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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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EPAS1
endothelial PAS domain protein 1

The human orthologue of this gene is associated
with the following human disease:

Erythrocytosis, familial, 4

Gene

Official Symbol	EPAS1
Official Full Name	endothelial PAS domain protein 1
CGNC ID	49393
also known as	HIF2a, endothelial PAS domain-containing protein 1, endothelial PAS domain protein 1 , HIF2alpha, Hypoxia-inducible factor 2 alpha
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204807
Polypeptide	NP_990138
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.43355

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	2034	ENSG00000116016	MIM:611783	MIM:603349
Mouse	13819	ENSMUSG00000024140	All phenotypic alleles (8):Targeted, knock-out(3) Targeted, other(5)	MGI:109169
Xenopus	448117, 444145			981611
Zebrafish	555192, 566886	ENSDARG00000057671, ENSDARG00000008697	ZDB-GENE-060607-11, ZDB-GENE-030131-4490	ZFIN:ZDB-GENE-060607-11, ZFIN:ZDB-GENE-030131-4490

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395596
Ensembl Gene	ENSGALG00000010005
KEGG	gga:395596

Entry 1

GEISHA Id	N19	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show GCAACAATATGAGTAGGTCATCATTGCCACCATACCACAACCAAGCCAGCACTCCGCTGTCTTCGATGGGGGGTAGACC AAACACCCAGTGGCCACCTGATCCGCCATTAGAATATGTTCCTTCTAAATGGAGACTCATGGATAAATACTCAGGAACC CTATCAAGTTCCCCCTCAGGACCCCCAGTGCGTTCTCCCAACATGCCTTCATATCACTAAAGAAAATGGAACAGCTGGC AATGGTACAGAAGGTGCAAAATCGAGCCATAGAAACTGAGAACCCAGCAAGGTAATTGCTTTGTAGACATCCAGTTCCA AACTGAAGAGACAACTGGATTACGAAGATGCATTCTAGCATTGCACTGACAGCTTGCAGAGAGGGAGATCCATCTGGGT TCATCAACCCACCTCAGTTAGATTGCTGTGATAGAGAATGAAATTTCTCAAACGGGATACATACTGTGCACTCGCTTAC AGAAAAGAAGTCTCTCAGCACAAGTGATCTTACTGATGAGTATGTCTGCATACTCGAGAGGTCTAAGCCAACCAATGAA TTACAACTGCAGTCCTTATTGCAGGCAGGTCAATCAACAGTTGTGTTGCTTTATGCTCTTTTTTTCTGGTGAACAATCT GAAAGCAGGAGCGTACTCCCATAAAGTGAATTTATAGTCCCCATTATCAGGAATATACTGTGCAGTCAGCTCATAAAGA GTCAACATGTAACGAATCGAAAATGCTGGCAAGTCTTCAGATTTGAACCATATTTGCAGTGCCAAGGACTTAAAGGCAT CAAAGACTAAAGACACTGTGAAGTAAACGTCCCTGTTTTCGGTTTCTTATTTGTGTCCACGCTTCTGCAGGGCATTAAA AACTGCTATAGAGCCCTAGACCAGGCAACCTAAAACAATCCTGCAAAAATATTCCCTGGCCTATAATATTCAAACAGCT TCACTTTTTAATCATAATTATTTGCAGTAGATCGATATTGCTGAATAACCTATTGACAATATTATAACTATATGGGAAC TTTAATTTGACCTAAGTGAAATGTACCCGTTGACAAATGAGTCCGCTTATTAAAGTATACTCACTCCTATAATCAAATA AAAAAAAAAAAAAAAAAAAAAAAAAAAA

Stage

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Location (click to highlight)

