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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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SIX3
SIX homeobox 3

Gene

Official Symbol	SIX3
Official Full Name	SIX homeobox 3
CGNC ID	49119
also known as	CSIX3, homeobox protein SIX3\|sine oculis homeobox homolog 3
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204364
Polypeptide	NP_989695
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.291

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human
Mouse
Xenopus
Zebrafish

Gene Ontology

Molecular Function	DNA binding, more...
Biological Process	brain development, eye development, negative regulation of transcription, DNA-templated, more...
Cellular Component	nucleus

Links to other databases

Entrez Gene	378786
Ensembl Gene
KEGG	gga:378786

Entry 1

GEISHA Id	SIX3.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	CCCATTTCTTCCTGCCCAAC
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGTGCTGGAGCCTGTTTTTAGCC	cDNA Template Length	727
Forward cDNA Template Probe	show TCCTGTAAAGGTCCTGCCGGTTCCGCACCCGCTGGACGCTGCAAGTCCTCTCCTTGAAGCAATGCGTCTTCTGCTCACC ATCCCAAATGGGCCTGGGCAGCGGAAACTTCTTCCTCACCCTGTATTTATCAACCGGCCCCAGCGGGCGGCCCCGCATT TTCTCAGCCTCCTGGTAGAGCGCTTCGAGCGACATGGCCTGCAGCTTGCCGTGCGACTCCTTGGTGAATTTGTGGTTCT CCAGGATGTGGTAAAGGCCACGGAAATTGCCCTTGTGGAAGGTCACCACCGCCCGGGCGCGCAGGATGGATTCATGCTT GTTGAAGGCCTCCCATGCCCCCGGCCCCACCGACAAACGACCAGAGGAACCTCCCCAGCCTTTCTATTTCTCCGGTCCC CTACAGCGTCCCGAACACCCTGCCAACTTGCTCCGGGGAGAAATTTACAGGGCGCACCTAAAACTTTTAATAAGTCTTT AATACAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGGCTGGGGAGGTTCCTCTGGTCG CTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCGCACGGGCGGTGGTGGCCTTCC ACACGGGCAACTTCCGCGACCTCTACCACATCATGGAGAACCACAAATTCACCAAGGAGTCGCACGGGCAGCTGCAAGC CATGTGGCTCCAAGCGCACTAACAGGAGGCCGACAAGCTGCGGGGCCGCCCACTGGGGCCGATTGATAAATACAGGGTG AAGAAGAAATTTTCGCGGCCCAGGACCTTTGGGATTGCCAGCAAAAACCCCCTGCTTCACGAGAGGACTCCCAACCTCC TAAGGGATTGATACTTGCCGGACCCTTACCCCATCCAGCCGNAAAGGGAAATAGCCCAGGCCACGAGGTTCCCCCGGCG CCGTAGGCCGTGGTTCCAAACCAAAGCCAAAACCCACCCCCGCCCCCTAAACCAGCTCCCCAATTTATGGGGGAATAAT AA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

Early Endoderm
Early Mesoderm
Epiblast

7-12

stage 8

stage 9

stage 12

Eye
Forebrain
Foregut
Head Mesenchyme
Lateral Plate Mesoderm

13-18

stage 13

stage 17

stage 18

Eye
Face Mesenchyme
Forebrain
Foregut
Nasal Placode/Nerve
Oral Pharynx
Pharynx

19-24

stage 22

stage 23

stage 24

Eye
Forebrain
Hindbrain
Nasal Placode/Nerve
Oral Pharynx

Entry 2

GEISHA Id	Six3.Chapman.2002	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Chapman SC, Schubert FR, Schoenwolf GC, Lumsden A. Analysis of spatial and temporal gene expression patterns in blastula and gastrula stage chick embryos. Dev Biol. 2002 May 1;245(1):187-99.
Copyright	2002 Elsevier Science (USA). All rights reserved.
Comments	No mapping for this gene on the present genome build

