, Burguera D, Rodríguez-Gallardo L, Garcia-Fernández J, Puelles L, Ferran JL, Hidalgo-Sánchez M. Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development. Dev Dyn. 2011 Jun;240(6):1475-92.
Copyright	Copyright © 2011 Wiley-Liss, Inc.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204803.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

1-3

stage 3

Hensen's Node

Stage HH3d

4-6

stage 4

stage 5

Early Endoderm
Early Mesoderm
Epiblast

Stage HH4+
Stage HH5+
pm, precardiac mesoderm

7-12

stage 7

stage 8

stage 11

Anterior Intestinal Portal
Diencephalon
Early Endoderm
Early Mesoderm
Eye
Foregut
Hindbrain
Lateral Plate Mesoderm
Midbrain
Neural Plate/Tube
Notochord
Pronephros
Rhombomeres
Sclerotome
Somatic Mesoderm
Somites
Spinal Cord
Splanchnic Mesoderm

pm, precardiac mesoderm

13-18

stage 14

stage 16

stage 18

Atria
Cranial Ganglia
Dermomyotome
Duodenum
Ear/Otic Placode
Esophagus
Eye
Face Mesenchyme
Hindbrain
Intermediate Mesoderm
Isthmus/MHB
Lateral Plate Mesoderm
Limb Buds
Mesencephalon
Nasal Placode/Nerve
Notochord
Pancreas
Paraxial Mesoderm
Pharyngeal Arches and Clefts
Pharynx
Rhombomeres
Sinus Venosus
Spinal Cord
Stomach
Tail
Telencephalon
Trunk Mesenchyme
Widespread Expression

stage HH18-20

Entry 5

GEISHA Id	MEIS2.Bobak.2009	Data Source	Publication
Complete cDNA Template Probe	show ATGGCGCAAAGGTACGATGAGCTGCCCCACTACGGCGGGATGGACGGCGTAGGGGTGCCGGCGTCCATGTACGGGGACC CGCACGCCCCCCGGCCGATCCCCCCGGTGCACCACCTCAACCATGGGCCGCCGCTACACGCCGGACAGCACTACGGCGC CCACGCCCCGCACCCCAACGTCATGCCGGCCAGCATGGGCTCCGCTGTCAACGACGCTCTGAAGCGGGACAAGGATGCG ATCTACGGGCACCCGCTGTTTCCCCTCCTCGCCCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACGCCCCGGGAGC CCGGCGTGGCCGGCGGGGACGTCTGCTCCTTCGACTCCTTCAACGAGGACATCGCCGTCTTCGCCAAGCAGGTCCGCGC TGAAAAACCACTTTTTTCTTCAAACCCAGAGTTGGACAATTTGATGATCCAAGCAATACAAGTACTAAGGTTCCACCTC CTGGAGTTAGAGAAGGTTCACGAATTGTGCGATAACTTCTGCCATCGGTACATTAGTTGTTTGAAAGGGAAAATGCCAA TAGACCTCGTGATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAACTCTCAGGATCTTCCACAAATTTAGC CGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTCGGCAGGCACACCGGGGCCCTCCAGT GGGGGCCATGCTTCCCAGAGTGGAGACAACAGCAGCGAGCAAGGGGATGGTTTAGACAACAGTGTAGCCTCACCTGGTA CTGGGGATGATGATGACCCAGACAAGGACAAAAAGCGACAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATAT CATGAGAGCATGGCTTTTCCAGCATCTCACACATCCATATCCTTCAGAGGAGCAGAAGAAACAGTTAGCCCAAGACACA GGACTTACAATTCTACAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCTATGATTGACCAGTCAA ATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTT TGTATTGGATGGTCAGCAGCACATGGGAATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAT GGGCAATGGCACTACATGTAACCTTCATCTTGTAAATCAGTCGCAAA
Citation	Bobak N, Agoston Z, Schulte D. Evidence against involvement of Bmp receptor 1b signaling in fate specification of the chick mesencephalic alar plate at HH16. Neurosci Lett. 2009 Sep 25;461(3):223-8. Epub 2009 Jun 16
Copyright	Reprinted with permission from Elsevier. Copyright © 2009 Elsevier B.V. All rights reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204803.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