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4-6

stage 4

Primitive Streak

7-12

stage 8

stage 12

Extraembryonic

13-18

stage 13

stage 14

stage 16

Extraembryonic

19-24

stage 21

stage 23

stage 24

Extraembryonic

Entry 2

GEISHA Id	EPAS1.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	GGCTGGAAACTCAAGGGACCG
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGGCATTGGTTGGCTCAGACCTCTCG	cDNA Template Length	1370
Forward cDNA Template Probe	show CCCTCGATCACTCAGTAAAACTCTCGTAGAAACTTGTGCTGAGAGACTTCTTTTCTGTAAGCCCCTTTACAGTGTTTCC CCTTTGAGAAATTTCATTCTCTTCCACACTTAACTGAGGTGGGTTAATGACAGATGGATCTCCCCCACTCAGCTGTTGC AATGCTTGCTCTTCGTAATCCAGTTGTCTCTTCAGTTTCAAACTATTAGACAAAGCAATTCTTGCTGGGTTTATATCTA TGCCTCGTTGCCCCAAACCATCCAGCGGCCTTTTTTTATATATGGGCATGTTGGGAGAACGCACTGGGGGTCCTGAGGG GGAACTTGATAGGGTTCCTGAGTATTTATCCATGAGTCTCCATTTAGAAGGAACATATTCTAATGGCGGATCAGGTGGC CACTGGGTGTTTGGTCTACCCCCCATCCAAAACAGCGGAGTGCTGGCTTGGTTGTGGTATGGTGGCAATGATGACCTAC TCATATTGTTGAAGAACACCGATGATAAGGACCCATGACCAGGGTTAATGTTTTTATTTGATAGTTGTGGGCAATATTT CTCTGGGAGGAACTGATTCTGTGAAGCAGAAACAAGAAGTTGGAAAATGGTACTCCTGCTACTTAGAAACAACTGGGTA TTTTGTGCCCTTTCACAGAAAGAAAGTTCTTCTTGTCAGATAGGGCTGAACTGGAAATCTTCTCCATCCATAAGAATGT AAAGAGTTTAAGGTTTCTAGGTCCAGTTCTTTGAAATCAGTCTGACAGTTTGAACAGACTTTTTGATTTCTGTGTTCAA

Stage

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7-10

stage 9

stage 10

Area Opaca
Blood Islands
Extraembryonic

Entry 3

GEISHA Id	Hif2alpha.Ota.2007	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show AGCAAGACCTTCATGAGTCGCCATAGCATGGACATGAAATTCACCTACTGTGATGACAGAATAACAGAATTGATTGGAT ACCACCCAGAAGAGTTGCTGGGCCGTTCAGCATATGAGTTCTACCATGCCTTGGACTCAGAGAACATGACCAAAAGTCA TCAGAACTTGTGTACAAAAGGTCAAGTAGTGACTGGCCAGTACCGTATGCTTGCCAAGCATGGTGGATACGTGTGGCTG GAAACTCAAGGGACCGTCATTTACAACACGCGCAACCTACAGCCTCAGTGTATCATCTGTGTCAACTATGTGCTGAGTG AAATTGAGAAGAATGATATTGTCTTCTCTATGGACCAAACGGAATCGCTCTTCAAGCCACACCTGTTGACGATGAGCAG TGCCTTTGAGAATGGGATCTCAGGGAGGGACAAGAGTGATTTATTGTTTACTAAGCTAAAAGAAGAACCGGAGGAACTT GCACAACTGGCTCCAACACCTGGAGATGCCATTATTTCCCTGGATTTTGAACTCCATCCAGGGATACAGAAGTTTGAGG AAGCCCCTGCCTATACGAGCGCTGTTTTGACACCAAACAAACCGTGGCCAGTAGAAGTGAAAAGCCATGCTGCTCAAGG TGAAACGCTGACAATACCATCCTTTACAATGCCACAGATTGCACCTGGCAGCAGTACTCCAAGTGCAAGCAGCAACAGT AGCTGTTCCACGCCAAACAGCCCGGAGGATTACTACACTTCTGTGGATGATGATCTTA
Comments	Copyright © 2007 Elsevier B.V. All rights reserved.

