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SMAD6
SMAD family member 6| Gene | | Official Symbol | SMAD6 | | Official Full Name | SMAD family member 6 | | CGNC ID | 5950 | | also known as | MADH6, mothers against decapentaplegic homolog 6|MAD homolog 6|mothers against DPP homolog 6 | | gene type | protein-coding |
| | Genomic Map | | | Sequence Information | | | Gene Expression | | | Orthology | | | Gene Ontology | | Molecular Function | chromatin binding, co-SMAD binding, I-SMAD binding, metal ion binding, R-SMAD binding, more...sequence-specific DNA binding transcription factor activity, transcription regulatory region DNA binding, transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity, type I activin receptor binding, type I transforming growth factor beta receptor binding, ubiquitin protein ligase binding | | Biological Process | cell-substrate adhesion, immune response, negative regulation of apoptotic process, more...negative regulation of BMP signaling pathway, negative regulation of cell proliferation, negative regulation of pathway-restricted SMAD protein phosphorylation, negative regulation of SMAD protein complex assembly, negative regulation of transforming growth factor beta receptor signaling pathway, response to laminar fluid shear stress, transcription, DNA-templated, transforming growth factor beta receptor signaling pathway, ureteric bud development, zygotic specification of dorsal/ventral axis | | Cellular Component | nucleus, transcription factor complex |
| | Links to other databases | |
Entry 1| GEISHA Id | Smad6.Lincoln.2004 | Data Source | Publication | | Complete cDNA Template Probe | show CCAGAGTCTCCGCCGCCTCCCTACTCCCGGCTGTCTCCTAACGACGAGCAAAAGCCACTGGATCTCTCGGATTCCACGT
TGTCTTACACTGAAACAGAGGCGACGAACTCACCCAACGTCACGCCCGGGGAGTTCTCAGACGCCAGCACGTCGCCCGA
TGCCGTGAAGAGGAGCCATTGGTGCAACGTGGCCTACTGGGAGCACCGGACGCGCGTCGGCCGCCTCTACACAGTGTAC
GAACAGTCTGTCAGTATATTTTATGACCTACCTCAAGGAAACGGCTTCTGCCTCGGACAGCTAAACCTGGAAAACAGGA
GCGAGACTGTGAGAAGGACTCGAAGTAAAATCGGTTACGGGATTTTACTTAGCAAAGAACCGGACGGTGTGTGGGCTTA
CAATCGCAGCGAGCATCCCATCTTCGTCAACTCCCCAACACTGGACATCCCCAACTGTAGGACTTTGATAGTGCGCAAG
GTGATGCCGGGCTATTCCATCAAGGTGTTTGACTACGAGAAGTCCTGCCTCTTGCAGCACACTGCAGAGCTGGATTATG
CAGACGGGCCCTACGACCCCAACAGCGTGCGGATCAGCTTTGCCAAGGGCTGGGGGCCGTGTTACTCGAGACAGTTCAT
CACGTCTTGCCCGTGTTGGCTGGAGATCTTGCTCAGTAACAATCGATAACAGTCAGCCTCTGACGAAAG | | Citation | Lincoln J, Alfieri CM, Yutzey KE. Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn. 2004 Jun;230(2):239-50. | | Copyright | Wiley-Liss, Inc. 2004 |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 25-30 |
 | | stage 29 |
| Heart
| | 31-36 |  | | stage 36 |
| Heart
|
Entry 2| GEISHA Id | Smad6.Zuzarte.2004 | Data Source | Publication | | Complete cDNA Template Probe | show GCCACTGGATCTCTCGGATTCCACGTTGTCTTACACTGAAACAGAGGCGACGAACTCACCCAACGTCACGCCCGGGGAG
TTCTCAGACGCCAGCACGTCGCCCGATGCCGTGAAGAGGAGCCATTGGTGCAACGTGGCCTACTGGGAGCACCGGACGC
GCGTCGGCCGCCTCTACACAGTGTACGAACAGTCTGTCAGTATATTTTATGACCTACCTCAAGGAAACGGCTTCTGCCT
CGGACAGCTAAACCTGGAAAACAGGAGCGAGACTGTGAGAAGGACTCGAAGTAAAATCGGTTACGGGATTTTACTTAGC
AAAGAACCGGACGGTGTGTGGGCTTACAATCGCAGCGAGCATCCCATCTTCGTCAACTCCCCAACACTGGACATCCCCA
ACTGTAGGACTTTGATAGTGCGCAAGGTGATGCCGGGCTATTCCATCAAGGTGTTTGACTACGAGAAGTCCTGCCTCTT
GCAGCACACTGCAGAGCTGGATTATGCAGACGGGCCCTACGACCCCAACAGCGTGCGGATCAGCTTTGCCAAGGGCTGG | | Citation | Zuzarte-Luís V, Montero JA, Rodriguez-León J, Merino R, Rodríguez-Rey JC, Hurlé JM. A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways. Dev Biol. 2004 Aug 1;272(1):39-52. | | Copyright | Reprinted from Developmental Biology, Volume 272, Issue 1, V Zuzarte-Luıs, J.A. Montero, J Rodriguez-León, R Merino, J.C Rodrıguez-Rey, and J.M Hurlé, A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways, Pages 39-52, Copyright 2004, with permission from Elsevier.
