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 | SMAD3
SMAD family member 3 | The human orthologue of this gene is associated
with the following human disease: |
| Gene | | Official Symbol | SMAD3 | | Official Full Name | SMAD family member 3 | | CGNC ID | 5954 | | also known as | mothers against decapentaplegic homolog 3|MAD homolog 3|SMAD 3|SMAD, mothers against DPP homolog 3|TGF-beta response effector Smad3|mad3|mothers against DPP homolog 3, SMAD3 | | gene type | protein-coding |
| | Genomic Map | | | Sequence Information | | | Gene Expression | | | Orthology | | | Gene Ontology | | Molecular Function | beta-catenin binding, chromatin DNA binding, core promoter proximal region sequence-specific DNA binding, more...co-SMAD binding, phosphatase binding, protein binding transcription factor activity, protein homodimerization activity, protein kinase binding, RNA polymerase II activating transcription factor binding, R-SMAD binding, sequence-specific DNA binding transcription factor activity, transforming growth factor beta receptor binding, transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding | | Biological Process | activation of cysteine-type endopeptidase activity involved in apoptotic process, more...cell-cell junction organization, cell cycle arrest, evasion or tolerance of host defenses by virus, extrinsic apoptotic signaling pathway, immune response, negative regulation of cell growth, negative regulation of inflammatory response, negative regulation of mitotic cell cycle, negative regulation of osteoblast proliferation, negative regulation of protein catabolic process, negative regulation of protein phosphorylation, negative regulation of wound healing, nodal signaling pathway, osteoblast differentiation, positive regulation of canonical Wnt signaling pathway, positive regulation of catenin import into nucleus, positive regulation of chondrocyte differentiation, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression involved in extracellular matrix organization, positive regulation of transcription, DNA-templated, positive regulation of transcription factor import into nucleus, protein stabilization, regulation of immune response, regulation of transforming growth factor beta2 production, response to hypoxia, T cell activation, transcription, DNA-templated, transforming growth factor beta receptor signaling pathway, transport, ureteric bud development | | Cellular Component | cytoplasm, nuclear inner membrane, nucleus, receptor complex, SMAD protein complex, more...transcription factor complex |
| | Links to other databases | |
Entry 1| GEISHA Id | ChEST553l8 | Data Source | GEISHA ISH Analysis | | Forward cDNA Template Probe | show GGCGGCTCGAGATTCGGATGAGCTTCGTCAAGGGTTGGGGAGCAGAATACAGGCGGCAGACGGTGACCAGCACTCCCTG
