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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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ALPL
alkaline phosphatase, liver/bone/kidney

The human orthologue of this gene is associated
with the following human diseases:

Gene

Official Symbol	ALPL
Official Full Name	alkaline phosphatase, liver/bone/kidney
CGNC ID	49750
also known as	alkaline phosphatase, tissue-nonspecific isozyme\|AP-TNAP\|TNSALP\|tissue-nonspecific alkaline phosphatase
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_205360
Polypeptide	NP_990691
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.760

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	41135			FBgn0043791
Human	249	ENSG00000162551	MIM:146300	MIM:171760
Mouse	11647	ENSMUSG00000028766	All phenotypic alleles (7):Chemically induced(1) Targeted, knock-out(3) Targeted, other(3)	MGI:87983
Xenopus	100485467, 380589			1010300
Zebrafish	393982		ZDB-GENE-040420-1	ZFIN:ZDB-GENE-040420-1

Gene Ontology

Molecular Function	alkaline phosphatase activity, metal ion binding
Biological Process
Cellular Component	anchored component of membrane, plasma membrane

Links to other databases

Entrez Gene	396317
Ensembl Gene
KEGG	gga:396317

Entry 1

GEISHA Id	ALPL.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	CCTGCTGGAGATGGACAAGTTC
Reverse cDNA Template Primer	AATTAACCCTCACTAAAGGAACCGCCAAAGGTGAAGACG	cDNA Template Length	908
Forward cDNA Template Probe	show TGGTGGCGGTGAGAGCTGAGTGTGTCGCGGGGGGAGGTGAGGCGCCCCGCCAGCCCCACGGCGCGGTCCAGCTCCACCG CCTCGTGCAGCGCCTGCTTGGCCTTCCCCTCGTGGTGCCCGTGGTCGATGCGGCCTCCTTCCACCAGCAGGAAGAAGCC CCGCGGGTTTTTCTGCAGCATCCTTATGGCCACAGCCACCATCTCGCTGAGCGACGGGTCGGTCTCGTTGTTCCTGTCC AGCTCATACACCATATCCCCCGGCTCAAAGAGACCCAGCAGGAAGTCCACACGGCTGACGTTCAGCGCCAGCAGCTCCC TCCGGTGCCACACGTACTTGGCGACCTTCCCCGCAGGCTTAGTGTCGTGCCACGCCTGCACCAGGTCCTTGCCGTCCAG GCGGGTGCCGCGGTGCCGCTCCTCCTGCGGGTACTCCACATCGCTGGTGTTCTTGGGGAACATGTACTTGCGCCCACCC CCCAGGATCACCTCGATGTCAGGGATGTTCTCCACCAGCTGCCGGGCGATGTCTTTGCAGCCGCCCTCCAGTGCATCCA GGGGCATCTCTCCATCTGAGTACCAGTCACGGTTGGCTGAGTGCGCGTAGGCAGCGCTGGGTGTCGCGTGGGTCACCCG CGTGGTGGTGACAATGCCCACCGCCTTGCCTTCATCCTTAGCCCAGCGGAGGATGGAGGTCACCTCCTGGCCCTTGGTG GTGTTGCAGCGGTCACGGGTGACACCGGCGCTGACTCCCACTGTCCCCTCGTTGGCTTTGACGCCGCAAAGGTAAGCAG TGGCTGTGCCCGCGCTGTCGGGCACCTGTGCGTTGGTGTTGTANGTCTTGGCCAGGGCAACGTATGGGAACTTGTCC

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 6

Early Mesoderm
Epiblast
Extraembryonic Mesoderm
Headfold
Neural Plate/Tube
extraembryonic ectoderm

7-12

stage 7

stage 10

stage 11

Amnion
Anterior Neuropore
Blood Islands
Ear/Otic Placode
Ectoderm
Extraembryonic Blood Vessels
Extraembryonic Mesoderm
Eye
Forebrain
Head Mesenchyme
Headfold
Heart
Hindbrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Neural Plate/Tube
Notochord
Paraxial Mesoderm
Sinus Venosus
Somites
Veins
Ventricles
Widespread Expression
extraembryonic ectoderm
extraembryonic mesoderm

