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Human Disease Gene Search
ROBO2 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol ROBO2 Official Full Name roundabout guidance receptor 2 CGNC ID 49245 also known as roundabout homolog 2|Roundabout2 protein|roundabout, axon guidance receptor, homolog 2|roundabout-like protein 2 gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Molecular Function Biological Process Cellular Component
Links to other databases
Entry 1 GEISHA Id Robo2.Jia.2005 Data Source Publication Complete cDNA Template Probe show ATGGGTCTGCTGACGCCACTCCTGCTCTTTGGATTTGCATTTTTTCAAGTCTACGGATCCCGTCTCCGCCAGGAGGACT
Citation Jia L, Cheng L, Raper J. Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk. Dev Biol. 2005 Jun 15;282(2):411-21. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_416674).
Entry 2 GEISHA Id Robo2.Shiau.2008 Data Source Publication Complete cDNA Template Probe show ATGGGTCTGCTGACGCCACTCCTGCTCTTTGGATTTGCATTTTTTCAAGTCTACGGATCCCGTCTCCGCCAGGAGGACT
Citation Shiau CE, Lwigale PY, Das RM, Wilson SA, Bronner-Fraser M. Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion. Nat Neurosci. 2008 Mar;11(3):269-76. Epub 2008 Feb 17.
Copyright Copyright © 2008, Nature Publishing Group Comments Insufficient information provided in publication to verify exact sequence to synthesize probe. Sequence below was obtained from NCBI (XM_416674).
Entry 3 GEISHA Id Robo2.Riley.2010 Data Source Publication Complete cDNA Template Probe show ATGGGTCTGCTGACGCCACTCCTGCTCTTTGGATTTGCATTTTTTCAAGTCTACGGATCCCGTCTCCGCCAGGAGGACT
Citation Riley KL, Gledhill S, Schubert FR. Early expression of axon guidance molecules in the embryonic chick mesencephalon and pretectum. Int J Dev Biol. 2010;54(4):743-53. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc #XM_416674.2)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 13
stage 13
stage 18
Midbrain Unlabeled 19-21 stage 21
Midbrain
Entry 4 Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 31-40 stage 31
stage 40
stage 40
Cranial Ganglia
Entry 5 GEISHA Id ROBO2.HalperinBarlev.2011 Data Source Publication Complete cDNA Template Probe show GGAATTGCTCTCGAAAACGATCGGGATTGCTTTTAATATGTCAAAATGGGTCTGCTGACGCCACTCCTGCTCTTTGGAT
Citation Halperin-Barlev O, Kalcheim C., Sclerotome-derived Slit1 drives directional migration and differentiation of Robo2-expressing pioneer myoblasts. Development. 2011 Jul;138(14):2935-45. Epub 2011 Jun 8. Copyright Permission from the authors and the Company of Biologists Ltd. Copyright held by the authors. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_416674.3 ).
Entry 6 GEISHA Id ROBO2.Battisti.2008 Data Source Publication Complete cDNA Template Probe show GGAATTGCTCTCGAAAACGATCGGGATTGCTTTTAATATGTCAAAATGGGTCTGCTGACGCCACTCCTGCTCTTTGGAT
Citation Battisti AC, Fekete DM. Slits and Robos in the developing chicken inner ear. Dev Dyn. 2008 Feb;237(2):476-84. Copyright Copyright © 2008 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # XM_416674.3).
Entry 7 GEISHA Id ROBO2.Giovannone.2012 Data Source Publication Complete cDNA Template Probe show GGAATTGCTCTCGAAAACGATCGGGATTGCTTTTAATATGTCAAAATGGGTCTGCTGACGCCACTCCTGCTCTTTGGAT
Citation Giovannone D, Reyes M, Reyes R, Correa L, Martinez D, Ra H, Gomez G, Kaiser J, Ma L, Stein MP, de Bellard ME. Slits affect the timely migration of neural crest cells via Robo receptor. Dev Dyn. 2012 Aug;241(8):1274-88. Copyright Copyright © 2012 Wiley Periodicals, Inc. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_416674.3).
Entry 8 GEISHA Id ROBO2.Ratie.2013 Data Source Publication Complete cDNA Template Probe show CTTTTTTCACAATCCTGACATCTTTTCTCTTTTCTGCTGGACACGAGCATTACTGTTTTTATCATTTTCAATCAAGCTC
Citation Leslie Ratié, Michelle Ware, Frédérique Barloy-Hubler, Hélène Romé, Isabelle Gicquel, Christèle Dubourg, Véronique David and Valérie Dupé. Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. Neural Dev. 2013 Dec 23;8:25. doi: 10.1186/1749-8104-8-25. Copyright © 2013 Ratié et al.; licensee BioMed Central Ltd. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (Acc. # XM_015298528.2).
Entry 9 GEISHA Id Robo2.Vargesson.2001 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show TGAGAAACTCTGCAGCTTGAACTGATTTGGGGGGGAGAGAGAGAGAGAAAAGAAAGGGGTAGGGCGAGGGGAGAGGAAA
Comments The complete cDNA template sequence was obtained from the information in the publication as described in Vargesson et al. 2001.
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
Limb Buds 25-30 stage 25
stage 25
stage 26
stage 28
stage 30
Limb Buds 31-44 stage 32
stage 32
stage 36
stage 44
stage 44
stage 44
Leg Mesenchyme Limb Buds
Data from NCBI Unigene EST ProfileGga.34286
Mouse Frog Fruit Fly Zebra Finch Zebrafish
