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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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ID2
inhibitor of DNA binding 2, HLH protein

Gene

Official Symbol	ID2
Official Full Name	inhibitor of DNA binding 2, HLH protein
CGNC ID	12279
also known as	DNA-binding protein inhibitor ID-2\|inhibitor of DNA binding 2, dominant negative helix-loop-helix protein\|transcriptional regulator Id2
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_205002
Polypeptide	NP_990333
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.3125

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	3398	ENSG00000115738		MIM:600386
Mouse	15902	ENSMUSG00000020644	All phenotypic alleles (6):Targeted, knock-out(4) Targeted, other(2)	MGI:96397
Xenopus	394480, 398111			481296
Zebrafish	266599, 321364	ENSDARG00000055283, ENSDARG00000029544	ZDB-GENE-020910-1, ZDB-GENE-030131-15	ZFIN:ZDB-GENE-020910-1, ZFIN:ZDB-GENE-030131-15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395852
Ensembl Gene	ENSGALG00000016403
KEGG	gga:395852

Entry 1

GEISHA Id	D36	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show GGGGAACGGCAGGCAGCGCGCTCCGCAGGCTCCGTGCGCTCTCCCCGCGCCCGCCTTTCAGCATGAAAGCTTTCAGCCC CGTGCGGTCCGTGCGGAAGAACGGCCTTTCGGAGCACAACCTGGGCATCTCCCGCAGCAAGACCCCGGTGGACGACCCC ATGAGCCTGCTGTACAACATGAACGACTGCTACTCCAAGCTGAAGGAGCTGGTGCCCAGCATCCCGCAGAACAAGAAGG TCAGCAAGATGGAAATCCTGCAGCACGTCATCGACTACATCCTGGACCTGCAGATCGCGCTGGACTCGCACCCGTCCAT CGTCAGCCTCCACCACCAGCGGCCGGGGCAGAACGCCGCCTCCCGGACCCCGCTGACCACGCTCAACACAGACATCAGC ATCCTCTCCCTACAGGCAGCCGAGTTCCCCTCAGAACTAATGGCGAGTGACAGCAAAGCGCTCTGTGGCTGAATCGCAC GGTGTTCCGCTGAGGAGGTTTTTCTTTTCCTTTTCTTGTTTTCTTCCTTTTTTTTTTTCTTTTTTTTTTTTTTTTTTGC ACAAGAATTACGTCCACAGGATTTGGGTTTTTGTCTTGAGGTGCTGAATTTCTCACCTGTACCTGGAGGGGAGGAATCC ACGCTAACTAAACTGAAAGGACCTTTAGAAACCAATAAAGAAGAGGAAAGAGGGGAAAAAAAAAAAATCATCGAGATTG CTCTTTATCCCCCCACCCCGTTCTTCAAGTTGGACTGAACCTAGTTATTTATGAAGAGACTCTTTAAATACCCTTTCCC TAGTCGGAAGGCTTCCTTTATATACTATTCCCAACATGGGGAGCGAAACAAAATCACACGCGGAGTTGCCCATTTTAAA GCAGACTTTGCCTTTTCTTCCAAAGGTGGAGCGTGAGTACCAGAAGGACCCGGCGTTCAGTTCTTTAGGGGAGTCCGGG GTCAGAAATTGCCTTTCTGACCCAAGCCTAGGACTGAATGCTGTGTATATATTTATATATAAATATATATATATGAGTG AACCCTTGTGAACTCTTTAATTAGAGTTTTCTTGTATAGTGGCAGAAATGGACGTTTCTGCAAAAAGTGTAATGATGTA CTTAATCATGCTAAACTTTTTATAAAAGTTTAGTTGTAAACTTAACCCCTTTTTATACAAAAATAAATCGAGTGTGTTT ATGAAAAAAAAAAAAAAAAAA

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 6

7-12

stage 8

stage 10

Extraembryonic
Heart Tube
Neural Plate/Tube
Somites
Surface Ectoderm

13-18

stage 13

stage 15

Extraembryonic
Neural Crest
Somites
Surface Ectoderm

19-23

stage 19

stage 23

Extraembryonic
Face Mesenchyme
Lateral Plate Mesoderm
Limb Buds
Mesoderm, early
Neural Plate/Tube
Pharyngeal Arches and Clefts
Somites
Surface Ectoderm
Wing Mesenchyme