13-18

stage 17

Amnion
Atria
Dermatome
Ectoderm
Endoderm
Esophagus
Extraembryonic Blood Vessels
Eye
Forebrain
Foregut
Head Mesenchyme
Heart
Hindbrain
Leg Mesenchyme
Mesonephros
Midbrain
Neural Plate/Tube
Notochord
Pharyngeal Arches and Clefts
Sclerotome
Sinus Venosus
Somatic Mesoderm
Splanchnic Mesoderm
Tail
Widespread Expression
Wing Mesenchyme

19-24

stage 23

stage 24

Dermatome
Diencephalon
Forebrain
Foregut
Head Mesenchyme
Heart
Hindbrain
Leg Mesenchyme
Mesonephros
Midbrain
Nasal Placode/Nerve
Pharyngeal Arches and Clefts
Sclerotome
Sinus Venosus
Somatic Mesoderm
Spinal Cord
Spinal Ganglia and Nerves
Wing Mesenchyme

Entry 2

GEISHA Id	TNAP.MacRae.2010	Data Source	Publication
Complete cDNA Template Probe	show CTCCCATCCATTTCCCAAGAGGAGCTTTGAAGGGGCACAATGAAGGCTTTCCTCCTCACCCTCCTGGCCCAACTCTGCT CGGCATCGCTGGTCCCCGAGAGGGAGAAGGACCCCGAATACTGGAGGCAGCAGGCGCAGGAGACGCTGCGGGATGCACT GCGGCTGCAGCACCTCAACCAGAATGTGGCCAAGAACCTCATCCTCTTCCTGGGCGACGGTATGGGCGTCTCCACTGTG ACGGCCGCGCGCATCCTCAAGGGTCAGCTGCAGCACCGCAAGGGCGAGGAGAGCCTGCTGGAGATGGACAAGTTCCCAT ACGTTGCCCTGGCCAAGACCTACAACACCAACGCACAGGTGCCCGACAGCGCGGGCACAGCCACTGCTTACCTCTGCGG CGTCAAAGCCAACGAGGGGACAGTGGGAGTCAGCGCCGGTGTCACCCGTGACCGCTGCAACACCACCAAGGGCCAGGAG GTGACCTCCATCCTCCGCTGGGCTAAGGATGAAGGCAAGGCGGTGGGCATTGTCACCACCACGCGGGTGACCCACGCGA CACCCAGCGCTGCCTACGCGCACTCAGCCAACCGTGACTGGTACTCAGATGGAGAGATGCCCCTGGATGCACTGGAGGG CGGCTGCAAAGACATCGCCCGGCAGCTGGTGGAGAACATCCCTGACATCGAGGTGATCCTGGGGGGTGGGCGCAAGTAC ATGTTCCCCAAGAACACCAGCGATGTGGAGTACCCGCAGGAGGAGCGGCACCGCGGCACCCGCCTGGACGGCAAGGACC TGGTGCAGGCGTGGCACGACACTAAGCCTGCGGGGAAGGTCGCCAAGTACGTGTGGCACCGGAGGGAGCTGCTGGCGCT GAACGTCAGCCGTGTGGACTTCCTGCTGGGTCTCTTTGAGCCGGGGGATATGGTGTATGAGCTGGACAGGAACAACGAG ACCGACCCGTCGCTCAGCGAGATGGTGGCTGTGGCTATAAGGATGCTGCAGAAAAACCCACGGGGCTTCTTCCTGCTGG TGGAAGGTGGGGGGGCCAGGTGGTGCAGGGGGGTGCCGAGGGGCATGAGGAAGTGA
Citation	Macrae VE, Davey MG, McTeir L, Narisawa S, Yadav MC, Millan JL, Farquharson C. Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. Bone. 2010 Apr;46(4):1146-55.
Copyright	© 2009 Elsevier Inc.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # XM_423297).