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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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TBX22
T-box 22

The human orthologue of this gene is associated
with the following human disease:

Cleft palate with ankyloglossia

Gene

Official Symbol	TBX22
Official Full Name	T-box 22
CGNC ID	48947
also known as	T-box transcription factor TBX22
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204106
Polypeptide	NP_989437
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.39941

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	50945	ENSG00000122145	MIM:303400	MIM:300307
Mouse	245572	ENSMUSG00000031241	All phenotypic alleles (3):Targeted, knock-out(2) Targeted, other(1)	MGI:2389465
Xenopus	100494512			994521
Zebrafish	556143	ENSDARG00000091748	ZDB-GENE-090626-2	ZFIN:ZDB-GENE-090626-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	373895
Ensembl Gene	ENSGALG00000004093
KEGG	gga:373895

Entry 1

GEISHA Id	ChEST87l4	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show TGGGCGAATTGGAGCTCCACCGCGGTGGCGGCCGCGGCTCGAGGTACGGCTACAGCTTCTCCATGCCATCCAGACTGAC GAGCACGGCGAGCCATTTCGGAGTGAGTGACAGCCTGCCCGCTGCCTTCAGGGACGGCCGATGCAATCACCCCAGCTGG CACTCAGCAATTAACCACTGCCTTTAGCAGGACGTTGTCATGTTTCCGAGCGTCGGTATGTAATGCAAATCCGTTCCCC GGTCGGATGCAGGGTCTTGCTAATTGCTGAGTATGAAACACGGTGCGGTGCAGGAGCAGTCTGGAGGGCCTTTAATTTG GGGGTAAACATGCAGTATTGTTGGGAGTACAGAGGGCTGTAGTGATCCAAGCAGGCTGATACCCATCACTGGTATTGGT GTAGGGCTGCAGGGGATGGGCGAGCAGTGCAGACACCTTTCTACTATTTGCACTCTGAAATGGGAACGTAGATGTGTGC ATTTCCACAGATCTGTTCTCTTGAAACTATCGAGCTTCCCTGCAGTCAGTCCTGAGCCCCGCCGGCTCCCGCTCATCCC TCCTGCTGATTTCCCCTATTTCCAAATGGACCCTTAAAGAATGTGGGTCAGCAGAGGAGCTGCATGCAGCTGGGGGCTG GAGTGCGCTCACACATTGACCTGGAGCTGGTCAACCCCATGGAAATGCCTCGATGCTGCGGGACCCACATCACAATGCA GACATAGATTGAAGGCTCTGGTGCTACATTAAGGACACAGAGCCCCAGGCAGGGCTTCCCAGAGCCATCCCCATGCATC CCATCCCCATGCATCCCATCCCCATGCAGTGCTGGGGGTGACGAGAGCAGGAGCTGCAGAGGATGAGGATTGAGCAGAG TTACGGACACCCCTCCCGCAGTCCCATCTGTTTTATTTTCACCTGTGATAATTGTGTTATTCCTGTAAATAATCTCTGG CTCCAGGGGCACAGTGCAGCTCGCTGTAAGTTGGGGCACAGCTTATATTCGCTCCCCAAAGCCACTTCTGTTACCTATG ACAGATGTGATACAAAGTGCCTGGCGGGGACCCGCCGTATTTTGGGATTAAGTAAAGACAATTCTGTATCTACAAACAT AACAGCAATATATAAGGATTAAATGTAGGTTTAAAAACCAAAAAAAGAATTCGATATCAAGCTTATCGATACCGTCGAC CTCGAGGGGGCCC

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

7-12

stage 7

Paraxial Mesoderm

13-18

stage 13

stage 16

stage 18

Head Mesenchyme
Hindbrain
Midbrain
Somites

19-20

stage 20

Head Mesenchyme
Pharyngeal Arches and Clefts
Somites

Entry 2

GEISHA Id	TBX22.Fuchs.2010	Data Source	Publication
Complete cDNA Template Probe	show GGGAAGCACTTAATTGTTCCCTACATCCTCCATATGGTTTGTACGGCTACAGCTTCTCCATGCCATCCAGACTGACGAG CGCGGCGAGCCATTTCGGAGTGAGTGACAGCCTGCCCGCTGCCTTCAGGGACAGCCGATGCAATCACCCCAGCTGGCAC TCAGCAATTAACCACTGCCTTTACAGGACGTTGTCATGCTTCCGAGCGTCGGTATGTAATGCAAATCCGTTCCCCGGTC GGATGCAGGTTCTTGCTAATTGCTGAGTATGAAACACGGTGCGGTGCAGGAGCAGTCTGGAGGGCCTTTAATTTGGGGG TAAACATGCAGTATTGTTGGGAGTACAGAGGGCTGTAGTGATCCAAGCAGGCTGATACCCATCGCTGGTATTGGTGTAG GGCTGTAGAGGATGGGCGAGCAGTGCAGACACCTTTCTACTATTTGCACTCTGAAGGGGGAACGTAGATGTGTGCATTT CCACAGATCTGTTCTCCTGAAACTATCGAGCTTCCCTGCAGTCAGTCCTGAGCCCCGCCGGCTCCCGCTCATCCCTCCT GCTGATTTCCCCTATTTCCAAATGGACCCTTAAAGAATGTGGGTCAGCAGAGGAGCTGCATGCAGCTGGGGGCTGGAGT GCGCTCACACATTGACCTGGAGCTGGTCAACCCCATGGAAATGCCTCGATGCTGCGGGACCCACATCACAATGCAGACA TAGATTGAACGGCTCTGGTGCTGCATTAAGGACACAGAGCCCCAGGCAGGGCTTCCAGAGCCATCCCATGCATCCCATC CC
Citation	Fuchs A, Inthal A, Herrmann D, Cheng S, Nakatomi M, Peters H, Neubüser A. Regulation of Tbx22 during facial and palatal development. Dev Dyn. 2010 Nov;239(11):2860-74.
Copyright	© 2010 Wiley-Liss, Inc.
Comments	The cDNA template for the TBX22 antisense probe was obtained from BBSRC - ChEST294k6 as described in Fuchs et al.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 18

