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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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MEOX2
mesenchyme homeobox 2

Gene

Official Symbol	MEOX2
Official Full Name	mesenchyme homeobox 2
CGNC ID	8206
also known as	homeobox protein MOX-2\|mesenchyme homeo box 2 (growth arrest-specific homeo box), mesenchyme homeobox 2, Meox2
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001005427
Polypeptide	NP_001005427
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.90

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	4223	ENSG00000106511		MIM:600535
Mouse	17286		All phenotypic alleles (4):Spontaneous(1) Targeted, knock-out(1) Targeted, other(2)	MGI:103219
Xenopus	100144655, 380365, 100337513			852817
Zebrafish	556898, 64266	ENSDARG00000040911	ZDB-GENE-060503-853, ZDB-GENE-080613-1	ZFIN:ZDB-GENE-060503-853, ZFIN:ZDB-GENE-080613-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	374137
Ensembl Gene
KEGG	gga:374137

Entry 1

GEISHA Id	MEOX2.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	AAAAAAGGCACGCTGCTCCC
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGCTGAAGATGAAGAGACATTTCCGC	cDNA Template Length	954
Forward cDNA Template Probe	show AAGAGCCGGTATTAATGGTACTCAGTGGATGACAAAGTAGAAATGGAATAATCCCTTTCTGGGGGTTTCCACCTGAGCA TGAAAATTTTGTGGCAGGGTTACTGGACTATCCTTATGATCCTAAAAATCATTTTTTTGCAGTTATAAGATAAGAAGAA TTGAGGAGCTAGGTAAGTTTAATAATACCCTATTAGCAGCAGTTGATAGTAAATGCAACATAATGTTTGTTTTGTCTGT CATACAAGGACGTGTCCTAGCAGATACGTTCTCTACTTGAACAAAAGTATCTGCATGTATTGTATGTCTTTGGCGAAAC AAAACAAAAATTAAAGAGACAAAAAGCCATTTATTGTCATGAGTGACTATTGCCATCAGCTAATATGAATGCATTGCTA AAATTAGTGAAGACAGGAAAATGCTGTAAGGTAAATATATACAGAGTTAAAATACATTTCTTATCCACTAGATAGTGAT TTTGTGGCACTGTGGTTTTCAGAATATAACGTCTGTTGAGAGCAATGTAATTTTCAGTGCAAGCTAAAGCAAAATACCT GCCCGCTGTCATAAACATGACAAACAAATCTGGAATGTTCAAAGTTCATCTTCCACTTCTCCACTCTTGAGGCACCTTT AAGACATGGCACTTACTGTAAACCATCTAAAAATCAAGAAAAACAGACACAATAAGCCTGAATCTTCCATAACAACTTT AAAAATCACTGCCAGTCACTTGCATACGTAAACGATGCCTGTGTAAGGCTTGCCAGCAAAGCATCTTTCCTGAGAACGG AGCTGGGACACTCTCTGTGTATCATAAGTGTGCGTGCTCAGAGCTGTGATCGCTGTCGTGGCTGTCATCATTCGCTAGT GAGTCCCCCGTGTGCTGGAGACCAGCTGCCCCAATGCCAGAGAGCTCGGAGGGGAGCACGGGCCCCCTTTTTT
Comments	No expression detected at or before stage 9.

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 5

Unlabeled

Stages 4 & 5.

7-12

stage 9

stage 11

stage 12

Neural Plate/Tube
Somites
Unlabeled

Stages 8 & 9.

13-18

stage 13

stage 17

stage 18

Endocardium
Head Mesenchyme
Neural Plate/Tube
Somites

19-24

stage 20

stage 21

stage 23

stage 24

Eye
Head Mesenchyme
Hindgut
Leg Mesenchyme
Midgut
Pharyngeal Arches and Clefts
Somites
Wing Mesenchyme

Low level expression in leg mesenchyme.
Low level expression in wing mesenchyme.

