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DICER1
dicer 1, ribonuclease III

The human orthologue of this gene is associated
with the following human diseases:

Gene

Official Symbol	DICER1
Official Full Name	dicer 1, ribonuclease III
CGNC ID	8359
also known as	dicer, endoribonuclease Dicer\|dicer 1, ribonuclease type III\|helicase-moi
gene type	protein-coding

Genomic Map

Sequence Information

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.33735

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	23405	ENSG00000100697	MIM:138800	MIM:606241
Mouse	192119	ENSMUSG00000041415	All phenotypic alleles (16):Targeted, knock-out(6) Targeted, other(8) Gene trapped(2)	MGI:2177178
Xenopus	100170154, 100316917			491113
Zebrafish	324724	ENSDARG00000001129	ZDB-GENE-030131-3445	ZFIN:ZDB-GENE-030131-3445

Gene Ontology

Molecular Function	ATP binding, ATP-dependent helicase activity, metal ion binding, ribonuclease III activity, RNA binding
Biological Process	pre-miRNA processing, production of siRNA involved in RNA interference, more...
Cellular Component	cytoplasm, RISC complex

Links to other databases

GEISHA Id	DICER1.Carraco.2014	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show GGATCCAGAACTGGCTTACATCAGTAGCAATTTCATAACTGGACATGGCATTGGCAAGAATCAGCCTCGTAACAAGCAG ATGGAAGTAGAATTCAGAAAGCAGGAAGAGGTTCTTAGAAAATTTCGAGCACACGAGACCAATCTTCTTATCGCTACCA GTATTGTAGAAGAGGGTGTTGACATACCAAAATGCAATTTGGTGGTGCGTTTTGATTTGCCCACAGAATACCGTTCCTA TGTGCAGTCAAAAGGAAGAGCTAGAGCACCAATTTCCAATTATATAATGTTAGCAGATACAGACAAAATTAAAAGTTTT GAGGAAGATCTTAAGACATATAAAGCAATTGAGAAGATCCTGAGGAATAAATGCTCAAAATCTGTTGATACCAGCGAAA CCGAAACTGAACCCATTGTTGATGATGATGATGTGTTTCCACCCTATGTGCTGAGGACAGATGAGAACAGTCCAAGAGT TACTATCAACACTGCAATTGGACACATAAATAGGTACTGCGCTAGATTACCAAGTGATCCATTTACACACCTAGCTCCC AAGTGTAAAACCCGAGAACTACCTGATCATACATTCTACTCTACTCTCTACCTGCCAATCAACTCACCTCTTCGAGCAT CAATTGTTGGTCCTCCAATGAGTTGTGCAAGATTGGCTGAGAGAGTTGTAGCTCTTATTTGCTGTGAAAAACTGCACAA AATCGGTGAACTGGATGACCATTTGATGCCAGTTGGAAAAGAAACTGTTAAATATGAGGAAGAGCTTGATTTACATGAT GAAGAAGAAACCAGTGTGC
Citation	Carraco G, Gonçalves AN, Serra C, Andrade RP. MicroRNA processing machinery in the developing chick embryo. Gene Expr Patterns. 2014 Nov;16(2):114-21. Epub 2014 Oct 1. DOI: 10.1016/j.gep.2014.09.002.
Copyright	Copyright © 2014 Elsevier B.V.
Comments	Authors indicated the probe was amplified by PCR using the following primers: 5′-GGATCCAGAACTGGCTTACATC-3′ and 5′-GCACACTGGTTTCTTCTTCATCA-3′. Above sequence was extracted from NCBI accession number NM_001040465.1