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PTEN
phosphatase and tensin homolog

The human orthologue of this gene is associated
with the following human diseases:
Gene
Official SymbolPTEN
Official Full Namephosphatase and tensin homolog
CGNC ID2653
also known asPTENP1, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN|phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN|phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
Gallus-Browse
Sequence Information
Genomic
RNAXM_421555
PolypeptideXP_421555
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST Profile
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly43991FBgn0026379
Human5728ENSG00000171862MIM:153480MIM:601728
Mouse19211ENSMUSG00000013663All phenotypic alleles (20):Chemically induced(1) Targeted, knock-out(10) Targeted, other(9) MGI:109583
Xenopus100144716, 399142491432
Zebrafish368415, 794088ENSDARG00000056623, ENSDARG00000071018ZDB-GENE-030616-47, ZDB-GENE-030131-3776ZFIN:ZDB-GENE-030616-47, ZFIN:ZDB-GENE-030131-3776
Gene Ontology
Molecular Function
Biological Process
Cellular Component
Links to other databases
Entrez Gene423675
Ensembl Gene
KEGGgga:423675
GEISHA IdPTEN.Li.2013Data SourcePublication
Complete cDNA Template Probeshow
AGCGGCCCCCGCCTGCCAGACATGACCGCCATCATCAAAGAGATCGTCAGCAGGAACAAAAGGCGCTACCAGGAGGATG
GCTTCGACCTGGACCTGACCTATATTTATCCAAACATAATTGCTATGGGTTTTCCTGCGGAGAGGCTTGAAGGAGTATA
CCGGAACAATATTGATGATGTAGTAAGGTTTTTGGATTCAAAGCATAAAAACCATTACAAGATATACAATCTATGTGCT
GAAAGACATTATGACACCGCCAAATTTAACTGCAGAGTTGCACAGTACCCCTTTGAAGACCATAACCCACCACAGTTAG
AGCTTATCAAACCTTTTTGTGAAGATCTTGACCAATGGCTAAGTGAAGATGACAATCATGTTGCAGCAATCCACTGTAA
AGCTGGAAAGGGACGAACTGGTGTAATGATATGTGCATATTTGTTGCATCGAGGCAAGTTTTTAAAGGCTCAAGAAGCC
CTAGATTTCTATGGGGAAGTAAGGACCAGAGACAAGAAGGGAGTCACAATTCCCAGTCAGAGACGCTACGTGTACTACT
ATAGCTACCTGTTAAAGAATCACCTTGATTACAGACCAGTGGCACTGCTGTTTCACAAGATGATGTTTGAAACAATTCC
CATGTTCAGTGGCGGAACTTGCAATCCTCAGTTTGTGGTGTACCAGCTAAAGGTAAAGATATTCACCTCCCCTTCAGGA
CCCTCAAGACGTGAAGACAAGTATATGTACTTTGAATTCCCTCAACCTTTGCCGGTATGCGGTGATATCAAAGTGGAGT
TCTTCCACAAACAGAACAAGATGTTGAAAAAGGACAAAATGTTTCACTTTTGGGTAAATACATTCTTCATAGGACTGGA
TGAAAATTCAGACAAAGTAGAAAATGGAAGTCTAGTTGCAGATCAGGAACTTGATGGTATTTTCAGTACAGAGCGCTCA