Entry 2

GEISHA Id	Id2.Martinsen.2004	Data Source	Publication
Complete cDNA Template Probe	show AATTCCGCCGAGAGGGGAACGGCAGGCAGCGCGCTCCGCAGGCTCCGTGCGCTCTCCCCGCGCCCGCCTTTCAGCATGA AAGCTTTCAGCCCCGTGCGGTCCGTGCGGAAGAACGGCCTTTCGGAGCACAACCTGGGCATCTCCCGCAGCAAGACCCC GGTGGACGACCCCATGAGCCTGCTGTACAACATGAACGACTGCTACTCCAAGCTGAAGGAGCTGGTGCCCAGCATCCCG CAGAACAAGAAGGTCAGCAAGATGGAAATCCTGCAGCACGTCATCGACTACATCCTGGACCTGCAGATCGCGCTGGACT CGCACCCGTCCATCGTCAGCCTCCACCACCAGCGGCCGGGGCAGAACGCCGCCTCCCGGACCCCGCTGACCACGCTCAA CACAGACATCAGCATCCTCTCCCTACAGGCAGCCGAGTTCCCCTCAGAACTAATGGCGAGTGACAGCAAAGCGCTCTGT GGCTGAATCGCACGGTGTTCCGCTGAGGAGGTTTTTCTTTTCCTTTTCTTGTTTTCTTCTTTTTTTTTCTTTTCTTTTT TTTTTTTTTTTGCACAAGAATTACGTCGACAGGATTTGGGTTTTTGTCTTGAGGTGCTGAATTTCTCAGCTGTACCTGG AGGGGAGGAATCCACGCTAACTAAACTGAAAGGACCTTTAGAAACGAATAGAGAAGAGGAAAGAGGGGAAAAAAAAATC ATCGAGATTGCTCTTTATCCCCCCACCCCGTTCTTCAAGTTGGACTGAACCTAGTTATTTATGAAGAGACTCTTTAAAT ACCCTTTCCCTAGTCGGAAGGCTTCCTTTATATACTATTCCCAACATGGGGAGCGAAACAAAATCACACGCGGAGTTGC CCATTTTAAAGCAGACTTTGCCTTTTCTTCCAAAGGTGGAGCGTGAGTACCAGAAGGACCCGGCGTTCAGTTCTTTAGG GGAGTCCGGGGTCAGAAATTGCCTTTCTGACCCAAGCCTAGGACTGAATGCTGTGTATATATTTATATATAAATATATA TATATGAGTGAACCCTTGTGAACTCTTTAATTAGAGTTTTCTTGTATAGTGGCAGAAATGGACGTTTCTGCAAAAAGTG TAATGATGTACTTAATCATGCTAAACTTTTTATAAAAGTTTAGTTGTAAACTTAACCCCTTTTTATACAAAAATAAATC GAGTGTGTTTATTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Citation	Martinsen BJ, Frasier AJ, Baker CV, Lohr JL. Cardiac neural crest ablation alters Id2 gene expression in the developing heart. Dev Biol. 2004 Aug 1;272(1):176-90.
Copyright	Reprinted from Developmental Biology, Volume 272, Issue 1, Brad J Martinsen, Allison J Frasier, Clare V.H Baker, and Jamie L Lohr, Cardiac neural crest ablation alters Id2 gene expression in the developing heart, Pages 176-190, Copyright 2004, with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved.
Comments	Authors said: A linearized plasmid of chick Id2 (either full length or from nucleotide 554 to 848) was used as a template to generate a digoxigenin-labeled antisense probe (Martinsen and Bronner-Fraser, 1998). Probe sequence used was from Acc# NM_205002.1)

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 12

Anterior Intestinal Portal
Forebrain
Myocardium
Neural Crest
Neural Plate/Tube
Outflow Tract
Somites
Splanchnic Mesoderm

Anatomy.