Eye
Face Mesenchyme
Nasal Placode/Nerve

19-24

stage 19

stage 23

Eye
Face Mesenchyme
Nasal Placode/Nerve

25-27

stage 26

stage 27

Eye
Face Mesenchyme

mx, maxilla; mn mandible
op, olfactory pit

Entry 3

GEISHA Id	TBX22.Paxton.2010	Data Source	Publication
Complete cDNA Template Probe	show GGCCTTTAATTTGGGGGTAAACATGCAGTATTGTTGGGAGTACAGAGGGCTGTAGTGATCCAAGCAGGCTGATACCCAT CACTGGTATTGGTGTAGGGCTGCAGGGGATGGGCGAGCAGTGCAGACACCTTTCTACTATTTGCACTCTGAAATGGGAA CGTAGATGTGTGCATTTCCACAGATCTGTTCTCTTGAAACTATCGAGCTTCCCTGCAGTCAGTCCTGAGCCCCGCCGGC TCCCGCTCATCCCTCCTGCTGATTTCCCCTATTTCCAAATGGACCCTTAAAGAATGTGGGTCAGCAGAGGAGCTGCATG CAGCTGGGGGCTGGAGTGCGCTCACACATTGACCTGGAGCTGGTCAACCCCATGATCGAAATGCCTCGATGCTGCGGGA CCCACATCACAATGCAGACATAGATTGAAGGCTCTGGTGCTACATTAAGGACACAGAGCCCCAGGCAGGGCTTCCCAGA GCCATCCCCATGCATCCCATCCCCATGCATCCCATCCCCATGCAGTGCTGGGGGTGACGAGAGCAGGAGCTGCAGAGGA TGAGGATTGAGC
Citation	Paxton CN, Bleyl SB, Chapman SC, Schoenwolf GC. Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns. 2010 Jan;10(1):31-43. Epub 2009 Nov 11.
Copyright	2009 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204106)

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 5

Unlabeled

7-12

stage 7

stage 8

stage 11

Ear/Otic Placode
Early Mesoderm
Head Mesenchyme
Mesoderm
Neural Plate/Tube
Somites