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

stage 6

Area Opaca
Ectoderm
Extraembryonic

Stage 4+

7-12

stage 7

stage 8

stage 9

stage 10

stage 12

Area Opaca
Blood Islands
Ectoderm
Endoderm
Extraembryonic

13-14

stage 14

Blood Islands
Ectoderm
Endoderm
Extraembryonic

Entry 4

GEISHA Id	HIF-2a.Nanka.2006	Data Source	Publication
Complete cDNA Template Probe	show CCCGCCGCCGAGCCGCTGCCGTCTGCCGTGTCGCCGCCGCTGCCTCCCCCGGGCGGGCCGTACAATCCTCGGCAGTGTC CTGAGACTGTACGCCCGCCTCGGGGGCGACCCGGCACAGCCGGCCACGCCGACCCCAGCCGACCCCGACCGGCCGCCCG CGGAGTCTCGCGTCCCGCGTGCAGGTGCTGAGCCCGCCCCGGCCCGAGAGGCGGCGCAGGAGCCGACAGCCGACGCGAT GACAGCTGACAAGGAGAAGAAGAGGAGCAGTTCTGAGCGGAGGAAGGAGAAATCAAGAGATGCAGCAAGATGCAGGAGA AGCAAAGAGACGGAAGTATTCTACGAACTGGCTCATGAACTGCCCCTGCCCCACAATGTCAGTTCCCACCTGGACAAGG CATCTATAATGCGCCTGGCAATCAGTTTCTTACGCACTCACAAGCTTCTGTCTTCAGTATGTGCCGACAACGAGAATGA ACTAGAAGCAGATCAGCAGATGGACAACTTGTACCTGAAAGCTTTGGAGGGATTTATTGCCGTGGTGACACAGGATGGA GACATGATCTTTTTGTCAGAGAATGTCAACAAATACATGGGTCTCACCCAGGTGGAATTAACTGGACACAGCATTTTTG ACTTCACTCATCCATGTGATCATGAGGAAATTAGAGAGAATCTGAGTCTGAAAAATGGTCCAGGCTTTGGAAAGAAAAA CAAGGAGATGTCAACTGAACGTGACTTCTTCATGAGGATGAAATGCACCGTTACTAACAGAGGCAGAACTGTTAACCTC AAATCTGCCACATGGAAGGTTTTGCACTGCACTGGACAAGTTAAAGTGTACAACACTTGCCCTCCTCACACTTTGTGTG GGTATAAAGAACCTCTTCTCACCTGCCTTATAATAATGTGTGAGCCTATTCAACATCCTTCAAACATTGATATCCCTCT GGACAGCAAGACCTTCATGAGTCGCCATAGCATGGACATGAAATTCACCTACTGTGATGACAGAATAACAGAATTGATT GGATATCACCCAGAGGAGTTGCTGGGCCGTTCAGTATATGAGTTCTACCATGCCTTGGACTCGGAGAACATGACCAAAA GTCATCAGAACTTGTGTACAAAAGGTCAAGTAGTGACTGGCCAGTACCGTATGCTTGCCAAGCATGGTGGATACGTGTG GCTGGAAACTCAAGGGACCGTCATTTACAACACGCGCAACCTACAGCCTCAGTGTATCATCTGTGTCAACTATGTGCTG AGTGAAATTGAGAAGAATGATGTTGTCTTCTCTATGGACCAAACGGAATCGCTCTTCAAGCCTCACCTGTTGACAATAA GCACTGCCTTTGAGAATGGGATCTCACGGAGGGATAAGAGTGACTTATTATTTACTAAGCTAAAAGAAGAACCGGAGGA AGTTGCACAGCTGGCTCCAACACCTGGAGATGCCATTATTTCCCTGGATTTTGAACTCCATCCAGGGATACAGAAGTTT GAGGAACCCCCTGACTATACCAGTGCTGTTTTGACACCAAACAAACCGTGGCCAGTAGAAGTGAAAAGCCATGCTGCTC AAGGTGAAACGCTGACAATGCCATCCTTTACAATGCCTCAGATTCCACCTGGCAACAGTACTCCAAGTGCAAGCAGCAA CAGTAGCTGTTCCACGCCAAACAGTCCAGAGGATTACTACACTTCTGTGGATGACGATCTTAAGATTGAGGTGATTGAA AAACTCTTTGCCATGGACACAGAATCAAAAAGTCAGTGCAACTCCCAGACTGATTTCAATGAACTGGACCTTGAAACCT TGGCTCCTTACATTCCTATGGATGGAGAAGATTTCCAGCTCAGCCCTATCTGCCAAGAAGAGCGTCCTCACTCTGAAAG TGCACAAAATACCCAGCAGAATCTAAGTAGCATGAGTACCATTTTCCAACCTGTTGCTTCTGCTTCACAGAATCAGTTC CTCCCAGAGAAATATTGCCCACAGCTATCAAATAAAAACATTAACCCTGGTCATGGGTCCCTATCATCTGTGTTCTTCA ACAATATGAGTAGGTCATCGTTGCCACCATACCACAACCAAGCCAGCACTCCGCTGTCTTCGATGGGGGGTAGACCAAA CACCCAGTGGCCACCTGATCCACCGTTAGAATATGTTCCTGCTAAATGGAGACTCATGGATAAATACTCAGGAACCCTA TCAAGTTCCCCCTCAGGACCCCCAATACATTCTCCCAACATGCCCGTATATAAAAAAAGGCTGCTGGATGGTTTGGGGC AACGAGGCATAGATATAAACCCAGCAAGAATTGCTTTGTCTAATAGTTTGAAGCTGAAGCGACAGTTGGATTATGAAGA GCAGGCAATGCAACAGCTGACTGGGGGAGACCCATCTGCCATTAACCCATCTCAGTTAATGTGGAAGAGAATGAAATTT CTCAAAGGGGAAAACTGTTCCTTGCTTACGGAGAAGAAGTCTCTCAGCACAAGTGTTCTTACTGATGAGTTTGTCTGCA ACTCGAGAGGTCTGAGCCAACCAATGAATCAACTGCAGCTGCAGCAGCAACAGCAGCAACCCACCTGTGGCAGTCCTGG TGAAAATCTGAAAGCAGGAGCGTTTTCCCCTCAGTTTTACAGTCCCCATTATCAGGACTATACTGTGCAGTCAGCTCAT AAAGTGTCAGGTGTGACGAGTCGTCTGCTGGGGTCTTCCTATGAACCATATTTGCTGCCTGAGTTGACAAGATATGACT GTGAGGTAAACGTCCCTGTTTTGGGCAGTTCCACGCTTCTGCAGGGCAGCGAACTGCTCAGAGCCCTGGACCAGACAAC CTGAGCAATCCTGCAGTATTGGCCTATACTGTTCAAAACAGCTTCAGTTTTTAAATATATTTTTGCAAGTAGACGATTT CTAATACCAATACACTTTTACAGGATTTTACATAGATATTGAATCTGTCCACGTTACCAAATAGTGGCCTTTTGAAGTT ACTCACTTCTATTATTCATATTAAAGAAATACATCTACTGTATTTTCTCTATTCCAATTAAAGTGTTGGCGGCC
Citation	Nanka O, Valásek P, Dvoráková M, Grim M. Experimental hypoxia and embryonic angiogenesis. Dev Dyn. 2006 Mar;235(3):723-33.
Copyright	Copyright © 2006 Wiley-Liss, Inc.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (AF212989).

