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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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NKX2-2
NK2 homeobox 2

Gene

Official Symbol	NKX2-2
Official Full Name	NK2 homeobox 2
CGNC ID	25123
also known as	NKX-2.2, homeobox protein Nkx-2.2\|NK2 transcription factor related, locus 2
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001277718
Polypeptide	NP_001264647
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.435

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	4821	ENSG00000125820		MIM:604612
Mouse	18088	ENSMUSG00000027434	All phenotypic alleles (3):Targeted, knock-out(1) Targeted, other(2)	MGI:97347
Xenopus	100038077, 373624			482218
Zebrafish	30697, 493627	ENSDARG00000053298, ENSDARG00000052550	ZDB-GENE-980526-403, ZDB-GENE-050217-3	ZFIN:ZDB-GENE-980526-403, ZFIN:ZDB-GENE-050217-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	428549
Ensembl Gene
KEGG	gga:428549

Entry 1

GEISHA Id	NKX2-2.Gimeno.2007	Data Source	Publication
Complete cDNA Template Probe	show `NNNCTGACGCCCACCCAGGTGAATCGTGAATGCCAGAACCACCGCTACAAGATGAAGCGGGCCCGGCTTATAGAAGGTA TGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGGCAAGCCCTGCCACACGCT CAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGCGCCCAGTCCCTCCAGCAT ATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACTTGGTACAGGCGCAGCAAT GGACTTGGTGA`
Citation	Gimeno L, Martinez S. Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh. Dev Dyn. 2007 Aug;236(8):2285-97.
Copyright	Copyright © 2007 Wiley-Liss, Inc.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_426104).

Stage

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Location (click to highlight)

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19-20

stage 20

Forebrain
Hindbrain
Midbrain
Rhombomeres

Entry 2

GEISHA Id	NKX2-2.Pedersen.2005	Data Source	Publication
Complete cDNA Template Probe	show `NNNCTGACGCCCACCCAGGTGAATCGTGAATGCCAGAACCACCGCTACAAGATGAAGCGGGCCCGGCTTATAGAAGGTA TGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGGCAAGCCCTGCCACACGCT CAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGCGCCCAGTCCCTCCAGCAT ATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACTTGGTACAGGCGCAGCAAT GGACTTGGTGA`
Citation	Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P; Beta Cell Biology Consortium. Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol. 2005 Dec 15;288(2):487-501.
Copyright	Copyright © 2005 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_426104).

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 11

Anterior Intestinal Portal
Endoderm
Neural Plate/Tube
Pancreas

Chicken embryos with antisense probes recognizing Nkx6.1, Nkx6.2, Nkx6.3, Nkx2.2, and Pdx1.
Prospective Pancreatic Endoderm

13-17

stage 15

stage 17

Endoderm
Head Process
Neural Plate/Tube
Pancreas

Chicken embryos with antisense probes recognizing Nkx6.1, Nkx6.2, Nkx6.3, Nkx2.2, and Pdx1.
Pancreatic Endoderm

Entry 3

GEISHA Id	NKX2-2.Agarwala.2005	Data Source	Publication
Complete cDNA Template Probe	show `CTGACGCCCACCCAGGTGAATCGTGAATGCCAGAACCACCGCTACAAGATGAAGCGGGCCCGGCTTATAGAAGGTATGG AAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGGCAAGCCCTGCCACACGCTCAA AGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGCGCCCAGTCCCTCCAGCATATG CAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACTTGGTACAGGCGCAGCAATGGA CTTGGTGA`
Citation	Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21.
Copyright	Copyright © 2005 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_426104).

Stage

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25-26

stage 26

Spinal Cord

Lateral Floor Plate

Entry 4

GEISHA Id	Nkx2.2.Garcia-Lopez.2009	Data Source	Publication
Complete cDNA Template Probe	show `NNNCTGACGCCCACCCAGGTGAATCGTGAATGCCAGAACCACCGCTACAAGATGAAGCGGGCCCGGCTTATAGAAGGTA TGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGGCAAGCCCTGCCACACGCT CAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGCGCCCAGTCCCTCCAGCAT ATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACTTGGTACAGGCGCAGCAAT GGACTTGGTGA`
Citation	García-López R, Soula C, Martínez S. Expression analysis of Sulf1 in the chick forebrain at early and late stages of development. Dev Dyn. 2009 Sep;238(9):2418-29.
Copyright	Copyright © 2009 John Wiley & Sons, Inc. All Rights Reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_426104.2).

