GEISHA - A Chicken Embryo Gene Expression Database
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ALPL
alkaline phosphatase, liver/bone/kidney

The human orthologue of this gene is associated
with the following human diseases:
Gene
Official SymbolALPL
Official Full Namealkaline phosphatase, liver/bone/kidney
CGNC ID49750
also known asalkaline phosphatase, tissue-nonspecific isozyme|AP-TNAP|TNSALP|tissue-nonspecific alkaline phosphatase
gene typeprotein-coding
Genomic Map
 Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_205360
PolypeptideNP_990691
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.760
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly41135FBgn0043791
Human249ENSG00000162551MIM:146300MIM:171760
Mouse11647ENSMUSG00000028766All phenotypic alleles (7):Chemically induced(1) Targeted, knock-out(3) Targeted, other(3) MGI:87983
Xenopus100485467, 3805891010300
Zebrafish393982ZDB-GENE-040420-1ZFIN:ZDB-GENE-040420-1
Gene Ontology
Molecular Functionalkaline phosphatase activity, metal ion binding
Biological Process
Cellular Componentanchored component of membrane, plasma membrane
Links to other databases
Entrez Gene396317
Ensembl Gene
KEGGgga:396317

Entry 1

GEISHA IdALPL.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template PrimerCCTGCTGGAGATGGACAAGTTC
Reverse cDNA Template PrimerAATTAACCCTCACTAAAGGAACCGCCAAAGGTGAAGACGcDNA Template Length908
Forward cDNA Template Probeshow
TGGTGGCGGTGAGAGCTGAGTGTGTCGCGGGGGGAGGTGAGGCGCCCCGCCAGCCCCACGGCGCGGTCCAGCTCCACCG
CCTCGTGCAGCGCCTGCTTGGCCTTCCCCTCGTGGTGCCCGTGGTCGATGCGGCCTCCTTCCACCAGCAGGAAGAAGCC
CCGCGGGTTTTTCTGCAGCATCCTTATGGCCACAGCCACCATCTCGCTGAGCGACGGGTCGGTCTCGTTGTTCCTGTCC
AGCTCATACACCATATCCCCCGGCTCAAAGAGACCCAGCAGGAAGTCCACACGGCTGACGTTCAGCGCCAGCAGCTCCC
TCCGGTGCCACACGTACTTGGCGACCTTCCCCGCAGGCTTAGTGTCGTGCCACGCCTGCACCAGGTCCTTGCCGTCCAG
GCGGGTGCCGCGGTGCCGCTCCTCCTGCGGGTACTCCACATCGCTGGTGTTCTTGGGGAACATGTACTTGCGCCCACCC
CCCAGGATCACCTCGATGTCAGGGATGTTCTCCACCAGCTGCCGGGCGATGTCTTTGCAGCCGCCCTCCAGTGCATCCA
GGGGCATCTCTCCATCTGAGTACCAGTCACGGTTGGCTGAGTGCGCGTAGGCAGCGCTGGGTGTCGCGTGGGTCACCCG
CGTGGTGGTGACAATGCCCACCGCCTTGCCTTCATCCTTAGCCCAGCGGAGGATGGAGGTCACCTCCTGGCCCTTGGTG
GTGTTGCAGCGGTCACGGGTGACACCGGCGCTGACTCCCACTGTCCCCTCGTTGGCTTTGACGCCGCAAAGGTAAGCAG
TGGCTGTGCCCGCGCTGTCGGGCACCTGTGCGTTGGTGTTGTANGTCTTGGCCAGGGCAACGTATGGGAACTTGTCC
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 6
stage 6
Early Mesoderm
Epiblast
Extraembryonic Mesoderm
Headfold
Neural Plate/Tube
extraembryonic ectoderm
 
7-12
stage 7
stage 10
stage 10
stage 10
stage 10
stage 11
Amnion
Anterior Neuropore
Blood Islands
Ear/Otic Placode
Ectoderm
Extraembryonic Blood Vessels
Extraembryonic Mesoderm
Eye
Forebrain
Head Mesenchyme
Headfold
Heart
Hindbrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Midbrain
Neural Plate/Tube
Notochord
Paraxial Mesoderm
Sinus Venosus
Somites
Veins
Ventricles
Widespread Expression
extraembryonic ectoderm
extraembryonic mesoderm
 