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 5

stage 6

Endoderm
Hypoblast
Neural Plate/Tube

Chordin:red
Double labeled

Entry 3

GEISHA Id	Six3.Ohuchi.2007	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Ohuchi H, Hayashibara Y, Matsuda H, Onoi M, Mitsumori M, Tanaka M, Aoki J, Arai H, Noji S. Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development. Dev Dyn. 2007 Apr;236(4):1134-43.
Copyright	Copyright © 2007 Wiley-Liss, Inc.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204364).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-15

stage 15

Eye
Telencephalon

Entry 4

GEISHA Id	Six3.Abe.2006	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Abe Y, Chen W, Huang W, Nishino M, Li YP. CNBP regulates forebrain formation at organogenesis stage in chick embryos. Dev Biol. 2006 Jul 1;295(1):116-27. Epub 2006 Apr 19.
Copyright	Reprinted from Developmental Biology, 295, Yoko Abea, Wei Chena, Wei Huangc, Mizuho Nishinod and Yi-Ping Li, CNBP regulates forebrain formation at organogenesis stage in chick embryos, 116-127, Copyright 2006, with permission from Elsevier. Copyright © 2006 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc #NM_204364).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

stage 19

Forebrain

Entry 5

GEISHA Id	Six3.Chapman.2008	Data Source	Direct Submission
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Comments	Images Provided by Susan Chapman.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

stage 6

Forebrain
Neural Plate/Tube

Chd:red
Double labeled
Six3:blue

7-12

stage 7

stage 8

stage 9

stage 11

Forebrain
Neural Plate/Tube

13-14

stage 14

Eye
Forebrain

Entry 6

GEISHA Id	SIX3.Halilagic.2007	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Halilagic A, Ribes V, Ghyselinck NB, Zile MH, Dollé P, Studer M. Retinoids control anterior and dorsal properties in the developing forebrain. Dev Bio 2007 Mar 1;303(1):244-58
Copyright	Reprinted with permission from Elsevier. Copyright © 2007 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204364.1). Images are quail, but sequence and map shown are chick.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

stage 19

Eye
Nasal Placode/Nerve

quail embryo

Entry 7

GEISHA Id	SIX3.Merchan.2011	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Merchán,P, Bardet, SM, Puelles, L, Ferran, JL, Comparison of Pretectal Genoarchitectonic Pattern between Quail and Chicken Embryos. Front Neuroanat. 2011; 5: 23. Prepublished online 2010 December 29. Published online 2011 April 5
Copyright	Copyright © 2011 Merchán, Bardet, Puelles and Ferran.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc #NM_204364.1)

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

25-28

stage 26

stage 28

Diencephalon
Midbrain

Quail

Entry 8

GEISHA Id	SIX3.Sanchez-Arrones.2012	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Sanchez-Arrones L, Stern CD, Bovolenta P, Puelles L. Sharpening of the anterior neural border in the chick by rostral endoderm signaling. Development. 2012 Mar;139(5):1034-44.
Copyright	Published by The Company of Biologists © 2012.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204364.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

stage 6

Epiblast
Neural Plate/Tube

Control embryo
DLX5(purple)
SIX3(brown)
control embryo: stage 5+/6
control embryo: stage 5+/6
double-labeled in situ:

Entry 9

GEISHA Id	SIX3.Reza.2007	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Reza HM, Urano A, Shimada N, Yasuda K. Sequential and combinatorial roles of maf family genes define proper lens development. Mol Vis. 2007 Jan 16;13:18-30.
Copyright	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204364.1

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-16

stage 16

Eye

Entry 10

GEISHA Id	Six3.Reza.2002	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Reza HM, Ogino H, Yasuda K. L-Maf, a downstream target of Pax6, is essential for chick lens development. Mech Dev. 2002 Aug;116(1-2):61-73.
Copyright	Copyright © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204364.1

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-17

stage 17

Eye

Entry 11

GEISHA Id	SIX3.Ferran.2007	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Ferran JL, Sánchez-Arrones L, Sandoval JE, Puelles L. A model of early molecular regionalization in the chicken embryonic pretectum. J Comp Neurol. 2007 Dec 1;505(4):379-403.
Copyright	Copyright © 19992012 John Wiley & Sons, Inc. All Rights Reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204364.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 17

stage 18

Diencephalon
Head Mesenchyme
Hypothalamus
Mesencephalon

Double labeled: SIX3, in situ hybridization(blue), PAX3, immunoreaction(brown).

