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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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SMO
smoothened, frizzled class receptor

Gene

Official Symbol	SMO
Official Full Name	smoothened, frizzled class receptor
CGNC ID	5983
also known as	smoothened homolog\|smoothened, frizzled family receptor, Smoothened homolog precursor (SMO)
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC

Sequence Information

Genomic
RNA	XM_414970
Polypeptide	XP_414970

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	33196			FBgn0003444
Human	6608	ENSG00000128602	MIM:601500	MIM:601500
Mouse	319757	ENSMUSG00000001761	All phenotypic alleles (7):Chemically induced(1) Targeted, knock-out(3) Targeted, other(3)	MGI:108075
Xenopus	100491644, 100190780			487419
Zebrafish	30225		ZDB-GENE-980526-89	ZFIN:ZDB-GENE-980526-89

Gene Ontology

Molecular Function	G-protein coupled receptor activity
Biological Process	multicellular organismal development, smoothened signaling pathway
Cellular Component	integral component of membrane

Links to other databases

Entrez Gene	395949
Ensembl Gene	ENSGALG00000007910
KEGG	gga:395949

Entry 1

GEISHA Id	SMO.McCabe.2007	Data Source	Publication
Complete cDNA Template Probe	show `ATCCCAAAGTGCCTTCCAGCTCCCCTCGGCCGTCTGAGCGCACCTGAGAAAAGCTTTGGTTTTTGTTCGTTTTTAAATC TGTTTTTTAAAGAAAAAGGAACAAATTATATCCGAGCCCTGACGTAGGAGGACACCTGTCCTTGCTGGTGCTTTGTATC TGCCCCTTAGCCCTGTAAATGTCTTTTGAGTGTTTATTAAACCCCGGTAGGCTCACGGCTT`
Citation	McCabe KL, Shiau CE, Bronner-Fraser M. Identification of candidate secreted factors involved in trigeminal placode induction. Dev Dyn. 2007 Oct;236(10):2925-35.
Copyright	Copyright © 2007 Wiley-Liss, Inc.
Comments	Sequence below was obtained from NCBI (XM_414970) using the primers provided in the publication: SMO forward primer, 5'-ATCCCAAAGTGCCTTCCAG-3'; and reverse primer, 5'-GAGGAAGCCGTGAGCCTAC-3'.

Stage

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Location (click to highlight)

Comments (click to highlight)