Entry 2

GEISHA Id	Meox2.Reijntjes.2007	Data Source	Publication
Complete cDNA Template Probe	show TTCCTAAACTCTCCTGCCTGGAACCTGAGACTTGCATGCCATGGATCACACACTCTTTGGCTGCCTGCGCAGCCCCCAT GCCACCGCGCAGAGCTTGCATCCTTTCTCCCAGTCTTCTCTTGCCCTGCATGGAAGATCCGACCACATGTCCTACCCCG ATCTGTCTTCTTCTTCTTCCTCTTGCATAATAACGGGATACCCCAATGAGGAGGGCATGTTTGCCAGCCAGCATCATAG GGGGCACCACCACCACCACCATCACCACCACCATCACCACCAGCAACAGCAGCACCAGGCTTTGCAGACGAACTGGCAC ATCCCTCAGATGTCGTCTCCTCCCGCCGCGGCCAGGCACAGCCTCTGTCTCCAGCCGGACTCAGGAGGACCCCCGGAGC TGGGCAGCAGCCCCCCCGTGCTGTGTTCGAACTCCTCCAGCCTGGGCACTACCACCCCCACGGGGGCAGCGTGTGCGCC GGGGGACTATGGCAGGCAGGCTCTGTCCCCGGTGGAAACGGAGAAGAGGTCCGGCAAGAGGAAAAGCGACAGTTCAGAT TCCCAAGAAGGAAACTACAAGTCAGAGGTCAACAGTAAACCCAGGAAGGAAAGGACAGCTTTCACCAAGGAGCAAATCA GAGAGCTAGAAGCAGAATTTGCTCATCATAACTATTTGACCAGGCTGAGGAGATATGAGATAGCAGTAAACCTTGACCT CACTGAAAGACAGGTAAAAGTTTGGTTCCAGAACAGACGGATGAAATGGAAGCGGGTAAAAGGAGGCCAGCAAGGGGCA GCAACCCCGGAAAAGGAACTGGTGAATGTGAAAAAAGGCACGCTGCTCCCCTCCGAGCTCTCTGGCATTGGGGCAGCTG GTCTCCAACACACGGGGGACTCACTAGCGAATGATGACAGCCACGACAGCGATCACAGCTCTGAGCACGCACACTTATG ATACACAGAGAGTGTCCCAGCTCCGTTCTCAGGAAAGATGCTTTGCTGGCAAGCCTTACACAGGCATCGTTTACGTATG CAAGTGACTGGCAGTGATTTTTAAAGTTGTTATGGAAGATTCAGGCTTATTGTGTCTGTTTTTCTTGATTTTTAGATGG TTTACAGTAAGTGCATGTCTTAAAGGTGCCTCAAGAGTGGAGAAGTGGAAGATGAACTTTGAACATTCCAGATTTGTTT GTGATGTTTATGACAGCGGGCAGGTATTTTCCTTTAGCTTGCACTGAAAATTACATTGCTCTCAACAGACGTTATATCT GAAAACCACAGTGCCACAAAATCACTATTTAGTGGATAAGAAATGTATTTTAACTCTGTATATATTTACCTTACAGCAT TTTCCTGTCTTCACTAATTTTAGCAATGCATTCATATTAGCTGATGGCAATAGTCACTCATGACAATAAATGGCTTTTT GTCTCTTTAATTTTTGTTTTGTTTCGCCAAAGACATCCAATACATGCAGATACTTTTGTTCAAGTAGAGAAGGTATCTG CTAGGACACGTCCTTGTATGACAGACAAAACAAACATTATGTTGCATTTACTATCAACTGCTGCTAATAGGGTATTATT AAACTTACCTAGCTCCTCAATTCTTCTTATCTTATAACTGCAAAAAAATGATTTTTAGGATCATAAGGATAGTCCAGTA ACCTGCCACAAAATTTTCATGCTCAGTGGAAACCCCAGAAAGGATTATTCATTTCTACTTTGTCATCACTGAGTACATT AATACTGACTCTGCGGAAATGTCTCTTCATCTTCAGTTTAAAAAACAGCAGTCAGCTGAGTTATTATCAACTGCTTATG TTGGTAGGAATCAAAATATGAAGGTAACTCAGTATTGTGTCCCGTGTGTAAAATGAAGACATATTTTCTGTTAT
Citation	Reijntjes S, Stricker S, Mankoo BS. A comparative analysis of Meox1 and Meox2 in the developing somites and limbs of the chick embryo. Int J Dev Biol.(2007); 51(8:753-9.
Copyright	Reprinted from Int. J. Dev. Biol., 51, Reijntjes S, Stricker S, Mankoo BS, A comparative analysis of Meox1 and Meox2 in the developing somites and limbs of the chick embryo, 753-9, Copyright © 2007 UBC Press, with permission. All rights reserved.
Comments	According to authors ,a full length clone was used. The sequence below was obtained from NCBI (acc #NM_001005427).