GATAATGACAAGGAATATTTAATCCTTACATTAACAAAAAATGATCTAGACAAAGCAAATAAAGACAAAGCCAACAGAT
ATTTTTCTCCAAACTTCAAGGTGAAGCTATTTTTCACAAAAACAGTAGAAGAGCCATCAAATCCCGAGGCTAGCAGTTC
AACTTCTGTAACACCAGATGTTAGTGACAATGAACCTGATCATTACAGATACTCTGACACCACTGACTCTGATCCAGAG
AATGAACCTTTTGATGAAGATCAGCATACACAGATTACAAAAGTCTGAATATTTTTTTTTATCGGAGATAAAAAAAAAA
ACCAACAAAAACCCACGAAGAACGACAAACTTGAATAAACTGAAAAATGGACCTTTTTAAATGGCAATAGGACATAGTG
TCAGATTACCAATTATAGGAACAATTCTTTCCTGACCAATCTTGTTTTGCCCTATAAGTCTACAGGTTTGACACTTGTC
CAGTTGAATAAAAATGGTTACGTAGCTCTGATATGTATATACCTTTTTGTGTCAAAAGGACATTAAAACTTCAATTAGG
AACTATAAATATGGCACTTTCCCATTTTATTCCAGTTTTATAAAAGTGGAGACAGACTTAATGTGTATACGTAGGAATT
TTTCCTTTTGTGTTCTGTCACCAAACAAAGTTTTGAAAAAATGCAAATATACAGGTTCACATCCTGCCCCTTTTTTTTG
CACTTATGTGGCAACAGAAAAGTCTGCAGTTGGCTAAGAGATGTCTCTAGAAGGTTTTACTACATTCTAATGCATGTAT
TTTGGATGGGGGATGGAAAGTAATGCTCAGAAAGGAATATAGTCTGCTGGAGCTTGGCCTGTGTACCATATCCGGCTAT
TTACTTGCACCTTTCTTTAGCATGCTGCCGTAATTCATCCTGGACAATTGAAGAGTCGCCGCTGTCACTGCTTGTTGTT
TGTGCATTTTATTTTTTTTAAGTGTAATGGTGCTAGAAAAGGCAGCTAGAGGGAGTGATTCTGTATAGGGGTACAGGAA
TGAACCTTCACAACATCCTAAAGACCTGCAAAATGAAGGGAGAAAAATTATTGGGGTCACAGAAAGGAAACACACAGCA
ACAATGACTTAACCATACAAATGTGGAGGCTATCATCTTCAAATATGGGCTTGAAACAAATTGTTATAAAAGTTGTCGG
TGATTCATTAATTGTTTTTCTGAATTGTAACGGCTGCTCCATCTCCTGTGTAATCAAGATCAGTGCTGAAAGTCAGTTG
CTATTAGTACATAACGCCAGGCAACATCTTAACATTTCTTATTAGGTCTTCAATCATATTCCTGCTGAGAATACTTCAT
GTGCTGCCTTGCAAGCTTTTTTTCCTCATTAATATGAAAATATTTTGTAGTGGTGCACAGGAAATTTCAATTGGAGATT
CTTCAGGTTAGTGTTTATTTTGAAGATTTATGATGCATTTATTATTCAATCAAACCTCTGTCAGCCATTCCACCCCTTT
GACCTTACACGTTGTATTACAATGAGTTTTGCAGTTTTGCACACTTTTCTAAAAATGTCATTAACTGTTAGGAATTTTA
CTTGAATACTCATTACCTACAATATTTAAAAAGAAAAAAAAGACATTACAGAGGAGACAGTGTTGAATTCTTAACGCTG
TGTCTGTATGAAGATGTGTACTTTTCAAAAGCAGAAGTTGTCCCAAATGTATTGCTTGCCATTAAAAAAAGAAAACCAA
CAAAACTCACAAATGAAAACAAATTAGATTTCTCATCTGGCAGCGTTGTGTTTGTTCATAGGGCTAGAGCCAGGAGTAG
GGCTTTGAGGTTCACTTTCAGCATATAATTGCTGTGCCCAGACTGCAGATGACTTGAGAGTACAACTACTGTTGTATGG
ACATGTGAAGAAGCTGACAAAAATGATTCACTCTGAAGTACACCGAGGATTGCCATCCCCAAATTTACACTTGCTCGAT
TAAAATTTCTGCTTACTCAGTCAACTTAATGGGGCTGACATTGAAGTTCATTAGCTGTGTTCTCGCCTAGATAACAGCA
GTGTGTGTGGAATCCGTGAGGGCCCTGTACAACAGCATTAATGGTAAGGATTTGAAGGAGACGAGGCAGGACTCACTCT
TGGCGAAGGAAGGTATCGAGTGCTTTTTTTGGGATCCGTTGGTCAACTTTGCTCATCACATTCACGATTCTAACTTCTA