Stage

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Location (click to highlight)

Comments (click to highlight)

25-26

stage 26

Neural Plate/Tube

Entry 5

GEISHA Id	NKX2.2.Davey.2006	Data Source	Publication
Complete cDNA Template Probe	show ATGTCTCTGACCAACACAAAGACGGGTTTTTCCGTCAAGGACATCCTGGACCTCCCCGACACCAACGACGAGGACGGCT CCGCCGCGGAAGGGGGAGAGGAGGAGAGCGAAGCGCCGGAGCCTCCCAAGAAAGCGGCGGTGTTGGGCCAAACCCCCTT GGACGCTGTTCAGACGCTGCCTTTGAAGCCCCCTTTCTATGATAATAGCGATAATCCCTACACGCGCTGGCTGGCGAGC GCCGAGGGCATCCAGTACTCCCTGCACGGACTGGCGGCCGGAGCAGGCGGCCCGGAGGCCGGCTCCAAGTCCCCGGAGC CGTCGGCCGACGAATCGCCCGACAACGAGAAGGAGGCGGCGGGCGGAGGGGACGCGGGGAAGAAGAGGAAGAGGAGGGT GCTCTTCTCCAAGGCGCAGACCTACGAGCTGGAGCGGCGGTTCCGGCAGCAGCGGTACCTGTCGGCGCCGGAGAGGGAG CACCTGGCCAGCCTGATCCGCCTGACGCCCACCCAGGTGAAGATCTGGTTCCAGAACCACCGCTACAAGATGAAGCGGG CCCGGGCCGAGAAAGGTATGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGG CAAGCCCTGCCACACGCTCAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGC GCCCAGTCCCTCCAGCATATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACT TGGTACAGGCGCAGCAATGGACTTGGTGAGCGCGGGGTGAGCGCACGCACACGGCCCTCGCGCGCACCCACACACGCAG AGAGGAGGAAAAAATAACGATAAAGAGACACGAAAA
Citation	Davey MG, Paton IR, Yin Y, Schmidt M, Bangs FK, Morrice DR, Smith TG, Buxton P, Stamataki D, Tanaka M, Münsterberg AE, Briscoe J, Tickle C, Burt DW. The chicken talpid3 gene encodesa novel protein essentialfor Hedgehog signaling. Genes Dev. 2006 May 15; 20(10): 13651377.
Copyright	Copyright © 2006, Cold Spring Harbor Laboratory Press
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_003643807.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

19-20

stage 20

Spinal Cord

Entry 6

GEISHA Id	NKX2.2.Ferran.2007	Data Source	Publication
Complete cDNA Template Probe	show ATGTCTCTGACCAACACAAAGACGGGTTTTTCCGTCAAGGACATCCTGGACCTCCCCGACACCAACGACGAGGACGGCT CCGCCGCGGAAGGGGGAGAGGAGGAGAGCGAAGCGCCGGAGCCTCCCAAGAAAGCGGCGGTGTTGGGCCAAACCCCCTT GGACGCTGTTCAGACGCTGCCTTTGAAGCCCCCTTTCTATGATAATAGCGATAATCCCTACACGCGCTGGCTGGCGAGC GCCGAGGGCATCCAGTACTCCCTGCACGGACTGGCGGCCGGAGCAGGCGGCCCGGAGGCCGGCTCCAAGTCCCCGGAGC CGTCGGCCGACGAATCGCCCGACAACGAGAAGGAGGCGGCGGGCGGAGGGGACGCGGGGAAGAAGAGGAAGAGGAGGGT GCTCTTCTCCAAGGCGCAGACCTACGAGCTGGAGCGGCGGTTCCGGCAGCAGCGGTACCTGTCGGCGCCGGAGAGGGAG CACCTGGCCAGCCTGATCCGCCTGACGCCCACCCAGGTGAAGATCTGGTTCCAGAACCACCGCTACAAGATGAAGCGGG CCCGGGCCGAGAAAGGTATGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGG CAAGCCCTGCCACACGCTCAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGC GCCCAGTCCCTCCAGCATATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACT TGGTACAGGCGCAGCAATGGACTTGGTGAGCGCGGGGTGAGCGCACGCACACGGCCCTCGCGCGCACCCACACACGCAG AGAGGAGGAAAAAATAACGATAAAGAGACACGAAAA
Citation	Ferran JL, Sánchez-Arrones L, Sandoval JE, Puelles L. A model of early molecular regionalization in the chicken embryonic pretectum. J Comp Neurol. 2007 Dec 1;505(4):379-403.
Copyright	Copyright © 19992012 John Wiley & Sons, Inc. All Rights Reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # XM_003643807.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

