GEISHA - A Chicken Embryo Gene Expression Database
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MMP2
matrix metallopeptidase 2

The human orthologue of this gene is associated
with the following human disease:
Gene
Official SymbolMMP2
Official Full Namematrix metallopeptidase 2
CGNC ID49157
also known as72 kDa type IV collagenase|72 kDa gelatinase|MMP-2|gelatinase A|matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|matrix metalloproteinase-2, 72 kDa type IV collagenase precursor , 72 kDa gelatinase, Matrix metalloproteinase-2 (MMP-2) , Gelatinase A
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_204420
PolypeptideNP_989751
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.3199
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human4313ENSG00000087245MIM:259600MIM:120360
Mouse17390ENSMUSG00000031740All phenotypic alleles (1):Targeted, knock-out(1) MGI:97009
Xenopus548506, 380389482840
Zebrafish337179ENSDARG00000017676ZDB-GENE-030131-9123ZFIN:ZDB-GENE-030131-9123
Gene Ontology
Molecular Functionmetalloendopeptidase activity, zinc ion binding
Biological Processblood vessel maturation, bone trabecula formation, cellular response to amino acid stimulus, more...collagen catabolic process, embryo implantation, face morphogenesis, intramembranous ossification, proteolysis, response to hypoxia
Cellular Componentextracellular space, plasma membrane, proteinaceous extracellular matrix, sarcomere
Links to other databases
Entrez Gene386583
Ensembl Gene
KEGGgga:386583

Entry 1

GEISHA IdMMP2.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerGATGGATTCCTCTGGTGTTC
Reverse cDNA Template PrimerATTAACCCTCACTAAAGGGGTGAGTTTCTTTGGATAGCCcDNA Template Length930
Forward cDNA Template Probeshow
CCCTATCGGGTGCTGGCTGTATAAACCCAGTACTCATTTCCTGCAAAAAATACAGCCTTCTCATCCTGAGGGGACTCGT
AGACAGCATCGATTTTCTCTGGCAGATCAGGCCAGAATGTAGCAACGAGAAGAGGACCTGTGGGTTTTCCTCGAGGGTT
TACAGTCCTCCACATGAATCTGTCTTTGAAGAAAAATATTTCTCCTCTAATTTGTGCAACTCCATCAAATACAATGTCG
TGCTTGCAGAGCTCTGGAGTGACAGGTCCAAGGGTAGGACGTGGTCCTGGCCCTGGTCCTGGCCCTGGTCCAGGTTCCA
CATCAGGTGATACTTCATATAGCTCCTGAATCCCCTTAATGTCATCCTGAGAAAGGCGGAAGTTCTTGGTGTAGGTGTA
GATCGGGGCCATGAGAGCTCCTGGGTCCTCGGAGTGCTCTAATCCCATCGCATGGCCAAATTCGTGGGCAGCAACCAAG
AAGAGACTGTATCCTTGATCTGGACAAAAGCCCCACTTGCGGTCATCATCATAGCTGCTGGTAGAAGCACACCACAGCT
TGCCATCATTGCGACCTGCACTTGTACAGGAGTCGTATTTATTCCCAAGGAAGATGAAGGGGAATACACAAGGAGCTCC
TTCTGAATTTCCACCAACTGTTGACATGGCAGTTTCTGGGCAGAATCCGTATTTCTTATCTCTATCATAGTCTTCAGTG
GTTCCACACCATCTGTATCCATCTGTCCTGCCTTCTGTTGTACACTGGTCATAGGACTGGCCTTGAAATTTAAAGGGAA
ACTTGCAGGGCTGTCCATCACCATTGCCACCCATTGTAAAAAGTGACTCATGGGGACAAAAGCCATATTTGCCATCTGC
ATCAAAGTCTTTGGTTGTGGAACACCA
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 7
stage 8
stage 9
stage 9
stage 10
stage 10
stage 10
stage 10
stage 10
stage 10
stage 11
stage 11
stage 11
Blood Islands
Blood Vessels
Extraembryonic
Extraembryonic Blood Vessels
Forebrain
Head Mesenchyme
Heart
Hindbrain
Lateral Plate Mesoderm
Mesencephalon
Midbrain
Notochord
Somites
 
13-18
stage 15
stage 15
stage 15
stage 15
stage 16
stage 16
stage 16
stage 16
stage 16
Anterior/Second Heart Field
Endocardium
Extraembryonic Blood Vessels
Forebrain
Heart
Hindbrain
Midbrain
Neural Crest
Pharyngeal Arches and Clefts
Sclerotome
Somites
Surface Ectoderm
Trunk Mesenchyme
 
19-24
stage 19
stage 19
stage 20
stage 20
Dermomyotome
Eye
Forebrain
Gut
Heart
Hindbrain
Liver
Midbrain
Neural Crest
Pharyngeal Arches and Clefts
Sclerotome
Surface Ectoderm
 
25-26
stage 26
stage 26
Dermomyotome
Eye
Gut
Leg Mesenchyme
Liver
Mesonephros
Pharyngeal Arches and Clefts
Sclerotome
Wing Mesenchyme
 

