GEISHA - A Chicken Embryo Gene Expression Database
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CDH6
cadherin 6

Gene
Official SymbolCDH6
Official Full Namecadherin 6
CGNC ID9782
also known asc-cad6B, cadherin-6, cadherin-6B, cadherin-6|cadherin 6, type 2, K-cadherin (fetal kidney)|cadherin 6B, Cadherin-6 precursor , Cadherin-6B, c-cad6B
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_001001758
PolypeptideNP_001001758
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.600
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human1004ENSG00000113361MIM:603007
Mouse12563ENSMUSG00000039385All phenotypic alleles (4):Targeted, knock-out(2) Targeted, other(2) MGI:107435
Xenopus100495587, 373627484591
Zebrafish541393ENSDARG00000014522ZDB-GENE-050320-92ZFIN:ZDB-GENE-050320-92
Gene Ontology
Molecular Functioncalcium ion binding
Biological Processhomophilic cell adhesion
Cellular Componentcytoplasm, integral component of membrane, nucleus, plasma membrane
Links to other databases
Entrez Gene414842
Ensembl GeneENSGALG00000012917
KEGGgga:414842

Entry 1

GEISHA IdCDH6.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerCAAGTGGAAGATGTAGATGAACCCC
Reverse cDNA Template PrimerATTAACCCTCACTAAAGGTTCTGGCACAATGTCTCTGCGcDNA Template Length969
Forward cDNA Template Probeshow
GGCTCGGGANTCCCAGCGNCCGATATCAAATGCCTGGGTGTCTTCCTCTCCACCACGNTCATCATTATAACTGACAATG
TTGTCTCTGATGTCTTCTTTGGAAATAATCAAAGGCTCTTTTTTCCTTTGCCGTCTCAGTGCTGCAAACAACACCACTG
TAACAAGTAATATAATGATACAGAGAAGAATGGCAATAAGAGCCCCAGTGCTAAGACCAGTAGGATGAATCAAGGCTTC
CGCATTACAGGACAGCATCTTTCCTCGATGGTCACAAGCACATACACGAATAGTCACTGTTTCAGTGCTGCTCTGGATA
GGGTAGTCATTGTCTGATATTACCACTGGCAAAAGGTAGGTACTCATTTCATGCCGGTTATATCTGATTTTTCGGGTGA
AAATCCCCGCTGTGTTGTCTCTGTTGTCCTGGAGTGTAAAGTTTGAGCTGCTGGCTGCCTCTGGAGCTATGCTGAATGA
AAACTGGTGTCCACTGTAAGAGTCATCTTTATCAACAGCACTCAATGTTTGTATCAGCTGTTCTGCCTTTGCATTTTCA
CAGACAAAGGTCTCATAAAACATGGCAAACTCTGGAGCATTGTCGTTTACATCCAAAACCTTAATGAACACTGGGACAC
GGCTGCTTTGTTTTGGGTTGTTGATCTCTGCTGCTATTACTGTAATGTTGTGCCATAGCAATGTTTCCCGGTCAAGAGT
TTTTGACGTAAATATCGAACCATTTCCTGAGTTGATGTTGAATACTCTGTCCATATCAGTGTGTCGATCTACAGAATAC
TTGACAGGGTTCTTGGCAGCATCTGGATCCTGTGCTGTTACTGTTCCTATTACACTGTTTATTGGAACATCTTCTTTTC
ACTTCAATTATANATGCTGGTCTGCTGAACACAGGGGGGTTCATCTACATCTTTCCA
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 5
stage 6
Early Mesoderm
Neural Plate/Tube
 
7-12
stage 8
stage 8
stage 9
stage 10
stage 10
stage 10
stage 11
stage 11
stage 11
Blood Islands
Forebrain
Lateral Plate Mesoderm
Midbrain
Neural Plate/Tube
 
13-18
stage 15
stage 15
stage 15
stage 16
stage 16
Amnion
Diencephalon
Eye
Forebrain
Foregut
Heart
Hindbrain
Lateral Plate Mesoderm
Liver
Lung
Midbrain
Neural Plate/Tube
Pancreas
Pharynx
Somatic Mesoderm
Spinal Cord
Splanchnic Mesoderm
 