13-18

stage 18

Diencephalon

ABB, alar basal boundary

Entry 7

GEISHA Id	NKX2.2.GarciaCampmany.2007	Data Source	Publication
Complete cDNA Template Probe	show ATGTCTCTGACCAACACAAAGACGGGTTTTTCCGTCAAGGACATCCTGGACCTCCCCGACACCAACGACGAGGACGGCT CCGCCGCGGAAGGGGGAGAGGAGGAGAGCGAAGCGCCGGAGCCTCCCAAGAAAGCGGCGGTGTTGGGCCAAACCCCCTT GGACGCTGTTCAGACGCTGCCTTTGAAGCCCCCTTTCTATGATAATAGCGATAATCCCTACACGCGCTGGCTGGCGAGC GCCGAGGGCATCCAGTACTCCCTGCACGGACTGGCGGCCGGAGCAGGCGGCCCGGAGGCCGGCTCCAAGTCCCCGGAGC CGTCGGCCGACGAATCGCCCGACAACGAGAAGGAGGCGGCGGGCGGAGGGGACGCGGGGAAGAAGAGGAAGAGGAGGGT GCTCTTCTCCAAGGCGCAGACCTACGAGCTGGAGCGGCGGTTCCGGCAGCAGCGGTACCTGTCGGCGCCGGAGAGGGAG CACCTGGCCAGCCTGATCCGCCTGACGCCCACCCAGGTGAAGATCTGGTTCCAGAACCACCGCTACAAGATGAAGCGGG CCCGGGCCGAGAAAGGTATGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGG CAAGCCCTGCCACACGCTCAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGC GCCCAGTCCCTCCAGCATATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACT TGGTACAGGCGCAGCAATGGACTTGGTGAGCGCGGGGTGAGCGCACGCACACGGCCCTCGCGCGCACCCACACACGCAG AGAGGAGGAAAAAATAACGATAAAGAGACACGAAAA
Citation	García-Campmany L, Martí E. The TGFbeta intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord. Development. 2007 Jan;134(1):65-75. Epub 2006 Nov 30.
Copyright	Copyright by the authors. Published by the Company of Biologists Ltd.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_001277718.1

Stage

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Location (click to highlight)

Comments (click to highlight)

13-18

stage 16

stage 18

Neural Plate/Tube
Spinal Cord

19-20

stage 20

Spinal Cord

Entry 8

GEISHA Id	NKX2.2.Zhou.2001	Data Source	Publication
Complete cDNA Template Probe	show ATGTCTCTGACCAACACAAAGACGGGTTTTTCCGTCAAGGACATCCTGGACCTCCCCGACACCAACGACGAGGACGGCT CCGCCGCGGAAGGGGGAGAGGAGGAGAGCGAAGCGCCGGAGCCTCCCAAGAAAGCGGCGGTGTTGGGCCAAACCCCCTT GGACGCTGTTCAGACGCTGCCTTTGAAGCCCCCTTTCTATGATAATAGCGATAATCCCTACACGCGCTGGCTGGCGAGC GCCGAGGGCATCCAGTACTCCCTGCACGGACTGGCGGCCGGAGCAGGCGGCCCGGAGGCCGGCTCCAAGTCCCCGGAGC CGTCGGCCGACGAATCGCCCGACAACGAGAAGGAGGCGGCGGGCGGAGGGGACGCGGGGAAGAAGAGGAAGAGGAGGGT GCTCTTCTCCAAGGCGCAGACCTACGAGCTGGAGCGGCGGTTCCGGCAGCAGCGGTACCTGTCGGCGCCGGAGAGGGAG CACCTGGCCAGCCTGATCCGCCTGACGCCCACCCAGGTGAAGATCTGGTTCCAGAACCACCGCTACAAGATGAAGCGGG CCCGGGCCGAGAAAGGTATGGAAGTGACTCCTCTCCCCTCCCCGCGGCGGGTGGCCGTGCCGGTCCTGGTGCGGGACGG CAAGCCCTGCCACACGCTCAAAGCTCAGGACTTGGCGGCCGCCACCTTCCAGACGGGCATCCCCTTCTCCGCCTATAGC GCCCAGTCCCTCCAGCATATGCAATACAACGCCCAGTACAGCGCGGCCGGCAGCCCCCAGTACCCCACAGCGCACCACT TGGTACAGGCGCAGCAATGGACTTGGTGAGCGCGGGGTGAGCGCACGCACACGGCCCTCGCGCGCACCCACACACGCAG AGAGGAGGAAAAAATAACGATAAAGAGACACGAAAA
Citation	Zhou Q, Choi G, Anderson DJ. The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. Neuron. 2001 Sep 13;31(5):791-807
Copyright	Copyright 2001 by Cell Press
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_001277718.1).