13-18

stage 18

Myocardium
Outflow Tract
Sinus Venosus

Secondary Heart Field
Secondary heart field

19-24

stage 21

stage 24

Eye
Mesoderm
Neural Crest
Outflow Tract
Pharyngeal Arches and Clefts
Somites

Atrioventricular sulcus
Secondary heart field

stage 25

Endocardium
Neural Crest
Outflow Tract
Pharyngeal Arches and Clefts

Endocardial cushion
Endocaridal cushion

Entry 3

GEISHA Id	ID2.Lorda-Diez.2009	Data Source	Publication
Complete cDNA Template Probe	show `CCTGCTGTACAACATGAACGACTGCTACTCCAAGCTGAAGGAGCTGGTGCCCAGCATCCCGCAGAACAAGAAGGTCAGC AAGATGGAAATCCTGCAGCACGTCATCGACTACATCCTGGACCTGCAGATCGCGCTGGACTCGCACCCGTCCATCGTCA GCCTCCACCACCAGCGGCCGGGGCAGAACGCCGCCTCCCGGACCCCGCTGACCACGCTCAACACAGACATCAGCATCCT CTCCCTACAGGCAGCCGAGTTCCCCTCAGAACTAATGGCG`
Citation	Lorda-Diez CI, Torre-Pérez N, García-Porrero JA, Hurle JM, Montero JA. Expression of Id2 in the developing limb is associated with zones of active BMP signaling and marks the regions of growth and differentiation of the developing digits. Int J Dev Biol. 2009;53(8-10):1495-502.
Copyright	Reprinted from Int. J. Dev. Biol. Copyright (2009), with permission from UBC Press. All rights reserved.
Comments	The cDNA template used to generate the probe was obtained by PCR as described in Lorda-Diez et al.

Stage

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Location (click to highlight)

Comments (click to highlight)

19-24

stage 21

stage 24

Limb Buds
Wing Bones
Wing Mesenchyme

25-30

stage 25

stage 26

stage 30

Leg Bones
Leg Mesenchyme
Limb Buds
Wing Bones
Wing Mesenchyme

31-34

stage 34

Leg
Leg Bones
Leg Mesenchyme

tendons (arrows)

Entry 4

GEISHA Id	ID2.Olivera-Martinez.2014	Data Source	Publication
Complete cDNA Template Probe	show AATTCCGCCGAGAGGGGAACGGCAGGCAGCGCGCTCCGCAGGCTCCGTGCGCTCTCCCCGCGCCCGCCTTTCAGCATGA AAGCTTTCAGCCCCGTGCGGTCCGTGCGGAAGAACGGCCTTTCGGAGCACAACCTGGGCATCTCCCGCAGCAAGACCCC GGTGGACGACCCCATGAGCCTGCTGTACAACATGAACGACTGCTACTCCAAGCTGAAGGAGCTGGTGCCCAGCATCCCG CAGAACAAGAAGGTCAGCAAGATGGAAATCCTGCAGCACGTCATCGACTACATCCTGGACCTGCAGATCGCGCTGGACT CGCACCCGTCCATCGTCAGCCTCCACCACCAGCGGCCGGGGCAGAACGCCGCCTCCCGGACCCCGCTGACCACGCTCAA CACAGACATCAGCATCCTCTCCCTACAGGCAGCCGAGTTCCCCTCAGAACTAATGGCGAGTGACAGCAAAGCGCTCTGT GGCTGAATCGCACGGTGTTCCGCTGAGGAGGTTTTTCTTTTCCTTTTCTTGTTTTCTTCTTTTTTTTTCTTTTCTTTTT TTTTTTTTTTTGCACAAGAATTACGTCGACAGGATTTGGGTTTTTGTCTTGAGGTGCTGAATTTCTCAGCTGTACCTGG AGGGGAGGAATCCACGCTAACTAAACTGAAAGGACCTTTAGAAACGAATAGAGAAGAGGAAAGAGGGGAAAAAAAAATC ATCGAGATTGCTCTTTATCCCCCCACCCCGTTCTTCAAGTTGGACTGAACCTAGTTATTTATGAAGAGACTCTTTAAAT ACCCTTTCCCTAGTCGGAAGGCTTCCTTTATATACTATTCCCAACATGGGGAGCGAAACAAAATCACACGCGGAGTTGC CCATTTTAAAGCAGACTTTGCCTTTTCTTCCAAAGGTGGAGCGTGAGTACCAGAAGGACCCGGCGTTCAGTTCTTTAGG GGAGTCCGGGGTCAGAAATTGCCTTTCTGACCCAAGCCTAGGACTGAATGCTGTGTATATATTTATATATAAATATATA TATATGAGTGAACCCTTGTGAACTCTTTAATTAGAGTTTTCTTGTATAGTGGCAGAAATGGACGTTTCTGCAAAAAGTG TAATGATGTACTTAATCATGCTAAACTTTTTATAAAAGTTTAGTTGTAAACTTAACCCCTTTTTATACAAAAATAAATC GAGTGTGTTTATTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Citation	Isabel Olivera-Martinez, Nick Schurch, Roman A Li, Junfang Song, Pamela A Halley, Raman M Das, Dave W Burt, Geoffrey J Barton, Kate G Storey. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development 2014 Aug;141(16):3266-76. Epub 2014 Jul 25. DOI: 10.1242/dev.112623.
Copyright	Copyright © 2014. Published by The Company of Biologists Ltd.
Comments	Authors indicated the probe was made from gene construct provided by M. Bronner. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205002.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