13-18

stage 16

Mesencephalon
Midbrain

19-22

stage 22

Midbrain

Entry 6

GEISHA Id	MEIS2.Huber.2012	Data Source	Publication
Complete cDNA Template Probe	show ATGGCGCAAAGGTACGATGAGCTGCCCCACTACGGCGGGATGGACGGCGTAGGGGTGCCGGCGTCCATGTACGGGGACC CGCACGCCCCCCGGCCGATCCCCCCGGTGCACCACCTCAACCATGGGCCGCCGCTACACGCCGGACAGCACTACGGCGC CCACGCCCCGCACCCCAACGTCATGCCGGCCAGCATGGGCTCCGCTGTCAACGACGCTCTGAAGCGGGACAAGGATGCG ATCTACGGGCACCCGCTGTTTCCCCTCCTCGCCCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACGCCCCGGGAGC CCGGCGTGGCCGGCGGGGACGTCTGCTCCTTCGACTCCTTCAACGAGGACATCGCCGTCTTCGCCAAGCAGGTCCGCGC TGAAAAACCACTTTTTTCTTCAAACCCAGAGTTGGACAATTTGATGATCCAAGCAATACAAGTACTAAGGTTCCACCTC CTGGAGTTAGAGAAGGTTCACGAATTGTGCGATAACTTCTGCCATCGGTACATTAGTTGTTTGAAAGGGAAAATGCCAA TAGACCTCGTGATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAACTCTCAGGATCTTCCACAAATTTAGC CGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTCGGCAGGCACACCGGGGCCCTCCAGT GGGGGCCATGCTTCCCAGAGTGGAGACAACAGCAGCGAGCAAGGGGATGGTTTAGACAACAGTGTAGCCTCACCTGGTA CTGGGGATGATGATGACCCAGACAAGGACAAAAAGCGACAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATAT CATGAGAGCATGGCTTTTCCAGCATCTCACACATCCATATCCTTCAGAGGAGCAGAAGAAACAGTTAGCCCAAGACACA GGACTTACAATTCTACAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCTATGATTGACCAGTCAA ATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTT TGTATTGGATGGTCAGCAGCACATGGGAATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAT GGGCAATGGCACTACATGTAACCTTCATCTTGTAAATCAGTCGCAAA
Citation	Huber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H. HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system. Dev Biol. 2012 Mar 1;363(1):219-33. Epub 2011 Dec 24.
Copyright	Copyright © 2011 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204803.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

25-29

stage 27

stage 29

Unlabeled

Entry 7

GEISHA Id	MEIS2.Ferran.2007	Data Source	Publication
Complete cDNA Template Probe	show TACACGCCGGACAGCACTACGGCGCCCACGCCCCGCACCCCAACGTCATGCCGGCCAGCATGGGCTCCGCTGTCAACGA CGCTCTGAAGCGGGACAAGGATGCGATCTACGGGCACCCGCTGTTTCCCCTCCTCGCCCTGGTCTTTGAGAAGTGCGAG CTGGCGACCTGCACGCCCCGGGAGCCCGGCGTGGCCGGCGGGGACGTCTGCTCCTTCGACTCCTTCAACGAGGACATCG CCGTCTTCGCCAAGCAGGTCCGCGCTGAAAAACCACTTTTTTCTTCAAACCCAGAGTTGGACAATTTGATGATCCAAGC AATACAAGTACTAAGGTTCCACCTCCTGGAGTTAGAGAAGGTTCACGAATTGTGCGATAACTTCTGCCATCGGTACATT AGTTGTTTGAAAGGGAAAATGCCAATAGACCTCGTGATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAAC TCTCAGGATCTTCCACAAATTTAGCCGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTC GGCAGGCACACCGGGGCCCTCCAGTGGGGGCCATGCTTCCCA
Citation	Ferran JL, Sánchez-Arrones L, Sandoval JE, Puelles L. A model of early molecular regionalization in the chicken embryonic pretectum. J Comp Neurol. 2007 Dec 1;505(4):379-403.
Copyright	Copyright © 19992012 John Wiley & Sons, Inc. All Rights Reserved.
Comments	The sequence below was obtained from NCBI (acc #: AF199011 - Showing 598 bp region from base 124 to 728) using the information provided in the publication.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 17

