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Gene Family QuickSearch
Human Disease Gene Search
FGFR3 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol FGFR3 Official Full Name fibroblast growth factor receptor 3 CGNC ID 49846 also known as fibroblast growth factor receptor 3|FGFR-3|fibroblast growth factor receptor 3-IIIc|tyrosine kinase (cek2)|tyrosine kinase receptor CEK2, Fibroblast growth factor receptor 3 precursor , FGFR-3, Tyrosine kinase receptor CEK2, CEK2 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id FGFR3.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATAGGCGGCAGAATACTTGAGGAG Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGCGTCTTCAGCACTGTGACATAGGG cDNA Template Length 763 Complete cDNA Template Probe show CGCCTTTCTGGAAGAGTTGGTGTTTGGAAGTGGAGATACCATTGAACTTTCCTGTAACACCCAGAGCTCTTCTGTGTCA
Entry 2 GEISHA Id FGFR3b.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATGCTGAAGACGTCTTGGATCA Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGGCTCCTCTGCTTTTGGTTTG cDNA Template Length 146 Forward cDNA Template Probe show NNGTCTTGGATCAGTAAAAACGCTGAAGCCGATGCTAACCTAAATCTGTTCAATGTGGCAGAACAAGATGAAGGAGAAT
Reverse cDNA Template Probe show NTTTTGGGNNNCCCACTCCGCAGCCCGAGTGTGGAGCCAAAATGGCTTTTCGGCTATGCCTACGAAATTGTTGGCTCTA
Comments FGFR3b is a splice variant of FGFR3. The probe recognizes only the "b" variant.
Entry 3 GEISHA Id FGFR3c.UApcr Data Source GEISHA ISH Analysis Forward cDNA Template Primer TTATAAAAGCTTGCGGCCGCAGAATATGCTGAAGACGGCAGGTGTTA Reverse cDNA Template Primer GCTCTAGAAATTAACCCTCACTAAAGGGCTCCTCTGCTGGTAGCACC cDNA Template Length 141 Forward cDNA Template Probe show NCTGCTGAAGACGGCAGGTGTTAACACAACGGATAAGGAGCTAGAGATTCTGTACTTGCGAAATGTTACTTTTGAGGAT
Reverse cDNA Template Probe show GGGGTTGTTAGGGAGTTCAGCCAAGCAGAGTGATGTGAGAACCCAATAGAATTCCCTGCGAGACAAGTATATTCCCCAG
Comments FGFR3c is a splice variant of FGFR3. The probe recognizes only the "c" variant.
Entry 4 GEISHA Id Fgfr3.Lunn.2007 Data Source Publication Complete cDNA Template Probe show CGCCGCCGCCTCCCGCCCGCCGCCGCGGGGCTTGCGCAGCGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCG
Citation Lunn JS, Fishwick KJ, Halley PA, Storey KG. A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo.
Dev Biol. 2007 Feb 15;302(2):536-52. Epub 2006 Oct 14. Copyright Copyright © 2006 Elsevier Inc. All rights reserved. Comments Insufficient information in publication to verify exact sequence used to
synthesize probe. Sequence below was obtained from NCBI (acc #NM_205509).
Entry 5 GEISHA Id Fgfr3.Shin.2005 Data Source Publication Complete cDNA Template Probe show CGCCGCCGCCTCCCGCCCGCCGCCGCGGGGCTTGCGCAGCGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCG
Citation Shin M, Watanuki K, Yasugi S (2005).
Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach. Gene Expr Patterns. 2005 Apr;5(4):511-6. Copyright Copyright © 2004 Elsevier B.V. All rights reserved. Comments According to authors cFgfr3 and quail Fgfr4 were a gift from Dr C. Marcelle; Marics et al., 2002. As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205509). This sequence shows strong similarity to Stathmin-like 3, NW_001471567 on Chromosome 20 for nt 3241-3693. Nucleotides 1-3230 match with Fgfr3. These were selected to represent the probe.
Entry 6 GEISHA Id FGFR3.Yoshioka.2005 Data Source Publication Complete cDNA Template Probe show CGCCGCCGCCTCCCGCCCGCCGCCGCGGGGCTTGCGCAGCGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCG
Citation Yoshioka H, Ishimaru Y, Sugiyama N, Tsunekawa N, Noce T, Kasahara M, Morohashi K (2005). Mesonephric FGF signaling is associated with the development of sexually indifferent gonadal primordium in chick embryos. Dev Biol. 2005 Apr 1;280(1):150-61. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205509).
Entry 7 GEISHA Id FGFR3.Walshe.2000 Data Source Publication Complete cDNA Template Probe show TGCCGTCAGATCGAGGAAACTACACCTGTGTTGTGGAGAACAAATATGGCAATATTAGGCACACATACCAGCTTGATGT
Citation Walshe J, Mason I. Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo. Mech Dev. 2000 Jan;90(1):103-10. Copyright Copyright © 2000 Elsevier Ireland Ltd. All rights reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_205509.2)
Entry 8 GEISHA Id FGFR3/CEK2.Domowicz.2008 Data Source Publication Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Citation Domowicz MS, Sanders TA, Ragsdale CW, Schwartz NB. Aggrecan is expressed by embryonic brain glia and regulates astrocyte development. Dev Biol. 2008 Mar 1;315(1):114-24. Epub 2008 Jan 22. Copyright Copyright © 2008 Published by Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_205509.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-35 stage 35
stage 35
Hindbrain
Entry 9 GEISHA Id FGFR3.Nishita.2011 Data Source Publication Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Citation Nishita J, Ohta S, Bleyl SB, Schoenwolf GC. Detection of isoform-specific fibroblast growth factor receptors by whole-mount in situ hybridization in early chick embryos. Developmental Dynamics 240:1537-1547, 2011.
Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #: NM_205509.2 ).
Entry 10 GEISHA Id FGFR3b.Nishita.2011 Data Source Publication Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Citation Nishita J, Ohta S, Bleyl SB, Schoenwolf GC. Detection of isoform-specific fibroblast growth factor receptors by whole-mount in situ hybridization in early chick embryos. Developmental Dynamics 240:1537-1547, 2011.
Copyright Copyright © 2011 Wiley-Liss, Inc. Comments FGFR3b is a splice variant fragment isolated from FGFR3. The sequence was obtained from NCBI (acc# NM_205509.2).
Entry 11 GEISHA Id FGFR3c.Nishita.2011 Data Source Publication Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Citation Nishita J, Ohta S, Bleyl SB, Schoenwolf GC. Detection of isoform-specific fibroblast growth factor receptors by whole-mount in situ hybridization in early chick embryos. Developmental Dynamics 240:1537-1547, 2011.
Copyright Copyright © 2011 Wiley-Liss, Inc. Comments FGFR3c is a splice variant fragment isolated from FGFR3. The sequence was obtained from NCBI (acc# NM_205509.2).
Entry 12 GEISHA Id FGFR3.Hardy.2011 Data Source Publication Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Citation Hardy KM, Yatskievych TA, Konieczka J, Bobbs AS, Antin PB. FGF signalling through RAS/MAPK and PI3K pathways regulates cell movement and gene expression in the chicken primitive streak without affecting E-cadherin expression. BMC Dev Biol. 2011 Mar 21;11:20.
Copyright © 2011 Hardy et al; licensee BioMed Central Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205509).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4 stage 4
stage 4
stage 4
Epiblast Primitive Streak
Entry 13 GEISHA Id FGFR3.Paxton.2010 Data Source Publication Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Citation Paxton CN, Bleyl SB, Chapman SC, Schoenwolf GC.
Identification of differentially expressed genes in early inner ear development. Gene Expr Patterns. 2010 Jan;10(1):31-43. Epub 2009 Nov 11.
Copyright 2009 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205509).
Entry 14 GEISHA Id FGFR3.Moura.2011 Data Source Publication Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Citation Moura RS, Coutinho-Borges JP, Pacheco AP, Damota PO, Correia-Pinto J. FGF signaling pathway in the developing chick lung: expression and inhibition studies. PLoS One. 2011 Mar 11;6(3):e17660. Copyright PLoS One is an open access journal Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205509).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Lung 25-29 stage 27
stage 29
Lung
Entry 15 GEISHA Id FGFR3.Sheeba.2010 Data Source Publication Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Citation Sheeba CJ, Andrade RP, Duprez D, Palmeirim I.
Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development. Int J Dev Biol. 2010;54(10):1517-26.
Copyright © UBC Press Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #NM_205509 ).
Entry 16 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Wing 25-30 stage 30
Wing Ectoderm
Entry 17 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Wing 25-30 stage 30
Wing Ectoderm
Entry 18 GEISHA Id FGFR3.Domowicz.2009 Data Source Publication Complete cDNA Template Probe show ANCNTNATNNCATNTACTNCTNTTNCATANNCACCNCNCNTNATNNCATNTACTNCTNTNCATANNCACCNCCGCAGCA
Citation Domowicz MS, Cortes M, Henry JG, Schwartz NB. Aggrecan modulation of growth plate morphogenesis. Dev Biol. 2009 May 15;329(2):242-57. Epub 2009 Mar 3. Copyright Copyright © 2009 Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NC_006091.3)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
stage 29
Leg Bones 31-38 stage 34
stage 34
stage 38
stage 38
Leg Bones
Entry 19 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 21
stage 21
Head Mesenchyme Limb Buds 25-30 stage 26
stage 28
stage 28
stage 28
stage 30
Leg Bones Limb Buds
Entry 20 GEISHA Id FgfR3.Abzhanov.2007 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (acc # NM_205509.2 ).
Entry 21 GEISHA Id FGFR3.Anderson.2021 Data Source Direct Submission Complete cDNA Template Probe show CGCAGCAGCGGAGCGGAGCGCTGAGCGGCGGCAGCATGCGGCCGGGGGATGTCTGAGGCGGGCGGCGGTGCGGCGGCGG
Comments Images provided by Claire Anderson. As insufficient information was provided to verify sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_205509.2).
Related article: Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j. yd bio. 2019.07.003. Epub 2019 Jul 5. (PMID: 31283921).
Entry 22 GEISHA Id FGFR3.Anderson.2019 Data Source Publication Complete cDNA Template Probe show GGGCAGACGTTGGAGCGCCGCGGCGGCGGGCGGGAGGCGGCGGCTCCTCCATGCGCGGTGCGCGGGCGGCCGCGGGGCT
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_015285877 )
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Proepicardium all
Data from NCBI Unigene EST ProfileGga.14066
Mouse Frog Fruit Fly Zebra Finch Zebrafish