Copyright © 2004 Elsevier B.V. All rights reserved. | | Comments | Fragments of chicken Smad6 (702 bp) ... ... genes were obtained by RT-PCR. cSmad6, 5′-AGTACAAGCCACTGGATCTGTCCGA-3′(sense) and 5′-CCAGCCCTTGGCGAAGCTGATGC-3′ (antisense) |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 25-30 |  | | stage 30 |
| Unlabeled
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Entry 3| GEISHA Id | SMAD6.Alev.2010 | Data Source | Publication | | Complete cDNA Template Probe | show CTGAAGGCCCTGTGCGAATGTCAGAGCTTCGGGGCGGCCGACGGCCCCACCGTGTGCTGCAATCCGTACCACTTCAGCC
GGCTCTGTGGGCCAGAGTCTCCGCCGCCTCCCTACTCCCGGCTGTCTCCTAACGACGAGCAAAAGCCACTGGATCTCTC
GGATTCCACGTTGTCTTACACTGAAACAGAGGCGACGAACTCACCCAACGTCACGCCCGGGGAGTTCTCAGACGCCAGC
ACGTCGCCCGATGCCGTGAAGAGGAGCCATTGGTGCAACGTGGCCTACTGGGAGCACCGGACGCGCGTCGGCCGCCTCT
ACACAGTGTACGAACAGTCTGTCAGTATATTTTATGACCTACCTCAAGGAAACGGCTTCTGCCTCGGACAGCTAAACCT
GGAAAACAGGAGCGAGACTGTGAGAAGGACTCGAAGTAAAATCGGTTACGGGATTTTACTTAGCAAAGAACCGGACGGT
GTGTGGGCTTACAATCGCAGCGAGCATCCCATCTTCGTCAACTCCCCAACACTGGACATCCCCAACTGTAGGACTTTGA
TAGTGCGCAAGGTGATGCCGGGC | | Citation | Alev C, Wu Y, Kasukawa T, Jakt LM, Ueda HR, Sheng G. Transcriptomic landscape of the primitive streak. Development. 2010 Sep 1;137(17):2863-74. Epub 2010 Jul 28. | | Copyright | Published by The Company of Biologists 2010. This material is protected by a copyright retained by the authors. Permission granted by Dr. G Sheng. | | Comments | The probe for SMAD6 was amplified by PCR using the following primers:
Forward Primer: GAAACAGAGGCGACGAACTC
Reverse Primer: GAGCAAGATCTCCAGCCAAC
Base Pair Numbers: 832-1407
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| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 4 |  | | stage 4 |
 | | stage 4 |
| Epiblast
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Entry 4| GEISHA Id | SMAD6.Xie.2011 | Data Source | Publication | | Complete cDNA Template Probe | show GCCGCCGGGGACGCCCCCCTCCCCCTTTCTTTTTCCTCCCCCGTTTTATGCCCGGGCGCTGCCCCCCCGCCTCGGCCCC
CCCGTCCCCATGGCTCCCTGAGCCCCCCCTATGCCCCCCGCCTATGCCCTCCCCGCTGGGCGCTCCCCATCCCCTCCGC
CGCCGCCTTCCCCCATGGTGCGGCCCCGCCGCGGGCCGGGCGCTGCGGGCGGCTCCGGGGGCGGCGGCTCCGGGGGCGG
AGGCGGCGGACGGGCGATGAGGAGATAGAGGCGCGGAGCGGAGCGAGCCCCGGGCCGCCCTCGTATCGTATGTTCAGGT
CCAAACGCTCAGGGCTGGTGCGGCGGCTTTGGAGGAGCCGCGTTATCCCGGAGAGGGACGGAGGAGATGGGAACGGCCA