stage 18

Mesencephalon
Midbrain

19-24

stage 23

Mesencephalon

stage 25

Mesencephalon

Entry 8

GEISHA Id	MEIS2.Mercader.2000	Data Source	Publication
Complete cDNA Template Probe	show `TGTTTGAAAGGGAAAATGCCAATAGACCTCGTGATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAACTCT CAGGATCTTCCACAAATTTAGCCGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTCGGC AGGCACACCGGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGTGGAGACAACAGCAGCGAGCAAGGGGATGGTTTAGAC AACAGTGTAGCCTCACCTGGTACTGGGGATGATGATGACCCAGACAAGGACAAAAAGCGACAGAAGAAAAGAGGCATTT TCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTTTTCCAGCATCTCACACATCCATATCCTTCAGAGGAGCAGAA GAAACAGTTAGCCCAAGACACAGGACTTACAATTCTACAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGA`
Citation	Mercader N, Leonardo E, Piedra ME, Martínez-A C, Ros MA, Torres M. Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes. Development. 2000 Sep;127(18):3961-70.
Copyright	© The Company of Biologists Limited 2000
Comments	The sequence below was obtained from NCBI (acc # NM_204803.1 - Showing 468 bp region from base 532 to 999) using the information provided in the publication.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

19-22

stage 19

stage 20

stage 22

Blood Vessels
Leg
Limb Buds
Notochord
Wing

control embryo
control embryo
control wing
left side = control side
left wing = control side
right side = -AER
right side = -AER +RAA
right side = FGF1 bead
right side = FGF8 +RA bead
right side = FGF8 +RAA bead
right side = FGF8 bead

Entry 9

GEISHA Id	MEIS2.Heine.2008	Data Source	Publication
Complete cDNA Template Probe	show ATGGCGCAAAGGTACGATGAGCTGCCCCACTACGGCGGGATGGACGGCGTAGGGGTGCCGGCGTCCATGTACGGGGACC CGCACGCCCCCCGGCCGATCCCCCCGGTGCACCACCTCAACCATGGGCCGCCGCTACACGCCGGACAGCACTACGGCGC CCACGCCCCGCACCCCAACGTCATGCCGGCCAGCATGGGCTCCGCTGTCAACGACGCTCTGAAGCGGGACAAGGATGCG ATCTACGGGCACCCGCTGTTTCCCCTCCTCGCCCTGGTCTTTGAGAAGTGCGAGCTGGCGACCTGCACGCCCCGGGAGC CCGGCGTGGCCGGCGGGGACGTCTGCTCCTTCGACTCCTTCAACGAGGACATCGCCGTCTTCGCCAAGCAGGTCCGCGC TGAAAAACCACTTTTTTCTTCAAACCCAGAGTTGGACAATTTGATGATCCAAGCAATACAAGTACTAAGGTTCCACCTC CTGGAGTTAGAGAAGGTTCACGAATTGTGCGATAACTTCTGCCATCGGTACATTAGTTGTTTGAAAGGGAAAATGCCAA TAGACCTCGTGATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAACTCTCAGGATCTTCCACAAATTTAGC CGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTCGGCAGGCACACCGGGGCCCTCCAGT GGGGGCCATGCTTCCCAGAGTGGAGACAACAGCAGCGAGCAAGGGGATGGTTTAGACAACAGTGTAGCCTCACCTGGTA CTGGGGATGATGATGACCCAGACAAGGACAAAAAGCGACAGAAGAAAAGAGGCATTTTCCCCAAAGTAGCAACAAATAT CATGAGAGCATGGCTTTTCCAGCATCTCACACATCCATATCCTTCAGAGGAGCAGAAGAAACAGTTAGCCCAAGACACA GGACTTACAATTCTACAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAGTACAGCCTATGATTGACCAGTCAA ATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCCAGAGGGTCAGCCCATGGGGAGCTT TGTATTGGATGGTCAGCAGCACATGGGAATCCGGCCTGCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAT GGGCAATGGCACTACATGTAACCTTCATCTTGTAAATCAGTCGCAAA
Citation	Heine P, Dohle E, Bumsted-O'Brien K, Engelkamp D, Schulte D. Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development. Development. 2008 Mar;135(5):805-11. doi: 10.1242/dev.012088. Epub 2008 Jan 23.
Copyright	Copyright held by the authors. Published by the Company of Biologists Ltd.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