7-10

stage 10

Neural Plate/Tube
Somites

all

Entry 5

GEISHA Id	ID2.Anderson.2021	Data Source	Direct Submission
Complete cDNA Template Probe	show AGTGCGAGCTCCGGCGGCGCCGAGAGGGGAACGGCAGGCAGCGCGCTCCGCAGGCTCCGTGCGCTCTCCCCGCGCCCGC CTTTCAGCATGAAAGCTTTCAGCCCCGTGCGGTCCGTGCGGAAGAACGGCCTTTCGGAGCACAACCTGGGCATCTCCCG CAGCAAGACCCCGGTGGACGACCCCATGAGCCTGCTGTACAACATGAACGACTGCTACTCCAAGCTGAAGGAGCTGGTG CCCAGCATCCCGCAGAACAAGAAGGTCAGCAAGATGGAAATCCTGCAGCACGTCATCGACTACATCCTGGACCTGCAGA TCGCGCTGGACTCGCACCCGTCCATCGTCAGCCTCCACCACCAGCGGCCGGGGCAGAACGCCGCCTCCCGGACCCCGCT GACCACGCTCAACACAGACATCAGCATCCTCTCCCTACAGGCAGCCGAGTTCCCCTCAGAACTAATGGCGAGTGACAGC AAAGCGCTCTGTGGCTGAATCGCACGGTGTTCCGCTGAGGAGGTTTTTCTTTTCCTTTTCTTGTTTTCTTCTTTTTTTT TTTTCTTTTTTTTTTTTTTTTTTGCACAAGAATTACGTCGACAGGATTTGGGTTTTTGTCTTGAGGTGCTGAATTTCTC AGCTGTACCTGGAGGGGAGGAATCCACGCTAACTAAACTGAAAGGACCTTTAGAAACGAATAGAGAAGAGGAAAGAGGG GAAAAAAAAAAATCATCGAGATTGCTCTTTATCCCCCCACCCCGTTCTTCAAGTTGGACTGAACCTAGTTATTTATGAA GAGACTCTTTAAATACCCTTTCCCTAGTCGGAAGGCTTCCTTTATATACTATTCCCAACATGGGGAGCGAAACAAAATC ACACGCGGAGTTGCCCATTTTAAAGCAGACTTTGCCTTTTCTTCCAAAGGTGGAGCGTGAGTACCAGAAGGACCCGGCG TTCAGTTCTTTAGGGGAGTCCGGGGTCAGAAATTGCCTTTCTGACCCAAGCCTAGGACTGAATGCTGTGTATATATTTA TATATAAATATATATATATGAGTGAACCCTTGTGAACTCTTTAATTAGAGTTTTCTTGTATAGTGGCAGAAATGGACGT TTCTGCAAAAAGTGTAATGATGTACTTAATCATGCTAAACTTTTTATAAAAGTTTAGTTGTAAACTTAACCCCTTTTTA TACAAAAATAAATCGAGTGTGTTTATTGAACCGATTGCTGGCTTTCTTCTTTGGGGGACCAACTGTTTGCTGGCTCTGA TTTGTGCTGTTTGTGGTTTTTATTTTGTCTTTTAAATACTTTAAGCCTTCTGTTACGATTTACTGAGCAAGTTTAAACG TGTAGAGAATATAAAGAATAAAATGACCTGAAGTGAATCATAA
Comments	Images provided by Claire Anderson. As insufficient information was provided to verify sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205002.2). Reference paper: Anderson C, Khan MAF, Wong F, Solovieva T, Oliveira NMM, Baldock RA, Tickle C, Burt DW, Stern CD. A strategy to discover new organizers identifies a putative heart organizer. Nat Commun. 2016 7:12656. doi: 10.1038/ncomms12656.