AAGCTCGGAGCGAAACGCGACGGCGGTGACGGCCGAGGGACAGCGCATGGCACAGCCGCGCCGGGCGCAGGAGGGCGAG
GGCCGCCCGGTGCGCTGCTGCCTGTTCGCCGAGCGGCCCGGCCCCGAGCTGCCGCCGCCGCCGCCTCCTCCTCCTCCCG
GCGGCGCCTCTCCCCCCGGGCCGGGCGGAGGCGAAGCGCGGTCGCGGTTGGTGCTGCTGGAGCGGGAGCTGAAGGCCGT
CACCTACGCGCTGCTGAAGCGGCTGAAGGAGCGCTCCCTGCACAGCCTCCTGCAGGCGGTGGAGTCGCGCGGCGGCACT
CCGGGCGGCTGCGTGTTGGTGGCCCGCGGGGAGCTGCGCCTGGGGGCGGCCAGGCGGCCCCCCCCACACCTGCTGCTGG
GGAAGCTGTTCCGCTGGCCCGACCTGCAGCACCCCGCCGAGCTGAAGGCCCTGTGCGAATGTCAGAGCTTCGGGGCGGC
CGACGGCCCCACCGTGTGCTGCAATCCGTACCACTTCAGCCGGCTCTGTGGGCCAGAGTCTCCGCCGCCTCCCTACTCC
CGGCTGTCTCCTAACGACGAGCAAAAGCCACTGGATCTCTCGGATTCCACGTTGTCTTACACTGAAACAGAGGCGACGA
ACTCACCCAACGTCACGCCCGGGGAGTTCTCAGACGCCAGCACGTCGCCCGATGCCGTGAAGAGGAGCCATTGGTGCAA
CGTGGCCTACTGGGAGCACCGGACGCGCGTCGGCCGCCTCTACACAGTGTACGAACAGTCTGTCAGTATATTTTATGAC
CTACCTCAAGGAAACGGCTTCTGCCTCGGACAGCTAAACCTGGAAAACAGGAGCGAGACTGTGAGAAGGACTCGAAGTA
AAATCGGTTACGGGATTTTACTTAGCAAAGAACCGGACGGTGTGTGGGCTTACAATCGCAGCGAGCATCCCATCTTCGT
CAACTCCCCAACACTGGACATCCCCAACTGTAGGACTTTGATAGTGCGCAAGGTGATGCCGGGCTATTCCATCAAGGTG
TTTGACTACGAGAAGTCCTGCCTCTTGCAGCACACTGCAGAGCTGGATTATGCAGACGGGCCCTACGACCCCAACAGCG
TGCGGATCAGCTTTGCCAAGGGCTGGGGGCCGTGTTACTCGAGACAGTTCATCACGTCTTGCCCGTGTTGGCTGGAGAT
CTTGCTCAGTAACAATCGATAACAGTCAGCCTCTGACGAAAGGAAAACAAAACAGAAAGACACAGACTATCCCAAATAT
CATCTACCTAGATTTAATATAAAGTTTTATATATTATATGAAAATATATATTATACTTGTAATTATGGAGTCATTTTTA
CAATGTAATTATTTATGTATGGTGCAATGTGTATATGGACAAAAAACAGAAAATGCACTTTGGCTTATATAATTCTTTC
AATACAGATTTAAAGAAAAAAAAAATTATACAGCAAAAATAGGAGAGAAAAGCCCTAATTTTGATGTATGGTTTTTTTT
GAAATATTATTAATACCCAGACAAAAAGCTAATACCAGTCACTCATTGATAATAAAGTATTCGCCTCGTGC | | Citation | Xie Z, Chen Y, Li Z, Bai G, Zhu Y, Yan R, Tan F, Chen YG, Guillemot F, Li L, Jing N., Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/beta-catenin pathway. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12119-24. Epub 2011 Jul 5. | | Copyright | Copyright ©2012 by the National Academy of Sciences | | Comments | As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204248.1). |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 19-24 |  | | stage 24 |
 | | stage 24 |
| Spinal Cord
|
Entry 5| GEISHA Id | SMAD6.Olivera-Martinez.2014 | Data Source | Publication | | Complete cDNA Template Probe | show GGCGCTGCGGGCGGCTCCGGGGGCGGCGGCTCCGGGGGCGGAGGCGGCGGACGGGCGATGAGGAGATAGAGGCGCGGAG