19-24
stage 21
stage 21
stage 21
stage 21
stage 21
stage 23
Cranial PNS
Diencephalon
Foregut
Heart
Hindbrain
Hindgut
Liver
Lung
Midgut
Pancreas
Spinal Cord
Trunk Mesenchyme
 
25
stage 25
stage 25
stage 25
stage 25
stage 25
stage 25
Aorta
Cardinal Veins
Cranial PNS
Foregut
Heart
Hindgut
Liver
Lung
Mesonephros
Midgut
Pancreas
Pineal Gland
Spinal Cord
Spinal Ganglia and Nerves
Trunk Mesenchyme
 

Entry 2

GEISHA IdCad6B.Jiankai.2007Data SourcePublication
Complete cDNA Template Probeshow
GGTTCGAAGACGATCAGATAGAGAGCCCCCTCGGCTCGGGCTGCCTGCATGCGGGAGTTAAAAAGTGCTGCCGGTCGAG
CGGCAGCCCCAGTGAGCGGCGGGGAGGCTGAGAGCGGGCAGCAGGGGCCGGGAGCCGCCGCCACCCATCCCAGCTTGGC
CCTGCGAGCCGAGATCCTCTGAGACTGCAAAGACTACTTAAAGAACGAAGACGGCATGAGATTGGATTTGATCCAGTAA
AATAGGTTAGCTTGAGGACAAGAAAAACAGTTGCTATTTAGATCTTCTCTTGTTGCCGTGATGAGAACTTACCATTGCT
TCTGGTTGCTGTTTTGGGCTGGCCAGCCCCACCAAAGTTTTTTAACTTTGCTGTCCAAAAGGACTAGTGGCTTTCCAGA
GAAGGAAAAGGTTTTGGTATTGTCTGGAAACAGCAGGAGAGACCTCAGTCGTTCCAAAAGGAGTTGGATGTGGAATCAG
TTCTTTTTACTGGAAGAATATACAGGAACTGACTATCAGTATGTTGGCAAGCTGCATTCAGACCAGGATAAAGGAGATG
GATCACTTAAGTACATCCTTTCTGGAGATGGAGCAGGAGACCTCTTCATTATCAATGAAAACACTGGTGACATCCAAGC
CACAAAGAGACTAGACAGAGAAGAAAAGCCTGTGTACATACTTCGTGCCCAGGCTATAAACCGAAGAACTGGAAGACCA
GTGGAACCAGAATCTGAGTTCATCATCAAGATCCATGATATCAACGACAATGAGCCAATGTTTACAAAGGACGTTTACA
ATGCCAGCATTCCAGAAATGTCAGATGTTGGTACCTTTGTTGTGCAAGTCACTGCAACTGATGCCGATGATCCTACATA
TGGGAACAGCGCTAAAGTTGTCTACAGCATTCTCCAGGGACAACCATATTTCTCTGTAGAATCTGAGACAGGTATTATT
AAAACTGCTTTGCTAAACATGGACCGTGAAAACAGGGAGCAATATCAAGTGGTCATCCAAGCTAAGGACATGGGAGGCC
AGATGGGCGGATTATCAGGAACCACCACTGTGAACATCACACTGACCGACGTAAATGACAATCCTCCTCGGTTCCCCCA
GAGCACCTACCAATTCAGAGCTCCTGAGTCTACGCCACCTGACTCACCAATTGGCAGGATTAAAGCTAATGATGCAGAT
GTGGATGAAAATGCAGAGATTGAATACAGCATCACTGAGGGGGATGGATATGACATGTTTGGAATTACCACAGACAAGG