7-10

stage 8

stage 10

Neural Crest
Neural Plate/Tube

Presumptive Trigeminal Placode, Neural Folds
Trigeminal Placode

Entry 2

GEISHA Id	SMO.Aglyamova.2007	Data Source	Publication
Complete cDNA Template Probe	show ATGGGATGGAAGTGGGATGGAGAGGAGCTCTGCAGTGGGCTGATGCTGTACTGGGATGGAGCTCCGTACTGGGATGGAA CTGGGATGGAGAGGGGCTGTGCTGGGTGCACTCCTGACCGCTTCCCCGAGGGCTGCCCGAACGAGGTGCAGAACATCAA GTTCAACAGCTCAGGGCAGTGCGAGGCGCCGTTGGTGCGCACGGACAACCCCAAGAGCTGGTATGAGGATGTGGAGGGC TGCGGAATCCAGTGCCAGAACCCACTCTTCACTGAGACAGAGCACCGTGAGATGCACGTCTACATCGCCGCCTTCAGCT CCGTCACCATCTTCTGCACCTTCTTCACTCTGGCCACCTTCGTTGCCGACTGGAGGAACTCCAACCGCTACCCCGCTGT CATCCTCTTCTATGTCAATGCCTGCTTCTTTGTGGGCAGTATCGGCTGGCTGGCGCAGTTCATGGACGGCGCCCGAGAT GAGATCGTGTGCCGTGCTGATGGCACCATGAGGCTGGGGGAGCCCACCTCCAACGAGACGCTCTCCTGCGTCATCATCT TTGTCATTGTCTACTACTCTCTGATGTCGGGTGTCATCTGGTTTGTCATGCTGACCTACGCCTGGCACACGTCCTTCAA GGCGCTGGGCACCACCTACCAGCCGCTGCTGGGCAAGACCTCCTACTTCCACCTCATCACCTGGTCCATCCCTTTCGTA CTCACCGTGGCCATCCTGGCTGTGGCACAGGTGGATGGTGACTCCGTCAGCGGTATCTGCTTCGTGGGTTACAAGAACT ATCGCTACCGTGCCGGCTTTGTCCTGGCACCCATCGGGCTCGTCCTCATCGTTGGGGGCTATTTCCTCATTCGGGGGGT CATGACGCTCTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCGGCCAGCAAGATCAACGAAACCATG CTGCGGCTGGGCATCTTTGGGTTCTTGGCTTTTGGCTTTGTCTTCATCACTTTTGGCTGCCACTTCTACGACTTCTTCA ACCAGGCGGAGTGGGAGCGAAGCTTTCGGGAATATGTCCTGTGTGAGGCCAACGTGACCATCGCTACGCAGACCAATAA ACCCATCCCAGAGTGTGAGATCAAGAACCGGCCGAGCCTGCTGGTGGAGAAGATCAACCTCTTTGCCATGTTTGGCACT GGCATCTCCATGAGCACCTGGGTCTGGACCAAGGCCACCCTGCTCATCTGGAAGCGCACCTGGTGCAGGCTGACAGGGC AGAGCGACGACCAGCCCAAGAGGATCAAGAAGAGCAAGATGATTGCCAAAGCCTTCTCCAAGCGCAAGGAGCTGCTGCG TGACCCAGGCCGGGAGCTGTCCTTCAGTATGCACACCGTCTCGCACGACGGCCCCGTGGCTGGTTTGGCGTTTGACATC AATGAGCCATCAGCCGATGTGTCCTCCGCGTGGGCTCAGCACGTCACCAAGATGGTGGCCAGGAGAGGGGCTATCCTGC CCCAGGATGTCTCCGTCACGCCGGTGGCAACACCTGTGCCACCGGAGGAGCGGAGCAACCTCTGGGTGGTGGAGGCCGA TGTCTCCCCAGAGCTGCAGAAGCGCAGCCGCAAGAAGAAGCGGAGGAAGAAGAAGAAGGAGGAGGTGTGCCCCGAGCGC CGCGCCGGGCTCTCCGTGGCCCCCCTGACCCCCAGCTCCGTGCCTCGCCTGCCTCGGCTGCCCCAGCAGCCCTGCTTGG TGGCCATCCCCCGGCATAGAGGGGACACCTTCATCCCCACTGTCCTCCCGGGGCTGTCCAACGGTGCTGGGGGGCTGTG GGACGGCCGGCGCCGAGCCCACGTCCCCCACCTCATCACCAACCCCTTCTGCCCTGAGAGTGGCTCCCCAGAGGATGAG GAGAACCCCGGCCCCAGCGTCGGGCACCGGCAGCACAACGGGGGCCCTCGATGGCCACCTGAGCCCCTTCCTGGTGGCA GTGGGGTGACGAGGACTCGGGGCAGACGCGCCGGCTTGGCTCCCATCCACTCCCGGACCAACCTGGTGAACGCGGAGCT GCTGGACGCCGACTTAGACTTCTGAGCCCTGCAGGATCCTGGGGACAACGGAGCCCACCGGCATCCGGGTAGCCCCAAG GGGACGCTGGAGCCCACCCAACACCGGGGTCCGGATGGATTTGATGTTCATCCCAACCCACCAACGGGATTTGAGGATG GGAGGAGAGAAGAAACTGGTGGGGCAGCACCCCTGGAAGGCGCTGCCAGGATTTAGGGGTGAAGGGGACGCTCCCTCAC ACCCAGCGCTGGTAGGCAGCTTAAGGTGTTGATTTCGGTCCCCACACATGGACTGCTCCGCCGCCCCACAGCTAGATGG TACGTAGAGCTTCCCAACACTTTTACGGTGCCAATAGGGTTTTTAAACAGTTCTTTTTGTATTCTTTGTGATACACCGA GACGTGGCCGCCCTGCACGGGGTGCAGCAGCATCCCCGTTTTTCGGGCTCTGCTGCGGGGATCCCAAAGTGCCTTCCAG CTCCCCTCGGCCGTCTGAGCGCACCTGAGAAAAGCTTTGGTTTTTGTTCGTTTTTAAATCTGTTTTTTAAAGAAAAAGG AACAAATTATATCCGAGCCCTGACGTAGGAGGACACCTGTCCTTGCTGGTGCTTTGTATCTGCCCCTTAGCCCTGTAAA TGTCTTTTGAGTGTTTATTAAACCCCGGTAGGCTCACGGCTTTCTCCCTACTCCCCCCTACCCCCCACCTCCCCCCTCC CGGCGACCTCCACGGGTTGATTTTTGCTGTGTAAAGCAGAAACCTTCCTGTATCAGTATTAAATTTGCCAAGTTTCCAA TTGC
Citation	Aglyamova GV, Agarwala S. Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord. Dev Dyn. 2007 May;236(5):1363-73
Copyright	Copyright © 2007 Wiley-Liss, Inc.
Comments	According to the authors, "Digoxigenin- or FL-conjugated antisense riboprobes were prepared from chick cDNAs." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (XM_414970).