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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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CCND2
cyclin D2

Gene

Official Symbol	CCND2
Official Full Name	cyclin D2
CGNC ID	12983
also known as	G1/S-specific cyclin-D2
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204213
Polypeptide	NP_989544
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.3974

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	32551			FBgn0010315
Human	894	ENSG00000118971		MIM:123833
Mouse	12444	ENSMUSG00000000184	All phenotypic alleles (3):Targeted, knock-out(1) Targeted, other(2)	MGI:88314
Xenopus	100038071, 734882, 373667			481218
Zebrafish	799608, 565038	ENSDARG00000051748	ZDB-GENE-070424-30, ZDB-GENE-050420-354	ZFIN:ZDB-GENE-070424-30, ZFIN:ZDB-GENE-050420-354

Gene Ontology

Molecular Function	protein kinase binding
Biological Process	cell cycle, cell division, positive regulation of cyclin-dependent protein kinase activity
Cellular Component	chromatin, cyclin-dependent protein kinase holoenzyme complex, cytosol, nuclear membrane, nucleolus

Links to other databases

Entrez Gene	374047
Ensembl Gene	ENSGALG00000017283
KEGG	gga:374047

Entry 1

GEISHA Id	CCND2	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	ACAACTTACTGACGATAGAGGAGCG
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGGTGGCACAAAGGGCAATGAAC	cDNA Template Length	486
Complete cDNA Template Probe	show `ACAACTTACTGACGATAGAGGAGCGGTATCTGCCCCAGTGCTCCTACTTCAAGTGCGTGCAGAAGGACATCCAGCCCTT CATGAGGAGGATGGTGGCCACTTGGATGTTGGAGGTCTGTGAAGAACAGAAGTGTGAAGAAGAAGTTTTCCCTCTGGCT ATGAATTACTTGGACAGATTCTTAGCTGTGGTGCCCACTCGAAAGTGCCATCTGCAACTACTGGGGGCAGTGTGCATGT TCCTGGCCTCCAAACTAAAAGAGACAATCCCCCTCACAGCAGAGAAGCTTTGCATATACACGGACAATTCCATCAAACC CCAAGAGCTGCTGGAATGGGAGCTCGTGGTATTGGGGAAGTTGAAGTGGAACCTTGCAGCAGTCACCCCACATGATTTC ATTGAGCACATCCTACGGAAGCTGCCTCTACCTAAAGACAAGTTGGTTTTGATCCGGAAACATGCACAAACGTTCATTG CCCTTTGTGCCA`

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

Early Mesoderm
Epiblast
Extraembryonic Mesoderm
Neural Plate/Tube
Primitive Streak

7-12

stage 9

stage 12

Amnion
Anterior Intestinal Portal
Forebrain
Foregut
Head Mesenchyme
Hindbrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Neural Plate/Tube
Sinus Venosus
Somites

19-24

stage 19

stage 20

Allantois
Aorta
Eye
Forebrain
Foregut
Head Mesenchyme
Hindbrain
Leg Mesenchyme
Liver
Lung
Midbrain
Myotome
Neural Plate/Tube
Notochord
Pharyngeal Arches and Clefts
Sclerotome
Sinus Venosus
Somatic Mesoderm
Ventricles
Wing Mesenchyme

stage 25

Allantois
Atria
Dermomyotome
Forebrain
Hindbrain
Leg Mesenchyme
Liver
Midbrain
Myotome
Outflow Tract
Pharyngeal Arches and Clefts
Sclerotome
Somatic Mesoderm
Spinal Cord
Spinal Ganglia and Nerves
Ventricles
Wing Mesenchyme