19-24

stage 23

Diencephalon
Mesencephalon
Midbrain

stage 25

Diencephalon

Entry 12

GEISHA Id	SIX3.Hirashima.2008	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Hirashima M, Kobayashi T, Uchikawa M, Kondoh H, Araki M. Anteroventrally localized activity in the optic vesicle plays a crucial role in the optic development. Dev Biol. 2008 May 15;317(2):620-31. doi: 10.1016/j.ydbio.2008.03.010. Epub 2008 Mar 20.
Copyright	Copyright © 2008 Elsevier Inc. All rights reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204364.1

Stage

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Location (click to highlight)

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7-11

stage 11

Eye

Entry 13

GEISHA Id	SIX3.Yuan.1999B	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGAGCGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCC GCGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTC CCTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTA TCCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGC AGCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTC AGCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAG GCTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGC GCCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGG AGTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGG GCCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGC TTCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAAC TGGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAACTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGC GGCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCAC AGCTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGCGTCTCCAGTTTGACAGAAAGAGCCGAGACGGGCA CCTCCATCCTCTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAA CAACAACAA
Citation	Yuan S, Schoenwolf GC. Reconstitution of the organizer is both sufficient and required to re-establish a fully patterned body plan in avian embryos. Development. 1999 Jun;126(11):2461-73
Copyright	Great Britain © The Company of Biologists Limited 1999
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204364.2).

no images

Entry 14

GEISHA Id	Six3.Hsieh.2002	Data Source	Publication
Complete cDNA Template Probe	show GCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGGCCGGTTGA TAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCTTCAAGGAG AGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACTGGCTCAGG CCACGGGGCTCACCCCCACGCAAGTAGGCAACTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCGGCTAAAAA CAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACAGCTCGGCC GAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGCGTCTCCAGTTTGACAGAAAGAGCCGAGACGGGCACCTCCATCC TCTCGGTAACCTCCAGCGACTCGGAATGTGATGTATG
Citation	Hsieh YW, Zhang XM, Lin E, Oliver G, Yang XJ. The homeobox gene Six3 is a potential regulator of anterior segment formation in the chick eye. Dev Biol. 2002 Aug 15;248(2):265-80.
Copyright	copyright © 2002 Elsevier Science (USA)
Comments	The complete cDNA template sequence was obtained from the information in the publication as described in Hsieh et al. 2002.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 14

Diencephalon
Ectoderm
Eye
Hindbrain
Lens
Nasal Placode/Nerve
Retina

pigmented epithelium
pigmented epithelium, prechordal plate

19-24

stage 23

stage 24

Lens
Retina

corneal epithelium, ciliary margin
pigmented epithelium

25-30

stage 29

Eye
Lens
Retina

ciliary margin
ganglion cell layer

31-44

stage 36

stage 42

stage 44

Retina

ganglion cell layer
outer nuclear layer, , inner nuclear layer, ganglion cell layer

Entry 15

GEISHA Id	cSix3.Bovolenta.1998	Data Source	Publication
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGACGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCCG CGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTCC CTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTAT CCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGCA GCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTCA GCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAGG CTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGCG CCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGGA GTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGGG CCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGCT TCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAACT GGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAATTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGCG GCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCACA GTTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGTGTTTCCAGTTTGACAGAAAGAGCCGAGACGGGCAC CTCCATCCTTTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAAC AACAACAACAAAAGAAAAA
Citation	Bovolenta P, Mallamaci A, Puelles L, Boncinelli E. Expression pattern of cSix3, a member of the Six/sine oculis family of transcription factors. Mech Dev. 1998 Jan;70(1-2):201-3
Copyright	Copyright © 1998 Elsevier Science Ireland Ltd.
Comments	The complete cDNA template sequence was obtained from the information as described in the publication in Bovolenta et al. 1998.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 6

Early Mesoderm
Headfold
Neural Plate/Tube

anterior portion
pcp, prechordal plate

7-12

stage 8

stage 10

stage 11

Anterior Neuropore
Eye
Forebrain
Foregut

ov, optic vesicle; fg, foregut; rf, rostral forebrain
ov, optic vesicle; rn, rostral neuropore
rn, rostral neuropore; in, infundibulum; ov, optic vesicle