Stage

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Location (click to highlight)

Comments (click to highlight)

1-3

stage 2

Extraembryonic Mesoderm
Hypoblast
Kohler's Sickle

4-6

stage 4

stage 5

stage 6

Area Opaca
Early Mesoderm
Ectoderm
Epiblast
Extraembryonic Blood Vessels
Extraembryonic Mesoderm
Germinal Crescent
Headfold
Lateral Plate Mesoderm
Neural Plate/Tube
Primitive Streak
extraembryonic ectoderm

HH6+

7-12

stage 7

stage 8

stage 9

stage 10

stage 11

stage 12

Allantois
Amnion
Anterior Intestinal Portal
Anterior/Second Heart Field
Atria
Blood Islands
Dermomyotome
Ectoderm
Endoderm
Extraembryonic Mesoderm
Eye
Forebrain
Foregut
Head Mesenchyme
Head Process
Heart
Hindbrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Myocardium
Neural Crest
Neural Plate/Tube
Outflow Tract
Pharynx
Primitive Streak
Sinus Venosus
Somites
Tail
Ventricles
extraembryonic ectoderm
extraembryonic endoderm
extraembryonic mesoderm

HH8+
section 1
section 11
section 2
section 3
section 5
section 8

13-14

stage 13

stage 14

Amnion
Anterior Intestinal Portal
Anterior/Second Heart Field
Atria
Blood Islands
Central Nervous System
Dermomyotome
Ear/Otic Placode
Endoderm
Eye
Forebrain
Foregut
Head Mesenchyme
Hindbrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Myocardium
Neural Crest
Neural Plate/Tube
Notochord
Outflow Tract
Pharyngeal Arches and Clefts
Sinus Venosus
Somites
Tail
Ventricles
extraembryonic ectoderm
extraembryonic endoderm
extraembryonic mesoderm

section 11
section 13
section 2
section 7

Entry 6

GEISHA Id	ID2.Trevers.2023	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show AGTGCGAGCTCCGGCGGCGCCGAGAGGGGAACGGCAGGCAGCGCGCTCCGCAGGCTCCGTGCGCTCTCCCCGCGCCCGC CTTTCAGCATGAAAGCTTTCAGCCCCGTGCGGTCCGTGCGGAAGAACGGCCTTTCGGAGCACAACCTGGGCATCTCCCG CAGCAAGACCCCGGTGGACGACCCCATGAGCCTGCTGTACAACATGAACGACTGCTACTCCAAGCTGAAGGAGCTGGTG CCCAGCATCCCGCAGAACAAGAAGGTCAGCAAGATGGAAATCCTGCAGCACGTCATCGACTACATCCTGGACCTGCAGA TCGCGCTGGACTCGCACCCGTCCATCGTCAGCCTCCACCACCAGCGGCCGGGGCAGAACGCCGCCTCCCGGACCCCGCT GACCACGCTCAACACAGACATCAGCATCCTCTCCCTACAGGCAGCCGAGTTCCCCTCAGAACTAATGGCGAGTGACAGC AAAGCGCTCTGTGGCTGAATCGCACGGTGTTCCGCTGAGGAGGTTTTTCTTTTCCTTTTCTTGTTTTCTTCTTTTTTTT TTTTCTTTTTTTTTTTTTTTTTTGCACAAGAATTACGTCGACAGGATTTGGGTTTTTGTCTTGAGGTGCTGAATTTCTC AGCTGTACCTGGAGGGGAGGAATCCACGCTAACTAAACTGAAAGGACCTTTAGAAACGAATAGAGAAGAGGAAAGAGGG GAAAAAAAAAAATCATCGAGATTGCTCTTTATCCCCCCACCCCGTTCTTCAAGTTGGACTGAACCTAGTTATTTATGAA GAGACTCTTTAAATACCCTTTCCCTAGTCGGAAGGCTTCCTTTATATACTATTCCCAACATGGGGAGCGAAACAAAATC ACACGCGGAGTTGCCCATTTTAAAGCAGACTTTGCCTTTTCTTCCAAAGGTGGAGCGTGAGTACCAGAAGGACCCGGCG TTCAGTTCTTTAGGGGAGTCCGGGGTCAGAAATTGCCTTTCTGACCCAAGCCTAGGACTGAATGCTGTGTATATATTTA TATATAAATATATATATATGAGTGAACCCTTGTGAACTCTTTAATTAGAGTTTTCTTGTATAGTGGCAGAAATGGACGT TTCTGCAAAAAGTGTAATGATGTACTTAATCATGCTAAACTTTTTATAAAAGTTTAGTTGTAAACTTAACCCCTTTTTA TACAAAAATAAATCGAGTGTGTTTATTGAACCGATTGCTGGCTTTCTTCTTTGGGGGACCAACTGTTTGCTGGCTCTGA TTTGTGCTGTTTGTGGTTTTTATTTTGTCTTTTAAATACTTTAAGCCTTCTGTTACGATTTACTGAGCAAGTTTAAACG TGTAGAGAATATAAAGAATAAAATGACCTGAAGTGAATCATAA
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205002).