ACAGAGCTGATAAATGCTTTCTGGCATAGAGATCTGATCAAGCTGTAGTGTTGGTGGAGCAGGAGGCTGGTTCCAGTGC
TCGCTGCTCCCGGTGGTGTTGACAAGCAGGAAGTGGTTACCTGGGGACATGACGTTAACTCTTACCCTTTTAATCATGT
TTCACCCTGTCTGATTTTAACAGTTGGGAAAAAAAAAGGTCGTGTTGGCTAATAAACAAACCTGTTCATGCTTTAAAAG
TGCTGAGATATCGACACCGTTCTGTGTCCCGCTTTGGAGGCTGTGATAACAAAATGGGATCGGTGTGCTTCTGGTGCGT
AATGCCAAGGGCTGGATTGGAAATGACGTGATGGGCTTTTGCACTGTTATTTTTCCTTTGGAATGTGAAAGGTTGGAAT
GAGGGTTTTGATTTTGAATGTTTCGATGTTTCTGAGAAGCCTTGCTTACATTTTATGGTGTAGTCATTGGAAATGGAAA
AAATGGCATTATATATATATATATTATATATATAAATATATATTATACATACTCTCCTATACTTTATTTCAGTTACCAC
CCCCATAGAAGTTGACAAGAATTACTACGACTGAAAGGTTTTTGAGTCCTTATTAAAACTTTATTTATGACAGTATTCA
TAATTAGCTTGAAACGCATTCTGTAGGTAATCTCTCCTTGAGTTTCTGGACTGTACGCTTAAACTTCTGGATGTGCAGC
AGCTTACATGTCTGAAACTACTTGAAGGCATCACTTCTGTAAGAGCTTACTGTTAGGCCCTAAGCATCCCTGGTCATTG
GTAGCCCCACTCAAAATATTTGCCGCAGCTCTTAAGGGCAGCTGTACAAATAGCATCTGGATTTGTGGCACACGTTGGG
AACTGGAGTTCACATGCAGCATCAGATGTTTCGGCTTGGAAAGCAAAACTAAAAATAGGATGCTAGCGTGTGAGCTCCA
TGTTTAGTCATAGCGAATGTGTGCAATATGCTAACGATGCCTGTGGTTGCCACGAAGTGCCTCGTTTACCTTTTCGATA
CCATTAAGAAGCGCCATGCATGCAGATGGATGGGGTGGAACTGTGCACTAAAAGGGGCTCCAACTGCAGCGTTTGGCAG
AGCTGCCTTTCTCTGCCAGTTCTAATTTTCAGTCTGTTTTCATATAGCATATATATATATAGATACTAAAAGAAAAAAA
AAATCAGTCTGTTAAGCAGCCTTACTCTGATTCAGCCTCTTCAAATACTATTGTGCTGTGCAACAGTGGCTCTGTGTGT
AATGCTATGCACTGAGAATACACAAAACAAAGTATGACATGTACAGGATAATGCCTCATACAAATCAGATGTCCGTTTG
TTATTGTGTTTAACAACCCTTTATCTCTTAGTGTTAAAACTCCACTTAAAACTGATTAAAGTCTCATTCTTGTCAC
CitationLi Y, Wang XY, Wu T, Chuai M, Lee KK, Wang LJ, Yang X. PTEN is involved in modulation of vasculogenesis in early chick embryos. Biol Open. 2013 June 15; 2(6): 587–595. Published online 2013 May 9.
CopyrightCopyright held by the authors.
CommentsAs insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_421555.4
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
Area Opaca
Area Pellucida
Primitive Streak
 
7-11
stage 7
stage 7
stage 8
stage 11
stage 11
Area Opaca
Area Pellucida
Blood Islands
HH Stage 8+

Mouse

EmageMGI:109583
EurexpressMGI:109583
MGI GXDMGI:109583

Frog

Xenbase491432

Fruit Fly

BDGPFBgn0026379

Zebra Finch

ZEBrAPTEN

Zebrafish

ZFINZDB-GENE-030616-47, ZDB-GENE-030131-3776
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