13-16

stage 14

stage 16

Head Mesenchyme
Somites

Entry 4

GEISHA Id	TBX22.SzaboRogers.2009	Data Source	Publication
Complete cDNA Template Probe	show TCTCCTCTCGCCTCACTCGGAGCACCTCGCCGTGCCCGCTGCCCCCCGACGGCCGCCGGCTGCGGGCCCCCCCCGCGCC CTCATGGAGCCGCCGCCCGGAGCTCCGCCGCCCGCCTGAGCCCCGCGGCCGCCCGGGGGGAGCCCGGCCCGGGCTGGGG GGGGGATGGCGCTCAGCTCCCGGGCTCACGCCTTCTCGGTGGAAGCCCTCGTGGGCCGCTCGGCCAAGAGAAAGGGACC CGACGGCCGCGACGAGGAGAGCGGGGCGGGCTGCAGGCAGAGCCGCAGAGCCTCCGAGCCCGAGAAGCGGCCCAAGGCC GGCGCCGAGAGCCGGGAGGTGGGGGACGAGGTGCAGGTGGAGCTGCAGGGCTCCGAGCTCTGGAAGAGGTTCCACGAGA TCGGCACCGAGATGATCATCACCAAGGCCGGCAGGCGGATGTTCCCATCGGTCAGGGTGAAGGTGAAGGGGCTGGAGCC ACTGCAGCAGTATTACATCGCCATCGATGTTGTGCCAGTGGACTCCAAACGGTACAGGTATGTCTACCACAGCTCACAG TGGATGGTGGCAGGGAACACGGACCACTCCTGCATCACACCACGGCTCTACATCCACCCCGACTCCCCCTGCTCGGGGG AAACGTGGATGAGGCAAATCATCAGCTTCGACCGGGTGAAGCTCACCAACAACGAGATGGACGACAAGGGGCACATCAT CCTGCAGTCCATGCACAAGTACAAGCCCCGTGTCCACGTTATCGCCCAGGACTCCCGCTTCGACCTGGCGCAGATTCAG TCGCTGCCGGCTGAGGGGGTGCGCACCTTCTCCTTCCAGGAGACCGAGTTCACCACGGTCACAGCCTACCAGAACCAGC AGATCACCAAGCTGAAGATCGATAGGAACCCCTTCGCCAAAGGCTTTCGGGACCCTGGCAGGAACAGGGGAGTGCTGGA TGGGCTCCTGGAGCCCTTCCCATGGCGGCCACCGCTCGCTCTGGACTTGAAGGCCTTTGGCGCAGACAGCCAGGGCAGC AGCTCCAGCTCTTCCCCGGTGACCTCCAGTGCTGGGACACCCTCTCCTCTCAACCCACTGCTGTCCCCTCCGTGCTCAC CTCCCACCTTCCACCTGGCTGTGAGCGGTGCCAGTGCGCCGTGCCCTGAGTCCCACCTGCCCGGCCTCGGCGTGCCCCT CTGCTACCGGCTGTGCCCTGCCAACCTCCTCCGTCAGCAGCCCCTCATCCTCCCCAGCCACCAGAAGCCAGGCGGCCCC GGTCCCCCCATCCTGCCCCACTTTGTGGTCGATGTACCCAAGCTCTCCTCCCTCGGCATCGCCAGCCTGAAGAGCGCTA AGTCTGAAGACCTGAGCGGGCCGTGTCTGCAGGTCCCCAACTCCGCCAGCCAAATGCTGTATGGATTACATGCATCTGG AAACATTTTCCCATCGAGTCCCATTGCTCGGGAAGCACTTAATTGTTCCCTACATCCTCCATATGGTTTGTACGGCTAC AGCTTCTCCATGCCATCCAGACTGACGAGCACGGCGAGCCATTTCGGAGTGAGTGACAGCCTGCCCGCTGCCTTCAGGG ACGGCCGATGCAATCACCCCAGCTGGCACTCAGCAATTAACCACTGCCTTTAGCAGGACGTTGTCATGTTTCCGAGCGT CGGTATGTAATGCAAATCCGTTCCCCGGTCGGATGCAGGGTCTTGCTAATTGCTGAGTATGAAACACGGTGCGGTGCAG GAGCAGTCTGGAGGGCCTTTAATTTGGGGGTAAACATGCAGTATTGTTGGGAGTACAGAGGGCTGTAGTGATCCAAGCA GGCTGATACCCATCACTGGTATTGGTGTAGGGCTGCAGGGGATGGGCGAGCAGTGCAGACACCTTTCTACTATTTGCAC TCTGAAATGGGAACGTAGATGTGTGCATTTCCACAGATCTGTTCTCTTGAAACTATCGAGCTTCCCTGCAGTCAGTCCT GAGCCCCGCCGGCTCCCGCTCATCCCTCCTGCTGATTTCCCCTATTTCCAAATGGACCCTTAAAGAATGTGGGTCAGCA GAGGAGCTGCATGCAGCTGGGGGCTGGAGTGCGCTCACACATTGACCTGGAGCTGGTCAACCCCATGATCGAAATGCCT CGATGCTGCGGGACCCACATCACAATGCAGACATAGATTGAAGGCTCTGGTGCTACATTAAGGACACAGAGCCCCAGGC AGGGCTTCCCAGAGCCATCCCCATGCATCCCATCCCCATGCATCCCATCCCCATGCAGTGCTGGGGGTGACGAGAGCAG GAGCTGCAGAGGATGAGGATTGAGCAGAGTTACGGACACCCCTCCCGCAGTCCCATCTGTTTTATTTTCACCTGTGATA ATTGTGTTATTCCTGTAAATAATCTCTGGCTCCAGGGGCACAGTGCAGCTCGCTGTAAGTTGGGGCACAGCTTATATTC GCTCCCCAAAGCCACTTCTGTTACCTATGACAGATGTGATACAAAGTGCCTGGCGGGGACCCGCCGTATTTTGGGATTA AGTAAAGACAATTCTGTATCTACAAACATAACAGCAATATATAAGGATTAAATGTAGGTTTAAAAATCAAAAAAAAAAA AAAAAAAAAAA
Citation	Szabo-Rogers HL, Geetha-Loganathan P, Whiting CJ, Nimmagadda S, Fu K, Richman JM. Novel skeletogenic patterning roles for the olfactory pit. Development. 2009 Jan;136(2):219-29. Epub 2008 Dec 4.
Copyright	Published by The Company of Biologists 2009. This material is protected by a copyright retained by the authors. Permission requested from Dr. Richman.
Comments	As insufficient information is provided in publication to verify the exact sequence used to synthesize probe, the sequence below was obtained from NCBI acc# NM_204106.