ACACACAGGAAGGAATTATAACTGTCAAAAAGGCACTGGATTTTGAAAATAAAAACTTGTATATTCTGAAGGTGGAAGC
CACCAATACTCACGTGGACCCTCGATTCCTCTACTTGGGGCCATTCAAGGATTCAGCCACAATCAGAATTCAAGTGGAA
GATGTAGATGAACCCCCTGTGTTCAGCAGACCAGCATATATAATTGAAGTGAAAGAAGATGTTCCAATAAACAGTGTAA
TAGGAACAGTAACAGCACAGGATCCAGATGCTGCCAAGAACCCTGTCAAGTATTCTGTAGATCGACACACTGATATGGA
CAGAGTATTCAACATCAACTCAGGAAATGGTTCGATATTTACGTCAAAAACTCTTGACCGGGAAACATTGCTATGGCAC
AACATTACAGTAATAGCAGCAGAGATCAACAACCCAAAACAAAGCAGCCGTGTCCCAGTGTTCATTAAGGTTTTGGATG
TAAACGACAATGCTCCAGAGTTTGCCATGTTTTATGAGACCTTTGTCTGTGAAAATGCAAAGGCAGAACAGCTGATACA
AACATTGAGTGCTGTTGATAAAGATGACTCTTACAGTGGACACCAGTTTTCATTCAGCATAGCTCCAGAGGCAGCCAGC
AGCTCAAACTTTACACTCCAGGACAACAGAGACAACACAGCGGGGATTTTCACCCGAAAAATCAGATATAACCGGCATG
AAATGAGTACCTACCTTTTGCCAGTGGTAATATCAGACAATGACTACCCTATCCAGAGCAGCACTGAAACAGTGACTAT
TCGTGTATGTGCTTGTGACCATCGAGGAAAGATGCTGTCCTGTAATGCGGAAGCCTTGATTCATCCTACTGGTCTTAGC
ACTGGGGCTCTTATTGCCATTCTTCTCTGTATCATTATATTACTTGTTACAGTGGTGTTGTTTGCAGCACTGAGACGGC
AAAGGAAAAAAGAGCCTTTGATTATTTCCAAAGAAGACATCAGAGACAACATTGTCAGTTATAATGATGAAGGTGGTGG
AGAGGAAGACACCCAGGCATTTGATATCGGCACGCTGAGGAATCCCGAAGCCATAGATGATAATAAATTACGCAGAGAC
ATTGTGCCAGAAACGCTTTTTATGCCACGGCGGACTGCAACAGCCCGAGATAACACGGATGTCAGAGATTTCATTAACC
AAAGGTTAAAGGAGAATGATACAGACCCAGCAGCCCCCCCGTATGACTCGTTAGCGACCTACGCATACGAAGGTAATGG
TTCTGTGGCAGAGTCCCTCAGCTCTCTGGAGTCGGTGACTACAGACGGAGACCAGGACTATGATTACCTCAGTGACTGG
GGGCCGCGGTTTAAAAAGTTGGCAGATATGTATGGCTCAATGGACAGTGACAAAGACTCTTAATATGTTGCCTCTAG
CitationLuo J, Wang H, Lin J, Redies C. Cadherin expression in the developing chicken cochlea. Dev Dyn. 2007 Aug;236(8):2331-7.
CopyrightCopyright © 2007 Wiley-Liss, Inc.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_001001758).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
31-44
stage 37
stage 40
stage 44
Ear/Otic Placcode
 