stage 25

Extraembryonic Mesoderm
Eye
Retina

Entry 10

GEISHA Id	MEIS2.Trevers.2023	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show GTGGTGGTGGTGGTGGTGGTGGTCCGTAGAGAAAGAAAAAAGGAAAAAGAGAGAGAGAAAGAAAAAGGAAAGAGAGAGA AAAAAGAAGAAACACACAGAAACTCATCGTGCTCGCTGGCTGTTTTTTGTGCGTTCTCGTTGCCGGTGGTGGTGGTGGT GGTGTTTCCCCGTACCGGAGGATAGGAGAAGTCTGTAAGTGGGTGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAGACTCTTCTTCACTCTAAATCACTTTCTTTGCTGGACTGGGACACTGGGATATTAAATATACGGCACATCC AGGAGTTTATTGGAGCGCAGACTGATGGCGCAAAGGTACGATGAGCTGCCCCACTACGGCGGGATGGACGGCGTAGGGG TGCCGGCGTCCATGTACGGGGACCCGCACGCCCCCCGGCCGATCCCCCCGGTGCACCACCTCAACCATGGGCCGCCGCT ACACGCCGGACAGCACTACGGCGCCCACGCCCCGCACCCCAACGTCATGCCGGCCAGCATGGGCTCCGCTGTCAACGAC GCTCTGAAGCGGGACAAGGATGCGATCTACGGGCACCCGCTGTTTCCCCTCCTCGCCCTGGTCTTTGAGAAGTGCGAGC TGGCGACCTGCACGCCCCGGGAGCCCGGTGTGGCCGGCGGGGACGTCTGCTCCTCCGACTCCTTCAACGAGGACATCGC CGTCTTCGCCAAGCAGGTCCGCGCTGAAAAACCACTTTTTTCTTCAAACCCAGAGTTGGACAATTTGATGATCCAAGCA ATACAAGTACTAAGGTTCCACCTCCTGGAGTTAGAGAAGGTTCACGAATTGTGCGATAACTTCTGCCATCGGTACATTA GTTGTTTGAAAGGAAAAATGCCAATAGACCTCGTTATCGATGAAAGGGATGGCAGCTCCAAGTCAGACCACGAGGAACT CTCAGGATCTTCCACAAATTTAGCCGACCATAATCCTTCATCTTGGAGAGACCACGATGATGCAACCTCAACGCACTCG GCAGGCACACCGGGGCCCTCCAGTGGGGGCCATGCTTCCCAGAGTGGAGACAACAGCAGCGAGCAAGGGGATGGTTTAG ACAACAGTGTAGCCTCACCTGGTACTGGGGATGATGATGACCCAGACAAGGACAAAAAGCGACAGAAGAAAAGAGGCAT TTTCCCCAAAGTAGCAACAAATATCATGAGAGCATGGCTTTTCCAGCATCTCACACATCCATATCCTTCAGAGGAGCAG AAGAAACAGTTAGCCCAAGACACAGGACTTACAATTCTACAAGTAAACAACTGGTTTATTAATGCCAGAAGAAGAATAG TACAGCCTATGATTGACCAGTCAAATCGAGCAGGTTTTCTTCTTGATCCTTCAGTGAGCCAAGGAGCAGCATATAGTCC