13-18

stage 13

stage 14

stage 16

Eye
Forebrain
Lens
Nasal Placode/Nerve
Retina

optic vesicle
in, infundibulum
ppe, presumptive pigment epithelium; lv, lens vesicle; nr, neural retina;
ppe, presumptive pigment epithelium; pnr, presumptive neural retina
ppe, presumptive pigment epithelium; pnr, presumptive neural retina; in, infundibulum; lp, lens placode;
rf, rostral forebrain;op, olfactory pit;

19-24

stage 21

Hypothalamus
Lens
Retina

pe, pigment epithelium; nr, neural retina

25-30

stage 27

Eye
Hypothalamus
Pineal Gland
Pituitary (Rudiment)
Retina

adenohypophisis
gcl, ganglion cell layer; pe, pigment epithelium

31-44

stage 32

stage 39

stage 44

Eye
Forebrain
Nasal Placode/Nerve
Pineal Gland
Pituitary (Rudiment)

gcl, ganglion cell layer;
inl, inner nuclear layer; gcl, ganglion cell layer;
oe, olfactory epithelium
preoptic area; choroid plexus; stratium
stratium

Entry 16

GEISHA Id	SIX3.Trevers.2023	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show GGCGGCGCGGGGCCGGGCGCGTGTGAGCGCGTGAGTGTGTGCGTGAGTGTGTGCGCGTGTGTGTGCGTGCGTGTGCCCC GCGCCTCTATGTGGCTGCGTGTGCGTGTGCGGGTGTGGATGCGTGCGCGGTGCGGGTGCCCTTTCCTCCCTTCTTCCTC CCTTTCTTTCTTTTCTCCGTGATCGCTCTCCCCCTCTCCCCGGTCATCCCATGGTGTTCAGGTCCCCGCTAGAGCTCTA TCCCACCCATTTCTTCCTGCCCAACTTCGCCGCCGACCCGCACCACCGCTCCCTCCTTCTCGCCAGCGGCGGCAGCGGC AGCGGCTCGGGCTGCAGCCCCGGGGCCGGCGGCGGCGGCGGCAGCTCCCGGGCGCCCCACGAAGAGTTGTCAATGTTTC AGCTGCCCACGCTCAACTTCTCCCCGGAGCAAGTGGCCAGCGTCTGCGAGACGCTGGAGGAGACCGGAGACATAGAGAG GCTGGGGAGGTTCCTCTGGTCGCTGCCGGTGGCGCCGGGGGCATGCGAGGCCATCAACAAGCACGAGTCCATCCTGCGC GCCCGGGCGGTGGTGGCCTTCCACACGGGCAACTTCCGCGACCTCTACCACATCCTGGAGAACCACAAATTCACCAAGG AGTCGCACGGCAAGCTGCAGGCCATGTGGCTCGAAGCGCACTACCAGGAGGCCGAGAAGCTGCGGGGCCGCCCGCTGGG GCCGGTTGATAAATACAGGGTGAGGAAGAAGTTTCCGCTGCCCAGGACCATTTGGGATGGCGAGCAGAAGACGCACTGC TTCAAGGAGAGGACTCGCAGCCTCCTGAGGGAGTGGTACCTGCAGGACCCTTACCCCAATCCGAGCAAGAAAAGGGAAC TGGCTCAGGCCACGGGGCTCACCCCCACGCAAGTAGGCAACTGGTTCAAAAACCGAAGGCAAAGAGACAGAGCGGCGGC GGCTAAAAACAGGCTCCAGCACCAGGCGATAGGACAGAGCGGCATGCGGTCGTTGGCAGAGCCCGGCTGCCCGACGCAC AGCTCGGCCGAGTCCCCGTCCACGGCGGCCAGCCCGACCACCAGCGTCTCCAGTTTGACAGAAAGAGCCGAGACGGGCA CCTCCATCCTCTCGGTAACCTCCAGCGACTCGGAATGTGATGTATGATATCGGAAAACAAACAAACAAACAAATCACAA CAACAACAA
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204364 ).