Entry 2

GEISHA Id	CyclinD2.Lobjois.2004	Data Source	Publication
Complete cDNA Template Probe	show ATGGAGTTGCTGTGCTGCGAGGTGGATCCTATGAGGAGAGCTTTGCCGGACCCGAACTTGCTCTACGACGACCGTGTTT TGCACAACTTACTGACGATAGAGGAGCGGTATCTGCCCCAGTGCTCCTACTTCAAGTGCGTGCAGAAGGACATCCAGCC CTTCATGAGGAGGATGGTGGCCACTTGGATGTTGGAGGTCTGTGAAGAACAGAAGTGTGAAGAAGAAGTTTTCCCTCTG GCTATGAATTACTTGGACAGATTCTTAGCTGTGGTGCCCACTCGAAAGTGCCATCTGCAACTACTGGGGGCAGTGTGCA TGTTCCTGGCCTCCAAACTAAAAGAGACAATCCCCCTCACAGCAGAGAAGCTTTGCATATACACGGACAATTCCATCAA ACCCCAAGAGCTGCTGGAATGGGAGCTCGTGGTATTGGGGAAGTTGAAGTGGAACCTTGCAGCAGTCACCCCACATGAT TTCATTGAGCACATCCTACGGAAGCTGCCTCTACCTAAAGACAAGTTGGTTTTGATCCGGAAACATGCACAAACGTTCA TTGCCCTTTGTGCCACAGATTTTAACTTTGCCATGTACCCTCCATCAATGATAGCAACTGGAAGTGTGGGAGCAGCCAT CTGTGGCCTTCAGCTTGATGATGGGGACAGATCACTCTCTGGTGACAGCCTAACAGACTTTCTGGCCAAGATTACAAGC ACAGATGTGGACTGCCTTAAAGCTTGTCAAGAACAGATTGAGTCGGTGCTAGTAAGCAACCTTAGGCAAGTCCGGCAGC AGCAACAACAAAGCAATCCTTCTAAGACCATTGAGGAACTGGACCAGGCCAGCACTCCCACAGATGTGAGAGATATCAA CCTGTGA
Citation	Lobjois V, Benazeraf B, Bertrand N, Medevielle F, Pituello F. Specific regulation of cyclins D1 and D2 by FGF and Shh signaling coordinates cell cycle progression, patterning, and differentiation during early steps of spinal cord development. Dev Biol. 2004 Sep 15;273(2):195-209.
Copyright	Reprinted from Developmental Biology, Volume 273, Issue 2, Valérie Lobjois, Bertrand Benazeraf, Nicolas Betrand, François Medevielle and Fabienne Pituello, Specific regulation of cyclins D1 and D2 by FGF and Shh signaling coordinates cell cycle progression, patterning, and differentiation during early steps of spinal cord development, Pages 195-209, Copyright 2004, with permission from Elsevier. Copyright © 2004 Elsevier B.V. All rights reserved.
Comments	Authors said: Gene expression patterns were analyzed using the antisense digoxigeninRNA probe prepared from the the coding region of cyclin D2 cDNA (1.1 kb). As this sequence is not available, we used 876 bp from NM_204213.1

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 9

stage 10

stage 12

Lateral Plate Mesoderm
Neural Plate/Tube
Notochord

Anatomy.

Entry 3

GEISHA Id	CyclinD2.Pickering.2019	Data Source	Publication
Complete cDNA Template Probe	show ATGGAGTTGCTGTGCTGCGAGGTGGATCCTATGAGGAGAGCTTTGCCGGACCCGAACTTGCTCTACGACGACCGTGTTT TGCACAACTTACTGACGATAGAGGAGCGGTATCTGCCCCAGTGCTCCTACTTCAAGTGCGTGCAGAAGGACATCCAGCC CTTCATGAGGAGGATGGTGGCCACTTGGATGTTGGAGGTCTGTGAAGAACAGAAGTGTGAAGAAGAAGTTTTCCCTCTG GCTATGAATTACTTGGACAGATTCTTAGCTGTGGTGCCCACTCGAAAGTGCCATCTGCAACTACTGGGGGCAGTGTGCA TGTTCCTGGCCTCCAAACTAAAAGAGACAATCCCCCTCACAGCAGAGAAGCTTTGCATATACACGGACAATTCCATCAA ACCCCAAGAGCTGCTGGAATGGGAGCTCGTGGTATTGGGGAAGTTGAAGTGGAACCTTGCAGCAGTCACCCCACATGAT TTCATTGAGCACATCCTACGGAAGCTGCCTCTACCTAAAGACAAGTTGGTTTTGATCCGGAAACATGCACAAACGTTCA TTGCCCTTTGTGCCACAGATTTTAACTTTGCCATGTACCCTCCATCAATGATAGCAACTGGAAGTGTGGGAGCAGCCAT CTGTGGCCTTCAGCTTGATGATGGGGACAGATCACTCTCTGGTGACAGCCTAACAGACTTTCTGGCCAAGATTACAAGC ACAGATGTGGACTGCCTTAAAGCTTGTCAAGAACAGATTGAGTCGGTGCTAGTAAGCAACCTTAGGCAAGTCCGGCAGC AGCAACAACAAAGCAATCCTTCTAAGACCATTGAGGAACTGGACCAGGCCAGCACTCCCACAGATGTGAGAGATATCAA CCTGTGA
Citation	Pickering J, Chinnaiya K, Towers M. An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development. Elife. 2019 Sep 23;8. pii: e47625. DOI: 10.7554/eLife.47625.
Copyright	Copyright © 2019, Pickering et al.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_204213.1).