AGAGGGTCAGCCGATGGGGAGCTTTGTATTGGATGGTCAGCAGCACATGGGAATCCGGCCTGCAGGTTTGCAAGGCATG CCAGGGGACTACGTATCTCAGGGTGGTCCTATGGGTATGAGTATGGCACAGCCAAGTTACACTCCTCCCCAGATGACCC CACACCCTCCTCAATTAAGACATGGACCCCCAATCCACTCATATTTGCCAAGTCACCCCCATCACCCAGCCATGATGAT GCACGGAGGACCCCCTACCCACCCTGGAATGACCATGTCAGCACAGAGCCCTTCAATGTTAAATTCTGTAGACCCCAAT GTTGGTGGACAGGTTATGGACATTCATGCCCAATAGTATAAGGGAACTCAAGGGAAAAACAAAACAAAAACAAAACAAA ACAAAAACAAAAACTATTTTAAGACTTTTGAACTTTGACCAGATGTTGACACTTAATACGAAATTCCAGACAGCTGTGA TTATTTTTTACTTTTTGTCATTTTTCATCAACAACAGAGGACCAACGAAACAAGAACACAGATGTGAAATCATGGGCTC ACTGAAATGAATATGTCCATGTACAGATCCTCTGGAGAAAAAAAAAAAAAGAAAAAAAAGAAAAAAAAAAAGACTCCAA GAGTTATAACTACTGTAGTATAAACATAGGAACTAAGTTAACTTGTACATTTCTGTTGATCACTCCGTTACGTTGCCTC AAATAGTTTTAGAAGAAAAAAAAAATCCTTGTTTTCCACACTATGTGTGTTGTTCCCAAAAGAATGACTGTTTTGGTTC AGCAGTGAAGTCACTATCCATGAAAGACCTGTTTTGGCCAGTGAGAAAAGAACTACCCTGGAGATGAAGATGAAAAGTC TTGCTGGGTCTCTCATCACTCAGAAGACTGTTCCAAGAAGGCCTTGCCATCCCCTCGTTTTGTTCCTTCATAAAATGTG TCCTTTAGTTTCAAACAGATCTTTATAGTTTGTGCTTCATTAAGTCTCTCCCCATTCCTTCCCAGTCTATTTTTTTTTT CTTTTTCTTGGACTCTTCTTCCAAGAGCTTGCAGGTGAAGATTTAAAAGACAGAAAAGACAGAGCAGGAGCTTCTTCCA GTAGTTCTGAGCCTTGGCTTTGGACAAAACAAAACTAAAAGTTGGGCAGCTTTCCTCAATGAAAGAAGTTACTAACGGT GTTTGCACCAAACCTAGAACTTTATCATGAACTCAAAGCTTGGGAAAAAAAAAAAAAAAAAAAAAGCAAGAGAATACTG TAACAAACTTCGTACAGAGTTCGGTCTATTAATTGTTTCATGTTAGATATTCTATGTGTTTACCTCAATTGAAAAAAAA AAAAAAAAGAATGTTTTTGCTAGTATCAGATCTGCTGTGGAATTGGTATTGTATGTCCATGAATTCTTCCTTTCTCAGC ACGTGTTCCTCACTAGAAGAAAATGCTGTTACCTTTAAGCTTTGTCAAAATTTACATTAAAATACTTGTATGAGGACTG TGACGTTATGTTTTAAAAAAAAAAAAAAGGTGTTAAGTCACAAAATGCGGTAATAAATATTTCATTTTTGATTTTTT
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001397970).