Entry 3

GEISHA IdCadherin6B.Taneyhill.2005Data SourcePublication
Complete cDNA Template Probeshow
GGTTCGAAGACGATCAGATAGAGAGCCCCCTCGGCTCGGGCTGCCTGCATGCGGGAGTTAAAAAGTGCTGCCGGTCGAG
CGGCAGCCCCAGTGAGCGGCGGGGAGGCTGAGAGCGGGCAGCAGGGGCCGGGAGCCGCCGCCACCCATCCCAGCTTGGC
CCTGCGAGCCGAGATCCTCTGAGACTGCAAAGACTACTTAAAGAACGAAGACGGCATGAGATTGGATTTGATCCAGTAA
AATAGGTTAGCTTGAGGACAAGAAAAACAGTTGCTATTTAGATCTTCTCTTGTTGCCGTGATGAGAACTTACCATTGCT
TCTGGTTGCTGTTTTGGGCTGGCCAGCCCCACCAAAGTTTTTTAACTTTGCTGTCCAAAAGGACTAGTGGCTTTCCAGA
GAAGGAAAAGGTTTTGGTATTGTCTGGAAACAGCAGGAGAGACCTCAGTCGTTCCAAAAGGAGTTGGATGTGGAATCAG
TTCTTTTTACTGGAAGAATATACAGGAACTGACTATCAGTATGTTGGCAAGCTGCATTCAGACCAGGATAAAGGAGATG
GATCACTTAAGTACATCCTTTCTGGAGATGGAGCAGGAGACCTCTTCATTATCAATGAAAACACTGGTGACATCCAAGC
CACAAAGAGACTAGACAGAGAAGAAAAGCCTGTGTACATACTTCGTGCCCAGGCTATAAACCGAAGAACTGGAAGACCA
GTGGAACCAGAATCTGAGTTCATCATCAAGATCCATGATATCAACGACAATGAGCCAATGTTTACAAAGGACGTTTACA
ATGCCAGCATTCCAGAAATGTCAGATGTTGGTACCTTTGTTGTGCAAGTCACTGCAACTGATGCCGATGATCCTACATA
TGGGAACAGCGCTAAAGTTGTCTACAGCATTCTCCAGGGACAACCATATTTCTCTGTAGAATCTGAGACAGGTATTATT
AAAACTGCTTTGCTAAACATGGACCGTGAAAACAGGGAGCAATATCAAGTGGTCATCCAAGCTAAGGACATGGGAGGCC
AGATGGGCGGATTATCAGGAACCACCACTGTGAACATCACACTGACCGACGTAAATGACAATCCTCCTCGGTTCCCCCA
GAGCACCTACCAATTCAGAGCTCCTGAGTCTACGCCACCTGACTCACCAATTGGCAGGATTAAAGCTAATGATGCAGAT
GTGGATGAAAATGCAGAGATTGAATACAGCATCACTGAGGGGGATGGATATGACATGTTTGGAATTACCACAGACAAGG
ACACACAGGAAGGAATTATAACTGTCAAAAAGGCACTGGATTTTGAAAATAAAAACTTGTATATTCTGAAGGTGGAAGC
CACCAATACTCACGTGGACCCTCGATTCCTCTACTTGGGGCCATTCAAGGATTCAGCCACAATCAGAATTCAAGTGGAA
GATGTAGATGAACCCCCTGTGTTCAGCAGACCAGCATATATAATTGAAGTGAAAGAAGATGTTCCAATAAACAGTGTAA
TAGGAACAGTAACAGCACAGGATCCAGATGCTGCCAAGAACCCTGTCAAGTATTCTGTAGATCGACACACTGATATGGA
CAGAGTATTCAACATCAACTCAGGAAATGGTTCGATATTTACGTCAAAAACTCTTGACCGGGAAACATTGCTATGGCAC
AACATTACAGTAATAGCAGCAGAGATCAACAACCCAAAACAAAGCAGCCGTGTCCCAGTGTTCATTAAGGTTTTGGATG
TAAACGACAATGCTCCAGAGTTTGCCATGTTTTATGAGACCTTTGTCTGTGAAAATGCAAAGGCAGAACAGCTGATACA
AACATTGAGTGCTGTTGATAAAGATGACTCTTACAGTGGACACCAGTTTTCATTCAGCATAGCTCCAGAGGCAGCCAGC
AGCTCAAACTTTACACTCCAGGACAACAGAGACAACACAGCGGGGATTTTCACCCGAAAAATCAGATATAACCGGCATG
AAATGAGTACCTACCTTTTGCCAGTGGTAATATCAGACAATGACTACCCTATCCAGAGCAGCACTGAAACAGTGACTAT
TCGTGTATGTGCTTGTGACCATCGAGGAAAGATGCTGTCCTGTAATGCGGAAGCCTTGATTCATCCTACTGGTCTTAGC
ACTGGGGCTCTTATTGCCATTCTTCTCTGTATCATTATATTACTTGTTACAGTGGTGTTGTTTGCAGCACTGAGACGGC
AAAGGAAAAAAGAGCCTTTGATTATTTCCAAAGAAGACATCAGAGACAACATTGTCAGTTATAATGATGAAGGTGGTGG
AGAGGAAGACACCCAGGCATTTGATATCGGCACGCTGAGGAATCCCGAAGCCATAGATGATAATAAATTACGCAGAGAC
ATTGTGCCAGAAACGCTTTTTATGCCACGGCGGACTGCAACAGCCCGAGATAACACGGATGTCAGAGATTTCATTAACC
AAAGGTTAAAGGAGAATGATACAGACCCAGCAGCCCCCCCGTATGACTCGTTAGCGACCTACGCATACGAAGGTAATGG
TTCTGTGGCAGAGTCCCTCAGCTCTCTGGAGTCGGTGACTACAGACGGAGACCAGGACTATGATTACCTCAGTGACTGG
GGGCCGCGGTTTAAAAAGTTGGCAGATATGTATGGCTCAATGGACAGTGACAAAGACTCTTAATATGTTGCCTCTAG
CitationTaneyhill LA, Bronner-Fraser M. Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest. Mol Biol Cell. 2005 Nov;16(11):5283-93. Epub 2005 Aug 31.
CopyrightCopyright 2004, MBC Online by The American Society for Cell Biology.
CommentsInsufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_001001758).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-16
stage 16
stage 16
stage 16
stage 16
Neural Crest
Unlabeled
 

