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Gene Family QuickSearch
Human Disease Gene Search
MSX1 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol MSX1 Official Full Name msh homeobox 1 CGNC ID 11159 also known as CHOX-7, GHOX-7, HOX-7, homeobox protein MSX-1|Hbox 7|homeobox protein GHOX-7|homeobox protein Hox-7|msh homeo box homolog 1|msh homeobox 1-like protein|msh homeobox homolog 1, Homeobox protein GHOX-7, Hox-7, CHOX-7
, Msx1 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function p53 binding , more... RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity , RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription , sequence-specific DNA binding , sequence-specific DNA binding transcription factor activity Biological Process activation of meiosis , anterior/posterior pattern specification , apoptotic nuclear changes , more... BMP signaling pathway , BMP signaling pathway involved in heart development , bone morphogenesis , cartilage morphogenesis , embryonic forelimb morphogenesis , embryonic hindlimb morphogenesis , embryonic nail plate morphogenesis , epithelial to mesenchymal transition involved in endocardial cushion formation , face morphogenesis , forebrain development , in utero embryonic development , mammary gland epithelium development , mesenchymal cell proliferation , midbrain development , middle ear morphogenesis , multicellular organismal development , muscle organ development , negative regulation of apoptotic process , negative regulation of cell growth , negative regulation of cell proliferation , negative regulation of striated muscle cell differentiation , negative regulation of transcription from RNA polymerase II promoter , negative regulation of transcription regulatory region DNA binding , odontogenesis of dentin-containing tooth , palate development , positive regulation of BMP signaling pathway , positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator , positive regulation of mesenchymal cell apoptotic process , protein localization to nucleus , protein stabilization , regulation of odontogenesis , signal transduction involved in regulation of gene expression Cellular Component nucleus , transcription factor complex
Links to other databases
Entry 1 GEISHA Id Msx1.Kamimura.2004 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACACGGGGCCGCCCTGCA
Citation Kamimura, M, Matsumoto, K, Koshiba-Takeuchi, K, Ogura, T. Vertebrate Crossveinless 2 Is Secreted and Acts as an Extracellular Modulator of the BMP Signalling Cascade. Dev Dyn. 2004 Jul;230(3):434-45. Copyright Wiley-Liss, Inc. 2004 Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205488).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17
stage 17
Endocardium
Entry 2 GEISHA Id Msx1.Wu.2006 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACACGGGGCCGCCCTGCA
Citation Wu P, Jiang TX, Shen JY, Widelitz RB, Chuong CM. Morphoregulation of avian beaks: comparative mapping of growth zone activities and morphological evolution. Dev Dyn. 2006 May;235(5):1400-12. Copyright Copyright © 2006 Wiley-Liss, Inc.
Entry 3 GEISHA Id MSX1.Shigetani.2000 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACACGGGGCCGCCCTGCA
Citation Shigetani Y, Nobusada Y, Kuratani S. (2000). Ectodermally derived FGF8 defines the maxillomandibular region in the early chick embryo: epithelial-mesenchymal interactions in the specification of the craniofacial ectomesenchyme. Dev Biol. 2000 Dec 1;228(1):73-85. Copyright Reprinted with permission from Elsevier. Copyright © 2000 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Entry 4 GEISHA Id Msx1.Holleville.2007 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACACGGGGCCGCCCTGCA
Citation Holleville N, Matéos S, Bontoux M, Bollerot K, Monsoro-Burq AH. Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme. Dev Biol. 2007 Apr 15;304(2):860-74. Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Authors indicated the probe was described in Monsoro-Burq et al, 1995, who said: Chick Msxl cDNA, a gift of Dr Susuki, was digested
by Pstl to generate a fragment specific for Msxl, located
3 to the homeobox. As information provided is insufficient to verify exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (Acc# NM_205488.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 38
stage 38
Face Mesenchyme
Entry 5 GEISHA Id MSX1.Streit.2002 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACACGGGGCCGCCCTGCA
Citation Streit, A. Extensive cell movements accompany formation of the otic placode. 2002 DEVELOPMENTAL BIOLOGY 249(2), 237-54. Copyright "Reprinted from Developmental Biology, 249(2), Streit A., Extensive cell movements accompany formation of the otic placode, 237-54, Copyright (2002), with permission from Elsevier".