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 11

Somites

13-18

stage 16

Dermomyotome
Midgut
Sclerotome
Somites

19-24

stage 20

stage 22

Dermomyotome
Leg Muscles
Limb Buds
Sclerotome
Somites

stage 25

Limb Buds
Pharyngeal Arches and Clefts
Somites

2nd arch

Entry 3

GEISHA Id	MEOX2.Reijntjes.2010	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show TTCCTAAACTCTCCTGCCTGGAACCTGAGACTTGCATGCCATGGATCACACACTCTTTGGCTGCCTGCGCAGCCCCCAT GCCACCGCGCAGAGCTTGCATCCTTTCTCCCAGTCTTCTCTTGCCCTGCATGGAAGATCCGACCACATGTCCTACCCCG ATCTGTCTTCTTCTTCTTCCTCTTGCATAATAACGGGATACCCCAATGAGGAGGGCATGTTTGCCAGCCAGCATCATAG GGGGCACCACCACCACCACCATCACCACCACCATCACCACCAGCAACAGCAGCACCAGGCTTTGCAGACGAACTGGCAC ATCCCTCAGATGTCGTCTCCTCCCGCCGCGGCCAGGCACAGCCTCTGTCTCCAGCCGGACTCAGGAGGACCCCCGGAGC TGGGCAGCAGCCCCCCCGTGCTGTGTTCGAACTCCTCCAGCCTGGGCACTACCACCCCCACGGGGGCAGCGTGTGCGCC GGGGGACTATGGCAGGCAGGCTCTGTCCCCGGTGGAAACGGAGAAGAGGTCCGGCAAGAGGAAAAGCGACAGTTCAGAT TCCCAAGAAGGAAACTACAAGTCAGAGGTCAACAGTAAACCCAGGAAGGAAAGGACAGCTTTCACCAAGGAGCAAATCA GAGAGCTAGAAGCAGAATTTGCTCATCATAACTATTTGACCAGGCTGAGGAGATATGAGATAGCAGTAAACCTTGACCT CACTGAAAGACAGGTAAAAGTTTGGTTCCAGAACAGACGGATGAAATGGAAGCGGGTAAAAGGAGGCCAGCAAGGGGCA GCAACCCCGGAAAAGGAACTGGTGAATGTGAAAAAAGGCACGCTGCTCCCCTCCGAGCTCTCTGGCATTGGGGCAGCTG GTCTCCAACACACGGGGGACTCACTAGCGAATGATGACAGCCACGACAGCGATCACAGCTCTGAGCACGCACACTTATG ATACACAGAGAGTGTCCCAGCTCCGTTCTCAGGAAAGATGCTTTGCTGGCAAGCCTTACACAGGCATCGTTTACGTATG CAAGTGACTGGCAGTGATTTTTAAAGTTGTTATGGAAGATTCAGGCTTATTGTGTCTGTTTTTCTTGATTTTTAGATGG TTTACAGTAAGTGCATGTCTTAAAGGTGCCTCAAGAGTGGAGAAGTGGAAGATGAACTTTGAACATTCCAGATTTGTTT GTGATGTTTATGACAGCGGGCAGGTATTTTCCTTTAGCTTGCACTGAAAATTACATTGCTCTCAACAGACGTTATATCT GAAAACCACAGTGCCACAAAATCACTATTTAGTGGATAAGAAATGTATTTTAACTCTGTATATATTTACCTTACAGCAT TTTCCTGTCTTCACTAATTTTAGCAATGCATTCATATTAGCTGATGGCAATAGTCACTCATGACAATAAATGGCTTTTT GTCTCTTTAATTTTTGTTTTGTTTCGCCAAAGACATCCAATACATGCAGATACTTTTGTTCAAGTAGAGAAGGTATCTG CTAGGACACGTCCTTGTATGACAGACAAAACAAACATTATGTTGCATTTACTATCAACTGCTGCTAATAGGGTATTATT AAACTTACCTAGCTCCTCAATTCTTCTTATCTTATAACTGCAAAAAAATGATTTTTAGGATCATAAGGATAGTCCAGTA ACCTGCCACAAAATTTTCATGCTCAGTGGAAACCCCAGAAAGGATTATTCATTTCTACTTTGTCATCACTGAGTACATT AATACTGACTCTGCGGAAATGTCTCTTCATCTTCAGTTTAAAAAACAGCAGTCAGCTGAGTTATTATCAACTGCTTATG TTGGTAGGAATCAAAATATGAAGGTAACTCAGTATTGTGTCCCGTGTGTAAAATGAAGACATATTTTCTGTTAT
Citation	Reijntjes S, Francis-West P, Mankoo BS. Retinoic acid is both necessary for and inhibits myogenic commitment and differentiation in the chick limb. Int J Dev Biol. 2010;54(1):125-34
Copyright	© 2009 UBC Press
Comments	The sequence was obtained from NCBI (acc # NM_001005427) using the information provided in the publication as described in Reijntjes et al. 2010.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

19-24

stage 22

Limb Buds

D. Stage 22 embryo: Shows normal expression.

25-30

stage 25

Limb Buds
Somites

E. Untreated/Control embryo: shows the normal expression of Meox2.
E. Untreated/Control embryo: Shows the normal expression of Meox2.