Entry 2

GEISHA IdMmp2.Duong.2004Data SourcePublication
Complete cDNA Template Probeshow
ACTCCTGTACAAGTGCAGGTCGCAATGATGGCAAGCTGTGGTGTGCTTCTACCAGCAGCTATGATGATGACCGCAAGTG
GGGCTTTTGTCCAGATCAAGGATACAGTCTCTTCTTGGTTGCTGCCCACGAATTTGGCCATGCGATGGGATTAGAGCAC
TCCGAGGACCCAGGAGCTCTCATGGCCCCGATCTACACCTACACCAAGAACTTCCGCCTTTCTCAGGATGACATTAAGG
GGATTCAGGAGCTATATGAAGTATCACCTGATGTGGAACCTGGACCAGGGCCAGGACCAGGGCCAGGACCACGTCCTAC
CCTTGGACCTGTCACTCCAGAGCTCTGCAAGCACGACATTGTATTTGATGGAGTTGCACAAATTAGAGGAGAAATATTT
TTCTTCAAAGACAGATTCATGTGGAGGACTGTAAACCCTCGAGGAAAACCCACAGGTCCTCTTCTCGTTGCTACATTCT
G
CitationDuong TD, Erickson CA.(2004) MMP-2 plays an essential role in producing epithelial-mesenchymal transformations in the avian embryo. Dev Dyn. Jan;229(1):42-53.
CopyrightWiley-Liss, Inc. 2004
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
7-12
stage 12
stage 12
stage 12
stage 12
stage 12
Lateral Plate Mesoderm
Midbrain
Sclerotome
Somites
head mesenchyme
13-18
stage 15
stage 15
stage 15
stage 15
stage 15
stage 15
stage 16
stage 16
stage 16
Eye
Face Mesenchyme
Myotome
Neural Crest
Neural Plate/Tube
Sclerotome
Somatopleure
Somites
head mesenchyme
somitocoel
19-24
stage 19
stage 19
stage 19
stage 19
stage 19
stage 21
stage 22
stage 24
stage 24
Dermatome
Face Mesenchyme
Limb Buds
Pharyngeal Arches and Clefts
Sclerotome
Somatopleure
Somites
Wing Mesenchyme
dermis
head mesenchyme
mesenchymal dermis
25-30
stage 28
stage 28
stage 30
stage 30
stage 30
Dermatome
Wing Mesenchyme
dermis
dermis
developing feather germs
31-35
stage 35
 dermis
developing feather germs