CTGGATTGAGCTGCACCTCAACGGCCCTCTGCAGTGGCTGGACAAGGTCCTCACACAGATGGGCTCCCCGAGCATCCGC
TGCTCCAGCGTCTCCTAAGGAAGCACCTCCTGGGGGCGGGCGGGGGAGCAAAGACTGGAGAGTGGAATTGGCTGAACCC
TTAGCAAAACACATAGAGAAGAGATTCCCAGTTACTGAAGTGATAAGGAGAAACAAATCTGCTCAAATAGTGGCTTTTC
TTGGTTTTGTTTCTTTTTTTTTTTTTTTTTAAACTTAAAGACCCATTGAAGCCACTTCCACTGAAACTGTTAGCACTTT
GGTTACAAGGCTGTGGGCCCTTGCAGTCAGAATGAAGCTGAAGTTTATCATGATAAAAGATGACTTTGTTTCAGCGGAG
ATAAGCCAGTGCTGTGCCTCCAGCCATGGCACGTCCCAGCCGCCCCACGCAGCCCCAGCATCTCCGACAGACACCACGG
GCCTTTGGGATGACTCTTGCTCATGCACTGCTGTCTCCATCCACCTGACGTGTGCCCATTCTTCCTGGGATTGCAGCAG
TAGGTGGAAAAGAAAGCGTGTAAAGCACATGCAAGGATTGATTGCCCGGTATTGCTCCTGAAAGGAACAGATTTCCACA
GTGCACAGCTCACTGAGAGGCAGCGCCTTGCTTTGTGCCCGAGCTGCCACTGTGCCCTGCTTGTCCCAGTCTGGATGTA
CATGAAGCAGAAGGCCAAAGTTACGGCCCTTTCTGACACTGCTGCAGCAACTTTTGACTAGAGCC |
Entry 2| GEISHA Id | SMAD3.GarciaCampmany.2007 | Data Source | Publication | | Complete cDNA Template Probe | show ATGTCCTCCATCCTGCCGTTCACCCCTCCCATCGTCAAGCGGCTCCTGGGCTGGAAGAAAGGGGAGCAGAACGGGCAGG
AGGAGAAATGGTGCGAGAAGGCGGTGAAGAGCCTGGTGAAGAAGCTGAAGAAGACGGGGCAGCTGGACGAGCTGGAGAA
GGCGATCACCACGCAGAACATCAACACCAAGTGCATCACCATCCCCAGGTCGCTGGATGGCCGGCTGCAGGTGTCCCAC
CGCAAGGGCCTTCCCCATGTCATCTACTGCCGGCTGTGGCGGTGGCCGGACCTGCATAGCCACCATGAGCTGCGGGCCA
TGGAGATGTGCGAGTACGCCTTCAACATGAAGAAGGACGAAGTCTGTGTGAATCCCTATCATTACCAACGAGTGGAGAC
CCCAGTGTTACCCCCAGTGCTGGTGCCTCGGCACACGGAGATCCCAGCTGAGTTCCCACCGTTGGACGATTACAGTCAC
TCTATCCCAGAGAACACTAACTTCCCAGCAGGCATTGAGCCGCAGAGCAACTACATCCCAGAGACACCTCCTCCAGGCT
ATTTGAGTGAGGATGGAGAAACTAGTGACCACCAGATGAACCCCAGCATGGATGCAGGTTCTCCAAACTTATCACCAAA
TCCTATGTCTCCGGCACACAATAATCTGGATCTGCAGCCCGTTACCTACTGCGAGCCGGCGTTCTGGTGCTCCATATCC
TACTATGAACTCAACCAGCGCGTGGGGGAGACGTTCCACGCCTCGCAGCCCTCCATGACCGTGGATGGTTTCACTGACC
CGTCGAATTCTGAACGCTTCTGCCTTGGTCTGCTCTCTAATGTGAACAGGAATGCAGCAGTGGAGCTCACGAGACGGCA
CATCGGAAGAGGAGTGAGGCTGTACTACATTGGTGGCGAGGTGTTTGCTGAGTGCCTTAGTGACAGTGCCATTTTTGTC
CAGTCTCCCAACTGCAACCAGCGCTACGGCTGGCACCCAGCAACAGTCTGCAAGATCCCACCAGGATGTAACTTGAAGA
TTTTTAACAACCAGGAATTCGCAGCTCTCTTGGCTCAGTCTGTAAACCAGGGCTTCGAAGCTGTGTACCAGCTGACCAG
GATGTGCACGATTCGGATGAGCTTCGTCAAGGGTTGGGGAGCAGAATACAGGCGGCAGACGGTGACTAGCACTCCCTGC
TGGATTGAGCTGCACCTCAACGGCCCTCTGCAGTGGCTGGACAAGGTCCTCACACAGATGGGCTCCCCGAGCATCCGCT
GCTCCAGCGTCTCCTAA | | Citation | García-Campmany L, Martí E. The TGFbeta intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord. Development. 2007 Jan;134(1):65-75. Epub 2006 Nov 30. | | Copyright | Copyright by the authors. Published by the Company of Biologists Ltd. | | Comments | As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204475.1 |
| | Data from NCBI Unigene EST Profile
Unigene ID: Gga.28197 |
MouseFrogFruit FlyZebra FinchZebrafish |
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