31-44

stage 44

Entry 4

GEISHA Id	Mox2.Rallis.2001	Data Source	Publication
Complete cDNA Template Probe	show TTCCTAAACTCTCCTGCCTGGAACCTGAGACTTGCATGCCATGGATCACACACTCTTTGGCTGCCTGCGCAGCCCCCAT GCCACCGCGCAGAGCTTGCATCCTTTCTCCCAGTCTTCTCTTGCCCTGCATGGAAGATCCGACCACATGTCCTACCCCG ATCTGTCTTCTTCTTCTTCCTCTTGCATAATAACGGGATACCCCAATGAGGAGGGCATGTTTGCCAGCCAGCATCATAG GGGGCACCACCACCACCACCATCACCACCACCATCACCACCAGCAACAGCAGCACCAGGCTTTGCAGACGAACTGGCAC ATCCCTCAGATGTCGTCTCCTCCCGCCGCGGCCAGGCACAGCCTCTGTCTCCAGCCGGACTCAGGAGGACCCCCGGAGC TGGGCAGCAGCCCCCCCGTGCTGTGTTCGAACTCCTCCAGCCTGGGCACTACCACCCCCACGGGGGCAGCGTGTGCGCC GGGGGACTATGGCAGGCAGGCTCTGTCCCCGGTGGAAACGGAGAAGAGGTCCGGCAAGAGGAAAAGCGACAGTTCAGAT TCCCAAGAAGGAAACTACAAGTCAGAGGTCAACAGTAAACCCAGGAAGGAAAGGACAGCTTTCACCAAGGAGCAAATCA GAGAGCTAGAAGCAGAATTTGCTCATCATAACTATTTGACCAGGCTGAGGAGATATGAGATAGCAGTAAACCTTGACCT CACTGAAAGACAGGTAAAAGTTTGGTTCCAGAACAGACGGATGAAATGGAAGCGGGTAAAAGGAGGCCAGCAAGGGGCA GCAACCCCGGAAAAGGAACTGGTGAATGTGAAAAAAGGCACGCTGCTCCCCTCCGAGCTCTCTGGCATTGGGGCAGCTG GTCTCCAACACACGGGGGACTCACTAGCGAATGATGACAGCCACGACAGCGATCACAGCTCTGAGCACGCACACTTATG ATACACAGAGAGTGTCCCAGCTCCGTTCTCAGGAAAGATGCTTTGCTGGCAAGCCTTACACAGGCATCGTTTACGTATG CAAGTGACTGGCAGTGATTTTTAAAGTTGTTATGGAAGATTCAGGCTTATTGTGTCTGTTTTTCTTGATTTTTAGATGG TTTACAGTAAGTGCATGTCTTAAAGGTGCCTCAAGAGTGGAGAAGTGGAAGATGAACTTTGAACATTCCAGATTTGTTT GTGATGTTTATGACAGCGGGCAGGTATTTTCCTTTAGCTTGCACTGAAAATTACATTGCTCTCAACAGACGTTATATCT GAAAACCACAGTGCCACAAAATCACTATTTAGTGGATAAGAAATGTATTTTAACTCTGTATATATTTACCTTACAGCAT TTTCCTGTCTTCACTAATTTTAGCAATGCATTCATATTAGCTGATGGCAATAGTCACTCATGACAATAAATGGCTTTTT GTCTCTTTAATTTTTGTTTTGTTTCGCCAAAGACATCCAATACATGCAGATACTTTTGTTCAAGTAGAGAAGGTATCTG CTAGGACACGTCCTTGTATGACAGACAAAACAAACATTATGTTGCATTTACTATCAACTGCTGCTAATAGGGTATTATT AAACTTACCTAGCTCCTCAATTCTTCTTATCTTATAACTGCAAAAAAATGATTTTTAGGATCATAAGGATAGTCCAGTA ACCTGCCACAAAATTTTCATGCTCAGTGGAAACCCCAGAAAGGATTATTCATTTCTACTTTGTCATCACTGAGTACATT AATACTGACTCTGCGGAAATGTCTCTTCATCTTCAGTTTAAAAAACAGCAGTCAGCTGAGTTATTATCAACTGCTTATG TTGGTAGGAATCAAAATATGAAGGTAACTCAGTATTGTGTCCCGTGTGTAAAATGAAGACATATTTTCTGTTAT
Citation	Rallis C, Stamataki D, Pontikakis S, Mankoo BS, Karagogeos D. Isolation of the avian homologue of the homeobox gene Mox2 and analysis of its expression pattern in developing somites and limbs. Mech Dev. 2001 Jun;104(1-2):121-4.
Copyright	Copyright © 2001 Elsevier Science Ireland Ltd.
Comments	The complete cDNA template sequence was obtained from the information in the publication as described in Rallis et al. 2001.