Copyright © (2002) Elsevier B.V. All rights reserved. Comments According to the authors, "cDNAs for msx1 were kind gifts(see text. As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc# NM_205488).
Entry 6 GEISHA Id MSX1.Allen.2001 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Allen SP, Bogardi JP, Barlow AJ, Mir SA, Qayyum SR, Verbeek FJ, Anderson RH, Francis-West PH, Brown NA, Richardson MK (2001). Misexpression of noggin leads to septal defects in the outflow tract of the chick heart. Dev Biol. 2001 Jul 1;235(1):98-109. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Entry 7 GEISHA Id MSX1.Streit.1999 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Streit A, Stern CD. Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity. Mech Dev. 1999 Apr;82(1-2):51-66. Copyright Copyright © 1999 Elsevier Science Ireland Ltd. All rights reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Entry 8 GEISHA Id MSX1.Stevens.2003 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Stevens CB, Davies AL, Battista S, Lewis JH, Fekete DM. Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear.
Dev Biol. 2003 Sep 1;261(1):149-64. Copyright Copyright © 2003 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Entry 9 GEISHA Id MSX1.Holleville.2003 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Holleville N, Quilhac A, Bontoux M, Monsoro-Burq AH. BMP signals regulate Dlx5 during early avian skull development. Dev Biol. 2003 May 1;257(1):177-89. Copyright Copyright © 2003 Elsevier Science (USA) All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-38 stage 38
stage 38
Head Mesenchyme
Entry 10 GEISHA Id MSX1.Taneyhill.2005 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Taneyhill LA, Bronner-Fraser M. Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest. Mol Biol Cell. 2005 Nov;16(11):5283-93. Epub 2005 Aug 31. Copyright Copyright 2004, MBC Online by The American Society for Cell Biology. Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-16 stage 16
stage 16
stage 16
Neural Plate/Tube
Entry 11 GEISHA Id MSX1.McLarren.2003 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation McLarren KW, Litsiou A, Streit A. DLX5 positions the neural crest and preplacode region at the border of the neural plate. Dev Biol. 2003 Jul 1;259(1):34-47. Copyright Copyright © 2003 Elsevier Science (USA). All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7 stage 7
stage 7
Neural Plate/Tube
Entry 12 GEISHA Id MSX1.Riley.2003 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Riley BB, Phillips BT. Ringing in the new ear: resolution of cell interactions in otic development. Dev Biol. 2003 Sep 15;261(2):289-312. Review. Copyright Copyright © 2003 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Entry 13 GEISHA Id MSX1.Khudyakov.2009 Data Source Publication Complete cDNA Template Probe show AGAAGCGGAGCGGAGCCCTGATGCAGAGCCCCGCTTCTCGCCGCCCCGCCCAGGCGGCTGAGCCCCCCCGCCTGCACCC
Citation Khudyakov J, Bronner-Fraser M. Comprehensive spatiotemporal analysis of early chick neural crest network genes. Dev Dyn. 2009 Mar;238(3):716-23. Copyright Published Online: 22 Feb 2009
Copyright © 2009 Wiley-Liss, Inc. Comments The sequence below was obtained from BBSRC ChEST Database (ChEST900p21) using the information provided in the publication.
Entry 14 GEISHA Id MSX1.Basch.2006 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Basch ML, Bronner-Fraser M, García-Castro MI. Specification of the neural crest occurs during gastrulation and requires Pax7. Nature. 2006 May 11;441(7090):218-22. Copyright Copyright © 2006, Nature Publishing Group Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-6 stage 6
stage 6
Area Opaca
Entry 15 GEISHA Id MSX1.Fuchs.2010 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Fuchs A, Inthal A, Herrmann D, Cheng S, Nakatomi M, Peters H, Neubüser A. Regulation of Tbx22 during facial and palatal development. Dev Dyn. 2010 Nov;239(11):2860-74.
Copyright © 2010 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205488).