Entry 4

GEISHA IdCadherin6B.Taneyhill.2007Data SourcePublication
Complete cDNA Template Probeshow
GGTTCGAAGACGATCAGATAGAGAGCCCCCTCGGCTCGGGCTGCCTGCATGCGGGAGTTAAAAAGTGCTGCCGGTCGAG
CGGCAGCCCCAGTGAGCGGCGGGGAGGCTGAGAGCGGGCAGCAGGGGCCGGGAGCCGCCGCCACCCATCCCAGCTTGGC
CCTGCGAGCCGAGATCCTCTGAGACTGCAAAGACTACTTAAAGAACGAAGACGGCATGAGATTGGATTTGATCCAGTAA
AATAGGTTAGCTTGAGGACAAGAAAAACAGTTGCTATTTAGATCTTCTCTTGTTGCCGTGATGAGAACTTACCATTGCT
TCTGGTTGCTGTTTTGGGCTGGCCAGCCCCACCAAAGTTTTTTAACTTTGCTGTCCAAAAGGACTAGTGGCTTTCCAGA
GAAGGAAAAGGTTTTGGTATTGTCTGGAAACAGCAGGAGAGACCTCAGTCGTTCCAAAAGGAGTTGGATGTGGAATCAG
TTCTTTTTACTGGAAGAATATACAGGAACTGACTATCAGTATGTTGGCAAGCTGCATTCAGACCAGGATAAAGGAGATG
GATCACTTAAGTACATCCTTTCTGGAGATGGAGCAGGAGACCTCTTCATTATCAATGAAAACACTGGTGACATCCAAGC
CACAAAGAGACTAGACAGAGAAGAAAAGCCTGTGTACATACTTCGTGCCCAGGCTATAAACCGAAGAACTGGAAGACCA
GTGGAACCAGAATCTGAGTTCATCATCAAGATCCATGATATCAACGACAATGAGCCAATGTTTACAAAGGACGTTTACA
ATGCCAGCATTCCAGAAATGTCAGATGTTGGTACCTTTGTTGTGCAAGTCACTGCAACTGATGCCGATGATCCTACATA
TGGGAACAGCGCTAAAGTTGTCTACAGCATTCTCCAGGGACAACCATATTTCTCTGTAGAATCTGAGACAGGTATTATT
AAAACTGCTTTGCTAAACATGGACCGTGAAAACAGGGAGCAATATCAAGTGGTCATCCAAGCTAAGGACATGGGAGGCC
AGATGGGCGGATTATCAGGAACCACCACTGTGAACATCACACTGACCGACGTAAATGACAATCCTCCTCGGTTCCCCCA
GAGCACCTACCAATTCAGAGCTCCTGAGTCTACGCCACCTGACTCACCAATTGGCAGGATTAAAGCTAATGATGCAGAT
GTGGATGAAAATGCAGAGATTGAATACAGCATCACTGAGGGGGATGGATATGACATGTTTGGAATTACCACAGACAAGG
ACACACAGGAAGGAATTATAACTGTCAAAAAGGCACTGGATTTTGAAAATAAAAACTTGTATATTCTGAAGGTGGAAGC
CACCAATACTCACGTGGACCCTCGATTCCTCTACTTGGGGCCATTCAAGGATTCAGCCACAATCAGAATTCAAGTGGAA
GATGTAGATGAACCCCCTGTGTTCAGCAGACCAGCATATATAATTGAAGTGAAAGAAGATGTTCCAATAAACAGTGTAA
TAGGAACAGTAACAGCACAGGATCCAGATGCTGCCAAGAACCCTGTCAAGTATTCTGTAGATCGACACACTGATATGGA
CAGAGTATTCAACATCAACTCAGGAAATGGTTCGATATTTACGTCAAAAACTCTTGACCGGGAAACATTGCTATGGCAC
