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A chicken embryo gene expression database

	Anatomical Location
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	Gene Name
	GEISHA ID
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DHFR
dihydrofolate reductase

The human orthologue of this gene is associated
with the following human disease:

Megaloblastic anemia due to dihydrofolate reductase deficiency

Gene

Official Symbol	DHFR
Official Full Name	dihydrofolate reductase
CGNC ID	53049
also known as	dihydrofolate reductase
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001006584
Polypeptide	NP_001006584
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.48831

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	42003			FBgn0004087
Human	1719	ENSG00000228716	MIM:613839	MIM:126060
Mouse	13361	ENSMUSG00000021707	All phenotypic alleles (5):Targeted, knock-out(1) Targeted, other(4)	MGI:94890
Xenopus	733465, 495375			975266
Zebrafish	81882	ENSDARG00000004251	ZDB-GENE-010406-5	ZFIN:ZDB-GENE-010406-5

Gene Ontology

Molecular Function	dihydrofolate reductase activity, drug binding, mRNA binding, NADP binding
Biological Process	glycine biosynthetic process, nucleotide biosynthetic process, one-carbon metabolic process, more...
Cellular Component

Links to other databases

Entrez Gene	427317
Ensembl Gene
KEGG	gga:427317

GEISHA Id	DHFR.Roy.2013	Data Source	Publication
Complete cDNA Template Probe	show GAGGGAGGCATGGTGCGCTCGCTCAATTCCATCGTGGCCGTATGTCAGAACATGGGCATCGGGAAGGACGGGAACCTGC CCTGGCCCCCGCTGAGGAATGAGTACAAGTACTTCCAGAGAATGACCAGCACCTCCCATGTGGAAGGTAAACAGAATGC AGTGATAATGGGTAAAAAAACCTGGTTCTCCATTCCTGAGAAGAATCGTCCTCTAAAAGACAGAATTAATATAGTGCTC AGCAGGGAGCTCAAGGAAGCCCCAAAAGGAGCACATTATCTTTCTAAAAGCCTGGATGATGCCTTAGCTCTTTTGGATT CACCAGAATTAAAAAGTAAAGTAGACATGGTTTGGATTGTTGGAGGCACTGCAGTTTATAAGGCAGCAATGGAGAAGCC CATTAATCATCGACTGTTTGTGACAAGAATATTGCATGAATTTGAAAGCGACACATTCTTTCCAGAAATCGACTACAAA GACTTCAAACTTCTCACGGAATACCCAGGTGTCCCTGCTGATATTCAGGAAGAGAATGGCATCCAGTACAAATTTGAAG TGTATCAAAAATCTGTCTTGGCACAATAAAAACAAGGTTCTCTTTAGTTCTATATGCAACTGGGCATTTTAAATTATGA AATGTTATTGATTGAAAATATACATTACATACATATTACATCACTGTGAGAAAATCTATTTGATCGTGCAGTACCTCAA CAATGAAAGATCCCAGAGAACACACCCCACATTTTGAATGTGTACCCTGCAGTGGAAGTATGAGCGTGGTCAGCAGCAT TTGCAGCTCCCACTCTGACAGTGAAAACCTACAAGGAGGGGTCCTTACCTCTGTTTCATTGCTGATCAATCTGAGAGCA GAAGAGGTTGATGTTTTTGTTTTTTTTTTAGTTATAACCCAAAACTTTGCTGTATCCCCAAAGTATTTCTAAAGCATCA TAAAGCATCATCTTATTAAGCAATTTTGAGGGAAATTCACGTAATGTTGGCCTTAATTGTTGCACTAAGTCTCCATTCT AACATCAGCAAGGGTTGCAGTGGACAATTGCAAGTTTATGCAATTTATGACTGTTCAACAGGGCATAACATTGGCCAGT TTTCTATGAGAAGTTAAAACCTTCATTTTGCATGCTTTTGAAAAGCAATAACGAAACCTCGTGTATTAAGAGAAAAACA CACAAAGTATCAGCTTTAAACAGCTGTTGAATTTCTCATGGCAGTTCTACAGCAGTAAACTGTTGCAAAAATAATTTTT GTTGTCTCAGTTTTCTTTGTGTTCCTTTTTCAGTCTTAAAAATGTAAGTACTTTGCTACACTGATCTTCTTTTTCCATA TGTACTTTTTACATCAATCAATAAAGATTTAAATATCAATATTATATGCCTGCATTAAATTGAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAACCAAAAAAAAAAAAAAAAAAAAAAAAAA
Citation	Roy P, Kumar B, Shende A, Singh A, Meena A, Ghosal R, Ranganathan M, Bandyopadhyay A. A Genome-Wide Screen Indicates Correlation between Differentiation and Expression of Metabolism Related Genes. PLoS One. 2013 May 22;8(5):e63670
Copyright	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_001006584