Stage

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Location (click to highlight)

Comments (click to highlight)

19-24

stage 22

Arteries
Blood Vessels
Endocardium
Veins

Endothelial Cells

25-28

stage 28

Entry 5

GEISHA Id	hif2alpha.Ota.2007	Data Source	Publication
Complete cDNA Template Probe	show AGCAAGACCTTCATGAGTCGCCATAGCATGGACATGAAATTCACCTACTGTGATGACAGAATAACAGAATTGATTGGAT ACCACCCAGAAGAGTTGCTGGGCCGTTCAGCATATGAGTTCTACCATGCCTTGGACTCAGAGAACATGACCAAAAGTCA TCAGAACTTGTGTACAAAAGGTCAAGTAGTGACTGGCCAGTACCGTATGCTTGCCAAGCATGGTGGATACGTGTGGCTG GAAACTCAAGGGACCGTCATTTACAACACGCGCAACCTACAGCCTCAGTGTATCATCTGTGTCAACTATGTGCTGAGTG AAATTGAGAAGAATGATATTGTCTTCTCTATGGACCAAACGGAATCGCTCTTCAAGCCACACCTGTTGACGATGAGCAG TGCCTTTGAGAATGGGATCTCAGGGAGGGACAAGAGTGATTTATTGTTTACTAAGCTAAAAGAAGAACCGGAGGAACTT GCACAACTGGCTCCAACACCTGGAGATGCCATTATTTCCCTGGATTTTGAACTCCATCCAGGGATACAGAAGTTTGAGG AAGCCCCTGCCTATACGAGCGCTGTTTTGACACCAAACAAACCGTGGCCAGTAGAAGTGAAAAGCCATGCTGCTCAAGG TGAAACGCTGACAATACCATCCTTTACAATGCCACAGATTGCACCTGGCAGCAGTACTCCAAGTGCAAGCAGCAACAGT AGCTGTTCCACGCCAAACAGCCCGGAGGATTACTACACTTCTGTGGATGATGATCTTA
Citation	Ota K, Nagai H, Sheng G. Expression and hypoxic regulation of hif1alpha and hif2alpha during early blood and endothelial cell differentiation in chick. Gene Expr Patterns. 2007 Aug;7(7):761-6. Epub 2007 Jun 12.
Copyright	"Reprinted from Gene Expression Patterns, Volume number 7, Ota K, Nagai H, Sheng G, Expression and hypoxic regulation of hif1alpha and hif2alpha during early blood and endothelial cell differentiation in chick,761-766. Copyright (2007), with permission from Elsevier". Copyright © (2007) Elsevier B.V. All rights reserved.