AACATTACAGTAATAGCAGCAGAGATCAACAACCCAAAACAAAGCAGCCGTGTCCCAGTGTTCATTAAGGTTTTGGATG
TAAACGACAATGCTCCAGAGTTTGCCATGTTTTATGAGACCTTTGTCTGTGAAAATGCAAAGGCAGAACAGCTGATACA
AACATTGAGTGCTGTTGATAAAGATGACTCTTACAGTGGACACCAGTTTTCATTCAGCATAGCTCCAGAGGCAGCCAGC
AGCTCAAACTTTACACTCCAGGACAACAGAGACAACACAGCGGGGATTTTCACCCGAAAAATCAGATATAACCGGCATG
AAATGAGTACCTACCTTTTGCCAGTGGTAATATCAGACAATGACTACCCTATCCAGAGCAGCACTGAAACAGTGACTAT
TCGTGTATGTGCTTGTGACCATCGAGGAAAGATGCTGTCCTGTAATGCGGAAGCCTTGATTCATCCTACTGGTCTTAGC
ACTGGGGCTCTTATTGCCATTCTTCTCTGTATCATTATATTACTTGTTACAGTGGTGTTGTTTGCAGCACTGAGACGGC
AAAGGAAAAAAGAGCCTTTGATTATTTCCAAAGAAGACATCAGAGACAACATTGTCAGTTATAATGATGAAGGTGGTGG
AGAGGAAGACACCCAGGCATTTGATATCGGCACGCTGAGGAATCCCGAAGCCATAGATGATAATAAATTACGCAGAGAC
ATTGTGCCAGAAACGCTTTTTATGCCACGGCGGACTGCAACAGCCCGAGATAACACGGATGTCAGAGATTTCATTAACC
AAAGGTTAAAGGAGAATGATACAGACCCAGCAGCCCCCCCGTATGACTCGTTAGCGACCTACGCATACGAAGGTAATGG
TTCTGTGGCAGAGTCCCTCAGCTCTCTGGAGTCGGTGACTACAGACGGAGACCAGGACTATGATTACCTCAGTGACTGG
GGGCCGCGGTTTAAAAAGTTGGCAGATATGTATGGCTCAATGGACAGTGACAAAGACTCTTAATATGTTGCCTCTAG
CitationTaneyhill LA, Coles EG, Bronner-Fraser M. Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest. Development. 2007 Apr;134(8):1481-90. Epub 2007 Mar 7.
CopyrightDivision of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
CommentsInsufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_001001758).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-14
stage 14
stage 14
Neural Crest
Neural Plate/Tube
 
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.600

Mouse

EmageMGI:107435
EurexpressMGI:107435
MGI GXDMGI:107435

Frog

Xenbase484591

Fruit Fly

BDGP

Zebra Finch

ZEBrACDH6

Zebrafish

ZFINZDB-GENE-050320-92
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