13-18
stage 17
stage 17
stage 17
Amnion
Atria
Dermatome
Ectoderm
Endoderm
Esophagus
Extraembryonic Blood Vessels
Eye
Forebrain
Foregut
Head Mesenchyme
Heart
Hindbrain
Leg Mesenchyme
Mesonephros
Midbrain
Neural Plate/Tube
Notochord
Pharyngeal Arches and Clefts
Sclerotome
Sinus Venosus
Somatic Mesoderm
Splanchnic Mesoderm
Tail
Widespread Expression
Wing Mesenchyme
 
19-24
stage 23
stage 23
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
Dermatome
Diencephalon
Forebrain
Foregut
Head Mesenchyme
Heart
Hindbrain
Leg Mesenchyme
Mesonephros
Midbrain
Nasal Placode/Nerve
Pharyngeal Arches and Clefts
Sclerotome
Sinus Venosus
Somatic Mesoderm
Spinal Cord
Spinal Ganglia and Nerves
Wing Mesenchyme
 

Entry 2

GEISHA IdTNAP.MacRae.2010Data SourcePublication
Complete cDNA Template Probeshow
CTCCCATCCATTTCCCAAGAGGAGCTTTGAAGGGGCACAATGAAGGCTTTCCTCCTCACCCTCCTGGCCCAACTCTGCT
CGGCATCGCTGGTCCCCGAGAGGGAGAAGGACCCCGAATACTGGAGGCAGCAGGCGCAGGAGACGCTGCGGGATGCACT
GCGGCTGCAGCACCTCAACCAGAATGTGGCCAAGAACCTCATCCTCTTCCTGGGCGACGGTATGGGCGTCTCCACTGTG
ACGGCCGCGCGCATCCTCAAGGGTCAGCTGCAGCACCGCAAGGGCGAGGAGAGCCTGCTGGAGATGGACAAGTTCCCAT
ACGTTGCCCTGGCCAAGACCTACAACACCAACGCACAGGTGCCCGACAGCGCGGGCACAGCCACTGCTTACCTCTGCGG
CGTCAAAGCCAACGAGGGGACAGTGGGAGTCAGCGCCGGTGTCACCCGTGACCGCTGCAACACCACCAAGGGCCAGGAG
GTGACCTCCATCCTCCGCTGGGCTAAGGATGAAGGCAAGGCGGTGGGCATTGTCACCACCACGCGGGTGACCCACGCGA
CACCCAGCGCTGCCTACGCGCACTCAGCCAACCGTGACTGGTACTCAGATGGAGAGATGCCCCTGGATGCACTGGAGGG
CGGCTGCAAAGACATCGCCCGGCAGCTGGTGGAGAACATCCCTGACATCGAGGTGATCCTGGGGGGTGGGCGCAAGTAC
ATGTTCCCCAAGAACACCAGCGATGTGGAGTACCCGCAGGAGGAGCGGCACCGCGGCACCCGCCTGGACGGCAAGGACC
TGGTGCAGGCGTGGCACGACACTAAGCCTGCGGGGAAGGTCGCCAAGTACGTGTGGCACCGGAGGGAGCTGCTGGCGCT
GAACGTCAGCCGTGTGGACTTCCTGCTGGGTCTCTTTGAGCCGGGGGATATGGTGTATGAGCTGGACAGGAACAACGAG
ACCGACCCGTCGCTCAGCGAGATGGTGGCTGTGGCTATAAGGATGCTGCAGAAAAACCCACGGGGCTTCTTCCTGCTGG
TGGAAGGTGGGGGGGCCAGGTGGTGCAGGGGGGTGCCGAGGGGCATGAGGAAGTGA
CitationMacrae VE, Davey MG, McTeir L, Narisawa S, Yadav MC, Millan JL, Farquharson C. Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick. Bone. 2010 Apr;46(4):1146-55.
Copyright© 2009 Elsevier Inc.
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # XM_423297).
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
19-24
stage 23
stage 23
Widespread Expression
 
25-30
stage 26
Leg
 
31-36
stage 31
stage 31
stage 35
stage 35
stage 36
stage 36
stage 36
Leg Bones
Wing Bones
MT=metatarsals
R=Radius
R=radius
U=Ulna
U=ulna
arrow = metacarpal
asterisk denotes clavicle
femur
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.760

Mouse

EmageMGI:87983
EurexpressMGI:87983
MGI GXDMGI:87983

Frog

Xenbase1010300

Fruit Fly

BDGPFBgn0043791

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-040420-1
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