CGGAGCGAGCCCCGGGCCGCCCTCGTATCGTATGTTCAGGTCCAAACGCTCAGGGCTGGTGCGGCGGCTTTGGAGGAGC
CGCGTTATCCCGGAGAGGGACGGAGGAGATGGGAACGGCCAAAGCTCGGAGCGAAACGCGACGGCGGTGACGGCCGAGG
GACAGCGCATGGCACAGCCGCGCCGGGCGCATGAGGGCGAGGGCCGCCCGGTGCGCTGCTGCCTGTTCGCCGAGCGGCC
CGGCCCCGAGCTGCCGCCGCCGCCGCCTCCTCCTCCTCCCGGCGGCGCCTCTCCCCCCGGGCCGGGCGGAGGCGAAGCG
CGGTCGCGGTTGGTGCTGCTGGAGCGGGAGCTGAAGGCCGTCACCTACGCGCTGCTGAAGCGGCTGAAGGAGCGCTCCC
TGCACAGCCTCCTGCAGGCGGTGGAGTCGCGCGGCGGCACTCCGGGCGGCTGCGTGTTGGTGGCCCGCGGGGAGCTGCG
CCTGGGGGGCGGCCAGGCGGCCCCCCCACACCTGCTGCTGGGGAAGCTGTTCCGCTGGCCCGACCTGCAGCACCCCGCC
GAGCTGAAGGCCCTGTGCGAATGTCAGAGCTTCGGGGCGGCCGACGGCCCCACCGTGTGCTGCAATCCGTACCACTTCA
GCCGGCTCTGTGGGCCAGAGTCTCCGCCGCCTCCCTACTCCCGGCTGTCTCCTAACGACGAGCAAAAGCCACTGGATCT
CTCGGATCCCACGTTGTCTTACACTGAAACGGAGGCGACGAACTCACCCAACGTCACGCCCGGGGAGTTCTCAGACGCC
AGCACGTCGCCCGATGCCGTGAAGAGGAGCCATTGGTGCAACGTGGCCTACTGGGAGCACCGGACGCGCGTCGGCCGCC
TCTACACAGTGTACGAACAGTCTGTCAGTATATTTTATGACCTACCTCAAGGAAACGGCTTCTGCCTCGGACAGCTAAA
CCTGGAAAACAGGAGCGAGACTGTGAGAAGGACTCGAAGTAAAATCGGTTACGGGATTTTACTTAGCAAAGAACCGGAC
GGTGTGTGGGCTTACAATCGCAGCGAGCATCCCATCTTCGTCAACTCCCCGACACTGGACATCCCCAACTGTAGGACTT
TGATAGTGCGCAAGGTGATGCCGGGCTATTCCATCAAGGTGTTTGACTACGAGAAGTCCTGCCTCTTGCAGCACACTGC
GGAGCTGGATTATGCAGACGGGCCCTACGACCCCAACAGCGTGCGGATCAGCTTTGCCAAGGGCTGGGGGCCGTGTTAC
TCGAGACAGTTCATCACGTCTTGCCCGTGTTGGCTGGAGATCTTGCTCAGTAACAATCGATAACAGTCAGCCTCTGACG
AAAGGAAAACAAAACAGAAAGACACAGACTATCCCAAATATCATCTACCTAGATTTAATATAAAGTTTTATATATTATA
TGAAAATATATATTATACTTGTAATTATGGAGTCATTTTTACAATGTAATTATTTATGTATGGTGCAATGTGTATATGG
ACAAAAAACAGAAAATGCACTTTGGCTTATATAATTCTTTCAATACAGATTTAAAGAAAAAAAAATTATACAGCAAAAA
TAGGAGAGAAAAGCCCTAATTTTGATGTATGGTTTTTTTTGAAATATTATTAATACCCAGACAAAAAGCTAATACCAGT
CACTCATTGATAATAAAGTATTCGCAT | | Citation | Isabel Olivera-Martinez, Nick Schurch, Roman A Li, Junfang Song, Pamela A Halley, Raman M Das, Dave W Burt, Geoffrey J Barton, Kate G Storey. Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development 2014 Aug;141(16):3266-76. Epub 2014 Jul 25. DOI: 10.1242/dev.112623. | | Copyright | Copyright © 2014. Published by The Company of Biologists Ltd. | | Comments | Authors indicated the probe was made from gene construct provided by C. Stern. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_204248.2). |
| Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | | 7-10 |  | | stage 10 |
| Neural Plate/Tube
| | all | | |
Entry 6| GEISHA Id | SMAD6.Trevers.2023 | Data Source | GEISHA ISH Analysis | | Complete cDNA Template Probe | show GGCGCTGCGGGCGGCTCCGGGGGCGGCGGCTCCGGGGGCGGAGGCGGCGGACGGGCGATGAGGAGATAGAGGCGCGGAG
CGGAGCGAGCCCCGGGCCGCCCTCGTATCGTATGTTCAGGTCCAAACGCTCAGGGCTGGTGCGGCGGCTTTGGAGGAGC
CGCGTTATCCCGGAGAGGGACGGAGGAGATGGGAACGGCCAAAGCTCGGAGCGAAACGCGACGGCGGTGACGGCCGAGG
GACAGCGCATGGCACAGCCGCGCCGGGCGCAGGAGGGCGAGGGCCGCCCGGTGCGCTGCTGCCTGTTCGCCGAGCGGCC
CGGCCCCGAGCTGCCGCCGCCGCCGCCTCCTCCTCCTCCCGGCGGCGCCTCTCCCCCCGGGCCGGGCGGAGGCGAAGCG
CGGTCGCGGTTGGTGCTGCTGGAGCGGGAGCTGAAGGCCGTCACCTACGCGCTGCTGAAGCGGCTGAAGGAGCGCTCCC
TGCACAGCCTCCTGCAGGCGGTGGAGTCGCGCGGCGGCACTCCGGGCGGCTGCGTGTTGGTGGCCCGCGGGGAGCTGCG
CCTGGGGGGCGGCCAGGCGGCCCCCCCACACCTGCTGCTGGGGAAGCTGTTCCGCTGGCCCGACCTGCAGCACCCCGCC
GAGCTGAAGGCCCTCTGCGAATGTCAGAGCTTCGGGGCGGCCGACGGCCCCACCGTGTGCTGCAATCCGTACCACTTCA
GCCGGCTCTGTGGGCCAGAGTCTCCGCCGCCTCCCTACTCCCGGCTGTCTCCTAACGACGAGCAAAAGCCACTGGATCT
CTCGGATTCCACGTTGTCATACACTGAAACGGAGGCGACGAACTCACCCAACGTCACGCCCGGGGAGTTCTCAGACGCC
AGCACGTCGCCCGATGCCGTGAAGAGGAGCCATTGGTGCAACGTGGCCTACTGGGAGCACCGGACGCGCGTCGGCCGCC
TCTACACAGTGTACGAACAGTCTGTCAGTATATTTTATGACCTACCTCAAGGAAACGGCTTCTGCCTCGGACAGCTAAA
CCTGGAAAACAGGAGCGAGACTGTGAGAAGGACTCGAAGTAAAATCGGTTACGGGATTTTACTTAGCAAAGAACCGGAC
GGTGTGTGGGCTTACAATCGCAGCGAGCATCCCATCTTCGTCAACTCCCCGACACTGGACATCCCCAACTGTAGGACTT
TGATAGTGCGCAAGGTGATGCCGGGCTATTCCATCAAGGTGTTTGACTACGAGAAGTCCTGCCTCTTGCAGCACACTGC
GGAGCTGGATTATGCAGACGGGCCCTACGACCCCAACAGCGTGCGGATCAGCTTTGCCAAGGGCTGGGGGCCGTGTTAC
TCGAGACAGTTCATCACGTCTTGCCCGTGTTGGCTGGAGATCTTGCTCAGTAACAATCGATAACAGTCAGCCTCTGACG
AAAGGAAAACAAAACAGAAAGACACAGACTATCCCAAATATCATCTACCTAGATTTAATATAAAGTTTTATATATTATA
TGAAAATATATATTATACTTGTAATTATGGAGTCATTTTTACAATGTAATTATTTATGTATGGTGCAATGTGTATATGG
ACAAAAAACAGAAAATGCACTTTGGCTTATATAATTCTTTCAATACAGATTTAAAGAAAAAAAAATTATACAGCAAAAA
TAGGAGAGAAAAGCCCTAATTTTGATGTATGGTTTTTTTTGAAATATTATTAATACCCAGACAAAAAGCTAATACCAGT
CACTCATTGATAATAAAGTATTCGCATTATA | | Comments | Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204248). |
| | Data from NCBI Unigene EST Profile
Unigene ID: Gga.3878 |
MouseFrogFruit FlyZebra FinchZebrafish |
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