Entry 3

GEISHA IdMmp2.Linask.2005Data SourcePublication
Complete cDNA Template Probeshow
AATTCCGGCAAAAGAGAAAACGGTGCAGAGAGTTAAGATGTGCAGATAAGCAACTAGTGCACTGTGCAGCCAAAGTAAC
TGACAGTCAGTCAGAGAAATCTTTTAAAGAGGATTGCAAAAATATAGGCAGAATGAAGACTCACAGTGTTTTTGGCTTC
TTTTTTAAAGTACTATTAATCCAAGTGTATCTTTTTAACAAAACTTTAGCTGCACCGTCACCAATCATTAAGTTCCCTG
GAGACAGCACTCCAAAAACAGACAAAGAGCTAGCAGTGCAATACCTGAATAAATATTATGGATGCCCAAAAGACAATTG
CAACTTATTTGTATTGAAAGATACTTTGAAGAAAATGCAGAAATTTTTTGGGCTGCCTGAAACAGGAGATTTGGATCAA
AACACAATTGAGACAATGAAGAAACCCCGCTGTGGTAACCCCGATGTGGCCAATTACAACTTCTTTCCAAGAAAGCCAA
AATGGGAAAAGAATCATATAACATACAGGATTATAGGCTATACCCCGGATTTGGATCCTGAGACAGTAGATGATGCCTT
TGCCCGAGCCTTTAAAGTCTGGAGTGATGTCACGCCACTGAGATTTAACCGAATAAATGATGGAGAGGCAGACATTATG
ATTAATTTTGGCCGATGGGAACATGGTGATGGCTATCCATTTGATGGCAAAGATGGTCTCCTGGCTCACGCCTTTGCAC
CGGGGCCAGGAATTGGAGGAGACTCCCATTTTGATGATGATGAACTGTGGACTCTTGGAGAAGGGCAAGTGGTTAGAGT
AAAGTATGGAAATGCAGATGGTGAATACTGCAAATTTCCCTTCTGGTTCAATGGTAAGGAATACAACAGCTGCACAGAT
GCAGGACGTAATGATGGATTCCTCTGGTGTTCCACAACCAAAGACTTTGATGCAGATGGCAAATATGGCTTTTGTCCCC
ATGAGTCACTTTTTACAATGGGTGGCAATGGTGATGGACAGCCCTGCAAGTTTCCCTTTAAATTTCAAGGCCAGTCCTA
TGACCAGTGTACAACAGAAGGCAGGACAGATGGATACAGATGGTGTGGAACCACTGAAGACTATGATAGAGATAAGAAA
TACGGATTCTGCCCAGAAACTGCCATGTCAACAGTTGGTGGAAATTCAGAAGGAGCTCCTTGTGTATTCCCCTTCATCT
TCCTTGGGAATAAATACGACTCCTGTACAAGTGCAGGTCGCAATGATGGCAAGCTGTGGTGTGCTTCTACCAGCAGCTA
TGATGATGACCGCAAGTGGGGCTTTTGTCCAGATCAAGGATACAGTCTCTTCTTGGTTGCTGCCCACGAATTTGGCCAT
GCGATGGGATTAGAGCACTCCGAGGACCCAGGAGCTCTCATGGCCCCGATCTACACCTACACCAAGAACTTCCGCCTTT
CTCAGGATGACATTAAGGGGATTCAGGAGCTATATGAAGTATCACCTGATGTGGAACCTGGACCAGGGCCAGGACCAGG
GCCAGGACCACGTCCTACCCTTGGACCTGTCACTCCAGAGCTCTGCAAGCACGACATTGTATTTGATGGAGTTGCACAA
ATTAGAGGAGAAATATTTTTCTTCAAAGACAGATTCATGTGGAGGACTGTAAACCCTCGAGGAAAACCCACAGGTCCTC
TTCTCGTTGCTACATTCTGGCCTGATCTGCCAGAGAAAATCGATGCTGTCTACGAGTCCCCTCAGGATGAGAAGGCTGT
ATTTTTTGCAGGAAATGAGTACTGGGTTTATACAGCCAGCAACCTGGATAGGGGCTATCCAAAGAAACTCACCAGCCTG
GGACTACCCCCTGATGTGCAACGCATTGATGCAGCCTTCAACTGGGGCAGAAACAAGAAGACATATATTTTCTCTGGAG
ACAGATACTGGAAGTACAATGAAGAAAAGAAAAAAATGGAGCTTGCAACCCCAAAATTCATTGCGGATTCTTGGAATGG
AGTTCCAGATAACCTCGATGCTGTCCTGGGTCTTACTGACAGCGGGTACACCTATTTTTTCAAAGACCAGTACTATCTA
CAAATGGAAGACAAGAGTTTGAAGATTGTTAAAATTGGCAAGATAAGTTCTGACTGGTTGGGTTGCTGAACTGTAGAAT
ATATTAATAACCAAATATTTACTTTTTTGTTATATACCTTATCTGTAATTAGAAATAGATCTGAATGTCAATTACTGGA
CCAGTCAGGTACTGGCACCCAAACATTAAGTACCAGTACTGTACACATCTGATAATTTAAAAGTGTTTGCCTCCTCAAC
ATACAAAAGATGTTTACGTATCTATTCTGGTACAATTTTTCAGTTTTTGTGCTAGTCATAGCAATGCTAGTAGCAGAAC
ACGCACGGTTCTTTATTCCCCTGGTGCTTGAAGAAAGCATTGAAATCATTGGAGACTGGACCAGACCCCTGTGTTAAAT
CCATCTCAAATAGCCTCAAGTAAGATGTACCAGCAGTGCACTTTGATTTTTTTTTAATTTTTTTTTTTAAATACAACTC
TTTTATAAATAGATGGTTTGTGTTAATGTTTTAACCCTCTTGCGAGTTTGATCATTACTGCCATTTATTACATAATGAT
ACAAAAGACTGTCAAAGGCACAGGTTGCCACGGGATTTGATTTGTATTGATGCATGATGGAATCATGGCAAGAAACTGT
ATTAAAGTATTGTTTTAAAGTACTTTCTATTTTAAAACCTTAGTTCAACTTAGCAATTTGCTTCCTGCACTTTGTTACT
ACTCTATAACTTGTCTATACAGACAGAATGACTCAGATGTTTTAAATCAATGTATTATACACAGAAGTCAAGTATTACT
GTTTACCTTGTTTTATTTTTCTGTTCTTTATAATATTGAGTTTTTGTTTGGTTAGGCTTTCTGCTTAGGCATTGGGCAA
CAGAAGGTGTTCCTTTCACATATGATGGAATGTTTCTCATTAAAAAAAAAAAAGGTTAAAAAAATCCAGAAAACAATGT
CCCAAACATGAAATGCCAATGCTACAAATAAAATTAAATTACACTGTCAAAAAAAAAAAAAAACGGTTAAC
CitationLinask K, Han M, Cai D, Brauer P, Manisastry, S. Cardiac Morphogenesis: Matrix Metalloproteinase Coordination of Cellular Mechanisms Underlying Heart Tube Formation and Directionality of Looping. Dev Dyn. 2005 Jul;233(3):739-53.
CopyrightCopyright © 2005 Wiley-Liss, Inc.
CommentsInsufficient information provided to verify exact probe sequence. Sequence provided is entire cDNA sequence from Accession # U07775.
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
1-3
stage 1
Unlabeled Embryonic
sense probe
7-12
stage 12
stage 12
stage 12
stage 12
stage 12
Endocardium
Splanchnic Mesoderm
dorsal mesocardium
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.3199

Mouse

EmageMGI:97009
EurexpressMGI:97009
MGI GXDMGI:97009

Frog

Xenbase482840

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-030131-9123
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