Entry 16 GEISHA Id MSX1.Gibson.2011 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Gibson A, Robinson N, Streit A, Sheng G, Stern CD. Regulation of programmed cell death during neural induction in the chick embryo.Int J Dev Biol. 2011;55(1):33-43. Copyright "Reprinted from Int. J. Dev. Biol., 55(1), Copyright (2011), with permission from the authors and IJDB, Copyright © 2002 UBC Press". All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_205488).
Entry 17 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-35 stage 35
stage 35
stage 35
stage 35
Intermediate Mesoderm Unlabeled
Entry 18 GEISHA Id MSX1.Stuhlmiller.2012 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Stuhlmiller TJ, García-Castro MI. FGF/MAPK signaling is required in the gastrula epiblast for avian neural crest induction. Development. 2012 Jan;139(2):289-300. Copyright © 2012. Published by The Company of Biologists Ltd Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 4-5 stage 5
stage 5
Early Mesoderm Epiblast
Entry 19 GEISHA Id MSX1/2.Ohyama.2008 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Ohyama K, Das R, Placzek M. Temporal progression of hypothalamic patterning by a dual action of BMP. Development. 2008 Oct;135(20):3325-31. Epub 2008 Sep 11. Copyright requested from MP Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_205488.2)= MSX1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 9
Unlabeled 13-18 stage 14
stage 16
Diencephalon 25 stage 25
Diencephalon
Entry 20 GEISHA Id MSX1.Fisher.2008 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Fisher ME, Clelland AK, Bain A, Baldock RA, Murphy P, Downie H, Tickle C, Davidson DR, Buckland RA. Integrating technologies for comparing 3D gene expression domains in the developing chick limb. Dev Biol. 2008 May 1;317(1):13-23. Epub 2008 Feb 7. Copyright Copyright © 2008 Elsevier Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_205488.2 ).
Entry 21 GEISHA Id MSX1.Marcucio.2005 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Marcucio RS, Cordero DR, Hu D, Helms JA. Molecular interactions coordinating the development of the forebrain and face. Dev Biol. 2005 Aug 1;284(1):48-61. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_205488.2).
Entry 22 GEISHA Id Msx‐1.Afrakhte.2004 Data Source Publication Complete cDNA Template Probe show GCAGAGGCGCACGGCACTCCCCGGGCGGCCCCGGCCCCGCTCCAGCCACGCTCCGCATTCGCGATGGCTTCTCCTTCCA
Citation Afrakhte M, Schultheiss TM. Construction and analysis of a subtracted library and microarray of cDNAs expressed specifically in chicken heart progenitor cells. Dev Dyn. 2004 Jun;230(2):290-8. Copyright Copyright © 2004 Wiley‐Liss, Inc. Comments The complete cDNA template sequence was obtained from the information in the publication as described in Afrakhte et al. 2004.
Entry 23 GEISHA Id Msx‐1.Barlow.1999 Data Source Publication Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Barlow AJ, Bogardi JP, Ladher R, Francis-West PH. Expression of chick Barx-1 and its differential regulation by FGF-8 and BMP signaling in the maxillary primordia. Dev Dyn. 1999 Apr;214(4):291-302. Copyright Copyright © 1999 Wiley‐Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
stage 24
Mesoderm 25-30 stage 28
Mesoderm 31-44 stage 44
Entry 24 GEISHA Id MXS-1.Liem.1995 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGCGGGGCCGCCCTGC
Citation Liem Jr., K.F, Tremml G, Roelink H, Jessell T.M. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell. 1995; 82: 969-979. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488.2).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
stage 10
stage 10
Neural Plate/Tube all
Entry 25 GEISHA Id MSX1.Anderson.2019 Data Source Publication Complete cDNA Template Probe show GGACCGCGCCGACGGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGC
Citation Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5. Copyright Copyright © 2019 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488.3).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 12
stage 12
Proepicardium
Entry 26 GEISHA Id MSX1.Trevers.2023 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show GGACCGCGCCGACGGCTCCCGCGCCTCCGCCGCGCCCTCATGAGCCGCGGCCGCCGCTCCCGCGGAGCACGGCGACAGC
Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205488).
Data from NCBI Unigene EST ProfileGga.1905
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